{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:16:28Z","timestamp":1768770988394,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2016VBA074"],"award-info":[{"award-number":["2016VBA074"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ecoenv.2018.07.008","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T11:45:40Z","timestamp":1531309540000},"page":"218-224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Environmental toxicants impair liver and kidney function and sperm quality of captive pandas"],"prefix":"10.1016","volume":"162","author":[{"given":"Yi-ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Maltby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M.","family":"Ellison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2018.07.008_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/kfl055","article-title":"The 2005 World health organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds","volume":"93","author":"Berg","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.envpol.2012.11.028","article-title":"Breeding performance of blue tits (Cyanistes cauleus ultramarines) in relation to lead pollution and nest failure rates in rural, intermediate, and urban sites in Algeria","volume":"174","author":"Brahmia","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib3","unstructured":"Centers for Disease Control, 1991. Preventing lead poisoning in young children: a statement by the centers for disease control, October. (U.S. Department of Health and Human Services, 1991)."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib4","series-title":"How to Analyse the Physical Examination Report","first-page":"140","author":"Chen","year":"2006"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/fee.1310","article-title":"Captive pandas are at risk from environmental toxins","volume":"14","author":"Chen","year":"2016","journal-title":"Front. Ecol. Environ."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/eap.1494","article-title":"Atmospheric deposition exposes pandas to toxic pollutants","volume":"27","author":"Chen","year":"2017","journal-title":"Ecol. Appl."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.envpol.2015.08.045","article-title":"Occurrence, bioaccumulation and risk assessment of dioxin-like PCBs along the Chenab River, Pakistan","volume":"206","author":"Eqani","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0300-483X(02)00589-9","article-title":"Placental lead and outcome of pregnancy","volume":"185","author":"Falc\u00f3n","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.scitotenv.2015.07.162","article-title":"Levels and predictors of persistent organic pollutants in an adult population from four Spanish regions","volume":"538","author":"Fernandez-Rodriguez","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib10","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0093-691X(00)00458-1","article-title":"Sperm factors related to in vitro penetration of porcine oocytes","volume":"54","author":"Gades","year":"2000","journal-title":"Theriogenology"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib11","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.envpol.2007.07.001","article-title":"Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus)","volume":"152","author":"Gebbink","year":"2008","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.ecoenv.2018.07.008_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.envres.2015.02.011","article-title":"Hydroxylated polychlorinated biphenyls decrease circulating steroids in female polar bears (Ursus maritimus)","volume":"138","author":"Gustavson","year":"2015","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2018.07.008_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00420-010-0542-2","article-title":"Cadmium, chromium, lead, manganese and nickel concentrations in blood of women in non-polluted areas in Japan, as determined by inductively coupled plasma-sector field-mass spectrometry","volume":"84","author":"Ikeda","year":"2011","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/bmj.38050.593634.63","article-title":"Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study","volume":"328","author":"Kim","year":"2004","journal-title":"Br. Med. J."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.chemosphere.2012.02.053","article-title":"Lactational transfer of mercury and polychlorinated biphenyls in polar bears","volume":"88","author":"Knott","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s11434-008-0125-8","article-title":"Concentrations, profiles and gas-particle partitioning of PCDD\/Fs, PCBs and PBDEs in the ambient air of an E-waste dismantling area","volume":"53","author":"Li","year":"2008","journal-title":"Southeast China Chin. Sci. Bull."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.aca.2005.10.001","article-title":"Separation of polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and dibenzo-furans in environmental samples using silica gel and florisil fractionation chromatography","volume":"557","author":"Liu","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.envpol.2007.06.051","article-title":"Global fate of POPs: current and future research directions","volume":"150","author":"Lohmann","year":"2007","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib19","first-page":"377","article-title":"Hematologic and serum biochemical values for healthy captive giant pandas (Ailuropoda melanoleuca) at the Wolong reserve,\u00a0Sichuan, China","volume":"26","author":"Mainka","year":"1995","journal-title":"J. Zoo. Wildl. Med."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1039\/c2tx20064c","article-title":"Mechanisms of lead and manganese neurotoxicity","volume":"2","author":"Neal","year":"2013","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1357-2725(97)00109-X","article-title":"Heme oxygenase induction by UVA radiation. A response to oxidative stress in rat liver","volume":"30","author":"Ossola","year":"1998","journal-title":"Int. J. Biochem. Cell Boil."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib22","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S1590-8658(00)80850-6","article-title":"Hepatitis C virus carriers with persistently normal aminotransferase levels: healthy people or true patients?","volume":"32","author":"Puoti","year":"2000","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/nature.2013.12776","article-title":"Organic pollutants poison the roof of the world","author":"Qiu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib24","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jwmg.277","article-title":"Lead exposure in large carnivores in the Greater Yellowstone Ecosystem","volume":"76","author":"Rogers","year":"2012","journal-title":"J. Wildl. Manag."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib25","series-title":"The 4th National Survey Report on Giant Panda in China","author":"SFA (State Forestry Administration)","year":"2015"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.envpol.2013.08.026","article-title":"PCDD\/F and dioxin-like PCB bioaccumulation by Manila clam from polluted areas of Venice lagoon (Italy)","volume":"184","author":"Sfriso","year":"2014","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.ecoenv.2018.07.008_bib27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.chemosphere.2010.03.012","article-title":"Distribution of PCDD\/Fs, PCBs, PBDEs and organochlorine residues in children's blood from Zhejiang, China","volume":"80","author":"Shen","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib28","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirum is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.scitotenv.2015.07.018","article-title":"An assessment of health risks associated with arsenic exposure via consumption of homegrown vegetables near contaminated glassworks sites","volume":"536","author":"Uddh-S\u00f6derberg","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib30","first-page":"128","article-title":"The value of HBDH and LDH in clinic diagnoses of myocardial and liver damage","volume":"22","author":"Wang","year":"2006","journal-title":"Clin. Med. China"},{"key":"10.1016\/j.ecoenv.2018.07.008_bib31","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1289\/ehp.011091011","article-title":"Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of Northeastern Taiwan","volume":"109","author":"Wu","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2018.07.008_bib32","series-title":"Giant Panda Ex-situ Conservation: Theory and Practice","author":"Zhang","year":"2006"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651318305992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651318305992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:47:33Z","timestamp":1758948453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651318305992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":32,"alternative-id":["S0147651318305992"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.07.008","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental toxicants impair liver and kidney function and sperm quality of captive pandas","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}