{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:42:08Z","timestamp":1768286528685,"version":"3.49.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31602116"],"award-info":[{"award-number":["31602116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi","award":["2020L0150"],"award-info":[{"award-number":["2020L0150"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ecoenv.2020.111185","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T13:36:39Z","timestamp":1599053799000},"page":"111185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Antagonistic effect of N-acetyl-L-cysteine against cadmium-induced cytotoxicity and abnormal immune response on chicken peritoneal macrophages"],"prefix":"10.1016","volume":"206","author":[{"given":"Ding","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-ze","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-bao","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-rui","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-xia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2020.111185_bib1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1124\/mol.108.046862","article-title":"Elevated GSH level increases cadmium resistance through down-regulation of sp1-dependent expression of the cadmium transporter ZIP8","volume":"74","author":"Aiba","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib2","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/10715762.2018.1468564","article-title":"N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why","volume":"52","author":"Aldini","year":"2018","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib3","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.4049\/jimmunol.172.4.2522","article-title":"Involvement of reactive oxygen species in toll-like receptor 4-dependent activation of NF-\u03baB","volume":"172","author":"Asehnoune","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2249.2007.03441.x","article-title":"The expanding family of interleukin\u20101 cytokines and their role in destructive inflammatory disorders","volume":"149","author":"Barksby","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib5","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2174\/092986705774462987","article-title":"Chelators as antidotes of metal toxicity: therapeutic and experimental aspects","volume":"12","author":"Blanusa","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ecoenv.2020.111185_bib6","doi-asserted-by":"crossref","first-page":"117304","DOI":"10.1016\/j.lfs.2020.117304","article-title":"Decreased secretion of tumor necrosis factor-\u03b1 attenuates macrophages-induced insulin resistance in skeletal muscle","volume":"244","author":"Bu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2020.111185_bib7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.9734\/BJMMR\/2014\/5498","article-title":"Alteration of testicular macrophage morphology and associated innate immune functions in cadmium intoxicated Swiss albino mice","volume":"4","author":"Chakraborty","year":"2014","journal-title":"Br. J. Med. Med. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/nan.12103","article-title":"N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt\/mTOR pathway in mouse brain","volume":"40","author":"Chen","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1152\/ajplung.00022.2016","article-title":"Cadmium attenuates the macrophage response to LPS through inhibition of the NF-\u03baB pathway","volume":"311","author":"Cox","year":"2016","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib10","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.envpol.2018.01.002","article-title":"Significance of metallothioneins in differential cadmium accumulation kinetics between two marine fish species","volume":"236","author":"Croizier","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2020.111185_bib11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10534-010-9329-x","article-title":"Cadmium stress: an oxidative challenge","volume":"23","author":"Cuypers","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.ecoenv.2020.111185_bib12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4236\/odem.2019.74012","article-title":"Cadmium toxicity: oxidative stress, inflammation and tissue injury","volume":"7","author":"Das","year":"2019","journal-title":"Occup. Dis. Environ. Med."},{"key":"10.1016\/j.ecoenv.2020.111185_bib13","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neubiorev.2015.04.015","article-title":"Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review","volume":"55","author":"Deepmala","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ecoenv.2020.111185_bib14","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/BF02980269","article-title":"N-acetyicysteine prevents lps-lnduced pro-inflammatory cytokines and mmp2 production in gingival fibroblasts","volume":"30","author":"Do","year":"2007","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ecoenv.2020.111185_bib15","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1039\/c1mt00050k","article-title":"Zinc, cadmium and nickel increase the activation of NF-\u03baB and the release of cytokines from THP-1 monocytic cells","volume":"3","author":"Freitas","year":"2011","journal-title":"Metall"},{"key":"10.1016\/j.ecoenv.2020.111185_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar1917","article-title":"Interleukin-6 and chronic inflammation","volume":"8","author":"Gabay","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ecoenv.2020.111185_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cyto.2007.02.011","article-title":"Cadmium induces Interleukin-8 production via NF-\u03baB activation in the human intestinal epithelial cell, Caco-2","volume":"37","author":"Hyun","year":"2007","journal-title":"Cytokine"},{"key":"10.1016\/j.ecoenv.2020.111185_bib18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.taap.2006.11.033","article-title":"Alveolar macrophage cytokine response to air pollution particles: oxidant mechanisms","volume":"218","author":"Imrich","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.chemosphere.2015.08.084","article-title":"Cadmium exposure to murine macrophages decreases their inflammatory responses and increases their oxidative stress","volume":"144","author":"Jin","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111185_bib20","first-page":"947","article-title":"Oxidative stress-mediated cytotoxicity of cadmium in chicken splenic lymphocytes","volume":"19","author":"Jinlong","year":"2010","journal-title":"Pol. J. Environ. Stud."},{"key":"10.1016\/j.ecoenv.2020.111185_bib21","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/15287390600631144","article-title":"Cadmium-induced apoptosis in murine macrophages is antagonized by antioxidants and caspase inhibitors","volume":"69","author":"Kim","year":"2006","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.ecoenv.2020.111185_bib22","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4103\/0976-9668.117021","article-title":"Protective role of N-Acetyl L-Cysteine against reproductive toxicity due to interaction of lead and cadmium in male Wistar rats","volume":"4","author":"Kumar","year":"2013","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"10.1016\/j.ecoenv.2020.111185_bib23","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.toxlet.2010.01.015","article-title":"Cadmium-induced inflammatory responses in cells relevant for lung toxicity: expression and release of cytokines in fibroblasts, epithelial cells and macrophages","volume":"193","author":"Lag","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2020.111185_bib24","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib25","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.biopha.2018.09.054","article-title":"Cadmium nitrate-induced neuronal apoptosis is protected by N-acetyl-l-cysteine via reducing reactive oxygen species generation and mitochondria dysfunction","volume":"108","author":"Lee","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ecoenv.2020.111185_bib26","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.freeradbiomed.2004.03.020","article-title":"Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor","volume":"36","author":"Lemari\u00e9","year":"2004","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.ecoenv.2020.111185_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9741838","article-title":"Using ROS as a second messenger, NADPH oxidase 2 mediates macrophage senescence via interaction with NF-\u03baB during Pseudomonas aeruginosa infection","volume":"2018","author":"Li","year":"2018","journal-title":"Oxid. Med. Cell. Longevity."},{"key":"10.1016\/j.ecoenv.2020.111185_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ecoenv.2013.07.007","article-title":"Cadmium induced hepatotoxicity in chickens (Gallus domesticus) and ameliorative effect by selenium","volume":"96","author":"Li","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111185_bib29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12011-015-0314-7","article-title":"Ameliorative effects of selenium on cadmium-induced oxidative stress and endoplasmic reticulum stress in the chicken kidney","volume":"167","author":"Liu","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib30","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s12011-014-0070-0","article-title":"Cadmium-induced injury and the ameliorative effects of selenium on chicken splenic lymphocytes: mechanisms of oxidative stress and apoptosis","volume":"160","author":"Liu","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib31","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduction Targeted Ther"},{"key":"10.1016\/j.ecoenv.2020.111185_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ecoenv.2020.111185_bib33","first-page":"375","article-title":"The effect of heavy metals on the immune system at low concentrations","volume":"14","author":"Marth","year":"2001","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"10.1016\/j.ecoenv.2020.111185_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1742-4658.2009.07369.x","article-title":"ERK and cell death: cadmium toxicity, sustained ERK activation and cell death","volume":"277","author":"Martin","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.ecoenv.2020.111185_bib35","first-page":"11","article-title":"A review on various uses of N-acetyl cysteine","volume":"19","author":"Mokhtari","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2020.111185_bib36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3233\/JAD-2007-12210","article-title":"Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts","volume":"12","author":"Moreira","year":"2007","journal-title":"J. Alzhmers Dis."},{"key":"10.1016\/j.ecoenv.2020.111185_bib37","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3747\/pdi.2009.00073","article-title":"Effect of oral n-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: a placebo-controlled study","volume":"30","author":"Nascimento","year":"2010","journal-title":"Perit. Dial. Int."},{"key":"10.1016\/j.ecoenv.2020.111185_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cbi.2015.10.005","article-title":"Cadmium induced cardiac oxidative stress in rats and its attenuation by GSP through the activation of Nrf2 signaling pathway","volume":"242","author":"Nazimabashir","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ecoenv.2020.111185_bib39","doi-asserted-by":"crossref","first-page":"475","DOI":"10.18388\/abp.2012_2080","article-title":"Pro-inflammatory properties of cadmium","volume":"59","author":"Olszowski","year":"2012","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12011-017-1071-6","article-title":"Cadmium alters the concentration of fatty acids in THP-1 macrophages","volume":"182","author":"Olszowski","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib41","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.expneurol.2007.12.011","article-title":"Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine","volume":"210","author":"Paintlia","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00011-011-0323-8","article-title":"Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages","volume":"60","author":"Palacio","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib43","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/457327","article-title":"Oxidative stress in lead and cadmium toxicity and its amelioration","volume":"2011","author":"Patra","year":"2011","journal-title":"Vet. Med. Int."},{"key":"10.1016\/j.ecoenv.2020.111185_bib44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuro.2017.03.001","article-title":"Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-\u03baB pathways","volume":"60","author":"Phuagkhaopong","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ecoenv.2020.111185_bib45","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4103\/0976-9668.117021","article-title":"Protective role of N-Acetyl L-Cysteine against reproductive toxicity due to interaction of lead and cadmium in male Wistar rats","volume":"4","author":"Reddy","year":"2013","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"10.1016\/j.ecoenv.2020.111185_bib46","series-title":"The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine","article-title":"The use of N-acetylcysteine as a chelator for metal toxicity","author":"Rossignol","year":"2019"},{"key":"10.1016\/j.ecoenv.2020.111185_bib47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/antiox8050111","article-title":"Medical and dietary uses of N-acetylcysteine","volume":"8","author":"Salamon","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.ecoenv.2020.111185_bib48","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapourimoghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib49","first-page":"295","article-title":"Subtoxic doses of cadmium modulate inflammatory properties of murine RAW 264.7 macrophages","volume":"2015","author":"Sina","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ecoenv.2020.111185_bib50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tox.2017.10.016","article-title":"The critical role of autophagy in cadmium-induced immunosuppression regulated by endoplasmic reticulum stress-mediated calpain activation in RAW264.7 mouse monocytes","volume":"393","author":"So","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2020.111185_bib51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12011-016-0924-8","article-title":"Alleviation mechanisms of selenium on cadmium-spiked neutrophil injury to chicken","volume":"178","author":"Tan","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib52","doi-asserted-by":"crossref","first-page":"23967","DOI":"10.1007\/s11356-019-05638-5","article-title":"Protective effects of Ganoderma lucidum triterpenoids on oxidative stress and apoptosis in the spleen of chickens induced by cadmium","volume":"26","author":"Teng","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib53","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.taap.2009.01.013","article-title":"Cadmium and cellular signaling cascades: to be or not to be?","volume":"238","author":"Thevenod","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib54","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00204-013-1110-9","article-title":"Cadmium and cellular signaling cascades: interactions between cell death and survival pathways","volume":"87","author":"Thevenod","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib55","first-page":"30","article-title":"N-acetylcysteine: a potential treatment for substance use disorders: this otc antioxidant may benefit adults who use cocaine and adolescents who use marijuana","volume":"17","author":"Tomko","year":"2018","journal-title":"Curr. Psychiatry."},{"key":"10.1016\/j.ecoenv.2020.111185_bib56","series-title":"Mineral Commodity Summaries 2020","first-page":"p40","year":"2020"},{"key":"10.1016\/j.ecoenv.2020.111185_bib57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1567-5769(02)00232-1","article-title":"Regulation of macrophage function by the antioxidant N-acetylcysteine in mouse-oxidative stress by endotoxin","volume":"3","author":"Victor","year":"2003","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ecoenv.2020.111185_bib58","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12011-017-1193-x","article-title":"Ameliorative effects of selenium on cadmium-induced injury in the chicken ovary: mechanisms of oxidative stress and endoplasmic reticulum stress in cadmium-induced apoptosis","volume":"184","author":"Wan","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2020.111185_bib59","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.chemosphere.2018.07.129","article-title":"Turn bane into a boon: application of invasive plant species to remedy soil cadmium contamination","volume":"210","author":"Wei","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111185_bib60","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2020.111185_bib61","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/toxsci\/kfu018","article-title":"Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of Cd toxicity","volume":"139","author":"Young-Mi","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111185_bib62","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ecoenv.2018.07.069","article-title":"Protective effects of zinc and N-acetyl-L-cysteine supplementation against cadmium induced erythrocyte cytotoxicity in Arbor Acres broiler chickens (Gallus gallus domesticus)","volume":"163","author":"Zhang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111185_bib63","article-title":"Zinc supplementation protects against cadmium accumulation and cytotoxicity in madin-darby bovine kidney cells","volume":"9","author":"Zhang","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.ecoenv.2020.111185_bib64","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1021\/acs.jafc.9b00232","article-title":"Zn supplement-antagonized cadmium-induced cytotoxicity in macrophages in vitro: involvement of cadmium bioaccumulation and metallothioneins regulation","volume":"67","author":"Zhang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2020.111185_bib65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00232-011-9361-y","article-title":"Spectroscopic and microscopic studies on the mechanisms of mitochondrial toxicity induced by different concentrations of cadmium","volume":"241","author":"Zhang","year":"2011","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.ecoenv.2020.111185_bib66","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.chemosphere.2017.11.127","article-title":"Distribution and ecological risk assessment of cadmium in water and sediment in Longjiang River, China: implication on water quality management after pollution accident","volume":"194","author":"Zhao","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111185_bib67","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.tiv.2008.12.009","article-title":"The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK1 cells","volume":"23","author":"Zhou","year":"2009","journal-title":"Toxicol. Vitro"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320310241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320310241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:21:30Z","timestamp":1758950490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320310241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":67,"alternative-id":["S0147651320310241"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111185","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antagonistic effect of N-acetyl-L-cysteine against cadmium-induced cytotoxicity and abnormal immune response on chicken peritoneal macrophages","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111185"}}