{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T04:12:02Z","timestamp":1787371922272,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.ecoenv.2020.111058","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T23:51:53Z","timestamp":1596153113000},"page":"111058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Involvement of Bmal1 and circadian clock signaling in chondrogenic differentiation of ATDC5 cells by fluoride"],"prefix":"10.1016","volume":"204","author":[{"given":"Demin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2020.111058_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.21262","article-title":"Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation","author":"Adams","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ecoenv.2020.111058_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/0922-3371(90)90079-C","article-title":"A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells","author":"Atsumi","year":"1990","journal-title":"Cell Differ. Dev."},{"key":"10.1016\/j.ecoenv.2020.111058_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2018.06.006","article-title":"Transcriptomics provides mechanistic indicators of fluoride toxicology on endochondral ossification in the hind limb of Bufo gargarizans","author":"Chao","year":"2018","journal-title":"Aquat. Toxicol."},{"issue":"10","key":"10.1016\/j.ecoenv.2020.111058_bib4","first-page":"6672","article-title":"Hypertrophic chondrocyte-specific Col10a1 controlling elements in Cre recombinase transgenic studies","volume":"11","author":"Chen","year":"2019","journal-title":"Am. J. Transl. Res"},{"key":"10.1016\/j.ecoenv.2020.111058_bib5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1172\/JCI82755","article-title":"The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity","volume":"126","author":"Dudek","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ecoenv.2020.111058_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2011.12.024","article-title":"Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes","author":"Dy","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ecoenv.2020.111058_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2019.103275","article-title":"Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh\/PTHrP feedback loop during endochondral ossification","author":"Gao","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2020.111058_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.20652","article-title":"The control of chondrogenesis","author":"Goldring","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ecoenv.2020.111058_bib10","doi-asserted-by":"crossref","first-page":"23632","DOI":"10.1074\/jbc.M512362200","article-title":"Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes","volume":"281","author":"Hinoi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2020.111058_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)80959-9","article-title":"A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock","volume":"96","author":"Jin","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2020.111058_bib12","doi-asserted-by":"crossref","DOI":"10.1186\/s12896-014-0108-6","article-title":"Comparison of growth factor adsorbed scaffold and conventional scaffold with growth factor supplemented media for primary human articular chondrocyte 3D culture","author":"Klangjorhor","year":"2014","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.ecoenv.2020.111058_bib13","doi-asserted-by":"crossref","DOI":"10.1242\/dev.105536","article-title":"A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation","author":"Kozhemyakina","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2020.111058_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2020.111058_bib15","doi-asserted-by":"crossref","DOI":"10.1053\/joca.2001.0447","article-title":"L-Sox5, Sox6 and SOx9 control essential steps of the chondrocyte differentiation pathway","author":"Lefebvre","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ecoenv.2020.111058_bib16","article-title":"Fluoride inhibits longitudinal bone growth by acting directly at the growth plate in cultured neonatal rat metatarsal bones","author":"Ma","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2020.111058_bib17","doi-asserted-by":"crossref","DOI":"10.1080\/15384101.2019.1620572","article-title":"Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1\u03b1-VEGF signaling pathway","author":"Ma","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ecoenv.2020.111058_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.21342","article-title":"Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair","author":"Macsai","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ecoenv.2020.111058_bib19","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2013.1576","article-title":"Sodium fluoride induces apoptosis through the downregulation of hypoxia-inducible factor-1a in primary cultured rat chondrocytes","author":"Meng","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ecoenv.2020.111058_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2013.01.013","article-title":"Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1\/5\/8 translocation into nucleus","author":"Nishida","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ecoenv.2020.111058_bib21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcb.2013.07.002","article-title":"Molecular architecture of the mammalian circadian clock","volume":"24","author":"Partch","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ecoenv.2020.111058_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18040873","article-title":"Circadian clock, cell division, and cancer: from molecules to organism","author":"Shostak","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111058_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/S1534-5807(01)00003-X","article-title":"The transcription factors L-sox5 and Sox6 are essential for cartilage formation","author":"Smits","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ecoenv.2020.111058_bib24","doi-asserted-by":"crossref","first-page":"36081","DOI":"10.1074\/jbc.M112.408963","article-title":"Clock genes influence gene expression in growth plate and endochondral ossification in mice","volume":"287","author":"Takarada","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2020.111058_bib25","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M113.492843","article-title":"CCAAT\/enhancer-binding protein \u03b2 regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes","author":"Ushijima","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2020.111058_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.06.045","article-title":"Fluoride contamination, health problems and remediation methods in Asian groundwater: a comprehensive review","author":"Yadav","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111058_bib27","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1210\/en.2015-2042","article-title":"Clock gene Bmal1 modulates human cartilage gene expression by crosstalk with Sirt1","volume":"157","author":"Yang","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2020.111058_bib28","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jcb.24467","article-title":"ATDC5: an excellent in vitro model cell line for skeletal development","volume":"114","author":"Yao","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ecoenv.2020.111058_bib30","doi-asserted-by":"crossref","DOI":"10.1007\/s12011-016-0787-z","article-title":"Effect of choline on the composition and degradation enzyme of extracellular matrix of mice chondrocytes exposed to fluoride","author":"Zhao","year":"2017","journal-title":"Biol. Trace Elem. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320308976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320308976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:16:06Z","timestamp":1758950166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320308976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":28,"alternative-id":["S0147651320308976"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111058","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of Bmal1 and circadian clock signaling in chondrogenic differentiation of ATDC5 cells by fluoride","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111058"}}