{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:51:41Z","timestamp":1769817101425,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"MOST","doi-asserted-by":"publisher","award":["105-2320-B-039-037-MY3"],"award-info":[{"award-number":["105-2320-B-039-037-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ecoenv.2018.10.111","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T05:03:58Z","timestamp":1541480638000},"page":"18-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Is frying oil a dietary source of an endocrine disruptor? Anti-estrogenic effects of polar compounds from frying oil in rats"],"prefix":"10.1016","volume":"169","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1827-4731","authenticated-orcid":false,"given":"Yu-Shun","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shui-Yuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Fen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Tsung","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Min","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2018.10.111_bib1","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1073\/pnas.96.6.3287","article-title":"Insulin-like growth factor 1 is required for G2 progression in the estradiol-induced mitotic cycle","volume":"96","author":"Adesanya","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2018.10.111_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.toxlet.2014.01.030","article-title":"The estrogenic effects of apigenin, phloretin and myricetin based on uterotrophic assay inimmature Wistar albino rats","volume":"226","author":"Barlas","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0891-5849(01)00574-3","article-title":"Tocopherols are metabolized in HepG2 cells by side chain \u03b2-oxidation and consecutive \u03c9-oxidation","volume":"31","author":"Birringer","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/toxsci\/kfu064","article-title":"Benzo[a]pyrene effects on reproductive endpoints in Fundulus heteroclitus","volume":"140","author":"Booc","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib5","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1073\/pnas.1136688100","article-title":"The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription","volume":"100","author":"Brunnberg","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2018.10.111_bib6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/bj3260149","article-title":"Phosphorylation of serine-167 on the human oestrogen receptor is important for oestrogen response element binding and transcriptional activation","volume":"326","author":"Castano","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib7","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1093\/jn\/131.12.3166","article-title":"Oxidized frying oil up-regulates hepatic acyl-CoA oxidase and cyptochrome P450 4A1 genes in rats and activates PPAR\u03b1","volume":"131","author":"Chao","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib8","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/jcb.20257","article-title":"Egr-1 is activated by 17\u03b2-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1","volume":"93","author":"Chen","year":"2004","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib9","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1210\/me.2004-0274","article-title":"Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase-->AKT-->GSK-3beta-->cyclin D1-->pRB pathway to block uterine epithelial cell proliferation","volume":"19","author":"Chen","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jsbmb.2013.09.010","article-title":"Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells","volume":"139","author":"Clark","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib11","doi-asserted-by":"crossref","first-page":"12626","DOI":"10.1073\/pnas.93.22.12626","article-title":"Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor","volume":"93","author":"Curtis","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2018.10.111_bib12","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1289\/ehp.97105294","article-title":"Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins","volume":"105","author":"Danzo","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib13","doi-asserted-by":"crossref","first-page":"e0152989","DOI":"10.1371\/journal.pone.0152989","article-title":"In vivo performance and properties of tamoxifen metabolites for CreERT2 Control","volume":"11","author":"Felker","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2018.10.111_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1677\/joe.0.1690023","article-title":"Proliferation, mitosis orientation and morphogenetic changes in the uterus of mice following chronic treatment with both estrogen and glucocorticoid hormones","volume":"169","author":"Gunin","year":"2001","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1677\/joe.0.1820229","article-title":"Effects of peroxisome proliferator activated receptors-alpha and \u2013gamma agonists on estradiol-induced proliferation and hyperplasia formation in the mouse uterus","volume":"182","author":"Gunin","year":"2004","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib16","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1289\/ehp.0900758","article-title":"A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants","volume":"117","author":"Guyton","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.molmed.2009.04.002","article-title":"Epithelial metaplasia: adult stem cell reprogramming and (pre)neoplastic transformation mediated by inflammation?","volume":"15","author":"Herfs","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib18","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1210\/me.2004-0142","article-title":"Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism","volume":"19","author":"Hewitt","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1530\/JME-15-0254","article-title":"What's new in estrogen receptor action in the female reproductive tract","volume":"56","author":"Hewitt","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib20","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/BF02542385","article-title":"Effects of deteriorated frying oil and dietary protein levels on liver microsomal enzymes in rats","volume":"65","author":"Huang","year":"1988","journal-title":"J. Am. Oil Chem. Soc."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jnutbio.2014.01.005","article-title":"Oxidized frying oil and its polar fraction fed to pregnant mice are teratogenic and alter mRNA expressions of vitamin A metabolism genes in the liver of dams and their fetuses","volume":"25","author":"Huang","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/bbrc.2000.3891","article-title":"17 beta-estradiol inhibits tumor necrosis factor-alpha-induced nuclear factor-kappa B activation by increasing nuclear factor-kappa B p105 level in MCF-7 breast cancer cells","volume":"279","author":"Hsu","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib23","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3346\/jkms.2011.26.5.647","article-title":"CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer","volume":"26","author":"Kang","year":"2011","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib24","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.270.5241.1491","article-title":"Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase","volume":"270","author":"Kato","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2018.10.111_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1677\/ERC-08-0117","article-title":"Autocrine stimulation of IGF1 in estrogen-induced growth of endometrial carcinoma cells: involvement of the mitogen-activated protein kinase pathway followed by up-regulation of cyclin D1 and cyclin E","volume":"16","author":"Kashima","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ecoenv.2018.10.111_bib26","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1210\/en.2006-1394","article-title":"Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase\/Akt pathway","volume":"148","author":"Kazi","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2018.10.111_bib27","first-page":"794","article-title":"Signaling cross-talk between peroxisome proliferator-activated receptor\/retinoid X receptor and estrogen receptor through estrogen response elements","volume":"9","author":"Keller","year":"1995","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib28","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1074\/jbc.M109592200","article-title":"Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1\/estrogen receptor cross-talk","volume":"277","author":"Klotz","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5625\/lar.2012.28.2.71","article-title":"Functions and physiological roles of two types of estrogen receptors, ER\u03b1 and ER\u03b2, identified by estrogen receptor knockout mouse","volume":"28","author":"Lee","year":"2012","journal-title":"Lab. Anim. Res."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib30","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/jcp.21061","article-title":"IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells","volume":"212","author":"Lin","year":"2007","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib31","first-page":"1","article-title":"Teratogenic effects of polar compounds in oxidized frying oil","volume":"4","author":"Lin","year":"2016","journal-title":"Med. Res. Arch."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib32","article-title":"Peroxisome proliferator-activated receptor \u03b1 activation is not the main contributor to teratogenesis elicited by polar compounds from oxidized frying oil","volume":"18","author":"Lin","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib33","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1093\/jn\/126.9.2227","article-title":"Dietary oxidized frying oil enhances tissue -tocopherol depletion and radioisotope tracer excretion in vitamin E-deficient rats","volume":"126","author":"Liu","year":"1996","journal-title":"J. Nutr."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib34","first-page":"1437","article-title":"Selective estrogen receptor modulators: tissue specificity and clinical utility","volume":"9","author":"Martinkovich","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.ecoenv.2018.10.111_bib35","unstructured":"Moreira, R.G., Castell-Perez, M.E., Barrufet, M.A., 1991. Fried product processing and characteristics. In: Deep-Fat Frying: Fundamentals and Applications. Gaithersburg, Md.: Chapman & Hall Food Science Book. pp. 11\u201331."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib36","unstructured":"OPPTS, 2011. OPPTS 890.1600: Uterotrophic Assay, 2011, Endocrine DistruptorScreening Program Test Guidelines. EPA 740-C-09-0010."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib37","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.aquatox.2005.12.009","article-title":"Effects of benzo(a)pyrene exposure on killifish (Fundulus heteroclitus) aromatase activities and mRNA","volume":"77","author":"Patel","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4315\/0362-028X-69.1.199","article-title":"Polycyclic aromatic hydrocarbons in frying oils and snacks","volume":"69","author":"Purcaro","year":"2006","journal-title":"J. Food Prot."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib39","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J. Nutr."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib40","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1210\/me.2007-0128","article-title":"The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin","volume":"22","author":"R\u00fcegg","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib41","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/CEJ.0000000000000052","article-title":"The effect of estrogen on the proliferation of endometrial cancer cells is mediated by ERR\u03b3 through AKT and ERK1\/2","volume":"23","author":"Sun","year":"2014","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JME-08-0132","article-title":"Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders","volume":"43","author":"Swedenborg","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib43","first-page":"265","article-title":"Dietary oxidized frying oil decreased plasma and liver vitamin A in rats","volume":"23","author":"Tang","year":"1998","journal-title":"Nutr. Sci. J."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/bbrc.1996.1764","article-title":"The anti-estrogenic activity of selected polynuclear aromatic hydrocarbons in yeast expressing human estrogen receptor","volume":"229","author":"Tran","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib45","unstructured":"UPAC Standard Method 2.507, 1987. Determination of polar compounds in frying fats. In: Standard Methods for the Analysis of Oils, Fats and Derivatives. 7th ed. Oxford: International Union of Pure and Applied Chemistry, Blackwell."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib46","first-page":"488","article-title":"Molecular mechanisms of NF-\u03baB signaling pathway in the development and progression of esophageal carcinoma","volume":"11","author":"Yang","year":"2018","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/rmb2.12006","article-title":"Molecular mechanism of estrogen\u2013estrogen receptor signaling","volume":"16","author":"Ya\u015far","year":"2016","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.ecoenv.2018.10.111_bib48","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1097\/IGC.0b013e3182216ac9","article-title":"Crosstalk between estrogen receptor and mitogen-activated protein kinase signaling in the development and progression of endometrial cancer","volume":"21","author":"Zhou","year":"2011","journal-title":"Int. J. Gynecol. Cancer"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765131831131X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765131831131X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T03:26:55Z","timestamp":1545881215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765131831131X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":48,"alternative-id":["S014765131831131X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.10.111","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is frying oil a dietary source of an endocrine disruptor? Anti-estrogenic effects of polar compounds from frying oil in rats","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.10.111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}