{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:39:00Z","timestamp":1790530740577,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11475196"],"award-info":[{"award-number":["11475196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11975247"],"award-info":[{"award-number":["11975247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFA0201600"],"award-info":[{"award-number":["2016YFA0201600"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia","doi-asserted-by":"publisher","award":["2018LH08073"],"award-info":[{"award-number":["2018LH08073"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["QKH-2016-2804"],"award-info":[{"award-number":["QKH-2016-2804"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ecoenv.2019.109720","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:36:50Z","timestamp":1569908210000},"page":"109720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Selenium modulated gut flora and promoted decomposition of methylmercury in methylmercury-poisoned rats"],"prefix":"10.1016","volume":"185","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiating","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2019.109720_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.aquatox.2014.11.010","article-title":"Dietary selenomethionine influences the accumulation and depuration of dietary methylmercury in zebrafish (Danio rerio)","volume":"158","author":"Amlund","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0168-6445(03)00046-9","article-title":"Bacterial mercury resistance from atoms to ecosystems","volume":"27","author":"Barkay","year":"2003","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.ecoenv.2019.109720_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ecoenv.2019.109720_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbagen.2014.05.003","article-title":"Mucins: a biologically relevant glycan barrier in mucosal protection","volume":"1850","author":"Corfield","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ecoenv.2019.109720_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/253462a0","article-title":"Biosynthesis and degradation of methylmercury in human faeces","volume":"253","author":"Edwards","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2019.109720_bib6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1021\/es071948x","article-title":"Human exposure to methylmercury through rice intake in mercury mining areas, Guizhou province, China","volume":"42","author":"Feng","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib7","series-title":"Selenium","article-title":"Selenium as a cancer preventive agent","author":"Hatfield","year":"2001"},{"key":"10.1016\/j.ecoenv.2019.109720_bib8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0048-9697(02)00572-7","article-title":"Total mercury, methylmercury and selenium in mercury polluted areas in the province Guizhou, China","volume":"304","author":"Horvat","year":"2003","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2019.109720_bib9","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1021\/es304370g","article-title":"Mechanisms regulating mercury bioavailability for methylating microorganisms in the aquatic environment: a critical review","volume":"47","author":"Hsu-Kim","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib10","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.aquatox.2012.09.018","article-title":"The interactive effects of selenomethionine and methylmercury on their absorption, disposition, and elimination in juvenile white sturgeon","volume":"126","author":"Huang","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4093\/dmj.2015.39.3.198","article-title":"Gut microbiota and metabolic disorders","volume":"39","author":"Hur","year":"2015","journal-title":"Diabetes Metab. J"},{"key":"10.1016\/j.ecoenv.2019.109720_bib12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s00244-004-3188-9","article-title":"Detoxification mechanism of heavy metals in marine mammals and seabirds: interaction of selenium with mercury, silver, copper, zinc, and cadmium in liver","volume":"47","author":"Ikemoto","year":"2004","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib13","first-page":"55","article-title":"Effects of sodium selenite on methylmercury poisoned rats","volume":"33","author":"Jing","year":"2014","journal-title":"J Mountain Agric Biol"},{"key":"10.1016\/j.ecoenv.2019.109720_bib14","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1096\/fj.11-181990","article-title":"Dietary selenium affects host selenoproteome expression by influencing the gut microbiota","volume":"25","author":"Kasaikina","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2019.109720_bib15","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1897\/08-375.1","article-title":"Mercury-selenium compounds and their toxicological significance: toward a molecular understanding of the mercury-selenium antagonism","volume":"28","author":"Khan","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2019.109720_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.17219\/acem\/67222","article-title":"Selenium - a fascinating antioxidant of protective properties","volume":"27","author":"Kielczykowska","year":"2018","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.ecoenv.2019.109720_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/cells6040039","article-title":"Application of sodium selenite in the prevention and treatment of cancers","volume":"6","author":"Kieliszek","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2019.109720_bib18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s12011-010-8653-x","article-title":"Biotransformation of L-selenomethionine and selenite in rat gut contents","volume":"139","author":"Krittaphol","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2019.109720_bib19","doi-asserted-by":"crossref","first-page":"11313","DOI":"10.1021\/es302241v","article-title":"Organic selenium supplementation increases mercury excretion and decreases oxidative damage in long-term mercury-exposed residents from Wanshan, China","volume":"46","author":"Li","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib20","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1038\/ncomms9292","article-title":"The outer mucus layer hosts a distinct intestinal microbial niche","volume":"6","author":"Li","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2019.109720_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11104-015-2418-4","article-title":"The concentration of selenium matters: a field study on mercury accumulation in rice by selenite treatment in qingzhen, Guizhou, China","volume":"391","author":"Li","year":"2015","journal-title":"Plant Soil"},{"key":"10.1016\/j.ecoenv.2019.109720_bib22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00128-018-2512-4","article-title":"Intestinal methylation and demethylation of mercury","volume":"102","author":"Li","year":"2018","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib23","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/aoc.617","article-title":"Re-evaluation of distillation and comparison with HNO3 leaching\/solvent extraction for isolation of methylmercury compounds from sediment\/soil samples","volume":"18","author":"Liang","year":"2004","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.ecoenv.2019.109720_bib24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/1471-2105-7-371","article-title":"UniFrac-an online tool for comparing microbial community diversity in a phylogenetic context","volume":"7","author":"Lozupone","year":"2006","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ecoenv.2019.109720_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01438-14","article-title":"Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids","volume":"5","author":"Lukovac","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.ecoenv.2019.109720_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2180-9-123","article-title":"The Firmicutes\/Bacteroidetes ratio of the human microbiota changes with age","volume":"9","author":"Mariat","year":"2009","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1039\/c2mt00158f","article-title":"Exploring the structural basis for selenium\/mercury antagonism in Allium fistulosum","volume":"4","author":"McNear","year":"2012","journal-title":"Metallomics"},{"key":"10.1016\/j.ecoenv.2019.109720_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0091-3057(81)90276-8","article-title":"Properties of mercury and selenium in a high-molecular weight substance in rabbit tissues formed by simultaneous administration","volume":"15","author":"Naganuma","year":"1981","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.ecoenv.2019.109720_bib29","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/BF01685974","article-title":"Reduced mercury excretion with feces in germfree mice after oral administration of methyl mercury chloride","volume":"17","author":"Nakamura","year":"1977","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/00039896.1970.10667325","article-title":"Studies on the biotransformation of 203Hg-labeled methyl mercury chloride in rats","volume":"21","author":"Norseth","year":"1970","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.ecoenv.2019.109720_bib31","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/00039896.1971.10665903","article-title":"Intestinal transport of 203Hg-labeled methyl mercury chloride. Role of biotransformation in rats","volume":"22","author":"Norseth","year":"1971","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.ecoenv.2019.109720_bib32","first-page":"235","article-title":"Interpreting mercury in blood and urine of individual patients","volume":"34","author":"Nuttall","year":"2004","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.ecoenv.2019.109720_bib33","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/BF02135970","article-title":"The protective effect of small amounts of selenite in sublimate intoxication","volume":"23","author":"Parizek","year":"1967","journal-title":"Experientia"},{"key":"10.1016\/j.ecoenv.2019.109720_bib34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.taap.2015.12.017","article-title":"New frontiers in nanotoxicology: gut microbiota\/microbiome-mediated effects of engineered nanomaterials","volume":"299","author":"Pietroiusti","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1079\/PNS2005467","article-title":"Selenium in cancer prevention: a review of the evidence and mechanism of action","volume":"64","author":"Rayman","year":"2005","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.ecoenv.2019.109720_bib36","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1099\/ijs.0.63472-0","article-title":"Mucispirillum schaedleri gen. nov., sp. nov., a spiral-shaped bacterium colonizing the mucus layer of the gastrointestinal tract of laboratory rodents","volume":"55","author":"Robertson","year":"2005","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/00498257809060381","article-title":"Metabolism of methylmercuric chloride by the gastro-intestinal flora of the rat","volume":"8","author":"Rowland","year":"1978","journal-title":"Xenobiotica"},{"key":"10.1016\/j.ecoenv.2019.109720_bib38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/00039896.1984.10545872","article-title":"Effects of diet on mercury metabolism and excretion in mice given methylmercury: role of gut flora","volume":"39","author":"Rowland","year":"1984","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.ecoenv.2019.109720_bib39","doi-asserted-by":"crossref","first-page":"5786","DOI":"10.3390\/nu6125786","article-title":"Dysbiotic events in gut microbiota: impact on human health","volume":"6","author":"Schippa","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2019.109720_bib40","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0773.1981.tb00903.x","article-title":"Methyl mercury decomposition in mice treated with antibiotics","volume":"49","author":"Seko","year":"1981","journal-title":"Acta Pharmacol. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib41","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0946-672X(00)80035-8","article-title":"Effect of supplementation with organic selenium on mercury status as measured by mercury in pubic hair","volume":"14","author":"Seppanen","year":"2000","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib42","series-title":"Selenium Deficiency","author":"Shreenath","year":"2019"},{"key":"10.1016\/j.ecoenv.2019.109720_bib43","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4315\/0362-028X-66.2.300","article-title":"Total mercury and methylmercury content in edible fish from the Mediterranean Sea","volume":"66","author":"Storelli","year":"2003","journal-title":"J. Food Prot."},{"key":"10.1016\/j.ecoenv.2019.109720_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/268073a0","article-title":"A role of selenium against methylmercury toxicity","volume":"268","author":"Sumino","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2019.109720_bib45","series-title":"Method 1630: Methyl Mercury in Water by Distillation, Aqueous Ethylation, Purge and Trap, and CVFAS","year":"2001"},{"key":"10.1016\/j.ecoenv.2019.109720_bib46","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tox.2013.06.002","article-title":"Intestinal transport of methylmercury and inorganic mercury in various models of Caco-2 and HT29-MTX cells","volume":"311","author":"Vazquez","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2019.109720_bib47","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jhep.2013.11.034","article-title":"Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity","volume":"60","author":"Vrieze","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib48","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.envpol.2017.09.014","article-title":"Selenium induces the demethylation of mercury in marine fish","volume":"231","author":"Wang","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2019.109720_bib49","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1021\/acs.est.7b00923","article-title":"In vivo mercury demethylation in a marine fish (Acanthopagrus schlegeli)","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.109720_bib50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.envres.2013.01.010","article-title":"Selenium inhibits the phytotoxicity of mercury in garlic (Allium sativum)","volume":"125","author":"Zhao","year":"2013","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2019.109720_bib51","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1039\/C4MT00170B","article-title":"Selenium modulates mercury uptake and distribution in rice (Oryza sativa L.), in correlation with mercury species and exposure level","volume":"6","author":"Zhao","year":"2014","journal-title":"Metallomics"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319310516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319310516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:56:13Z","timestamp":1777488973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319310516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":51,"alternative-id":["S0147651319310516"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109720","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selenium modulated gut flora and promoted decomposition of methylmercury in methylmercury-poisoned rats","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109720","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109720"}}