{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:50:32Z","timestamp":1780901432985,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2010-2311608"],"award-info":[{"award-number":["RF-2010-2311608"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.ecoenv.2019.109566","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T17:47:03Z","timestamp":1566236823000},"page":"109566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Toxicological, gene expression and histopathological evaluations of environmentally realistic concentrations of polybrominated diphenyl ethers PBDE- 47, PBDE-99 and PBDE-209 on zebrafish embryos"],"prefix":"10.1016","volume":"183","author":[{"given":"Daniela","family":"Zezza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Tait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Della Salda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Amorena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Merola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Perugini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ecoenv.2019.109566_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00204-009-0495-y","article-title":"Toxicity of penta-and decabromodiphenyl ethers after repeated administration to rats: a comparative study","volume":"84","author":"Bruchajzer","year":"2010","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.ecoenv.2019.109566_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/0960327110371261","article-title":"The effect of short-term intoxication of rats with pentabromodiphenyl ether (in mixture mimic commercial products)","volume":"30","author":"Bruchajzer","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109566_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.aquatox.2011.10.013","article-title":"Disruption of the hypothalamic-pituitary-thyroid axis in zebrafish embryo\u2013larvae following waterborne exposure to BDE-47, TBBPA and BPA","volume":"108","author":"Chan","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109566_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.envpol.2016.04.040","article-title":"High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae","volume":"214","author":"Chen","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2019.109566_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aquatox.2012.01.008","article-title":"Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae","volume":"110","author":"Chen","year":"2012","journal-title":"Aquat. Toxicol."},{"issue":"6","key":"10.1016\/j.ecoenv.2019.109566_bib9","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.neuro.2007.08.007","article-title":"Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants","volume":"28","author":"Costa","year":"2007","journal-title":"Neurotoxicology (Little Rock)"},{"issue":"2","key":"10.1016\/j.ecoenv.2019.109566_bib10","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.envint.2010.11.007","article-title":"Novel brominated flame retardants: a review of their analysis, environmental fate and behaviour","volume":"37","author":"Covaci","year":"2011","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.ecoenv.2019.109566_bib13","first-page":"2156","article-title":"Scientific opinion on polybrominated diphenyl ethers (PBDEs) in food","volume":"9","author":"EFSA","year":"2011","journal-title":"EFSA Journal"},{"issue":"123","key":"10.1016\/j.ecoenv.2019.109566_bib14","article-title":"Histological analyses of acute alcoholic liver injury in zebrafish","author":"Ellis","year":"2017","journal-title":"J. Vis. Exp. JoVE"},{"issue":"3","key":"10.1016\/j.ecoenv.2019.109566_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.aquatox.2008.08.015","article-title":"Prolonged ELS test with the marine flatfish sole (Solea solea) shows delayed toxic effects of previous exposure to PCB 126","volume":"90","author":"Foekema","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109566_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.aquatox.2017.02.023","article-title":"Effects of food-borne exposure of juvenile rainbow trout (Oncorhynchus mykiss) to emerging brominated flame retardants 1, 2-bis (2, 4, 6-tribromophenoxy) ethane and 2-ethylhexyl-2, 3, 4, 5-tetrabromobenzoate","volume":"186","author":"Giraudo","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109566_bib19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aquatox.2017.06.020","article-title":"Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring","volume":"190","author":"Han","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109566_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jprot.2013.08.004","article-title":"Proteomic and metabolomic analysis of earthworm Eisenia fetida exposed to different concentrations of 2, 2\u2032, 4, 4\u2032-tetrabromodiphenyl ether","volume":"91","author":"Ji","year":"2013","journal-title":"J. Proteomics"},{"key":"10.1016\/j.ecoenv.2019.109566_bib21","first-page":"449e457","article-title":"Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2, 20, 4, 40-tetrabromodiphenyl ether (BDE 47)","volume":"140","author":"Ji","year":"2013","journal-title":"Aquat. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2019.109566_bib22","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.apr.2016.12.017","article-title":"A review of brominated flame retardants in the environment with emphasis on atmospheric levels, knowledge and information gaps in the African continent","volume":"8","author":"Katima","year":"2017","journal-title":"Atmos. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2019.109566_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.envint.2014.01.006","article-title":"Levels and trends of PBDEs and HBCDs in the global environment: status at the end of 2012","volume":"65","author":"Law","year":"2014","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.ecoenv.2019.109566_bib27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00204-015-1457-1","article-title":"Human exposure to PBDE and critical evaluation of health hazards","volume":"89","author":"Linares","year":"2015","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.109566_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/etc.3535","article-title":"Exposure to a PBDE\/OH\u2010BDE mixture alters juvenile zebrafish (Danio rerio) development","volume":"36","author":"Macaulay","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.109566_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/toxsci\/56.1.95","article-title":"Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro","volume":"56","author":"Meerts","year":"2000","journal-title":"Toxicol. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.ecoenv.2019.109566_bib31","first-page":"38","article-title":"DarT: the embryo test with the zebrafish Danio rerio\u2014a general model in ecotoxicology and toxicology","volume":"19","author":"Nagel","year":"2002","journal-title":"ALTEX"},{"key":"10.1016\/j.ecoenv.2019.109566_bib32","series-title":"Test No. 203: Fish, Acute Toxicity Test. OECD, Guideline for Testing of Chemicals","author":"OECD","year":"1992"},{"key":"10.1016\/j.ecoenv.2019.109566_bib33","series-title":"Test No. 236: Fish Embryo Acute Toxicity (FET) Test. OECD, Guideline for Testing of Chemicals","author":"OECD","year":"2013"},{"key":"10.1016\/j.ecoenv.2019.109566_bib35","series-title":"BDE-154 induces","author":"Pereira","year":"2014"},{"key":"10.1016\/j.ecoenv.2019.109566_bib36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.talanta.2017.02.043","article-title":"Quantification of polybrominated diphenyl ethers (PBDEs) in food. A review","volume":"167","author":"Pietro\u0144","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.ecoenv.2019.109566_bib37","unstructured":"Primer designing tool \u2013 NCBI \u2013 NIH, www.ncbi.nlm.nih.gov\/tools\/primer-blast.."},{"issue":"2","key":"10.1016\/j.ecoenv.2019.109566_bib39","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.tiv.2012.09.022","article-title":"BDE-99 congener induces cell death by apoptosis of human hepatoblastoma cell line\u2013HepG2","volume":"27","author":"Souza","year":"2013","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ecoenv.2019.109566_bib40","doi-asserted-by":"crossref","DOI":"10.1021\/es303471d","article-title":"Novel and high volume use flame retardants in US couches reflective of the 2005 PentaBDE phase out","volume":"46","author":"Stapleton","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.109566_bib41","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.fct.2017.07.041","article-title":"Relative toxicological ranking of eight polybrominated diphenyl ether congeners using cytotoxicity, chemical properties and exposure data","volume":"108","author":"Tait","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109566_bib43","article-title":"Proposal to list decabromodiphenyl ether (commercial Mixture, c-decaBDE) in annex A, B and\/or C to the Stockholm Convention on persistent organic pollutants","author":"UNEP","year":"2013","journal-title":"UNEP\/POPS\/POPRC.9\/2"},{"issue":"3","key":"10.1016\/j.ecoenv.2019.109566_bib44","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1677\/joe.1.05986","article-title":"Iodothyronine deiodinases and the control of plasma and tissue thyroid hormone levels in hyperthyroid tilapia (Oreochromis niloticus)","volume":"184","author":"Van der Geyten","year":"2005","journal-title":"J. Endocrinol."},{"issue":"8","key":"10.1016\/j.ecoenv.2019.109566_bib45","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.tiv.2011.06.007","article-title":"In vitro neurotoxicity data in human risk assessment of polybrominated diphenyl ethers (PBDEs): overview and perspectives","volume":"25","author":"Verner","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ecoenv.2019.109566_bib47","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jhazmat.2015.10.004","article-title":"Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2. 5","volume":"302","author":"Wu","year":"2016","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2019.109566_bib48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12864-014-1194-5","article-title":"High-throughput RNA sequencing reveals the effects of 2,2\u2032,4,4\u2032 -tetrabromodiphenyl ether on retina and bone development of zebrafish larvae","volume":"16","author":"Xu","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ecoenv.2019.109566_bib49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.aquatox.2014.12.011","article-title":"Evaluation of the toxic effects of brominated compounds (BDE-47, 99, 209, TBBPA) and bisphenol A (BPA) using a zebrafish liver cell line","volume":"159","author":"Yang","year":"2015","journal-title":"ZFL. Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109566_bib50","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.toxrep.2017.11.003","article-title":"Toxic effects of polybrominated diphenyl ethers (BDE 47 and 99) and localization of BDE-99\u2013induced cyp1a mRNA in zebrafish larvae","volume":"4","author":"Yang","year":"2017","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.ecoenv.2019.109566_bib51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.aquatox.2013.04.001","article-title":"Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole","volume":"138","author":"Yu","year":"2013","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2019.109566_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092465","article-title":"Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl) phthalate (MEHP)","volume":"9","author":"Zhai","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ecoenv.2019.109566_bib54","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.toxlet.2015.01.017","article-title":"Troxerutin inhibits 2, 2\u2032, 4, 4\u2032-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function","volume":"233","author":"Zhang","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2019.109566_bib55","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhazmat.2014.09.012","article-title":"Troxerutin protects against 2, 2\u2032, 4, 4\u2032-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD+-depletion","volume":"283","author":"Zhang","year":"2015","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2019.109566_bib56","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.etap.2016.10.004","article-title":"Life-cycle exposure to BDE-47 results in thyroid endocrine disruption to adults and offsprings of zebrafish (Danio rerio)","volume":"48","author":"Zhao","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"15","key":"10.1016\/j.ecoenv.2019.109566_bib57","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1021\/es5016839","article-title":"Measurements of selected brominated flame retardants in nursing women: implications for human exposure","volume":"48","author":"Zhou","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.ecoenv.2019.109566_bib60","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1365-2826.2004.01243.x","article-title":"Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings","volume":"16","author":"Zoeller","year":"2004","journal-title":"J. Neuroendocrinol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319308978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319308978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:56:21Z","timestamp":1777488981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319308978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":42,"alternative-id":["S0147651319308978"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109566","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxicological, gene expression and histopathological evaluations of environmentally realistic concentrations of polybrominated diphenyl ethers PBDE- 47, PBDE-99 and PBDE-209 on zebrafish embryos","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109566","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109566"}}