{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:45:12Z","timestamp":1792320312262,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Jilin Province Science and Technology Development Plan","award":["20190103078JH"],"award-info":[{"award-number":["20190103078JH"]}]},{"name":"Jilin Province Science and Technology Development Plan","award":["20160101112JC"],"award-info":[{"award-number":["20160101112JC"]}]},{"name":"Science and Technology Project of Jilin Provincial Education Department","award":["JJKH20190073KJ"],"award-info":[{"award-number":["JJKH20190073KJ"]}]},{"name":"Health Special Project of Jilin Provincial Finance Department","award":["sczsy201614"],"award-info":[{"award-number":["sczsy201614"]}]},{"name":"Health Special Project of Jilin Provincial Finance Department","award":["sczsy201716"],"award-info":[{"award-number":["sczsy201716"]}]},{"name":"Health Special Project of Jilin Provincial Finance Department","award":["2018scz034"],"award-info":[{"award-number":["2018scz034"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ecoenv.2019.06.017","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T23:23:59Z","timestamp":1560554639000},"page":"362-369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1\/PI3K\/Akt\/mTOR signaling pathway"],"prefix":"10.1016","volume":"181","author":[{"given":"Pu","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinggui","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2019.06.017_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.adolescence.2018.12.007","article-title":"Physiology of puberty in boys and girls and pathological disorders affecting its onset","volume":"71","author":"Alotaibi","year":"2019","journal-title":"J. Adolesc."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mce.2015.07.029","article-title":"Role of PI4K and PI3K-AKT in ERK1\/2 activation by GnRH in the pituitary gonadotropes","volume":"415","author":"Bar-Lev","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3109\/15376516.2016.1158894","article-title":"The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty","volume":"26","author":"Bulus","year":"2016","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib4","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/cen.12682","article-title":"The relationship between Insulin-like Growth Factor 1, sex steroids and timing of the pubertal growth spurt","volume":"82","author":"Cole","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.envint.2017.02.001","article-title":"Exposure of Portuguese children to the novel non-phthalate plasticizer di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH)","volume":"102","author":"Correia-Sa","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/0004-2730000003031","article-title":"Effects of endocrine disruptors in the development of the female reproductive tract","volume":"58","author":"Costa","year":"2014","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ecoenv.2018.10.025","article-title":"Neonatal and juvenile exposure to perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS): advance puberty onset and kisspeptin system disturbance in female rats","volume":"167","author":"Du","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.toxlet.2017.05.028","article-title":"Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERalpha, ERbeta, and AR","volume":"277","author":"Engel","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib9","doi-asserted-by":"crossref","first-page":"472","DOI":"10.5607\/en.2018.27.6.472","article-title":"Developmental exposure to di-(2-ethylhexyl) phthalate induces cerebellar granule cell apoptosis via the PI3K\/AKT signaling pathway","volume":"27","author":"Fu","year":"2018","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib10","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/etc.3689","article-title":"Chemical activity-based environmental risk analysis of the plasticizer di-ethylhexyl phthalate and its main metabolite mono-ethylhexyl phthalate","volume":"36","author":"Gobas","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/toxsci\/kfv317","article-title":"Acute exposure to di(2-ethylhexyl) phthalate in adulthood causes adverse reproductive outcomes later in life and accelerates reproductive aging in female mice","volume":"150","author":"Hannon","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib12","doi-asserted-by":"crossref","first-page":"13589","DOI":"10.1007\/s11356-018-1567-4","article-title":"Is there any association between phthalate exposure and precocious puberty in girls?","volume":"25","author":"Hashemipour","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib13","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nrendo.2016.70","article-title":"Control of puberty onset and fertility by gonadotropin-releasing hormone neurons","volume":"12","author":"Herbison","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib14","first-page":"e765","article-title":"[Hypertrichosis cubiti in a girl with precocious puberty: case report]","volume":"116","author":"Herrero-Morin","year":"2018","journal-title":"Arch. Argent. Pediatr."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/acer.13539","article-title":"Regulation of kisspeptin synthesis and release in the preoptic\/anterior hypothalamic region of prepubertal female rats: actions of IGF-1 and alcohol","volume":"42","author":"Hiney","year":"2018","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib16","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1007\/s12035-016-9898-y","article-title":"Bisphenol a represses dopaminergic neuron differentiation from human embryonic stem cells through downregulating the expression of insulin-like growth factor 1","volume":"54","author":"Huang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.envres.2016.11.014","article-title":"Does exposure to phthalates influence thyroid function and growth hormone homeostasis? The Taiwan Environmental Survey for Toxicants (TEST) 2013","volume":"153","author":"Huang","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.24953\/turkjped.2017.04.007","article-title":"Clinical and epidemiological characteristics of children with germ cell tumors: a single center experience in a developing country","volume":"59","author":"Incesoy-Ozdemir","year":"2017","journal-title":"Turk. J. Pediatr."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib19","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.envpol.2018.07.067","article-title":"Mechanistic toxicity of DEHP at environmentally relevant concentrations (ERCs) and ecological risk assessment in the Three Gorges Reservoir Area, China","volume":"242","author":"Junaid","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/09513590.2017.1423467","article-title":"The usefulness of circulating levels of leptin, kisspeptin, and neurokinin B in obese girls with precocious puberty","volume":"34","author":"Kang","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000491103","article-title":"Toward more targeted and cost-effective gonadotropin-releasing hormone analog treatment in girls with central precocious puberty","volume":"90","author":"Kaplowitz","year":"2018","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187922","article-title":"Pre-pubertal exposure with phthalates and bisphenol A and pubertal development","volume":"12","author":"Kasper-Sonnenberg","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib23","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0890-6238(02)00031-X","article-title":"NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate","volume":"16","author":"Kavlock","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib24","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.fertnstert.2017.01.015","article-title":"In vitro effects of phthalate esters in human myometrial and leiomyoma cells and increased urinary level of phthalate metabolite in women with uterine leiomyoma","volume":"107","author":"Kim","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib25","first-page":"590","article-title":"Disorders of puberty: an approach to diagnosis and management","volume":"96","author":"Klein","year":"2017","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/eurpub\/ckv153","article-title":"Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure","volume":"26","author":"Le Moal","year":"2016","journal-title":"Eur. J. Public Health"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s40618-017-0627-9","article-title":"The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP)","volume":"40","author":"Leka-Emiri","year":"2017","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib28","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1039\/C6FO01616B","article-title":"Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial","volume":"8","author":"Liu","year":"2017","journal-title":"Food Funct"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib29","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.envpol.2016.03.005","article-title":"Probabilistic assessment of risks of diethylhexyl phthalate (DEHP) in surface waters of China on reproduction of fish","volume":"213","author":"Liu","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13111130","article-title":"Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-uterus in pubertal female rats","volume":"13","author":"Liu","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib31","first-page":"848","article-title":"Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats","volume":"21","author":"Liu","year":"2018","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib32","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/toxsci\/kfl036","article-title":"Exposure of prepubertal female rats to inhaled di(2-ethylhexyl)phthalate affects the onset of puberty and postpubertal reproductive functions","volume":"93","author":"Ma","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.lfs.2015.10.022","article-title":"Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms","volume":"145","author":"Maqbool","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.envres.2017.11.052","article-title":"Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: the Hokkaido study on Environment and Children's Health","volume":"161","author":"Minatoya","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib35","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1073\/pnas.91.3.974","article-title":"Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa","volume":"91","author":"Portera-Cailliau","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib36","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1210\/en.2012-2056","article-title":"Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells","volume":"154","author":"Qiu","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.toxlet.2012.07.015","article-title":"Neonatal xenoestrogen exposure alters growth hormone-dependent liver proteins and genes in adult female rats","volume":"213","author":"Ramirez","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib39","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tem.2010.05.003","article-title":"Energy balance and puberty onset: emerging role of central mTOR signaling","volume":"21","author":"Roa","year":"2010","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.reprotox.2016.04.014","article-title":"Regulation of arcuate genes by developmental exposures to endocrine-disrupting compounds in female rats","volume":"62","author":"Roepke","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib41","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1210\/en.2016-1090","article-title":"Manganese-stimulated kisspeptin is mediated by the IGF-1\/Akt\/mammalian target of rapamycin pathway in the prepubertal female rat","volume":"157","author":"Srivastava","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.envres.2016.05.005","article-title":"Effects of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake on pre-pubertal growth characteristics in a Taiwanese population","volume":"149","author":"Tsai","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.yhbeh.2016.01.012","article-title":"Effects of early pubertal exposure to di-(2-ethylhexyl) phthalate on social behavior of mice","volume":"80","author":"Wang","year":"2016","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3322\/caac.21219","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward","year":"2014","journal-title":"Ca - Cancer J. Clin."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1210\/jc.2015-2706","article-title":"Relating phthalate and BPA exposure to metabolism in peripubescence: the role of exposure timing, sex, and puberty","volume":"101","author":"Watkins","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175536","article-title":"Phthalate exposure and reproductive hormones and sex-hormone binding globulin before puberty - phthalate contaminated-foodstuff episode in Taiwan","volume":"12","author":"Wen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib47","doi-asserted-by":"crossref","first-page":"15254","DOI":"10.3390\/ijerph121214974","article-title":"Association of PAEs with precocious puberty in children: a systematic review and meta-analysis","volume":"12","author":"Wen","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2019.06.017_bib48","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.yfrne.2014.05.007","article-title":"The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1)","volume":"35","author":"Wolfe","year":"2014","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.ecoenv.2019.06.017_bib49","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3345\/kjp.2016.59.9.355","article-title":"Effects of early menarche on physical and psychosocial health problems in adolescent girls and adult women","volume":"59","author":"Yoo","year":"2016","journal-title":"Korean J Pediatr"}],"updated-by":[{"DOI":"10.1016\/j.ecoenv.2022.113355","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000}}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319306554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319306554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T18:28:17Z","timestamp":1577730497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319306554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":49,"alternative-id":["S0147651319306554"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.06.017","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1\/PI3K\/Akt\/mTOR signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}