{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:13:28Z","timestamp":1790054008900,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21477119"],"award-info":[{"award-number":["21477119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"fundamental research funds for central public welfare research institutes of china","award":["2016YSKY-021"],"award-info":[{"award-number":["2016YSKY-021"]}]},{"name":"Kanazawa University","award":["17037"],"award-info":[{"award-number":["17037"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ecoenv.2019.04.049","type":"journal-article","created":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T18:05:45Z","timestamp":1556474745000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Genomic DNA methylation signatures in different tissues after ambient air particulate matter exposure"],"prefix":"10.1016","volume":"179","author":[{"given":"Zhigang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2019.04.049_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/MOP.0b013e32832925cc","article-title":"Epigenetics and environmental chemicals","volume":"21","author":"Baccarelli","year":"2009","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1164\/rccm.200807-1097OC","article-title":"Rapid DNA methylation changes after exposure to traffic particles","volume":"179","author":"Baccarelli","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4161\/epi.5.3.11377","article-title":"Repetitive element DNA methylation and circulating endothelial and inflammation markers in the va normative aging study","volume":"5","author":"Baccarelli","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000212","article-title":"DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments","volume":"2","author":"Bellavia","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4161\/epi.27584","article-title":"Air pollution and gene-specific methylation in the normative aging study: association, effect modification, and mediation analysis","volume":"9","author":"Bind","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1465-9921-11-99","article-title":"Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation","volume":"11","author":"Braber","year":"2010","journal-title":"Respir. Res."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib8","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1289\/ehp.1104439","article-title":"Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease","volume":"120","author":"Breton","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib9","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease an update to the scientific statement from the american heart association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib10","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.envres.2016.11.002","article-title":"Particulate matter exposure is associated with inflammatory gene methylation in obese subjects","volume":"152","author":"Cantone","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib11","doi-asserted-by":"crossref","first-page":"A340","DOI":"10.1289\/ehp.0900830","article-title":"Linking environmental particulate matter with genetic alterations","volume":"117","author":"Cetta","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/ana.24460","article-title":"Ambient air pollution and neurotoxicity on brain structure: evidence from women's health initiative memory study","volume":"78","author":"Chen","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib13","doi-asserted-by":"crossref","first-page":"11859","DOI":"10.1021\/acs.est.5b02527","article-title":"Fine particulate matter constituents, nitric oxide synthase DNA methylation and exhaled nitric oxide","volume":"49","author":"Chen","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib14","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.envint.2016.06.026","article-title":"DNA hypomethylation and its mediation in the effects of fine particulate air pollution on cardiovascular biomarkers: a randomized crossover trial","volume":"94","author":"Chen","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/em.21851","article-title":"Alterations of the lung methylome in allergic airway hyper-responsiveness","volume":"55","author":"Cheng","year":"2014","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib16","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1093\/nar\/18.13.3975","article-title":"CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2","volume":"18","author":"Comb","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/bdrc.20037","article-title":"DNA methylation in mammalian development and disease","volume":"75","author":"Dean","year":"2005","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mrgentox.2015.12.002","article-title":"Characteristics of DNA methylation changes induced by traffic-related air pollution","volume":"796","author":"Ding","year":"2016","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1749-6632.2003.tb05960.x","article-title":"Hypomethylation: one side of a larger picture","volume":"983","author":"Dunn","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.canlet.2008.02.026","article-title":"Oxidative stress, DNA methylation and carcinogenesis","volume":"266","author":"Franco","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cpcardiol.2015.01.003","article-title":"Air pollution and cardiovascular disease","volume":"40","author":"Franklin","year":"2015","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib21","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1289\/EHP124","article-title":"The association between ambient fine particulate air pollution and lung cancer incidence: results from the AHSMOG-2 study","volume":"125","author":"Gharibvand","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1139\/cjpp-2013-0014","article-title":"Cardiac structure\/function, protein expression, and DNA methylation are changed in adult female mice exposed to diethylstilbestrol in utero","volume":"91","author":"Haddad","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1440-1843.2012.02164.x","article-title":"Genomics and the respiratory effects of air pollution exposure","volume":"17","author":"Holloway","year":"2012","journal-title":"Respirology"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15010160","article-title":"Exposure to ambient air particles increases the risk of mental disorder: findings from a natural experiment in beijing","volume":"15","author":"Jia","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13072-017-0112-x","article-title":"Histone and DNA methylation control by h3 serine 10\/threonine 11 phosphorylation in the mouse zygote","volume":"10","author":"Lan","year":"2017","journal-title":"Epigenet. Chromatin"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1017\/S0029665114000081","article-title":"DNA methylation, ageing and the influence of early life nutrition","volume":"73","author":"Lillycrop","year":"2014","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib27","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/S0140-6736(12)61766-8","article-title":"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010","volume":"380","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/toxsci\/kfm290","article-title":"Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo","volume":"102","author":"Liu","year":"2008","journal-title":"Toxicol. Sci. : Off. J. Soc. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.chemosphere.2017.09.082","article-title":"The reproductive toxicology of male sd rats after pm2.5 exposure mediated by the stimulation of endoplasmic reticulum stress","volume":"189","author":"Liu","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1289\/ehp.1205284","article-title":"Long-term exposure to pm2.5 and incidence of acute myocardial infarction","volume":"121","author":"Madrigano","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases dnmt3a and dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib32","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s11892-015-0603-8","article-title":"Ambient air pollution: an emerging risk factor for diabetes mellitus","volume":"15","author":"Rao","year":"2015","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib33","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1164\/rccm.200507-1123OC","article-title":"Air pollution and markers of inflammation and coagulation in patients with coronary heart disease","volume":"173","author":"Ruckerl","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"232-239","key":"10.1016\/j.ecoenv.2019.04.049_bib34","first-page":"231","article-title":"Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children","volume":"129","author":"Salam","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph14010090","article-title":"Transcriptome profiling of the lungs reveals molecular clock genes expression changes after chronic exposure to ambient air particles","volume":"14","author":"Song","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-pharmtox-061008-103102","article-title":"Epigenetics, DNA methylation, and chromatin modifying drugs","volume":"49","author":"Szyf","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/35104508","article-title":"A histone h3 methyltransferase controls DNA methylation in neurospora crassa","volume":"414","author":"Tamaru","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1289\/ehp.11898","article-title":"Effects of particulate matter on genomic DNA methylation content and inos promoter methylation","volume":"117","author":"Tarantini","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib39","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.bbagen.2009.02.008","article-title":"Epigenetics and atherosclerosis","volume":"1790","author":"Turunen","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ecoenv.2019.04.049_bib40","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.envint.2016.07.001","article-title":"Personal exposure to fine particulate matter and blood pressure: a role of angiotensin converting enzyme and its DNA methylation","volume":"94","author":"Wang","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib41","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1096\/fj.201500142","article-title":"Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in beijing","volume":"30","author":"Wei","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib42","first-page":"104","article-title":"Long-term exposure to pm2.5 from automobile exhaust results in reproductive dysfunction in male rats","volume":"22","author":"Yan","year":"2016","journal-title":"Zhonghua Nan ke Xue Natl. J. Androl."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jn\/135.1.5","article-title":"Nutrition and aberrant DNA methylation patterns in atherosclerosis: more than just hyperhomocysteinemia?","volume":"135","author":"Zaina","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.ecoenv.2019.04.049_bib44","article-title":"DNA methylation signatures in peripheral blood strongly predict all-cause mortality","author":"Zhang","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319304828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319304828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:56:51Z","timestamp":1758949011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319304828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":44,"alternative-id":["S0147651319304828"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.04.049","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic DNA methylation signatures in different tissues after ambient air particulate matter exposure","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.04.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}