{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T01:30:02Z","timestamp":1778463002483,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373016"],"award-info":[{"award-number":["81373016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673189"],"award-info":[{"award-number":["81673189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Health and Family Planning Commission","award":["201640363"],"award-info":[{"award-number":["201640363"]}]},{"name":"Shanghai Jiao Tong University School of Medicine","award":["15QT10"],"award-info":[{"award-number":["15QT10"]}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"crossref","award":["20172016"],"award-info":[{"award-number":["20172016"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.ecoenv.2019.109441","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T05:13:32Z","timestamp":1565327612000},"page":"109441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Impacts of lead exposure and chelation therapy on bone metabolism during different developmental stages of rats"],"prefix":"10.1016","volume":"183","author":[{"given":"Yijing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leilei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chonghuai","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2019.109441_bib1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/toxsci\/kft093","article-title":"Developmental exposure to As, Cd, and Pb mixture diminishes skeletal growth and causes osteopenia at maturity via osteoblast and chondrocyte malfunctioning in female rats","volume":"134","author":"Abbas","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2019.109441_bib2","series-title":"Selected Aspects of the Spatial Distribution of Lead in Bone Neurotoxicology","first-page":"809","volume":"vol. 13","author":"Aufderheide","year":"1992"},{"key":"10.1016\/j.ecoenv.2019.109441_bib3","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1289\/ehp.7917","article-title":"A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs","volume":"113","author":"Barbosa","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.109441_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1289\/ehp.1205374","article-title":"Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling","volume":"121","author":"Beier","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.109441_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00216-003-2029-4","article-title":"High-throughput microwave-digestion procedures to monitor neurotoxic elements in body fluids by means of inductively coupled plasma mass spectrometry","volume":"377","author":"Bocca","year":"2003","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ecoenv.2019.109441_bib6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bone.2014.04.021","article-title":"Changes in bone Pb accumulation: cause and effect of altered bone turnover","volume":"64","author":"Brito","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.ecoenv.2019.109441_bib7","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1289\/ehp.9716","article-title":"The association between blood lead levels and osteoporosis among adults--results from the third national health and nutrition examination survey (NHANES III)","volume":"115","author":"Campbell","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.109441_bib8","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1289\/ehp.6555","article-title":"The association between environmental lead exposure and bone density in children","volume":"112","author":"Campbell","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.109441_bib9","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1289\/ehp.7596","article-title":"Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency","volume":"113","author":"Carmouche","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.109441_bib10","first-page":"171","article-title":"Bone turnover biomarkers and risk of osteoporotic hip fracture in an","volume":"83","author":"Dai","year":"2016","journal-title":"Asian Popul. Bone"},{"key":"10.1016\/j.ecoenv.2019.109441_bib11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s002239900214","article-title":"Effect of lead on bone development and bone mass: a morphometric, densitometric, and histomorphometric study in growing rats","volume":"60","author":"Escribano","year":"1997","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.ecoenv.2019.109441_bib12","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1289\/ehp.6615","article-title":"Levels of lead in breast milk and their relation to maternal blood and bone lead levels at one month postpartum","volume":"112","author":"Ettinger","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.109441_bib13","first-page":"185","article-title":"Progress in study on metabolite markers of bone collagen Foreign Medical Sciences","volume":"14","author":"Fang","year":"2003"},{"key":"10.1016\/j.ecoenv.2019.109441_bib14","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1289\/ehp.1206105","article-title":"Blood lead levels and serum insulin-like growth factor 1 concentrations in peripubertal boys","volume":"121","author":"Fleisch","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.109441_bib15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.envpol.2008.09.015","article-title":"Long-term effects of lead poisoning on bone mineralization in vultures exposed to ammunition sources","volume":"157","author":"Gangoso","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2019.109441_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF03256280","article-title":"Biomarkers for osteoporosis management: utility in diagnosis, fracture risk prediction and therapy monitoring","volume":"12","author":"Garnero","year":"2008","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.ecoenv.2019.109441_bib17","first-page":"65","article-title":"Osteopenia induced by long-term, low- and high-level exposure of the adult rat to lead","volume":"23","author":"Gruber","year":"1997","journal-title":"Miner. Electrolyte Metab."},{"key":"10.1016\/j.ecoenv.2019.109441_bib18","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1289\/ehp.00108527","article-title":"Effects of lead exposure before pregnancy and dietary calcium during pregnancy on fetal development and lead accumulation","volume":"108","author":"Han","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2019.109441_bib19","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/aje\/152.9.829","article-title":"Patterns and determinants of blood lead during pregnancy","volume":"152","author":"Hertz-Picciotto","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2019.109441_bib20","series-title":"Postnatal Growth Following Prenatal Lead Exposure and Calcium Intake Pediatrics","first-page":"1151","volume":"vol. 134","author":"Hong","year":"2014"},{"key":"10.1016\/j.ecoenv.2019.109441_bib21","first-page":"167","volume":"68","author":"Jarup","year":"2003","journal-title":"Hazards Heavy Metal Contam. Br. Med. Bull."},{"key":"10.1016\/j.ecoenv.2019.109441_bib22","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/MOP.0b013e32833b0b9e","article-title":"Interpretation and application of bone turnover markers in children and adolescents","volume":"22","author":"Jurimae","year":"2010","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.ecoenv.2019.109441_bib23","first-page":"2531","article-title":"Regulation of osteoblastic gene expression by lead Endocrinology","volume":"132","author":"Klein","year":"1993"},{"key":"10.1016\/j.ecoenv.2019.109441_bib24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/oxfordjournals.aje.a009471","article-title":"Calcitropic hormones and occupational lead exposure","volume":"147","author":"Kristal-Boneh","year":"1998","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2019.109441_bib25","first-page":"402","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods (San Diego, Calif)","volume":"25","author":"Livak","year":"2001"},{"key":"10.1016\/j.ecoenv.2019.109441_bib26","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/j.scitotenv.2011.02.004","article-title":"Prenatal exposure to lead in Spain: cord blood levels and associated factors Science of the","volume":"409","author":"Llop","year":"2011","journal-title":"Total Environ."},{"key":"10.1016\/j.ecoenv.2019.109441_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0013-9351(03)00020-3","article-title":"Release of lead from bone in pregnancy and lactation","volume":"92","author":"Manton","year":"2003","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2019.109441_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/096032719000900107","article-title":"Effect of occupational lead exposure on serum 1,25-dihydroxyvitamin D levels","volume":"9","author":"Mason","year":"1990","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109441_bib29","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.bone.2010.07.013","article-title":"The effect of lead on bone mineral properties from female adult C57\/BL6 mice","volume":"47","author":"Monir","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.ecoenv.2019.109441_bib30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/aje\/kwh296","article-title":"Bone density-related predictors of blood lead level among peri- and postmenopausal women in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994","volume":"160","author":"Nash","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2019.109441_bib31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/taap.1995.1072","article-title":"Physiologically based models for bone-seeking elements. V. Lead absorption and disposition in childhood","volume":"131","author":"O'Flaherty","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2019.109441_bib32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3200\/AEOH.60.4.195-204","article-title":"Calcitropic hormones, bone turnover, and lead exposure among female smelter workers","volume":"60","author":"Potula","year":"2005","journal-title":"Arch. Environ. Occup. Health"},{"key":"10.1016\/j.ecoenv.2019.109441_bib33","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1210\/jc.2006-1706","article-title":"Sex- and age-specific reference curves for serum markers of bone turnover in healthy children from 2 months to 18 years","volume":"92","author":"Rauchenzauner","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2019.109441_bib34","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.envres.2016.10.014","article-title":"The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort","volume":"152","author":"Renzetti","year":"2017","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2019.109441_bib35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/toxsci\/62.2.321","article-title":"Skeletal effects of developmental lead exposure in rats","volume":"62","author":"Ronis","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2019.109441_bib36","first-page":"160","article-title":"Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls Calcif Tissue","volume":"79","author":"Saito","year":"2006","journal-title":"Int"},{"key":"10.1016\/j.ecoenv.2019.109441_bib37","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/aje\/155.5.420","article-title":"Impact of breastfeeding on the mobilization of lead from bone","volume":"155","author":"Tellez-Rojo","year":"2002","journal-title":"Am. J. Epidemiol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319307729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319307729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:01:35Z","timestamp":1758949295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319307729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":37,"alternative-id":["S0147651319307729"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109441","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impacts of lead exposure and chelation therapy on bone metabolism during different developmental stages of rats","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109441"}}