{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:04:11Z","timestamp":1780416251028,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871169"],"award-info":[{"award-number":["81871169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010954"],"award-info":[{"award-number":["2019A1515010954"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ecoenv.2020.111511","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T01:01:27Z","timestamp":1603933287000},"page":"111511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Resveratrol alleviates zea-induced decidualization disturbance in human endometrial stromal cells"],"prefix":"10.1016","volume":"207","author":[{"given":"Sitong","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2020.111511_bb1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxicon.2016.08.009","article-title":"Zearalenone and 17 beta-estradiol induced damages in male rats reproduction potential; evidence for ERalpha and ERbeta receptors expression and steroidogenesis","volume":"120","author":"Adibnia","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.ecoenv.2020.111511_bb2","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1016\/j.fct.2010.07.012","article-title":"Fetal and neonatal exposure to the mycotoxin zearalenone induces phenotypic alterations in adult rat mammary gland","volume":"48","author":"Belli","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb3","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.molcel.2020.07.010","article-title":"Genome-wide screens reveal that resveratrol induces replicative stress in human cells","volume":"79","author":"Benslimane","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2020.111511_bb4","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2174\/0929867311320100009","article-title":"Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial","volume":"20","author":"Bo","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ecoenv.2020.111511_bb5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S0007114511000316","article-title":"Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients","volume":"106","author":"Brasny\u00f3","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ecoenv.2020.111511_bb6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/molecules24132474","article-title":"Treatment with, resveratrol, a SIRT1 activator, prevents zearalenone-induced lactic acid metabolism disorder in rat sertoli cells","volume":"24","author":"Cai","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2020.111511_bb7","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.ecoenv.2020.111511_bb8","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1177\/1933719119833485","article-title":"Effects of supraphysiologic levels of estradiol on endometrial decidualization, sFlt1, and HOXA10 expression","volume":"26","author":"Cottrell","year":"2019","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ecoenv.2020.111511_bb9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/0002-9378(83)90572-0","article-title":"Prolactin production during in vitro decidualization of proliferative endometrium","volume":"145","author":"Daly","year":"1983","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000338634","article-title":"Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects","volume":"61","author":"De Groote","year":"2012","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.ecoenv.2020.111511_bb11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/bs.apcsb.2019.01.001","article-title":"Estrogen receptor signaling mechanisms","volume":"116","author":"Fuentes","year":"2019","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.toxlet.2019.08.007","article-title":"Pubertal exposure to low doses of zearalenone disrupting spermatogenesis through ERalpha related genetic and epigenetic pathways","volume":"315","author":"Gao","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2020.111511_bb13","doi-asserted-by":"crossref","first-page":"14138","DOI":"10.1073\/pnas.94.25.14138","article-title":"Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor","volume":"94","author":"Gehm","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2020.111511_bb14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2020.111511_bb15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2017.08.010","article-title":"Zearalenone and alpha-zearalenol inhibit the synthesis and secretion of pig follicle stimulating hormone via the non-classical estrogen membrane receptor GPR30","volume":"461","author":"He","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1095\/biolreprod.106.054791","article-title":"Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators","volume":"76","author":"Hess","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2020.111511_bb17","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1210\/endo-121-6-2011","article-title":"Regulation of prolactin production by progestin, estrogen, and relaxin in human endometrial stromal cells","volume":"121","author":"RONG HUANG","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2020.111511_bb18","doi-asserted-by":"crossref","first-page":"13735","DOI":"10.1038\/srep13735","article-title":"FoxM1 directs STAT3 expression essential for human endometrial stromal decidualization","volume":"5","author":"Jiang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2020.111511_bb19","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1210\/jcem.87.8.8880","article-title":"Activin A promotes human endometrial stromal cell decidualization in vitro","volume":"87","author":"Jones","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2020.111511_bb20","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.devcel.2012.09.002","article-title":"Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation","volume":"23","author":"Kawagoe","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ecoenv.2020.111511_bb21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.etap.2016.10.015","article-title":"Zearalenone as an endocrine disruptor in humans","volume":"48","author":"Kowalska","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb22","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ecoenv.2019.01.115","article-title":"Estrogen receptor beta plays a protective role in zearalenone-induced oxidative stress in normal prostate epithelial cells","volume":"172","author":"Kowalska","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111511_bb23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1210\/me.2012-1247","article-title":"Induction of 11\u03b2-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells","volume":"27","author":"Kuroda","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.taap.2017.04.005","article-title":"Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation","volume":"325","author":"Lecomte","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb25","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1289\/ehp.1104689","article-title":"Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor alpha and beta in vitro","volume":"120","author":"Li","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2020.111511_bb26","doi-asserted-by":"crossref","first-page":"22744","DOI":"10.1038\/srep22744","article-title":"Non-coding RNA LINC00473 mediates decidualization of human endometrial stromal cells in response to cAMP signaling","volume":"6","author":"Liang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2020.111511_bb27","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41598-017-18643-w","article-title":"The high concentration of progesterone is harmful for endometrial receptivity and decidualization","volume":"8","author":"Liang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2020.111511_bb28","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/humrep\/dep429","article-title":"Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study","volume":"25","author":"Liu","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ecoenv.2020.111511_bb29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1177\/1933719112438447","article-title":"Cell cycle regulation of human endometrial stromal cells during decidualization","volume":"19","author":"Logan","year":"2012","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ecoenv.2020.111511_bb30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1095\/biolreprod.114.122846","article-title":"The human endometrium as a sensor of embryo quality","volume":"91","author":"Macklon","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2020.111511_bb31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tox.2009.06.023","article-title":"Induction of cells differentiation and ABC transporters expression by a myco-estrogen, zearalenone, in human choriocarcinoma cell line (BeWo)","volume":"263","author":"Prouillac","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2020.111511_bb32","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1039\/C6FO00191B","article-title":"The protective effect of resveratrol against cytotoxicity induced by mycotoxin, zearalenone","volume":"7","author":"Sang","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2020.111511_bb33","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/med.21565","article-title":"Health benefits of resveratrol: evidence from clinical studies","volume":"39","author":"Singh","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ecoenv.2020.111511_bb34","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ejphar.2014.07.057","article-title":"Phytoestrogens and their effects","volume":"741","author":"Sirotkin","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb35","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1210\/me.2013-1086","article-title":"Uterine deletion of Gp130 or Stat3 shows implantation failure with increased estrogenic responses","volume":"27","author":"Sun","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb36","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1210\/me.2007-0058","article-title":"Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells","volume":"21","author":"Takano","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb37","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jsbmb.2006.08.008","article-title":"Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro","volume":"103","author":"Takemura","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrg1808","article-title":"Roadmap to embryo implantation: clues from mouse models","volume":"7","author":"Wang","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ecoenv.2020.111511_bb39","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1210\/me.2012-1169","article-title":"Regulation of human endometrial stromal proliferation and differentiation by C\/EBPbeta involves cyclin E-cdk2 and STAT3","volume":"26","author":"Wang","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb40","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.febslet.2014.02.043","article-title":"Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization","volume":"588","author":"Xu","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ecoenv.2020.111511_bb41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.reprotox.2014.06.005","article-title":"Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice","volume":"47","author":"Zhao","year":"2014","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2020.111511_bb42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/toxsci\/kfs343","article-title":"Postweaning exposure to dietary zearalenone, a mycotoxin, promotes premature onset of puberty and disrupts early pregnancy events in female mice","volume":"132","author":"Zhao","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2020.111511_bb43","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.fct.2019.02.031","article-title":"Effects of zearalenone and its derivatives on the synthesis and secretion of mammalian sex steroid hormones: a review","volume":"126","author":"Zheng","year":"2019","journal-title":"Food Chem. Toxicol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320313488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320313488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:30:27Z","timestamp":1758951027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320313488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":43,"alternative-id":["S0147651320313488"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111511","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol alleviates zea-induced decidualization disturbance in human endometrial stromal cells","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111511","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111511"}}