{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:04:36Z","timestamp":1786381476910,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ecoenv.2019.109884","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T06:00:26Z","timestamp":1573020026000},"page":"109884","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["The associations of urinary phthalate metabolites with the intermediate and pregnancy outcomes of women receiving IVF\/ICSI treatments: A prospective single-center study"],"prefix":"10.1016","volume":"188","author":[{"given":"Taoran","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangcheng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2019.109884_bib1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.chemosphere.2019.03.146","article-title":"Couples exposure to phthalates and its influence on in vitro fertilization outcomes","volume":"226","author":"Al-Saleh","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2019.109884_bib2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.reprotox.2013.07.017","article-title":"Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation","volume":"42","author":"Angle","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109884_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2288-3-21","article-title":"Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio","volume":"3","author":"Barros","year":"2003","journal-title":"BMC Med. Res. Methodol."},{"issue":"12","key":"10.1016\/j.ecoenv.2019.109884_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082249","article-title":"Factors associated with failed treatment: an analysis of 121,744 women embarking on their first IVF cycles","volume":"8","author":"Bhattacharya","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ecoenv.2019.109884_bib6","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.fertnstert.2014.01.022","article-title":"Urinary bisphenol A, phthalates, and couple fecundity: the longitudinal investigation of fertility and the environment (LIFE) study","volume":"101","author":"Buck Louis","year":"2014","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.ecoenv.2019.109884_bib7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/andr.12171","article-title":"Paternal exposures to environmental chemicals and time-to-pregnancy: overview of results from the LIFE study","volume":"4","author":"Buck Louis","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.ecoenv.2019.109884_bib8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.scitotenv.2015.09.036","article-title":"Human exposure, hazard and risk of alternative plasticizers to phthalate esters","volume":"541","author":"Bui","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.109884_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jchromb.2004.02.006","article-title":"Automated solid phase extraction and quantitative analysis of human milk for 13 phthalate metabolites","volume":"805","author":"Calafat","year":"2004","journal-title":"J. Chromatogr. B-Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ecoenv.2019.109884_bib10","author":"Centers for Disease Control and Prevention (CDC)"},{"issue":"4","key":"10.1016\/j.ecoenv.2019.109884_bib11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/jcp.24222","article-title":"Abnormality of maternal-to-embryonic transition contributes to MEHP-induced mouse 2-cell block","volume":"228","author":"Chu","year":"2013","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.ecoenv.2019.109884_bib12","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1071\/RD12178","article-title":"Exposure to mono-n-butyl phthalate disrupts the development of preimplantation embryos","volume":"25","author":"Chu","year":"2013","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.ecoenv.2019.109884_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109541","article-title":"Urinary Levels of Phthalate Metabolites and Their Association with Lifestyle Behaviors in Chinese Adolescents and Young Adults","volume":"vol. 183","author":"Ding","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2019.109884_bib14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.reprotox.2015.09.007","article-title":"Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment","volume":"58","author":"Dodge","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109884_bib15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.reprotox.2016.04.005","article-title":"Follicular fluid and urinary concentrations of phthalate metabolites among infertile women and associations with in vitro fertilization parameters","volume":"61","author":"Du","year":"2016","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2019.109884_bib16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1530\/REP-13-0522","article-title":"Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected between 2006 and 2012","volume":"147","author":"Frederiksen","year":"2014","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.ecoenv.2019.109884_bib17","first-page":"585","article-title":"[Cumulative risk assessment of phthalates exposure in preschool children]","volume":"40","author":"Gao","year":"2019","journal-title":"Zhonghua Liuxingbingxue Zazhi"},{"key":"10.1016\/j.ecoenv.2019.109884_bib18","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ecoenv.2019.01.001","article-title":"Exposure and ecological risk of phthalate esters in the Taihu Lake basin, China","volume":"171","author":"Gao","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.ecoenv.2019.109884_bib19","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2019.109884_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fendo.2015.00008","article-title":"The effects of phthalates on the ovary","volume":"6","author":"Hannon","year":"2015","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.ecoenv.2019.109884_bib21","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1042\/BSR20120042","article-title":"The endocrine disruptor mono-(2-ethylhexyl) phthalate promotes adipocyte differentiation and induces obesity in mice","volume":"32","author":"Hao","year":"2012","journal-title":"Biosci. Rep."},{"issue":"6","key":"10.1016\/j.ecoenv.2019.109884_bib22","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1289\/ehp.1509760","article-title":"Urinary phthalate metabolite concentrations and reproductive outcomes among women undergoing in vitro fertilization: results from the EARTH study","volume":"124","author":"Hauser","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"8","key":"10.1016\/j.ecoenv.2019.109884_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16081366","article-title":"Distribution and dietary predictors of urinary phthalate metabolites among pregnant women in shanghai, China","volume":"16","author":"He","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2019.109884_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mce.2009.02.021","article-title":"Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: low doses induce elevated serum leptin and insulin, and overweight in mid-life","volume":"304","author":"Hines","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2019.109884_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.envint.2015.08.005","article-title":"Exposure assessment issues in epidemiology studies of phthalates","volume":"85","author":"Johns","year":"2015","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2019.109884_bib26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.reprotox.2013.10.001","article-title":"Human urinary phthalate metabolites level and main semen parameters, sperm chromatin structure, sperm aneuploidy and reproductive hormones","volume":"42","author":"Jurewicz","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2019.109884_bib28","doi-asserted-by":"crossref","first-page":"D748","DOI":"10.2741\/Latham","article-title":"Embryonic genome activation","volume":"6","author":"Latham","year":"2001","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ecoenv.2019.109884_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.envint.2017.11.011","article-title":"Urinary concentrations of biomarkers of phthalates and phthalate alternatives and IVF outcomes","volume":"111","author":"Machtinger","year":"2018","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.ecoenv.2019.109884_bib30","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/EDE.0000000000000525","article-title":"Urinary concentrations of phthalate metabolites and pregnancy loss among women conceiving with medically assisted reproduction","volume":"27","author":"Messerlian","year":"2016","journal-title":"Epidemiology"},{"issue":"17","key":"10.1016\/j.ecoenv.2019.109884_bib31","doi-asserted-by":"crossref","first-page":"10651","DOI":"10.1021\/acs.est.5b02617","article-title":"Levels of phthalate metabolites in urine of pregnant women and risk of clinical pregnancy loss","volume":"49","author":"Mu","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ecoenv.2019.109884_bib32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/10408347.2015.1004157","article-title":"Methods for the determination of endocrine-disrupting phthalate esters","volume":"46","author":"Qureshi","year":"2016","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.109884_bib33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.taap.2009.05.022","article-title":"Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells","volume":"239","author":"Reinsberg","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.ecoenv.2019.109884_bib34","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.rbmo.2011.06.018","article-title":"Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis","volume":"23","author":"Rittenberg","year":"2011","journal-title":"Reprod. Biomed. Online"},{"issue":"7","key":"10.1016\/j.ecoenv.2019.109884_bib35","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/jat.2902","article-title":"Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor alpha, beta, gamma subtypes: an in silico approach","volume":"34","author":"Sarath Josh","year":"2014","journal-title":"J. Appl. Toxicol."},{"issue":"6","key":"10.1016\/j.ecoenv.2019.109884_bib36","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijheh.2012.12.009","article-title":"Biomonitoring of phthalate metabolites in the Canadian population through the Canadian Health measures Survey (2007-2009)","volume":"216","author":"Saravanabhavan","year":"2013","journal-title":"Int. J. Hyg Environ. Health"},{"issue":"3","key":"10.1016\/j.ecoenv.2019.109884_bib37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1289\/ehp.6723","article-title":"Urinary levels of seven phthalate metabolites in the U.S. Population from the national Health and nutrition examination Survey (NHANES) 1999-2000","volume":"112","author":"Silva","year":"2004","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.ecoenv.2019.109884_bib38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1095\/biolreprod.112.102467","article-title":"Mono-(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles","volume":"87","author":"Wang","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2019.109884_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envres.2015.06.010","article-title":"Phthalate exposure and human semen quality: results from an infertility clinic in China","volume":"142","author":"Wang","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2019.109884_bib40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.envres.2015.11.023","article-title":"Phthalate exposure in association with serum hormone levels, sperm DNA damage and spermatozoa apoptosis: a cross-sectional study in China","volume":"150","author":"Wang","year":"2016","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.109884_bib41","first-page":"65","article-title":"Parental contributions to early embryo development: influences of urinary phthalate and phthalate alternatives among couples undergoing IVF treatment","volume":"32","author":"Wu","year":"2017","journal-title":"Hum. Reprod."},{"issue":"11","key":"10.1016\/j.ecoenv.2019.109884_bib42","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/humrep\/dex283","article-title":"Preconception urinary phthalate concentrations and sperm DNA methylation profiles among men undergoing IVF treatment: a cross-sectional study","volume":"32","author":"Wu","year":"2017","journal-title":"Hum. Reprod."},{"issue":"9","key":"10.1016\/j.ecoenv.2019.109884_bib43","first-page":"1894","article-title":"A pilot study on association between phthalate exposure and missed miscarriage","volume":"20","author":"Yi","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.ecoenv.2019.109884_bib44","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1021\/acs.est.5b00588","article-title":"Semen phthalate metabolites, spermatozoa apoptosis, and DNA damage: a cross-sectional study in China","volume":"49","author":"You","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ecoenv.2019.109884_bib45","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.rbmo.2013.04.006","article-title":"Blastocyst culture and cryopreservation to optimize clinical outcomes of warming cycles","volume":"27","author":"Zhu","year":"2013","journal-title":"Reprod. Biomed. Online"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319312151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319312151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:01:31Z","timestamp":1758949291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319312151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":43,"alternative-id":["S0147651319312151"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109884","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The associations of urinary phthalate metabolites with the intermediate and pregnancy outcomes of women receiving IVF\/ICSI treatments: A prospective single-center study","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109884","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109884"}}