{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:43:48Z","timestamp":1789461828720,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2018YFD0900902"],"award-info":[{"award-number":["2018YFD0900902"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2018YFD0900905"],"award-info":[{"award-number":["2018YFD0900905"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21407181"],"award-info":[{"award-number":["21407181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570511"],"award-info":[{"award-number":["31570511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MC011"],"award-info":[{"award-number":["ZR2019MC011"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["No.ZR2019MC011"],"award-info":[{"award-number":["No.ZR2019MC011"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ecoenv.2019.109776","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T22:46:24Z","timestamp":1570661184000},"page":"109776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Effects of low concentrations of triphenyltin on neurobehavior and the thyroid endocrine system in zebrafish"],"prefix":"10.1016","volume":"186","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2019.109776_bib1","doi-asserted-by":"crossref","first-page":"10524","DOI":"10.1021\/es202832g","article-title":"Speciation and degradation of triphenyltin in typical paddy fields and its uptake into rice plants","volume":"45","author":"Antes","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib43","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/etc.5620210629","article-title":"Integrated biomarker response: A useful tool for ecological risk assessment","volume":"21","author":"Beliaeff","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2019.109776_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408440601123529","article-title":"The hypothalamic-pituitary-thyroid (HPT) axis in fish and its role in fish development and reproduction","volume":"37","author":"Blanton","year":"2007","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib3","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.envpol.2017.07.061","article-title":"Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity","volume":"230","author":"Cheng","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2019.109776_bib42","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.chemosphere.2006.05.032","article-title":"Integrated biomarker response index as a useful tool for environmental assessment evaluated using transplanted mussels","volume":"66","author":"Damiens","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2019.109776_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/10408449609089891","article-title":"Ecotoxicology of organotin compounds","volume":"26","author":"Fent","year":"1996","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.chemosphere.2016.12.089","article-title":"Spatiotemporal distribution and risk assessment of organotins in the surface water of the Three Gorges Reservoir Region, China","volume":"171","author":"Gao","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2019.109776_bib6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.conb.2010.08.020","article-title":"Nonapeptide mechanisms of social cognition, behavior and species-specific social systems","volume":"20","author":"Goodson","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.scitotenv.2018.09.007","article-title":"Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring","volume":"650","author":"Guo","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2019.109776_bib8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aquatox.2017.06.020","article-title":"Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring","volume":"190","author":"Han","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib9","first-page":"252","article-title":"Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances","volume":"144","author":"Hinfray","year":"2006","journal-title":"Comp. Biochem. Physiol., C"},{"key":"10.1016\/j.ecoenv.2019.109776_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155632","article-title":"Long-term spatio-temporal trends of organotin contaminations in the marine environment of Hong Kong","volume":"11","author":"Ho","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2019.109776_bib11","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0883-2927(00)00067-6","article-title":"Organotin compounds in the environment - an overview","volume":"16","author":"Hoch","year":"2001","journal-title":"Appl. Geochem."},{"key":"10.1016\/j.ecoenv.2019.109776_bib12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.aquatox.2017.08.016","article-title":"Effects of triphenyltin on reproduction in Japanese medaka (Oryzias latipes) across two generations","volume":"192","author":"Horie","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.bcp.2009.11.006","article-title":"Endocrine disruptors and thyroid hormone physiology","volume":"79","author":"Jugan","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib14","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1021\/es980624t","article-title":"High percentage of butyltin residues in total tin in the livers of cetaceans from Japanese coastal waters","volume":"33","author":"Le","year":"1999","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cbpc.2014.02.001","article-title":"Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae","volume":"161","author":"Li","year":"2014","journal-title":"Comp. Biochem. Physiol. C-Toxicol. Pharmacol"},{"key":"10.1016\/j.ecoenv.2019.109776_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cbi.2014.12.010","article-title":"Evaluation of tributyltin toxicity in Chinese rare minnow larvae by abnormal behavior, energy metabolism and endoplasmic reticulum stress","volume":"227","author":"Li","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ecoenv.2019.109776_bib17","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.etap.2013.02.009","article-title":"Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase","volume":"35","author":"Liu","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib18","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.bbrc.2009.11.158","article-title":"Thyroglobulin (Tg) induces thyroid cell growth in a concentration-specific manner by a mechanism other than thyrotropin\/cAMP stimulation","volume":"391","author":"Noguchi","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2019.109776_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.talanta.2010.04.046","article-title":"Occurrence and chemical speciation analysis of organotin compounds in the environment: a review","volume":"82","author":"Oliveira","year":"2010","journal-title":"Talanta"},{"key":"10.1016\/j.ecoenv.2019.109776_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2009.05.011","article-title":"Thyroid gland development and function in the zebrafish model","volume":"312","author":"Porazzi","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib21","doi-asserted-by":"crossref","first-page":"2139021","DOI":"10.1063\/1.2742324","article-title":"Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems","volume":"90","author":"Reddy","year":"2007","journal-title":"Appl. Phys. Lett."},{"key":"10.1016\/j.ecoenv.2019.109776_bib22","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.aquatox.2019.02.004","article-title":"Parental exposure to tris(1,3-dichloro-2-propyl) phosphate results in thyroid endocrine disruption and inhibition of growth in zebrafish offspring","volume":"209","author":"Ren","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib23","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1139\/F09-069","article-title":"Behavioural toxicity of organic chemical contaminants in fish: application to ecological risk assessments (ERAs)","volume":"66","author":"Robinson","year":"2009","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.ecoenv.2019.109776_bib24","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.chemosphere.2011.11.039","article-title":"Environmental factors affecting thyroid function of wild sea bass (Dicentrarchus labrax) from European coasts","volume":"87","author":"Schnitzler","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2019.109776_bib25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.scitotenv.2019.02.198","article-title":"Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish","volume":"665","author":"Shi","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2019.109776_bib26","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3109\/10408444.2012.692114","article-title":"Endocrine disrupting chemicals and sexual behaviors in fish - a critical review on effects and possible consequences","volume":"42","author":"Soffker","year":"2012","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib27","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.scitotenv.2018.11.071","article-title":"Effects of 25 thyroid hormone disruptors on zebrafish embryos: a literature review of potential biomarkers","volume":"656","author":"Spaan","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2019.109776_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.aquatox.2011.04.018","article-title":"Influence of triphenyltin exposure on the hypothalamus-pituitary-gonad axis in male Sebastiscus marmoratus","volume":"104","author":"Sun","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1677\/joe.1.05986","article-title":"Iodothyronine deiodinases and the control of plasma and tissue thyroid hormone levels in hyperthyroid tilapia (Oreochromis niloticus)","volume":"184","author":"Van der Geyten","year":"2005","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.neubiorev.2003.08.006","article-title":"Dopamine phenotype and behaviour in animal models: in relation to attention deficit hyperactivity disorder","volume":"27","author":"Viggiano","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ecoenv.2019.109776_bib31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.aquatox.2014.11.001","article-title":"Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish","volume":"158","author":"Wang","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/czoolo\/58.1.9","article-title":"Pollutants and fish predator\/prey behavior: a review of laboratory and field approaches","volume":"58","author":"Weis","year":"2012","journal-title":"Curr. Zool."},{"key":"10.1016\/j.ecoenv.2019.109776_bib33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.aquatox.2018.05.009","article-title":"Tributyltin impaired reproductive success in female zebrafish through disrupting oogenesis, reproductive behaviors and serotonin synthesis","volume":"200","author":"Xiao","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aquatox.2017.05.009","article-title":"Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose","volume":"189","author":"Xiao","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib35","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.chemosphere.2012.01.041","article-title":"Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae","volume":"87","author":"Yan","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2019.109776_bib36","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.aquatox.2012.12.008","article-title":"Tributyltin exposure influences predatory behavior, neurotransmitter content and receptor expression in Sebastiscus marmoratus","volume":"128","author":"Yu","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib37","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.aquatox.2009.10.022","article-title":"Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae","volume":"97","author":"Yu","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ecoenv.2018.11.011","article-title":"Triphenyltin exposure affects mating behaviors and attractiveness to females during mating in male guppies (Poecilia reticulata)","volume":"169","author":"Zhang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2019.109776_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aquatox.2016.07.007","article-title":"Tributyltin affects shoaling and anxiety behavior in female rare minnow (Gobiocypris rarus)","volume":"178","author":"Zhang","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib40","doi-asserted-by":"crossref","first-page":"8133","DOI":"10.1021\/es801573x","article-title":"Reproductive inhibition and transgenerational toxicity of triphenyltin on medaka (Oiyzias latipes) at environmentally relevant levels","volume":"42","author":"Zhang","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2019.109776_bib41","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.etap.2013.09.022","article-title":"Effects of perchlorate on BDE-47-induced alteration thyroid hormone and gene expression of in the hypothalamus-pituitary-thyroid axis in zebrafish larvae","volume":"36","author":"Zhao","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319311078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319311078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:38:44Z","timestamp":1778629124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319311078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":43,"alternative-id":["S0147651319311078"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109776","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of low concentrations of triphenyltin on neurobehavior and the thyroid endocrine system in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109776"}}