{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:52:26Z","timestamp":1780710746856,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.ecoenv.2020.111046","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T07:29:36Z","timestamp":1595575776000},"page":"111046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Evaluation of modes of action of pesticides to Daphnia magna based on QSAR, excess toxicity and critical body residues"],"prefix":"10.1016","volume":"203","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei C.","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan H.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2020.111046_bib1","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1897\/03-438","article-title":"A food web bioaccumulation model for organic chemicals in aquatic ecosystems","volume":"23","author":"Arnot","year":"2004","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2020.111046_bib2","doi-asserted-by":"crossref","first-page":"7298","DOI":"10.1021\/acs.jafc.0c01962","article-title":"An overview on the mechanisms and applications of enzyme inhibition-based methods for determination of organophosphate and carbamate pesticides","volume":"68","author":"Cao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2020.111046_bib3","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.scitotenv.2019.06.301","article-title":"Nutrients and sediment modify the impacts of a neonicotinoid insecticide on freshwater community structure and ecosystem functioning","volume":"692","author":"Chara-Serna","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2020.111046_bib4","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/wer.1227","article-title":"Pesticides and herbicides","volume":"91","author":"Choudri","year":"2019","journal-title":"Water Environ. Res."},{"key":"10.1016\/j.ecoenv.2020.111046_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/1570159X11311030006","article-title":"Acetylcholinesterase inhibitors: pharmacology and toxicology","volume":"11","author":"\u010colovi\u0107","year":"2013","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ecoenv.2020.111046_bib6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/etc.3520","article-title":"Toxicity of three strobilurins (kresoxim-methyl, pyraclostrobin, and trifloxystrobin) on Daphnia magna","volume":"36","author":"Cui","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2020.111046_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.chemosphere.2016.11.073","article-title":"Effects of three diamides (chlorantraniliprole, cyantraniliprole and flubendiamide) on life history, embryonic development and oxidative stress biomarkers of Daphnia magna","volume":"169","author":"Cui","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ecoenv.2019.03.111","article-title":"Comparison of modes of action among different trophic levels of aquatic organisms for pesticides and medications based on interspecies correlations","volume":"177","author":"Fan","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111046_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.chemosphere.2016.10.043","article-title":"Toxicity of 13 different antibiotics towards freshwater green algae Pseudokirchneriella subcapitata and their modes of action","volume":"168","author":"Fu","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/eesa.1996.1481","article-title":"Influence of the energy relationships of organic compounds on toxicity to the cladoceran Daphnia magna and the fish pimephales promelas","volume":"36","author":"Genoni","year":"1997","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111046_bib11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0048-9697(91)90193-I","article-title":"QSAR for organic chemical bioconcentration in Daphnia, algae, and mussels","volume":"109","author":"Geyer","year":"1991","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2020.111046_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.chemosphere.2019.06.027","article-title":"Cardiotoxicity of forchlorfenuron (CPPU) in zebrafish (Danio rerio) and H9c2 cardiomyocytes","volume":"235","author":"Gong","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.chemosphere.2019.04.204","article-title":"QSAR modeling of Daphnia magna and fish toxicities of biocides using 2D descriptors","volume":"229","author":"Khan","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib14","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aquatox.2018.12.003","article-title":"QSAR for baseline toxicity and classification of specific modes of action of ionizable organic chemicals in the zebrafish embryo toxicity test","volume":"207","author":"Kluver","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111046_bib15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.chemosphere.2014.10.013","article-title":"Discrimination of excess toxicity from narcotic effect: influence of species sensitivity and bioconcentration on the classification of modes of action","volume":"120","author":"Li","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib16","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chemosphere.2015.12.009","article-title":"Discrimination of excess toxicity from baseline level for ionizable compounds: effect of pH","volume":"147","author":"Li","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.scitotenv.2017.10.308","article-title":"Development of thresholds of excess toxicity for environmental species and their application to identification of modes of acute toxic action","volume":"616\u2013617","author":"Li","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2020.111046_bib18","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.scitotenv.2019.07.052","article-title":"Anthropogenic contaminants of high concern: existence in water resources and their adverse effects","volume":"690","author":"Lopez-Pacheco","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2020.111046_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1039\/C8TX00322J","article-title":"Distribution of toxicity values across different species and modes of action of pesticides from PESTIMEP and PPDB databases","volume":"8","author":"Madariaga-Mazon","year":"2019","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.ecoenv.2020.111046_bib20","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1021\/es0351591","article-title":"Toxic ratio as an indicator of the intrinsic toxicity in the assessment of persistent, bioaccumulative, and toxic chemicals","volume":"38","author":"Maeder","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2020.111046_bib21","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/etc.5620110705","article-title":"Residue-based interpretation of toxicity and bioconcentration QSARs from aquatic bioassays: neutral narcotic organics","volume":"11","author":"McCarty","year":"1992","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2020.111046_bib22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/ieam.133","article-title":"The tissue residue approach for toxicity assessment: findings and critical reviews from a society of environmental toxicology and chemistry Pellston workshop","volume":"7","author":"Meador","year":"2011","journal-title":"Integrated Environ. Assess. Manag."},{"key":"10.1016\/j.ecoenv.2020.111046_bib23","series-title":"Guideline for Testing of Chemicals (202): Daphnia Sp. Acute Immobilisation Test","year":"2004"},{"issue":"6","key":"10.1016\/j.ecoenv.2020.111046_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2166\/wst.1996.0087","article-title":"Variability of species sensitivity to complex mixtures","volume":"33","author":"Pedersen","year":"1996","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.ecoenv.2020.111046_bib25","first-page":"835","article-title":"Estimation of molecular linear free energy relation descriptors using a group contribution approach","volume":"39","author":"Platts","year":"1999","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.ecoenv.2020.111046_bib26","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1021\/es200081n","article-title":"Epoxide and thiirane toxicity in vitro with the ciliates Tetrahymena pyriformis: structural alerts indicating excess toxicity","volume":"45","author":"Schramm","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2020.111046_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-1280(02)00614-0","article-title":"Quantitative structure-activity relationships (QSARs) in toxicology: a historical perspective","volume":"622","author":"Schultz","year":"2003","journal-title":"J. Mol. Struct.: THEOCHEM"},{"key":"10.1016\/j.ecoenv.2020.111046_bib28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ecoenv.2018.01.054","article-title":"Predictive ecotoxicity of MoA 1 of organic chemicals using in silico approaches","volume":"153","author":"Silva","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111046_bib29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.scitotenv.2014.03.040","article-title":"The discrimination of excess toxicity from baseline effect: effect of bioconcentration","volume":"484","author":"Su","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2020.111046_bib30","doi-asserted-by":"crossref","first-page":"109702","DOI":"10.1016\/j.ecoenv.2019.109702","article-title":"Acute and chronic toxicity of herbicides and their mixtures measured by Aliivibrio fischeri ecotoxicological assay","volume":"185","author":"Toth","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111046_bib31","series-title":"Washington, DC 20460: Office of Prevention, Pesticides, and Toxic Substances","year":"2006"},{"key":"10.1016\/j.ecoenv.2020.111046_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chemosphere.2017.04.017","article-title":"Diuron and diazinon alter the behavior of zebrafish embryos and larvae in the absence of acute toxicity","volume":"180","author":"Velki","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib33","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0045-6535(92)90280-5","article-title":"Classifying environmental pollutants","volume":"25","author":"Verhaar","year":"1992","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib34","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0045-6535(99)00317-3","article-title":"Classifying environmental pollutants: part 3. External validation of the classification system","volume":"40","author":"Verhaar","year":"2000","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111046_bib35","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1021\/tx0497954","article-title":"Structural alerts \u2013 a new classification model to discriminate excess toxicity from narcotic effect levels of organic compounds in the acute daphnid assay","volume":"18","author":"Von der Ohe","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111046_bib36","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jhazmat.2011.03.068","article-title":"Evaluation of acute toxicity and teratogenic effects of plant growth regulators by Daphnia magna embryo assay","volume":"190","author":"Wang","year":"2011","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2020.111046_bib37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ecoenv.2018.09.105","article-title":"Toxicity of some prevalent organic chemicals to tadpoles and comparison with toxicity to fish based on mode of toxic action","volume":"167","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111046_bib38","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jhazmat.2017.05.058","article-title":"Relationship between acute and chronic toxicity for prevalent organic pollutants in Vibrio fischeri based upon chemical mode of action","volume":"338","author":"Wang","year":"2017","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2020.111046_bib39","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11270-015-2427-1","article-title":"Investigation of critical body residues and modes of toxic action based on injection and aquatic exposure in fish","volume":"226","author":"Wen","year":"2015","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.ecoenv.2020.111046_bib40","first-page":"131","article-title":"Current status and future prognosis of malaria vector control pesticide ecotoxicology and Xenopus sp","volume":"252","author":"Wolmarans","year":"2020","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111046_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105114","article-title":"A nationwide survey of urinary concentrations of neonicotinoid insecticides in China","volume":"132","author":"Zhang","year":"2019","journal-title":"Environ. Int."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132030885X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014765132030885X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:23:09Z","timestamp":1758950589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014765132030885X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":41,"alternative-id":["S014765132030885X"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111046","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of modes of action of pesticides to Daphnia magna based on QSAR, excess toxicity and critical body residues","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111046"}}