{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:34:06Z","timestamp":1774038846781,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFC1600305"],"award-info":[{"award-number":["2017YFC1600305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2016YFD0501304"],"award-info":[{"award-number":["2016YFD0501304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Innovation Team of Dairy Industry","award":["1051\u201325015022"],"award-info":[{"award-number":["1051\u201325015022"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ecoenv.2019.01.050","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T12:47:50Z","timestamp":1548247670000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Ca2+ protect zebrafish embryos from water acidification"],"prefix":"10.1016","volume":"172","author":[{"given":"Xiaoyong","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangyang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ecoenv.2019.01.050_bib1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1211\/jpp.59.9.0008","article-title":"Effect of tetracycline on pancreas and liver function of adult male albino rats","volume":"59","author":"Asha","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"issue":"8","key":"10.1016\/j.ecoenv.2019.01.050_bib2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0043-1354(77)90096-3","article-title":"The effects of depressed pH on flagfish reproduction, growth and survival","volume":"11","author":"Craig","year":"1977","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.01.050_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chemosphere.2012.04.010","article-title":"DNA damage and biochemical toxicity of antibiotics in soil on the earthworm Eisenia fetida","volume":"89","author":"Dong","year":"2012","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.ecoenv.2019.01.050_bib4","doi-asserted-by":"crossref","first-page":"R470","DOI":"10.1152\/ajpregu.00200.2006","article-title":"Visualization in zebrafish larvae of Na(+) uptake in mitochondria-rich cells whose differentiation is dependent on foxi3a. American Journal of physiology-regulatory","volume":"292","author":"Esaki","year":"2007","journal-title":"Integr. Comp. Physiol."},{"key":"10.1016\/j.ecoenv.2019.01.050_bib5","series-title":"Summary report on antimicrobials sold or distributed for use in food-producing animals","author":"FDA","year":"2013"},{"issue":"10","key":"10.1016\/j.ecoenv.2019.01.050_bib6","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1016\/j.watres.2010.02.030","article-title":"The present is the key to the past, but what does the future hold for the recovery of surface waters from acidification?","volume":"44","author":"Helliwell","year":"2010","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.ecoenv.2019.01.050_bib7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0147-6513(02)00128-8","article-title":"Fertilization and embryonic development of whitefish (Coregonus lavaretus lavaretus) in acidic low-ionic-strength water with aluminum","volume":"55","author":"Kein\u00e4nen","year":"2003","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2019.01.050_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"issue":"11","key":"10.1016\/j.ecoenv.2019.01.050_bib9","doi-asserted-by":"crossref","first-page":"115101","DOI":"10.1088\/0957-4484\/24\/11\/115101","article-title":"Silver nanoparticle toxicity in the embryonic zebrafish is governed by particle dispersion and ionic environment","volume":"24","author":"Kim","year":"2013","journal-title":"Nanotechnology"},{"issue":"13","key":"10.1016\/j.ecoenv.2019.01.050_bib10","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1016\/j.watres.2013.04.021","article-title":"Characterization of tetracycline resistant bacterial community in saline activated sludge using batch stress incubation with high-throughput sequencing analysis","volume":"47","author":"Li","year":"2013","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2019.01.050_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhazmat.2016.05.100","article-title":"Photolytic and photocatalytic degradation of tetracycline: effect of humic acid on degradation kinetics and mechanisms","volume":"318","author":"Li","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2019.01.050_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-213X-12-12","article-title":"Disruption of the folate pathway in zebrafish causes developmental defects","volume":"12","author":"Lee","year":"2012","journal-title":"BMC Dev. Biol."},{"issue":"10","key":"10.1016\/j.ecoenv.2019.01.050_bib13","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.celrep.2015.02.034","article-title":"Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: a Call for Caution in Biomedical Research","volume":"10","author":"Moullan","year":"2015","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.ecoenv.2019.01.050_bib14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00244-014-0101-z","article-title":"Acute effects of tetracycline exposure in the freshwater fish Gambusia holbrooki: antioxidant effects, neurotoxicity and histological alterations","volume":"68","author":"Nunes","year":"2015","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"15","key":"10.1016\/j.ecoenv.2019.01.050_bib15","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1073\/pnas.1416967112","article-title":"Experimental ocean acidification alters the allocation of metabolic energy","volume":"112","author":"Pan","year":"2015","journal-title":"Proc. Natl. Acad. Sci. Usa."},{"issue":"7","key":"10.1016\/j.ecoenv.2019.01.050_bib16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0045-6535(99)00442-7","article-title":"Sorption and mobility of metronidazole, olaquindox, oxytetracycline and tylosin in soil","volume":"40","author":"Rab\u00f8lle","year":"2000","journal-title":"Chemosphere"},{"issue":"13","key":"10.1016\/j.ecoenv.2019.01.050_bib17","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1021\/es3035329","article-title":"Tetracycline resistance gene maintenance under varying bacterial growth rate, substrate and oxygen availability, and tetracycline concentration","volume":"47","author":"Rysz","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ecoenv.2019.01.050_bib18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.reprotox.2011.06.121","article-title":"Zebrafish embryos as an alternative to animal experiments\u2014a commentary on the definition of the onset of protected life stages in animal welfare regulations","volume":"33","author":"Str\u00e4hle","year":"2011","journal-title":"Reprod. Toxicol."},{"issue":"7","key":"10.1016\/j.ecoenv.2019.01.050_bib19","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3109\/17435390.2011.604440","article-title":"Media ionic strength impacts embryonic responses to engineered nanoparticle exposure","volume":"6","author":"Truong","year":"2012","journal-title":"Nanotoxicology"},{"issue":"10","key":"10.1016\/j.ecoenv.2019.01.050_bib20","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/tox.21843","article-title":"Toxicity evaluation of \u03b2-diketone antibiotics on the development of embryo-larval zebrafish ( Danio rerio)","volume":"29","author":"Wang","year":"2014","journal-title":"Environ. Toxicol."},{"issue":"7","key":"10.1016\/j.ecoenv.2019.01.050_bib21","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrm1149","article-title":"Calcium signalling during embryonic development","volume":"4","author":"Webb","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2019.01.050_bib22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.toxrep.2015.03.015","article-title":"Comparative Metal Oxide Nanoparticle Toxicity Using Embryonic Zebrafish","volume":"2","author":"Wehmas","year":"2015","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.ecoenv.2019.01.050_bib23","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.chemosphere.2015.10.126","article-title":"Occurrence of 13 veterinary drugs in animal manure-amended soils in Eastern China","volume":"144","author":"Wei","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2019.01.050_bib24","series-title":"The Zebrafish Book: a guide for the laboratory use of zebrafish (BrachyDanio rerio)","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.ecoenv.2019.01.050_bib25","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.envpol.2016.03.054","article-title":"Occurrence and distribution of antibiotics, antibiotic resistance genes in the urban rivers in Beijing, China","volume":"213","author":"Xu","year":"2016","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.ecoenv.2019.01.050_bib26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s10646-015-1417-9","article-title":"Effects of tetracycline on developmental toxicity and molecular responses in zebrafish ( Danio rerio) embryos","volume":"24","author":"Zhang","year":"2015","journal-title":"Ecotoxicology"},{"issue":"2","key":"10.1016\/j.ecoenv.2019.01.050_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jat.2843","article-title":"Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish","volume":"34","author":"Zhu","year":"2014","journal-title":"J. Appl. Toxicol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319300582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319300582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:51:45Z","timestamp":1758948705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319300582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":27,"alternative-id":["S0147651319300582"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.01.050","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ca2+ protect zebrafish embryos from water acidification","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.01.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}