{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:33:40Z","timestamp":1789994020723,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.ecoenv.2019.110094","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T06:12:54Z","timestamp":1576822374000},"page":"110094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Effect of NF-\u03baB signal pathway on mucus secretion induced by atmospheric PM2.5 in asthmatic rats"],"prefix":"10.1016","volume":"190","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ecoenv.2019.110094_bib1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/thoraxjnl-2013-204492","article-title":"Epidemiological time series studies of PM2.5 and daily mortality and hospital admissions: a systematic review and meta-analysis","volume":"69","author":"Atkinson","year":"2014","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.ecoenv.2019.110094_bib2","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1152\/ajpendo.00347.2013","article-title":"NF-\u03baB and STAT1 control CXCL1 and CXCL2 gene transcription","volume":"306","author":"Burke","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2019.110094_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2008.09.003","article-title":"Targeting the NF-\u03baB pathway in asthma and chronic obstructive pulmonary disease","volume":"121","author":"Edwards","year":"2009","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.110094_bib4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11356-015-5321-x","article-title":"The impact of PM2.5 on asthma emergency department visits: a systematic review and meta-analysis","volume":"23","author":"Fan","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"3","key":"10.1016\/j.ecoenv.2019.110094_bib5","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1513\/AnnalsATS.201311-405PS","article-title":"The global burden of respiratory disease","volume":"11","author":"Ferkol","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"8","key":"10.1016\/j.ecoenv.2019.110094_bib6","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1164\/rccm.2107057","article-title":"The burden of asthma in the United States: level and distribution are dependent on interpretation of the national asthma education and prevention program guidelines","volume":"166","author":"Fuhlbrigge","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.110094_bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/resp.12613","article-title":"Fine particulate matter (PM2.5) exposure during a prolonged wildfire period and emergency department visits for asthma","volume":"21","author":"Haikerwal","year":"2016","journal-title":"Respirology"},{"issue":"10","key":"10.1016\/j.ecoenv.2019.110094_bib8","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/jat.3482","article-title":"PM2.5-induced lung inflammation in mice: differences of inflammatory response in macrophages and type II alveolar cells","volume":"37","author":"He","year":"2017","journal-title":"J. Appl. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.110094_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-065X.2012.01098.x","article-title":"Regulation of NF-\u03baB by ubiquitination and degradation of the I\u03baBs","volume":"246","author":"Kanarek","year":"2012","journal-title":"Immunol. Rev."},{"issue":"Pt B","key":"10.1016\/j.ecoenv.2019.110094_bib10","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.envpol.2019.06.059","article-title":"Activation of NF-\u03baB pathways mediating the inflammation and pulmonary diseases associated with atmospheric methylamine exposure","volume":"252","author":"Li","year":"2019","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.110094_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ymeth.2012.10.004","article-title":"Methods for qPCR gene expression profiling applied to 1440 lymphoblastoid single cells","volume":"59","author":"Livak","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.ecoenv.2019.110094_bib12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.envres.2014.10.030","article-title":"Regional PM2.5 and asthma morbidity in an agricultural community: a panel study","volume":"136","author":"Loftus","year":"2015","journal-title":"Environ. Res."},{"issue":"5","key":"10.1016\/j.ecoenv.2019.110094_bib13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"The global burden of asthma: executive summary of the GINA dissemination committee report","volume":"59","author":"Masoli","year":"2004","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.ecoenv.2019.110094_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.mcp.0000198064.27586.37","article-title":"Mucus and MUC in asthma","volume":"12","author":"Morcillo","year":"2006","journal-title":"Curr. Opin. Pulm. Med."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2019.110094_bib15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.toxlet.2003.12.007","article-title":"The role of nitric oxide in the particulate matter (PM2.5)-induced NFkappaB activation in lung epithelial cells","volume":"148","author":"Nam","year":"2004","journal-title":"Toxicol. Lett."},{"issue":"12","key":"10.1016\/j.ecoenv.2019.110094_bib16","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1161\/01.RES.0000229683.81357.26","article-title":"Smooth Muscle alpha-actin is a direct target of Notch\/CSL","volume":"98","author":"Noseda","year":"2006","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2019.110094_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S2213-2600(12)70065-6","article-title":"China wakes up to the crisis of air pollution","volume":"1","author":"Ouyang","year":"2013","journal-title":"Lancet Resp. Med."},{"issue":"8","key":"10.1016\/j.ecoenv.2019.110094_bib18","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/thx.2010.151555","article-title":"Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis","volume":"66","author":"Plantier","year":"2011","journal-title":"Thorax"},{"issue":"8","key":"10.1016\/j.ecoenv.2019.110094_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135749","article-title":"Air pollution in China: mapping of concentrations and sources","volume":"10","author":"Rohde","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.ecoenv.2019.110094_bib20","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3390\/biom5031266","article-title":"NF-kappaB signaling in chronic inflammatory airway disease","volume":"5","author":"Schuliga","year":"2015","journal-title":"Biomolecules"},{"issue":"11","key":"10.1016\/j.ecoenv.2019.110094_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142149","article-title":"Estimating PM2.5 concentrations in xi'an city using a generalized additive model with multi-source monitoring data","volume":"10","author":"Song","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2019.110094_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.envres.2014.02.014","article-title":"Effects of ambient levels of traffic-derived air pollution on the ocular surface: analysis of symptoms, conjunctival goblet cell count and mucin 5AC gene expression","volume":"131","author":"Torricelli","year":"2014","journal-title":"Environ. Res."},{"issue":"12","key":"10.1016\/j.ecoenv.2019.110094_bib23","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.4049\/jimmunol.1301329","article-title":"Epithelial NF-\u03baB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling","volume":"191","author":"Tully","year":"2013","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.ecoenv.2019.110094_bib24","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/cea.12156","article-title":"The relationship between eosinophilia and airway remodelling in mild asthma","volume":"43","author":"Wilson","year":"2013","journal-title":"Clin. Exp. Allergy"},{"issue":"6","key":"10.1016\/j.ecoenv.2019.110094_bib25","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.3892\/mmr.2017.6428","article-title":"Anti-inflammatory effects of dihydromyricetin in a mouse model of asthma","volume":"15","author":"Xu","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.ecoenv.2019.110094_bib26","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00128-014-1443-y","article-title":"Concentrations and seasonal variation of ambient PM2.5 and associated metals at a typical residential area in beijing, China","volume":"94","author":"Yang","year":"2015","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2019.110094_bib27","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.envpol.2018.09.047","article-title":"Delineation of 3D dose-time-toxicity in human pulmonary epithelial Beas-2B cells induced by decabromodiphenyl ether (BDE209)","volume":"243","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.ecoenv.2019.110094_bib28","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s10753-018-0732-8","article-title":"Effect of atmospheric PM2.5 on expression levels of NF-\u03baB genes and inflammatory cytokines regulated by NF-\u03baB in human macrophage","volume":"41","author":"Zhang","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.ecoenv.2019.110094_bib29","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12944-019-1102-8","article-title":"Exposure to PM2.5 affects blood lipid levels in asthmatic rats through notch signaling pathway","volume":"18","author":"Zhang","year":"2019","journal-title":"Lipids Health Dis."},{"issue":"5","key":"10.1016\/j.ecoenv.2019.110094_bib30","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-\u03baB restricts inflammasome activation via elimination of damaged mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2019.110094_bib31","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.2147\/COPD.S164151","article-title":"Over-expression of nuclear factor-\u03baB family genes and inflammatory molecules is related to chronic obstructive pulmonary disease [J]","volume":"13","author":"Zhou","year":"2018","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319314253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651319314253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:05:55Z","timestamp":1758949555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651319314253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":31,"alternative-id":["S0147651319314253"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.110094","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of NF-\u03baB signal pathway on mucus secretion induced by atmospheric PM2.5 in asthmatic rats","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2019.110094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110094"}}