{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:16:48Z","timestamp":1788239808535,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010723","name":"Afyon Kocatepe \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.ecoenv.2020.111784","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T08:24:18Z","timestamp":1607675058000},"page":"111784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Proteomic analysis reveals the role of exogenous cysteine in alleviating chromium stress in maize seedlings"],"prefix":"10.1016","volume":"209","author":[{"given":"Hakan","family":"Terzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2020.111784_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Method Enzymol."},{"key":"10.1016\/j.ecoenv.2020.111784_bib2","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1002\/pmic.200701189","article-title":"Comparative proteomic study of arsenic-induced differentially expressed proteins in rice roots reveals glutathione plays a central role during As stress","volume":"8","author":"Ahsan","year":"2008","journal-title":"Proteomics"},{"key":"10.1016\/j.ecoenv.2020.111784_bib3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1104\/pp.106.082040","article-title":"Production and scavenging of reactive oxygen species in chloroplasts and their functions","volume":"141","author":"Asada","year":"2006","journal-title":"Plant Physiol."},{"key":"10.1016\/j.ecoenv.2020.111784_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jhazmat.2010.08.023","article-title":"Comparative proteomic analysis of Typha angustifolia leaf under chromium, cadmium and lead stress","volume":"184","author":"Bah","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2020.111784_bib5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","article-title":"Superoxide dismutase: improved assays and an assay applicable to acrylamide gels","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ecoenv.2020.111784_bib6","first-page":"248","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecoenv.2020.111784_bib7","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/elps.200305844","article-title":"Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis","volume":"25","author":"Candiano","year":"2004","journal-title":"Electrophoresis"},{"key":"10.1016\/j.ecoenv.2020.111784_bib8","first-page":"746","article-title":"Assay of catalase and peroxidase","volume":"2","author":"Chance","year":"1955","journal-title":"Method Enzym."},{"key":"10.1016\/j.ecoenv.2020.111784_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev.arplant.53.100301.135154","article-title":"Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis","volume":"53","author":"Cobbett","year":"2002","journal-title":"Annu. Rev. Plant Biol."},{"issue":"5","key":"10.1016\/j.ecoenv.2020.111784_bib10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2017.04.023","article-title":"The logic of the 26S proteasome","volume":"169","author":"Collins","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2020.111784_bib11","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1105\/tpc.104.023622","article-title":"The role of \u03941-pyrroline-5-carboxylate dehydrogenase in proline degradation","volume":"16","author":"Deuschle","year":"2004","journal-title":"Plant Cell"},{"key":"10.1016\/j.ecoenv.2020.111784_bib12","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.envpol.2016.03.035","article-title":"An emphasis of hydrogen sulfide-cysteine cycle on enhancing the tolerance to chromium stress in Arabidopsis","volume":"213","author":"Fang","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2020.111784_bib13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1042\/bj1040627","article-title":"A spectrophotometric method for the direct measurement of cysteine in the presence of other naturally occurring amino acids","volume":"104","author":"Gaitonde","year":"1967","journal-title":"Biochem. J."},{"issue":"13","key":"10.1016\/j.ecoenv.2020.111784_bib14","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1016\/j.jprot.2012.05.037","article-title":"Proteomic study of \u03b2-aminobutyric acid-mediated cadmium stress alleviation in soybean","volume":"75","author":"Hossain","year":"2012","journal-title":"J. Proteom."},{"key":"10.1016\/j.ecoenv.2020.111784_bib15","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1104\/pp.81.3.802","article-title":"Solubilization of plant membrane proteins for analysis by two-dimensional gel electrophoresis","volume":"81","author":"Hurkman","year":"1986","journal-title":"Plant Physiol."},{"key":"10.1016\/j.ecoenv.2020.111784_bib16","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.chemosphere.2018.12.145","article-title":"Impact of Cr(VI) on the oxidation of polyunsaturated fatty acids in Helianthus annuus roots studied by metabolomic tools","volume":"220","author":"Ibarra","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111784_bib17","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/jexbot\/51.348.1179","article-title":"Induced activity of adenine phosphoribosyltransferase (APRT) in iron-deficient barley roots: a possible role for phytosiderophore production","volume":"51","author":"Itai","year":"2000","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.ecoenv.2020.111784_bib18","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1021\/bi00289a034","article-title":"High-resolution proton nuclear magnetic resonance analysis of solution structures and conformational properties of mugineic acid and its metal complexes","volume":"22","author":"Iwashita","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/j.ecoenv.2020.111784_bib19","doi-asserted-by":"crossref","first-page":"39702","DOI":"10.1038\/srep39702","article-title":"Hydrogen sulfide\u2013cysteine cycle system enhances cadmium tolerance through alleviating cadmium-induced oxidative stress and ion toxicity in Arabidopsis roots","volume":"6","author":"Jia","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111784_bib20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/BST20130242","article-title":"Glyoxalases and stress tolerance in plants","volume":"42","author":"Kaur","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ecoenv.2020.111784_bib21","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s00299-013-1464-8","article-title":"Overexpression of the glutamine synthetase gene modulates oxidative stress response in rice after exposure to cadmium stress","volume":"32","author":"Lee","year":"2013","journal-title":"Plant Cell Rep."},{"key":"10.1016\/j.ecoenv.2020.111784_bib22","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1007\/s11738-011-0759-z","article-title":"In vivo and in situ visualization of early physiological events induced by heavy metals in pea root meristem","volume":"33","author":"Lehotai","year":"2011","journal-title":"Acta Physiol. Plant."},{"key":"10.1016\/j.ecoenv.2020.111784_bib23","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/bioinformatics\/bti551","article-title":"BiNGO: a cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks","volume":"21","author":"Maere","year":"2005","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.ecoenv.2020.111784_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.arplant.47.1.127","article-title":"The functions and regulation of glutathione S-transferases in plants","volume":"47","author":"Marrs","year":"1996","journal-title":"Ann. Rev. Plant Biol."},{"key":"10.1016\/j.ecoenv.2020.111784_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-3040.2007.01764.x","article-title":"Expression differences for genes involved in lignin, glutathione and sulphate metabolism in response to cadmium in Arabidopsis thaliana and the related Zn\/Cd-hyperaccumulator Thlaspi caerulescens","volume":"31","author":"van de Mortel","year":"2008","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.ecoenv.2020.111784_bib26","series-title":"Plant Stress Tolerance","first-page":"21","article-title":"Omics and system biology approaches in plant stress research","author":"Mosa","year":"2017"},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111784_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5511\/plantbiotechnology.14.0130a","article-title":"An improved tolerance to cadmium by overexpression of two genes for cysteine synthesis in tobacco","volume":"31","author":"Nakamura","year":"2014","journal-title":"Plant Biotechnol."},{"key":"10.1016\/j.ecoenv.2020.111784_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2017.07.013","article-title":"ROS-related redox regulation and signaling in plants","volume":"80","author":"Noctor","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.ecoenv.2020.111784_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5423\/PPJ.RW.08.2015.0150","article-title":"Heat shock proteins: a review of the molecular chaperones for plant immunity","volume":"31","author":"Park","year":"2015","journal-title":"Plant Pathol. J."},{"key":"10.1016\/j.ecoenv.2020.111784_bib30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11816-017-0426-y","article-title":"Down-regulation of hydroxycinnamoyl CoA: shikimate hydroxycinnamoyl transferase, cinnamoyl CoA reductase, and cinnamyl alcohol dehydrogenase leads to lignin reduction in rice (Oryza sativa L. ssp. japonica cv. Nipponbare)","volume":"11","author":"Ponniah","year":"2017","journal-title":"Plant Biotechnol. Rep."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111784_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0150431","article-title":"Morpho-physiological and proteome level responses to cadmium stress in sorghum","volume":"11","author":"Roy","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2020.111784_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tplants.2008.10.007","article-title":"The relationship between metal toxicity and cellular redox imbalance","volume":"14","author":"Sharma","year":"2009","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.ecoenv.2020.111784_bib33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.plantsci.2012.02.002","article-title":"Chromium-induced physiological and proteomic alterations in roots of Miscanthus sinensis","volume":"187","author":"Sharmin","year":"2012","journal-title":"Plant Sci."},{"key":"10.1016\/j.ecoenv.2020.111784_bib34","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.envexpbot.2007.12.005","article-title":"Nitric oxide (as sodium nitroprusside) supplementation ameliorates cd toxicity in hydroponically grown wheat roots","volume":"63","author":"Singh","year":"2008","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.ecoenv.2020.111784_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10311-013-0407-5","article-title":"Chromium toxicity and tolerance in plants","volume":"11","author":"Singh","year":"2013","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.ecoenv.2020.111784_bib36","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jenvman.2017.10.033","article-title":"Chromium tolerance, bioaccumulation and localization in plants: an overview","volume":"206","author":"Sinha","year":"2018","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.ecoenv.2020.111784_bib37","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/1615-9861(200107)1:7<835::AID-PROT835>3.0.CO;2-2","article-title":"A new silver staining apparatus and procedure for matrix-assisted laser desorption\/ionization-time of flight analysis of proteins after two-dimensional electrophoresis","volume":"1","author":"Sinha","year":"2001","journal-title":"Proteomics"},{"key":"10.1016\/j.ecoenv.2020.111784_bib38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11104-012-1458-2","article-title":"Proteomic analysis of copper stress responses in the roots of two rice (Oryza sativa L.) varieties differing in Cu tolerance","volume":"366","author":"Song","year":"2013","journal-title":"Plant Soil"},{"key":"10.1016\/j.ecoenv.2020.111784_bib39","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/mp\/sss065","article-title":"Improved growth and stress tolerance in the Arabidopsis oxt1 mutant triggered by altered adenine metabolism","volume":"5","author":"Sukrong","year":"2012","journal-title":"Mol. Plant"},{"key":"10.1016\/j.ecoenv.2020.111784_bib40","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/nar\/gkq973","article-title":"The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored","volume":"39","author":"Szklarczyk","year":"2011","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.ecoenv.2020.111784_bib41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-arplant-042110-103921","article-title":"Sulfur assimilation in photosynthetic organisms: molecular functions and regulations of transporters and assimilatory enzymes","volume":"62","author":"Takahashi","year":"2011","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.ecoenv.2020.111784_bib42","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.pbi.2005.05.014","article-title":"Functions of the respiratory burst oxidase in biotic interactions, abiotic stress and development","volume":"8","author":"Torres","year":"2005","journal-title":"Curr. Opin. Plant Biol."},{"issue":"8\u20139","key":"10.1016\/j.ecoenv.2020.111784_bib43","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1016\/j.envpol.2009.02.036","article-title":"Cysteine- and glutathione-mediated uptake of lead and cadmium into Zea mays and Brassica napus roots","volume":"157","author":"Vadas","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2020.111784_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1999-3110-55-35","article-title":"How plants cope with heavy metals","volume":"55","author":"Viehweger","year":"2014","journal-title":"Bot. Stud."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111784_bib45","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11738-010-0554-2","article-title":"Comparative proteomic analysis of Cd-responsive proteins in wheat roots","volume":"33","author":"Wang","year":"2011","journal-title":"Acta Physiol. Plant."},{"key":"10.1016\/j.ecoenv.2020.111784_bib46","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11105-012-0515-6","article-title":"Proteomic analysis of Cd-responsive proteins in Solanum torvum","volume":"31","author":"Wu","year":"2013","journal-title":"Plant Mol. Biol. Rep."},{"key":"10.1016\/j.ecoenv.2020.111784_bib47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ecoenv.2015.10.023","article-title":"Proteomic analysis of chromium stress and sulfur deficiency responses in leaves of two canola (Brassica napus L.) cultivars differing in Cr(VI) tolerance","volume":"124","author":"Y\u0131ld\u0131z","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2020.111784_bib48","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1007\/s11356-014-3535-y","article-title":"Effects of exogenous glutathione and cysteine on growth, lead accumulation, and tolerance of Iris lactea var. chinensis","volume":"22","author":"Yuan","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2020.111784_bib49","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ibiod.2016.09.003","article-title":"Kinetics of phyto-accumulation of hexavalent and trivalent chromium in rice seedlings","volume":"128","author":"Yu","year":"2018","journal-title":"Int. Biodeter. Biodegra."},{"key":"10.1016\/j.ecoenv.2020.111784_bib50","article-title":"Transcriptomic analysis of cytochrome P450 genes and pathways involved in chromium toxicity in Oryza sativa","volume":"29","author":"Yu","year":"2019","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.ecoenv.2020.111784_bib51","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00425-014-2077-3","article-title":"Physiological and proteomic alterations in rice (Oryza sativa L.) seedlings under hexavalent chromium stress","volume":"240","author":"Zeng","year":"2014","journal-title":"Planta"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320316201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320316201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:20:45Z","timestamp":1758950445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320316201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":51,"alternative-id":["S0147651320316201"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111784","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic analysis reveals the role of exogenous cysteine in alleviating chromium stress in maize seedlings","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111784"}}