{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:13:51Z","timestamp":1773274431482,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ecoenv.2018.09.002","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T10:00:15Z","timestamp":1536228015000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Mutagenicity assessment of environmental contaminations in a hospital centralized reconstitution unit"],"prefix":"10.1016","volume":"165","author":[{"given":"T.","family":"Chouquet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-7374","authenticated-orcid":false,"given":"A.","family":"Acramel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sauvageon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pl\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Jourdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Madelaine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Faure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mourah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9741-803X","authenticated-orcid":false,"given":"L.","family":"Goldwirt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2018.09.002_bib1","unstructured":"American Society of Clinical Oncology, 2018. ASCO Pratice & Guidelines. In: ASCO. \u3008https:\/\/www.asco.org\/practice-guidelines\/quality-guidelines\/guidelines\u3009."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/15459624.2014.949725","article-title":"Multicenter study of environmental contamination with antineoplastic drugs in 36 Canadian hospitals: a 2013 follow-up study","volume":"12","author":"Berruyer","year":"2015","journal-title":"J. Occup. Environ. Hyg."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib3","first-page":"37","article-title":"Dosage urinaire de m\u00e9dicaments dangereux: \u00e9tat des lieux, enjeux et perspectives","author":"Berruyer","year":"2013","journal-title":"Bull. d\u2032information Toxicol."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/jat\/bkt045","article-title":"A new, validated wipe-sampling procedure coupled to LC-MS analysis for the simultaneous determination of 5-Fluorouracil, doxorubicin and cyclophosphamide in surface contamination","author":"Bobin-Dubigeon","year":"2013","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4212\/cjhp.v65i6.1190","article-title":"Environmental contamination with hazardous drugs in quebec hospitals","volume":"65","author":"Bussi\u00e8res","year":"2012","journal-title":"Can. J. Hosp. Pharm."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mrgentox.2005.07.008","article-title":"Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees","volume":"587","author":"Cavallo","year":"2005","journal-title":"Mutat. Res"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib7","series-title":"General and molecular pharmacology: principles of drug action","author":"Clementi","year":"2015"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib8","first-page":"1","article-title":"Surface wipe sampling for antineoplastic (Chemotherapy) and other Hazardous Drug Residue in Healthcare Settings: methodology and recommendations","author":"Connor","year":"2016","journal-title":"J. Occup. Environ. Hyg."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib9","first-page":"619","article-title":"Environmental contamination with cytotoxic drugs in healthcare using positive air pressure isolators","volume":"49","author":"Crauste-Manciet","year":"2005","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib10","unstructured":"Department of Health and Human Services, 2014. NIOSH Alert: Preventing Occupational Exposures to Antineoplastic and other Hazardous Drugs in Healthcare Settings. No 2004-165 2004."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib11","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.3747\/co.22.2151","article-title":"Safe handling of cytotoxics: guideline recommendations","volume":"22","author":"Easty","year":"2015","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib12","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0140-6736(79)91939-1","article-title":"Mutagenicity in urine of nurses handling cytostatic drugs","volume":"1","author":"Falck","year":"1979","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mrgentox.2008.08.022","article-title":"Genotoxic effects of wastewater from an oncological ward","volume":"672","author":"Ferk","year":"2009","journal-title":"Mutat. Res"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib14","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/ejhpharm-2014-000549","article-title":"Evaluation of chemical contamination of surfaces during the preparation of chemotherapies in 24 hospital pharmacies","volume":"22","author":"Fleury-Souverain","year":"2015","journal-title":"Eur. J. Hosp. Pharm."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib15","first-page":"237","article-title":"Occupational dermal exposure to cyclophosphamide in Dutch hospitals: a pilot study","volume":"48","author":"Fransman","year":"2004","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5271\/sjweh.1433","article-title":"Cancer morbidity among Danish female pharmacy technicians","volume":"20","author":"Hansen","year":"1994","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib17","series-title":"Some antiviral and antineoplastic drugs, and other pharmaceutical agents. Evaluation of Carcinogenic Risks to Humans","author":"International Agency for Research on Cancer","year":"2000"},{"issue":"Suppl","key":"10.1016\/j.ecoenv.2018.09.002_bib18","first-page":"1","article-title":"ISOPP standards of practice","volume":"13","author":"International Society of Oncology Pharmacy Practicioners Standards Committee","year":"2007","journal-title":"Safe Handl. cytotoxics. J. Oncol. Pharm. Pract. Publ. Int Soc. Oncol. Pharm. Pract."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib19","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.1007\/s00216-015-8868-y","article-title":"A surface wipe sampling and LC-MS\/MS method for the simultaneous detection of six antineoplastic drugs commonly handled by healthcare workers","volume":"407","author":"Jeronimo","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib20","first-page":"331","article-title":"Vapour pressures, evaporation behaviour and airborne concentrations of hazardous drugs: implications for occupational safety","volume":"268","author":"Kiffmeyer","year":"2002","journal-title":"Pharm. J."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1201\/b18042-37","article-title":"Genotoxic assessment in different exposure groups working with antineoplastic agents","author":"Ladeira","year":"2015","journal-title":"Occup. Saf. Hyg. III"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib22","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1073\/pnas.79.23.7445","article-title":"A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens","volume":"79","author":"Levin","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib23","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1248\/yakushi.130.903","article-title":"Evaluation of environmental contaminations and occupational exposures involved in preparation of chemotherapeutic drugs","volume":"130","author":"Maeda","year":"2010","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib24","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1073\/pnas.72.3.979","article-title":"Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids","volume":"72","author":"McCann","year":"1975","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00420-013-0862-0","article-title":"Multicenter study of environmental contamination with antineoplastic drugs in 33 Canadian hospitals","volume":"87","author":"Merger","year":"2014","journal-title":"Int Arch. Occup. Environ. Health"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00420-014-0993-y","article-title":"Micronuclei and chromosome aberrations in subjects occupationally exposed to antineoplastic drugs: a multicentric approach","volume":"88","author":"Moretti","year":"2015","journal-title":"Int Arch. Occup. Environ. Health"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib27","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00216-011-5157-2","article-title":"Wipe sampling procedure coupled to LC\u2013MS\/MS analysis for the simultaneous determination of 10 cytotoxic drugs on different surfaces","volume":"402","author":"Nussbaumer","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib28","unstructured":"Organisation for Economic Co-operation and Development, 1997. OECD Guideline 471. \u3008https:\/\/www.oecd.org\/chemicalsafety\/risk-assessment\/1948418.pdf\u3009."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib29","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/ajhp\/53.14.1669","article-title":"Controlling occupational exposure to hazardous drugs. Occupational safety and health administration","volume":"53","author":"OSHA","year":"1996","journal-title":"Am. J. Health-Syst. Pharm. AJHP J. Am. Soc. Health-Syst. Pharm."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib30","first-page":"368","article-title":"Biological monitoring of nurses exposed to doxorubicin and epirubicin by a validated liquid chromatography\/fluorescence detection method","volume":"54","author":"Pieri","year":"2010","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00381017","article-title":"Handling of cytostatic drugs and urine mutagenesis","volume":"61","author":"Poyen","year":"1988","journal-title":"Int Arch. Occup. Environ. Health"},{"key":"10.1016\/j.ecoenv.2018.09.002_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/1078155210389215","article-title":"Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment","volume":"18","author":"Pretty","year":"2012","journal-title":"J. Oncol. Pharm. Pract."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib33","first-page":"285","article-title":"Patterns of dermal exposure to hazardous substances in European union workplaces","volume":"48","author":"Rajan-Sithamparanadarajah","year":"2004","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib34","first-page":"394","article-title":"Biological monitoring of occupational exposure to antineoplastic drugs in hospital settings","volume":"103","author":"Sabatini","year":"2012","journal-title":"Med Lav."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib35","first-page":"703","article-title":"Guidance values for surface monitoring of antineoplastic drugs in german pharmacies","volume":"53","author":"Schierl","year":"2009","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib36","first-page":"3","article-title":"Environmental contamination with cytostatic drugs: past, present, future","author":"Sessink","year":"2011","journal-title":"Saf. Consid. Oncol. Pharm."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib37","unstructured":"Sessink P.J., Sewell G.J., Vandenbroucke J., 2016. Preventing occupational exposure to cytotoxic and other hazardous drugs: European Policy Recommendations."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib38","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/rcm.2960","article-title":"Simultaneous determination of gemcitabine, taxol, cyclophosphamide and ifosfamide in wipe samples by high-performance liquid chromatography\/tandem mass spectrometry: protocol of validation and uncertainty of measurement","volume":"21","author":"Sottani","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.ecoenv.2018.09.002_bib39","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/mutage\/geq102","article-title":"Assessment of primary, oxidative and excision repaired DNA damage in hospital personnel handling antineoplastic drugs","volume":"26","author":"Villarini","year":"2011","journal-title":"Mutagenesis"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651318308522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651318308522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T22:45:54Z","timestamp":1751841954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651318308522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":39,"alternative-id":["S0147651318308522"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.09.002","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutagenicity assessment of environmental contaminations in a hospital centralized reconstitution unit","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}