{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:40:16Z","timestamp":1790631616332,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007065","name":"Universit\u00e0 degli Studi di Salerno","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ecoenv.2020.111475","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T20:43:51Z","timestamp":1602708231000},"page":"111475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Effects of environmental cocaine concentrations on COX and caspase-3 activity, GRP-78, ALT, CRP and blood glucose levels in the liver and kidney of the European eel (Anguilla anguilla)"],"prefix":"10.1016","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9044-2280","authenticated-orcid":false,"given":"Anna","family":"Capaldo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaminia","family":"Gay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-8030","authenticated-orcid":false,"given":"Lill\u00e0","family":"Lionetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetana","family":"Paolella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-1970","authenticated-orcid":false,"given":"Ilaria","family":"Di Gregorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Martucciello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2829-0436","authenticated-orcid":false,"given":"Mariana","family":"Di Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Rosati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Laforgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2020.111475_bb1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12026-013-8384-0","article-title":"C-reactive protein and the biology of disease","volume":"56","author":"Ansar","year":"2013","journal-title":"Immunol. Res."},{"issue":"8","key":"10.1016\/j.ecoenv.2020.111475_bb2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1575-0922(08)72799-2","article-title":"Hyperglycemia secondary to consumption of cocaine and atypical antipsychotic drugs","volume":"55","author":"Argente Villaplana","year":"2008","journal-title":"Endocrinol. Nutr."},{"issue":"3","key":"10.1016\/j.ecoenv.2020.111475_bb3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/jbt.10075","article-title":"Catalyzation of cocaine N-demethylation by cytochromes P4502B, P4503A, and P4502D in fish liver","volume":"17","author":"Arinc","year":"2003","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111475_bb4","series-title":"Insecticides: Development of Safer and More Effective Technologies","first-page":"103","article-title":"Physiological dysfunction in fish after insecticides exposure","author":"Banaee","year":"2013"},{"key":"10.1016\/j.ecoenv.2020.111475_bb5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1365-2761.1999.00134.x","article-title":"Histopathology in fish: proposal for a protocol to assess aquatic pollution","volume":"22","author":"Bernet","year":"1999","journal-title":"J. Fish. Dis.."},{"key":"10.1016\/j.ecoenv.2020.111475_bb6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2121-14-32","article-title":"Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis","volume":"14","author":"Brentnall","year":"2013","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.ecoenv.2020.111475_bb7","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s11270-011-1010-7","article-title":"Presence of cocaine in the tissues of the European eel, Anguilla anguilla, exposed to environmental cocaine concentrations","volume":"223","author":"Capaldo","year":"2012","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.ecoenv.2020.111475_bb8","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.scitotenv.2018.05.357","article-title":"Effects of environmental cocaine concentrations on the skeletal muscle of the European eel (Anguilla anguilla)","volume":"640\u2013641","author":"Capaldo","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2020.111475_bb9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ecoenv.2018.11.010","article-title":"Changes in the gills of the European eel (Anguilla anguilla) after chronic exposure to environmental cocaine concentration","volume":"169","author":"Capaldo","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111475_bb10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/02772249709358464","article-title":"Changes in carbohydrate metabolism in the eel Anguilla anguilla during short term exposure to diazinon","volume":"60","author":"Ceron","year":"1997","journal-title":"Toxicol. Environ. Chem."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111475_bb11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.neuroscience.2006.09.047","article-title":"Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax\/Bcl-2 ratio and through Caspase-3 apoptotic signalling","volume":"144","author":"Dey","year":"2007","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.ecoenv.2020.111475_bb12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123370","article-title":"Role of environmental pollutants in liver physiology: special references to peoples living in the oil drilling sites of Assam","volume":"10","author":"Dey","year":"2015","journal-title":"Plos One"},{"issue":"5","key":"10.1016\/j.ecoenv.2020.111475_bb13","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s11270-013-1579-0","article-title":"Endocrine disruption in the European eel, Anguilla anguilla, exposed to an environmental cocaine concentration","volume":"224","author":"Gay","year":"2013","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.ecoenv.2020.111475_bb14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/jfd.12362","article-title":"Histological and hormonal changes in the European eel (Anguilla anguilla) after exposure to environmental cocaine concentration","volume":"39","author":"Gay","year":"2016","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.ecoenv.2020.111475_bb15","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00216-007-1754-5","article-title":"Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography-ion trap tandem mass spectrometry","volume":"391","author":"Gheorghe","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"issue":"3","key":"10.1016\/j.ecoenv.2020.111475_bb16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: a guide for clinicians","volume":"172","author":"Giannini","year":"2005","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.ecoenv.2020.111475_bb17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0003-2697(72)90094-2","article-title":"Determination of protein: a modification of Lowry method that gives a linear photometric response","volume":"48","author":"Hartree","year":"1972","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ecoenv.2020.111475_bb18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2020.111475_bb19","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.bbabio.2011.07.001","article-title":"Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia\/reperfusion injury and inflammation","volume":"1817","author":"H\u00fcttemann","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.ecoenv.2020.111475_bb20","first-page":"272","article-title":"Rhabdomyolysis: a review of the literature","volume":"67","author":"Khan","year":"2009","journal-title":"Neth. J. Med."},{"key":"10.1016\/j.ecoenv.2020.111475_bb21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.fsi.2003.09.007","article-title":"Changes of C-reactive protein levels in rainbow trout (Oncorhynchus mykiss) sera after exposure to anti-ectoparasitic chemicals used in aquaculture","volume":"16","author":"Kodama","year":"2004","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.ecoenv.2020.111475_bb22","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.bbadis.2014.05.031","article-title":"Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis","volume":"1842","author":"Lee","year":"2014","journal-title":"Biochim. Byophys. Acta"},{"key":"10.1016\/j.ecoenv.2020.111475_bb23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.envpol.2016.02.036","article-title":"Occurrence of illicit drugs in surface waters in China","volume":"213","author":"Li","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2020.111475_bb24","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1007\/s00018-004-4073-4","article-title":"Modulation of hepatic mitochondrial energy efficiency with age","volume":"61","author":"Lionetti","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ecoenv.2020.111475_bb25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.fsi.2004.03.003","article-title":"Effect of turpentine oil on C-reactive protein (CRP) production in rainbow trout (Oncorhyncus mykiss)","volume":"17","author":"Liu","year":"2004","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.ecoenv.2020.111475_bb26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.biochi.2018.12.009","article-title":"Genetic depletion of p53 attenuates cocaine-induced hepatotoxicity in mice","volume":"158","author":"Mai","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.ecoenv.2020.111475_bb27","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.toxrep.2020.04.016","article-title":"Acute effects of chromium on hemato-biochemical parameters and morphology of erythrocytes in striped catfish Pangasianodon hypophthalmus","volume":"7","author":"Majharul Islam","year":"2020","journal-title":"Toxicol. Rep."},{"issue":"1","key":"10.1016\/j.ecoenv.2020.111475_bb28","first-page":"9","article-title":"Environmental cocaine concentration effects on Danio rerio development","volume":"60","author":"Monaco","year":"2016","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.ecoenv.2020.111475_bb29","series-title":"Fish Histology and Histopathology","author":"Mumford","year":"2007"},{"key":"10.1016\/j.ecoenv.2020.111475_bb30","first-page":"4","article-title":"Cocaine accumulation in zebrafish eyes leads to augmented amplitudes in the electroretinogram","volume":"1","author":"Niklaus","year":"2017","journal-title":"Matters"},{"key":"10.1016\/j.ecoenv.2020.111475_bb31","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.scitotenv.2012.05.086","article-title":"Illicit drugs and the environment \u2212 a review","volume":"463\u2013464","author":"Pal","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2020.111475_bb32","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.envpol.2017.04.046","article-title":"Environmental concentrations of cocaine and its main metabolites modulated antioxidant response and caused cyto-genotoxic effects in zebrafish embryo cells","volume":"226","author":"Parolini","year":"2017","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.ecoenv.2020.111475_bb33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/jfd.13149","article-title":"Increased melanomacrophage centres in the liver of reproductively dysfunctional female greater amberjack Seriola dumerili (Risso, 1810)","volume":"43","author":"Passantino","year":"2020","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.ecoenv.2020.111475_bb34","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3389\/fimmu.2019.00943","article-title":"Evolution of C-reactive protein","volume":"10","author":"Pathak","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111475_bb35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ceb.2010.09.007","article-title":"The critical role of GRP78 in physiologic and pathologic stress","volume":"23","author":"Pfaffenbach","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111475_bb36","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00128-019-02770-3","article-title":"Immunohistological biomarkers of toxicity by a pharmaceutical antidepressant in the freshwater cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)","volume":"104","author":"Rey V\u00e0zquez","year":"2020","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2020.111475_bb37","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ecoenv.2008.09.008","article-title":"Effects of propanil on the European eel Anguilla anguilla and post-exposure recovery using selected biomarkers as effect criteria","volume":"72","author":"Sancho","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111475_bb38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.scitotenv.2016.01.051","article-title":"Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone","volume":"548\u2013549","author":"Seabra-Pereira","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.ecoenv.2020.111475_bb39","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0002-9149(02)02289-0","article-title":"Effect of cocaine usage on C-reactive protein, von Willebrand factor, and fibrinogen","volume":"89","author":"Siegel","year":"2002","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111475_bb40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00204-011-0749-3","article-title":"Cocaine-induced kidney toxicity: an in vitro study using primary cultured human proximal tubular epithelial cells","volume":"86","author":"Valente","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111475_bb41","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainres.2013.10.017","article-title":"Cocaine reduces cytochrome oxidase activity in the prefrontal cortex and modifies its functional connectivity with brainstem nuclei","volume":"1542","author":"V\u00e9lez-Hern\u00e1ndez","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.ecoenv.2020.111475_bb42","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1242\/jeb.051789","article-title":"Molecular physiology and functional morphology of SO42\u2013 excretion by the kidney of seawater-adapted eels","volume":"214","author":"Watanabe","year":"2011","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ecoenv.2020.111475_bb43","unstructured":"World Drug Report, 2019. United Nations Publication, Sales No. E.19.XI.8."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320313129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320313129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:15:58Z","timestamp":1765188958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320313129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":43,"alternative-id":["S0147651320313129"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111475","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of environmental cocaine concentrations on COX and caspase-3 activity, GRP-78, ALT, CRP and blood glucose levels in the liver and kidney of the European eel (Anguilla anguilla)","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111475"}}