{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:15:38Z","timestamp":1790007338791,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.ecoenv.2020.110464","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T23:58:40Z","timestamp":1583971120000},"page":"110464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Exogenous hydrogen sulfide donor NaHS alleviates nickel-induced epithelial-mesenchymal transition and the migration of A549\u00a0cells by regulating TGF-\u03b21\/Smad2\/Smad3 signaling"],"prefix":"10.1016","volume":"195","author":[{"given":"Mengjuan","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haopei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feipeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanning","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2020.110464_bib1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/jat.3734","article-title":"Hydrogen sulfide attenuates paraquat-induced epithelial-mesenchymal transition of human alveolar epithelial cells through regulating transforming growth factor-beta1\/Smad2\/3 signaling pathway","volume":"39","author":"Bai","year":"2019","journal-title":"J. Appl. Toxicol.: JAT"},{"key":"10.1016\/j.ecoenv.2020.110464_bib2","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"Ca - Cancer J. Clin."},{"key":"10.1016\/j.ecoenv.2020.110464_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2017.7058","article-title":"A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?","volume":"31","author":"Cao","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ecoenv.2020.110464_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10555-016-9648-7","article-title":"EMT, cell plasticity and metastasis","volume":"35","author":"Chaffer","year":"2016","journal-title":"Canc. Metastasis Rev."},{"key":"10.1016\/j.ecoenv.2020.110464_bib5","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1038\/s41598-018-21807-x","article-title":"Hydrogen sulfide inhibits epithelial-mesenchymal transition in peritoneal mesothelial cells","volume":"8","author":"Cheng","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2020.110464_bib6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxlet.2015.05.019","article-title":"Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression","volume":"237","author":"Chiou","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2020.110464_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/em.21867","article-title":"Nickel accumulation in lung tissues is associated with increased risk of p53 mutation in lung cancer patients","volume":"55","author":"Chiou","year":"2014","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.ecoenv.2020.110464_bib8","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/bjc.1970.76","article-title":"Cancers of the lung and nasal sinuses in nickel workers","volume":"24","author":"Doll","year":"1970","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.ecoenv.2020.110464_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.lungcan.2016.07.015","article-title":"Somatic alterations in lung cancer: do environmental factors matter?","volume":"100","author":"Gibelin","year":"2016","journal-title":"Lung Canc."},{"key":"10.1016\/j.ecoenv.2020.110464_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20112767","article-title":"TGF-beta-Mediated epithelial-mesenchymal transition and cancer metastasis","volume":"20","author":"Hao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2020.110464_bib11","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022079","article-title":"Transcriptional control by the SMADs","volume":"8","author":"Hill","year":"2016","journal-title":"Cold Spring Harbor Perspec. Biol."},{"key":"10.1016\/j.ecoenv.2020.110464_bib12","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/mc.22802","article-title":"Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1","volume":"57","author":"Jose","year":"2018","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ecoenv.2020.110464_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00726-010-0510-x","article-title":"Hydrogen sulfide: its production, release and functions","volume":"41","author":"Kimura","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.ecoenv.2020.110464_bib14","first-page":"178","article-title":"Molecular mechanisms of epithelial-mesenchymal transition. Nature reviews","volume":"15","author":"Lamouille","year":"2014","journal-title":"Molecular cell Biol."},{"key":"10.1016\/j.ecoenv.2020.110464_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/occmed\/kqp197","article-title":"Mortality and cancer incidence in a nickel cohort","volume":"60","author":"Lightfoot","year":"2010","journal-title":"Occup. Med."},{"key":"10.1016\/j.ecoenv.2020.110464_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11010-005-8215-2","article-title":"Carcinogenic effect of nickel compounds","volume":"279","author":"Lu","year":"2005","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ecoenv.2020.110464_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3892\/mmr.2014.2161","article-title":"Inhibition of invasion and epithelial-mesenchymal transition of human breast cancer cells by hydrogen sulfide through decreased phospho-p38 expression","volume":"10","author":"Lv","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ecoenv.2020.110464_bib18","first-page":"2969","article-title":"Anticancer effect of exogenous hydrogen sulfide in cisplatinresistant A549\/DDP cells","volume":"39","author":"Ma","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ecoenv.2020.110464_bib19","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1248\/bpb.23.1125","article-title":"TGF-beta\/SMAD signaling and its involvement in tumor progression","volume":"23","author":"Miyazono","year":"2000","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ecoenv.2020.110464_bib20","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021873","article-title":"TGF-beta and the TGF-beta family: context-dependent roles in cell and tissue physiology","volume":"8","author":"Morikawa","year":"2016","journal-title":"Cold Spring Harbor Perspec. Biol."},{"key":"10.1016\/j.ecoenv.2020.110464_bib21","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/dvdy.24596","article-title":"Prospects for new lung cancer treatments that target EMT signaling","volume":"247","author":"Otsuki","year":"2018","journal-title":"Dev. Dynam. : An Off. publ. Am. Assoc. Anatomists"},{"key":"10.1016\/j.ecoenv.2020.110464_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ajim.22941","article-title":"Cancer mortality and exposure to nickel and chromium compounds in a cohort of Italian electroplaters","volume":"62","author":"Sciannameo","year":"2019","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.ecoenv.2020.110464_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0273-2300(02)00029-6","article-title":"Respiratory cancer risks associated with low-level nickel exposure: an integrated assessment based on animal, epidemiological, and mechanistic data","volume":"37","author":"Seilkop","year":"2003","journal-title":"Regul. Toxicol. Pharmacol. : RTP (Regul. Toxicol. Pharmacol.)"},{"key":"10.1016\/j.ecoenv.2020.110464_bib24","doi-asserted-by":"crossref","first-page":"36125","DOI":"10.1038\/srep36125","article-title":"Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics","volume":"6","author":"Szczesny","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2020.110464_bib25","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ecoenv.2020.110464_bib26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10555-015-9562-4","article-title":"Lung cancer and metastasis: new opportunities and challenges","volume":"34","author":"Wang","year":"2015","journal-title":"Canc. Metastasis Rev."},{"key":"10.1016\/j.ecoenv.2020.110464_bib27","doi-asserted-by":"crossref","first-page":"25292","DOI":"10.1074\/jbc.M111.291195","article-title":"Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation","volume":"287","author":"Wu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2020.110464_bib28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2015.08.004","article-title":"Hydrogen sulfide in cancer: friend or foe?","volume":"50","author":"Wu","year":"2015","journal-title":"Nitric Oxide : Biol. Chem."},{"key":"10.1016\/j.ecoenv.2020.110464_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cbi.2018.07.010","article-title":"Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4\/NF-kappaB signaling in A549cells","volume":"292","author":"Wu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ecoenv.2020.110464_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tox.2011.03.016","article-title":"Nickel promotes the invasive potential of human lung cancer cells via TLR4\/MyD88 signaling","volume":"285","author":"Xu","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2020.110464_bib31","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.molcel.2008.09.002","article-title":"TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta","volume":"31","author":"Yamashita","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2020.110464_bib32","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.bbapap.2016.09.008","article-title":"Nickel impact on human health: an intrinsic disorder perspective","volume":"1864","author":"Zambelli","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ecoenv.2020.110464_bib33","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022129","article-title":"Non-smad signaling pathways of the TGF-beta family","volume":"9","author":"Zhang","year":"2017","journal-title":"Cold Spring Harbor Perspec. Biol."},{"key":"10.1016\/j.ecoenv.2020.110464_bib34","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1038\/onc.2017.14","article-title":"LncRNA MEG3 downregulation mediated by DNMT3b contributes to nickel malignant transformation of human bronchial epithelial cells via modulating PHLPP1 transcription and HIF-1alpha translation","volume":"36","author":"Zhou","year":"2017","journal-title":"Oncogene"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320303031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320303031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:06:13Z","timestamp":1758949573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320303031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":34,"alternative-id":["S0147651320303031"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.110464","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exogenous hydrogen sulfide donor NaHS alleviates nickel-induced epithelial-mesenchymal transition and the migration of A549\u00a0cells by regulating TGF-\u03b21\/Smad2\/Smad3 signaling","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.110464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110464"}}