{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:42:27Z","timestamp":1792428147867,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2017485"],"award-info":[{"award-number":["2017485"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11575233"],"award-info":[{"award-number":["11575233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ecoenv.2018.12.002","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T02:43:48Z","timestamp":1544409828000},"page":"324-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["A potential involvement of plant systemic response in initiating genotoxicity of Ag-nanoparticles in Arabidopsis thaliana"],"prefix":"10.1016","volume":"170","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2018.12.002_bib1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.talanta.2014.08.050","article-title":"Nanoparticles applied to plant science: a review","volume":"131","author":"Arruda","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib2","first-page":"873","article-title":"DNA double-strand break repair by homologous recombination","volume":"383","author":"van den Bosch","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fpls.2016.00032","article-title":"Characterization of silver nanoparticles internalized by Arabidopsis plants using single particle ICP-MS analysis","volume":"7","author":"Bao","year":"2016","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.coche.2013.11.006","article-title":"Metal ions in the context of nanoparticles toward biological applications","volume":"4","author":"Carrillo-Carrion","year":"2014","journal-title":"Curr. Opin. Chem. Eng."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib5","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.3390\/ma5122850","article-title":"The toxic effects and mechanisms of CuO and ZnO nanoparticles","volume":"5","author":"Chang","year":"2012","journal-title":"Materials"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2229-9-45","article-title":"Nanoparticle penetration and transport in living pumpkin plants: in situ subcellular identification","volume":"9","author":"Corredor","year":"2009","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.arplant.51.1.167","article-title":"Trans)gene silencing in plants: How many mechanisms?","volume":"51","author":"Fargard","year":"2000","journal-title":"Annu. Rev. Plant Physiol. Plant Mol. Biol."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-313X.2004.02025.x","article-title":"Systemic plant signal triggers genome instability","volume":"38","author":"Filkowski","year":"2004","journal-title":"Plant J."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fpls.2015.00228","article-title":"Signal regulators of systemic acquired resistance","volume":"6","author":"Gao","year":"2015","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3109\/17435390.2012.658094","article-title":"Phytotoxicity, accumulation and transport of silver nanoparticles by Arabidopsis thaliana","volume":"7","author":"Geisler-Lee","year":"2013","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib11","first-page":"56","article-title":"Systemic acquired resistance","volume":"4","author":"Ghanbari","year":"2015","journal-title":"J. New Biol. Rep."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib12","doi-asserted-by":"crossref","first-page":"9216","DOI":"10.1021\/es9015553","article-title":"Modeled environmental concentrations of engineered nanomaterials (TiO2, ZnO, Ag, CNT, fullerenes) for different regions","volume":"43","author":"Gottschalk","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib13","doi-asserted-by":"crossref","first-page":"562","DOI":"10.4161\/epi.5.7.12518","article-title":"Epigenetic silencing of endogenous repetitive sequences by MORPHEUS\u2019 MOLECULE1 in Arabidopsis thaliana","volume":"5","author":"Habu","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib14","series-title":"Arabidopsis: A Laboratory Manual","first-page":"249","article-title":"Quantitative GUS activity assay","author":"Kirsten Bomblies","year":"2002"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib15","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nature01683","article-title":"Pathogen induced systemic plant signal triggers DNA rearrangements","volume":"423","author":"Kovalchuk","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib16","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1021\/nl903518f","article-title":"Uptake and distribution of ultrasmall anatase TiO2 alizarin red S nanoconjugates in Arabidopsis thaliana","volume":"10","author":"Kurepa","year":"2010","journal-title":"Nano Lett."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/mp\/ssq014","article-title":"Transgenerational inheritance and resetting of stress-induced loss of epigenetic gene silencing in Arabidopsis","volume":"3","author":"Lang-Mladek","year":"2010","journal-title":"Mol. Plant"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mrgentox.2010.04.009","article-title":"Genotoxicity\/mutagenicity of formaldehyde revealed by the Arabidopsis thaliana plants transgenic for homologous recombination substrates","volume":"699","author":"Li","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1667\/RR2052.1","article-title":"The induction of bystander mutagenic effects in vivo by \u03b1-irradiation in whole Arabidopsis thaliana plants","volume":"174","author":"Li","year":"2010","journal-title":"Radiat. Res."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib20","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1021\/es800422x","article-title":"Root uptake and phytotoxicity of ZnO nanoparticles","volume":"42","author":"Lin","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib21","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1126\/science.250.4983.1002","article-title":"Salicylic acid: a likely endogenous signal in the resistance response of tobacco to viral infection","volume":"250","author":"Malamy","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3184\/003685012X13294715456431","article-title":"Common nano-materials and their use in real world applications","volume":"95","author":"Mcintyre","year":"2012","journal-title":"Sci. Progress."},{"issue":"20","key":"10.1016\/j.ecoenv.2018.12.002_bib23","doi-asserted-by":"crossref","first-page":"7474","DOI":"10.1073\/pnas.1406611111","article-title":"Transcriptional gene silencing by Arabidopsis microrchidia homologues involves the formation of heteromers","volume":"111","author":"Moissiard","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib24","first-page":"235","article-title":"Dynamic response of plant genome to ultraviolet radiation and other genotoxic stresses","volume":"571","author":"Molinier","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib25","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-313X.2006.02927.x","article-title":"Isolation and characterization of the RAD54 gene from Arabidopsis","volume":"48","author":"Osakabe","year":"2006","journal-title":"Plant J."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.1147113","article-title":"Methyl salicylate is a critical mobile signal for plant systemic acquired resistance","volume":"318","author":"Park","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib27","doi-asserted-by":"crossref","first-page":"e5202","DOI":"10.1371\/journal.pone.0005202","article-title":"Transgenerational stress memory is not a general response in Arabidopsis","volume":"4","author":"Pecinka","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib28","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1105\/tpc.110.078493","article-title":"Epigenetic regulation of repetitive elements is attenuated by prolonged heat stress in Arabidopsis","volume":"22","author":"Pecinka","year":"2010","journal-title":"Plant Cell"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib29","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1007\/s11051-013-1630-5","article-title":"Effect of silver nanoparticle on concentration of silver element and growth indexes in cucumber (Cucumis sativus L. negeen)","volume":"15","author":"Shams","year":"2013","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib30","series-title":"Sustainable nanotechnology and the environment: Advances and Achievements","first-page":"165","article-title":"Stability and toxicity of silver nanoparticles in aquatic environment: a review","author":"Sharma","year":"2013"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ecoenv.2013.03.033","article-title":"Functional analyses of nanoparticle toxicity: a comparative study of the effects of TiO2 and Ag on tomatoes (Lycopersicon esculentum)","volume":"93","author":"Song","year":"2013","journal-title":"Ecotoxicol. Environ. Safe."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib32","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1101\/gad.295404","article-title":"BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis","volume":"18","author":"Takeda","year":"2004","journal-title":"Gene. Dev."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib33","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1021\/es4004334","article-title":"Phytostimulation of poplars and Arabidopsis exposed to silver nanoparticles and Ag+ at sublethal concentrations","volume":"47","author":"Wang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib34","first-page":"51","article-title":"Homologous recombination in Arabidopsis seeds along the track of energetic carbon ions","volume":"737","author":"Wang","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib35","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/17435390902725914","article-title":"Nano-silver\u2014a review of available data and knowledge gaps in human and environmental risk assessment","volume":"3","author":"Wijnhoven","year":"2009","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib36","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1667\/RR13909.1","article-title":"Radiation-induced bystander epigenetic effects demonstrated in Arabidopsis thaliana","volume":"183","author":"Xu","year":"2015","journal-title":"Radiat. Res."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib37","first-page":"56","article-title":"UV-C\u2013induced alleviation of transcriptional gene silencing through plant-plant communication: key roles of jasmonic acid and salicylic acid pathways","volume":"790","author":"Xu","year":"2016","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib38","series-title":"Nanotechnology and Plant Science: Nanoparticles and Their Impact on Plants","first-page":"77","article-title":"Interactions between engineered nanomaterials and plants: phytotoxicity, uptake, translocation, and biotransformation","author":"Zhang","year":"2015"},{"issue":"42","key":"10.1016\/j.ecoenv.2018.12.002_bib39","doi-asserted-by":"crossref","first-page":"18220","DOI":"10.1073\/pnas.1005225107","article-title":"Control of salicylic acid synthesis and systemic acquired resistance by two members of a plant-specific family of transcription factors","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2018.12.002_bib40","doi-asserted-by":"crossref","first-page":"11945","DOI":"10.1021\/jf404328e","article-title":"Influence of CeO2 and ZnO nanoparticles on cucumber physiological markers and bio-accumulation of Ce and Zn: a life cycle study","volume":"61","author":"Zhao","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib41","first-page":"260","article-title":"ZnO nanoparticle fate in soil and zinc bioaccumulation in corn plants (Zea mays) influenced by alginate","volume":"15","author":"Zhao","year":"2013","journal-title":"Environ. Sci. Proc. Imp."},{"key":"10.1016\/j.ecoenv.2018.12.002_bib42","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1039\/b805998e","article-title":"Uptake, translocation, and accumulation of manufactured iron oxide nanoparticles by pumpkin plants","volume":"10","author":"Zhu","year":"2008","journal-title":"J. Environ. Monit."}],"updated-by":[{"DOI":"10.1016\/j.ecoenv.2021.112560","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000}}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651318312892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651318312892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:13:25Z","timestamp":1792426405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651318312892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":42,"alternative-id":["S0147651318312892"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.12.002","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A potential involvement of plant systemic response in initiating genotoxicity of Ag-nanoparticles in Arabidopsis thaliana","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2018.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}