{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:58:28Z","timestamp":1787065108402,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010574","name":"China Academy of Space Technology","doi-asserted-by":"publisher","award":["2019QNRC001"],"award-info":[{"award-number":["2019QNRC001"]}],"id":[{"id":"10.13039\/501100010574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803227"],"award-info":[{"award-number":["81803227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ecoenv.2020.111401","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T07:18:02Z","timestamp":1602141482000},"page":"111401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Dibromoacetic acid exposure is associated with abnormal melatonin rhythm in rats via inhibition of p-CREB1-AANAT signalling pathway"],"prefix":"10.1016","volume":"208","author":[{"given":"Wenbo","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2294-630X","authenticated-orcid":false,"given":"Huanyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiTao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2020.111401_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-079X.2011.00928.x","article-title":"Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats","volume":"52","author":"Agil","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ecoenv.2020.111401_bib2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00733786","article-title":"Cellular and molecular mechanisms controlling melatonin release by mammalian pineal glands","volume":"7","author":"Cardinali","year":"1987","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2020.111401_bib3","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.3390\/ijms14048638","article-title":"Melatonin: buffering the immune system","volume":"14","author":"Carrillo-Vico","year":"2013","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111401_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10915810290096432","article-title":"Oral (drinking water) two-generation reproductive toxicity study of dibromoacetic acid (DBA) in rats","volume":"21","author":"Christian","year":"2002","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111401_bib5","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1210\/er.2018-00084","article-title":"Melatonin as a hormone: new physiological and clinical insights","volume":"39","author":"Cipolla-Neto","year":"2018","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2020.111401_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-079X.2006.00333.x","article-title":"Annual pattern of plasma melatonin and progesterone concentrations in hair and wool ewe lambs kept under natural photoperiod at lower latitudes in the southern hemisphere","volume":"41","author":"Coelho","year":"2006","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ecoenv.2020.111401_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00425-018-2881-2","article-title":"Proteomic analysis of melatonin-mediated osmotic tolerance by improving energy metabolism and autophagy in wheat (Triticum aestivum L.)","volume":"248","author":"Cui","year":"2018","journal-title":"Planta"},{"key":"10.1016\/j.ecoenv.2020.111401_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/toxsci\/kfn139","article-title":"Subacute oral exposure to dibromoacetic acid induced immunotoxicity and apoptosis in the spleen and thymus of the mice","volume":"105","author":"Gao","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111401_bib9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/0192623315612939","article-title":"Dibromoacetic acid induces thymocyte apoptosis by blocking cell cycle progression, increasing intracellular calcium, and the fas\/fasL pathway in vitro","volume":"44","author":"Gao","year":"2016","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.ecoenv.2020.111401_bib10","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.reprotox.2007.03.001","article-title":"Moderating influence of the drinking water disinfection by-product dibromoacetic acid on a dithiocarbamate-induced suppression of the luteinizing hormone surge in female rats","volume":"23","author":"Goldman","year":"2007","journal-title":"Reprod. Toxicol."},{"issue":"1\u201310","key":"10.1016\/j.ecoenv.2020.111401_bib11","article-title":"Dibromoacetic acid induced hepatotoxicity in mice through oxidative stress and toll-like receptor 4 signaling pathway activation","volume":"2019","author":"Gong","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2020.111401_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jhazmat.2006.10.063","article-title":"Chlorination byproducts, their toxicodynamics and removal from drinking water","volume":"140","author":"Gopal","year":"2007","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2020.111401_bib13","first-page":"20","article-title":"Aging, melatonin, and the pro- and anti-inflammatory networks","author":"Hardeland","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111401_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12508","article-title":"Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia","volume":"65","author":"Hobson","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ecoenv.2020.111401_bib15","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1039\/C7MB00246G","article-title":"DBA-induced caspase-3-dependent apoptosis occurs through mitochondrial translocation of cyt-c in the rat hippocampus","volume":"13","author":"Jiang","year":"2017","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.ecoenv.2020.111401_bib16","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s11011-017-0095-0","article-title":"The toxic influence of dibromoacetic acid on the hippocampus and pre-frontal cortex of rat: involvement of neuroinflammation response and oxidative stress","volume":"32","author":"Jiang","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ecoenv.2020.111401_bib17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ecoenv.2014.03.009","article-title":"Neurotoxic evaluation of two organobromine model compounds and natural AOBr-containing surface water samples by a Caenorhabditis elegans test","volume":"104","author":"Ju","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1\u20138","key":"10.1016\/j.ecoenv.2020.111401_bib18","article-title":"The mystery behind the pineal gland: melatonin affects the metabolism of cholesterol","volume":"2019","author":"Karolczak","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2020.111401_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1749-6632.1994.tb56818.x","article-title":"The pineal organ as a component of the biological clock. Phylogenetic and ontogenetic considerations","volume":"719","author":"Korf","year":"1994","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2020.111401_bib20","first-page":"9","article-title":"Effects of melatonin on glucose homeostasis, antioxidant ability, and adipokine secretion in ICR mice with NA\/STZ-induced hyperglycemia","author":"Lo","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ecoenv.2020.111401_bib21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tem.2007.03.001","article-title":"The mammalian pineal gland: known facts, unknown facets","volume":"18","author":"Maronde","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2020.111401_bib22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tox.2006.11.006","article-title":"Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice","volume":"230","author":"Melnick","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2020.111401_bib23","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/toxsci\/kfh081","article-title":"Neurotoxicity produced by dibromoacetic acid in drinking water of rats","volume":"79","author":"Moser","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111401_bib24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/ehjcvp\/pvv037","article-title":"Melatonin has multiorgan effects","volume":"2","author":"Opie","year":"2016","journal-title":"Eur. Heart J. Cardiovasc Pharmacother."},{"key":"10.1016\/j.ecoenv.2020.111401_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/em.10092","article-title":"Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by-products","volume":"40","author":"Plewa","year":"2002","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.ecoenv.2020.111401_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11906-018-0842-6","article-title":"Anti-inflammatory effects of melatonin in obesity and hypertension","volume":"20","author":"Prado","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.ecoenv.2020.111401_bib27","first-page":"18","article-title":"Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis","author":"Reiter","year":"2017","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111401_bib28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/pr.55.2.2","article-title":"Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters","volume":"55","author":"Simonneaux","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ecoenv.2020.111401_bib29","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jhazmat.2009.03.013","article-title":"Effects of operating conditions on THMs and HAAs formation during wastewater chlorination","volume":"168","author":"Sun","year":"2009","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2020.111401_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/toxsci\/kfh266","article-title":"Effect of dibromoacetic acid on DNA methylation, glycogen accumulation, and peroxisome proliferation in mouse and rat liver","volume":"82","author":"Tao","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111401_bib31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tiv.2017.11.006","article-title":"Dibromoacetic acid induced Cl.Ly1+2\/-9 T-cell apoptosis and activation of MAPKs signaling cascades","volume":"47","author":"Zhou","year":"2018","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.ecoenv.2020.111401_bib32","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1111\/bph.14116","article-title":"New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation","volume":"175","author":"Zisapel","year":"2018","journal-title":"Br. J. Pharmacol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320312380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320312380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:12:05Z","timestamp":1765188725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320312380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":32,"alternative-id":["S0147651320312380"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111401","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dibromoacetic acid exposure is associated with abnormal melatonin rhythm in rats via inhibition of p-CREB1-AANAT signalling pathway","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111401"}}