{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:54:15Z","timestamp":1790391255174,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["Y560020XB0"],"award-info":[{"award-number":["Y560020XB0"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11875061"],"award-info":[{"award-number":["11875061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11505244"],"award-info":[{"award-number":["11505244"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1632270"],"award-info":[{"award-number":["U1632270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFE0205100"],"award-info":[{"award-number":["2018YFE0205100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ecoenv.2020.110831","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T13:21:47Z","timestamp":1591881707000},"page":"110831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Heavy ion radiation-induced DNA damage mediates apoptosis via the Rpl27a-Rpl5-MDM2-p53\/E2F1 signaling pathway in mouse spermatogonia"],"prefix":"10.1016","volume":"201","author":[{"given":"Hongyan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"30","key":"10.1016\/j.ecoenv.2020.110831_bib1","doi-asserted-by":"crossref","first-page":"47875","DOI":"10.18632\/oncotarget.10293","article-title":"RPL27A is a target of miR-595 and may contribute to the myelodysplastic phenotype through ribosomal dysgenesis","volume":"7","author":"Alkhatabi","year":"2016","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.ecoenv.2020.110831_bib2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/sj.cdd.4400396","article-title":"The role of the tumor suppressor p53 in spermatogenesis","volume":"5","author":"Beumer","year":"1998","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.ecoenv.2020.110831_bib3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.bbadis.2013.08.014","article-title":"Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis","volume":"1842","author":"Bursac","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"5\u20136","key":"10.1016\/j.ecoenv.2020.110831_bib4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/08830189909088492","article-title":"Ribosomal proteins in cell proliferation and apoptosis","volume":"18","author":"Chen","year":"1999","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2020.110831_bib5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ecoenv.2019.02.024","article-title":"Chronic exposure to microcystin-LR reduces thyroid hormone levels by activating p38\/MAPK and MEK\/ERK signal pathway","volume":"173","author":"Chen","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"10.1016\/j.ecoenv.2020.110831_bib6","doi-asserted-by":"crossref","first-page":"13240","DOI":"10.18632\/oncotarget.14658","article-title":"The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells","volume":"8","author":"Dong","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ecoenv.2020.110831_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cytogfr.2016.02.001","article-title":"E2F1 transcription factor and its impact on growth factor and cytokine signaling","volume":"31","author":"Ertosun","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"issue":"23","key":"10.1016\/j.ecoenv.2020.110831_bib8","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.1038\/sj.emboj.7601424","article-title":"MDMX regulation of p53 response to ribosomal stress","volume":"25","author":"Gilkes","year":"2006","journal-title":"EMBO J."},{"issue":"16","key":"10.1016\/j.ecoenv.2020.110831_bib9","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1016\/j.febslet.2014.04.014","article-title":"p53 and ribosome biogenesis stress: the essentials","volume":"588","author":"Golomb","year":"2014","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.ecoenv.2020.110831_bib10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/jrr\/rrt090","article-title":"Low-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis","volume":"55","author":"Gong","year":"2014","journal-title":"J. Radiat. Res."},{"issue":"4","key":"10.1016\/j.ecoenv.2020.110831_bib11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3390\/cells1040774","article-title":"p53 -dependent and -independent nucleolar stress responses","volume":"1","author":"Holmberg Olausson","year":"2012","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.ecoenv.2020.110831_bib12","first-page":"2293","article-title":"p53 deficiency augments nucleolar instability after ionizing irradiation","volume":"42","author":"Kakoti","year":"2019","journal-title":"Oncol. Rep."},{"issue":"27","key":"10.1016\/j.ecoenv.2020.110831_bib13","doi-asserted-by":"crossref","first-page":"11286","DOI":"10.1073\/pnas.0701318104","article-title":"Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling","volume":"104","author":"Knezevic","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8\u20139","key":"10.1016\/j.ecoenv.2020.110831_bib14","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.dnarep.2004.03.029","article-title":"DNA damage-induced activation of ATM and ATM-dependent signaling pathways","volume":"3","author":"Kurz","year":"2004","journal-title":"DNA Repair"},{"issue":"1","key":"10.1016\/j.ecoenv.2020.110831_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/cdd.2009.77","article-title":"The multiple levels of regulation by p53 ubiquitination","volume":"17","author":"Lee","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2020.110831_bib16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.reprotox.2016.07.014","article-title":"Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice","volume":"65","author":"Li","year":"2016","journal-title":"Reprod. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2020.110831_bib17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.toxlet.2014.01.001","article-title":"Differential proteome and gene expression reveal response to carbon ion irradiation in pubertal mice testes","volume":"225","author":"Li","year":"2014","journal-title":"Toxicol. Lett."},{"issue":"12","key":"10.1016\/j.ecoenv.2020.110831_bib18","doi-asserted-by":"crossref","first-page":"22439","DOI":"10.1002\/jcp.28808","article-title":"Mitochondrial proteomics reveals the mechanism of spermatogenic cells apoptosis induced by carbon ion radiation in zebrafish","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.ecoenv.2020.110831_bib19","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s11517-007-0245-3","article-title":"Heavy-ion conformal irradiation in the shallow-seated tumor therapy terminal at HIRFL","volume":"45","author":"Li","year":"2007","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.ecoenv.2020.110831_bib20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ecoenv.2019.05.013","article-title":"Fine particulate matters induce apoptosis via the ATM\/P53\/CDK2 and mitochondria apoptosis pathway triggered by oxidative stress in rat and GC-2 spd cell","volume":"180","author":"Liu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.ecoenv.2020.110831_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.trecan.2016.03.002","article-title":"RP-MDM2-p53 pathway: linking ribosomal biogenesis and tumor surveillance","volume":"2","author":"Liu","year":"2016","journal-title":"Trends Canc."},{"key":"10.1016\/j.ecoenv.2020.110831_bib23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ecoenv.2017.06.042","article-title":"Radioactive impacts on nekton species in the Northwest Pacific and humans more than one year after the Fukushima nuclear accident","volume":"144","author":"Men","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.110831_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.ecoenv.2020.110831_bib25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1097-2765(01)00214-3","article-title":"PUMA, a novel proapoptotic gene, is induced by p53","volume":"7","author":"Nakano","year":"2001","journal-title":"Mol. Cell."},{"issue":"1","key":"10.1016\/j.ecoenv.2020.110831_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.gene.2015.01.014","article-title":"DNA damage stress induces the expression of ribosomal protein S27a gene in a p53-dependent manner","volume":"559","author":"Nosrati","year":"2015","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.ecoenv.2020.110831_bib27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.21037\/tau.2019.10.16","article-title":"Low-dose ionizing irradiation triggers apoptosis of undifferentiated spermatogonia in vivo and in vitro","volume":"8","author":"Qi","year":"2019","journal-title":"Transl. Androl. Urol."},{"issue":"1","key":"10.1016\/j.ecoenv.2020.110831_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3390\/ijms18010140","article-title":"Ribosomal proteins control or bypass p53 during nucleolar stress","volume":"18","author":"Russo","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ecoenv.2020.110831_bib29","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00204-018-2207-y","article-title":"Corticosteroid-binding globulin, induced in testicular Leydig cells by perfluorooctanoic acid, promotes steroid hormone synthesis","volume":"92","author":"Sun","year":"2018","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2020.110831_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cell.2005.07.034","article-title":"Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin","volume":"123","author":"Takagi","year":"2005","journal-title":"Cell"},{"issue":"24","key":"10.1016\/j.ecoenv.2020.110831_bib31","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1038\/sj.onc.1210136","article-title":"Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1","volume":"26","author":"Vassilev","year":"2007","journal-title":"Oncogene"},{"issue":"49","key":"10.1016\/j.ecoenv.2020.110831_bib32","doi-asserted-by":"crossref","first-page":"80450","DOI":"10.18632\/oncotarget.12608","article-title":"Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.ecoenv.2020.110831_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/med.21327","article-title":"Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications","volume":"35","author":"Wang","year":"2015","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ecoenv.2020.110831_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ecoenv.2019.01.049","article-title":"Complement regulatory protein CD59a plays a protective role in immune liver injury of trichloroethylene-sensitized BALB\/c mice","volume":"172","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.ecoenv.2020.110831_bib35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.15698\/cst2018.06.139","article-title":"Nucleolar Stress: hallmarks, sensing mechanism and diseases","volume":"2","author":"Yang","year":"2018","journal-title":"Cell stress"},{"key":"10.1016\/j.ecoenv.2020.110831_bib36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ecoenv.2018.01.005","article-title":"Transcriptional profiling analysis of Zearalenone-induced inhibition proliferation on mouse thymic epithelial cell line 1","volume":"153","author":"Zhang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"23","key":"10.1016\/j.ecoenv.2020.110831_bib37","doi-asserted-by":"crossref","first-page":"8902","DOI":"10.1128\/MCB.23.23.8902-8912.2003","article-title":"Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway","volume":"23","author":"Zhang","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2020.110831_bib38","doi-asserted-by":"crossref","first-page":"109465","DOI":"10.1016\/j.ecoenv.2019.109465","article-title":"Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K\/AKT pathway","volume":"183","author":"Zhang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"48","key":"10.1016\/j.ecoenv.2020.110831_bib39","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1038\/sj.onc.1208814","article-title":"Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway","volume":"24","author":"Zhang","year":"2005","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.ecoenv.2020.110831_bib41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: functions beyond the ribosome","volume":"7","author":"Zhou","year":"2015","journal-title":"J. Mol. Cell Biol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320306709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320306709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:59:03Z","timestamp":1777489143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320306709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":39,"alternative-id":["S0147651320306709"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.110831","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heavy ion radiation-induced DNA damage mediates apoptosis via the Rpl27a-Rpl5-MDM2-p53\/E2F1 signaling pathway in mouse spermatogonia","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.110831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110831"}}