{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:05:12Z","timestamp":1790809512600,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772803"],"award-info":[{"award-number":["31772803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.ecoenv.2020.111822","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T18:51:36Z","timestamp":1610045496000},"page":"111822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["The response of copper resistance genes, antibiotic resistance genes, and intl1\/2 to copper addition during anaerobic digestion in laboratory"],"prefix":"10.1016","volume":"210","author":[{"given":"Qin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenglin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ecoenv.2020.111822_bib1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1128\/AAC.46.5.1410-1416.2002","article-title":"tcrB, a gene conferring transferable copper resistance in Enterococcus faecium: occurrence, transferability, and linkage to macrolide and glycopeptide resistance","volume":"46","author":"Aarestrup","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111822_bib2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00248-010-9727-1","article-title":"Soil microbial abundance and diversity along a low precipitation gradient","volume":"60","author":"Bachar","year":"2010","journal-title":"Micro Ecol."},{"issue":"6969","key":"10.1016\/j.ecoenv.2020.111822_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nature02241","article-title":"SOS response promotes horizontal dissemination of antibiotic resistance genes","volume":"427","author":"Beaber","year":"2004","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ecoenv.2020.111822_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/nrmicro3399-c1","article-title":"Antibiotic resistance genes in the environment: prioritizing risks","volume":"13","author":"Bengtsson-Palme","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ecoenv.2020.111822_bib5","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.scitotenv.2016.06.228","article-title":"Elucidating selection processes for antibiotic resistance in sewage treatment plants using metagenomics","volume":"572","author":"Bengtsson-Palme","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"22","key":"10.1016\/j.ecoenv.2020.111822_bib6","doi-asserted-by":"crossref","first-page":"8724","DOI":"10.1021\/es101798r","article-title":"Cu exposure under field conditions coselects for antibiotic resistance as determined by a novel cultivation-independent bacterial community tolerance assay","volume":"44","author":"Berg","year":"2010","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.ecoenv.2020.111822_bib7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/10643380490434128","article-title":"Distribution and bioavailability of trace elements in livestock and poultry manure by-products","volume":"34","author":"Bolan","year":"2004","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.ecoenv.2020.111822_bib8","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.soilbio.2010.01.008","article-title":"Development of pollution induced community tolerance is linked to structural and functional resilience of a soil bacterial community following a five-year field exposure to copper","volume":"42","author":"Brandt","year":"2010","journal-title":"Soil Biol. Biochem."},{"key":"10.1016\/j.ecoenv.2020.111822_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.envint.2015.09.013","article-title":"Ecotoxicological assessment of antibiotics: a call for improved consideration of microorganisms","volume":"85","author":"Brandt","year":"2015","journal-title":"Environ. Int."},{"issue":"465\u201378","key":"10.1016\/j.ecoenv.2020.111822_bib10","article-title":"Microbiological effects of sublethal levels of antibiotics","volume":"12(7)","author":"Dan I Andersson","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ecoenv.2020.111822_bib11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.watres.2016.02.049","article-title":"Co-occurrence of integrase 1, antibiotic and heavy metal resistance genes in municipal wastewater treatment plants","volume":"94","author":"Di Cesare","year":"2016","journal-title":"Water Res."},{"issue":"9","key":"10.1016\/j.ecoenv.2020.111822_bib12","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1007\/s00253-015-6404-9","article-title":"Impacts of coexisting antibiotics, antibacterial residues, and heavy metals on the occurrence of erythromycin resistance genes in urban wastewater","volume":"99","author":"Gao","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"3","key":"10.1016\/j.ecoenv.2020.111822_bib13","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1128\/AAC.45.3.723-726.2001","article-title":"Incidence of class 1 and 2 integrases in clinical and commensal bacteria from livestock, companion animals, and exotics","volume":"45","author":"Goldstein","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"10.1016\/j.ecoenv.2020.111822_bib14","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1111\/j.1462-2920.2009.01973.x","article-title":"Chromosomal antioxidant genes have metal ion-specific roles as determinants of bacterial metal tolerance","volume":"11","author":"Harrison","year":"2009","journal-title":"Environ. Microbiol."},{"issue":"22","key":"10.1016\/j.ecoenv.2020.111822_bib15","doi-asserted-by":"crossref","first-page":"13120","DOI":"10.1021\/es5041267","article-title":"Dissemination of antibiotic resistance genes in representative broiler feedlots environments: identification of indicator ARGs and correlations with environmental variables","volume":"48","author":"He","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2020.111822_bib16","first-page":"341","article-title":"Bacterial tolerance in contaminated soils: potential of the PICT approach in microbial ecology","author":"Imfeld","year":"2011","journal-title":"Toler. Environ. Contam."},{"issue":"215","key":"10.1016\/j.ecoenv.2020.111822_bib17","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.chemosphere.2018.10.114","article-title":"Co-selection of multi-antibiotic resistance in bacterial pathogens in metal and microplastic contaminated environments: An emerging health threat","volume":"Jan","author":"Imran","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2020.111822_bib18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jhazmat.2012.07.040","article-title":"Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China","volume":"235\u2013236","author":"Ji","year":"2012","journal-title":"J. Hazard. Mater."},{"issue":"11","key":"10.1016\/j.ecoenv.2020.111822_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027300","article-title":"Antibiotic resistance gene abundances correlate with metal and geochemical conditions in archived Scottish soils","volume":"6","author":"Knapp","year":"2011","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.ecoenv.2020.111822_bib20","doi-asserted-by":"crossref","first-page":"8700","DOI":"10.1016\/j.biortech.2011.02.012","article-title":"Enhancement of bioenergy production from organic wastes by two-stage anaerobic hydrogen and methane production process","volume":"102","author":"Luo","year":"2011","journal-title":"Bioresour. Technol."},{"issue":"7843\u201353","key":"10.1016\/j.ecoenv.2020.111822_bib21","article-title":"Impact of metal pollution and Thlaspi caerulescens growth on soil microbial communities","volume":"76(23)","author":"Lur","year":"2010","journal-title":"Appl Environ Microbiol"},{"issue":"18","key":"10.1016\/j.ecoenv.2020.111822_bib22","doi-asserted-by":"crossref","first-page":"7855","DOI":"10.1021\/es200827t","article-title":"Effect of various sludge digestion conditions on sulfonamide, macrolide, and tetracycline resistance genes and class I integrons","volume":"45","author":"Ma","year":"2011","journal-title":"Environ. Sci. Technol."},{"issue":"10\u201315","key":"10.1016\/j.ecoenv.2020.111822_bib23","article-title":"Class 1 integrons as invasive species","volume":"38","author":"Michael R Gillings","year":"2017","journal-title":"Curr Opin Microbiol"},{"issue":"3","key":"10.1016\/j.ecoenv.2020.111822_bib24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1108\/WJE-06-2016-029","article-title":"The physiochemical properties of submicron particles from emissions of industrial furnace","volume":"13","author":"Niu","year":"2016","journal-title":"World J. Eng."},{"key":"10.1016\/j.ecoenv.2020.111822_bib25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1186\/s12864-015-2153-5","article-title":"Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential","volume":"16","author":"Pal","year":"2015","journal-title":"BMC Genom."},{"issue":"6","key":"10.1016\/j.ecoenv.2020.111822_bib26","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00203-015-1109-0","article-title":"Role of the cell envelope stress regulators BaeR and CpxR in control of RND-type multidrug efflux pumps and transcriptional cross talk with exopolysaccharide synthesis in Erwinia amylovora","volume":"197","author":"Pletzer","year":"2015","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ecoenv.2020.111822_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.envint.2017.10.016","article-title":"Review of antibiotic resistance in China and its environment","volume":"110","author":"Qiao","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2020.111822_bib28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3389\/fmicb.2012.00399","article-title":"Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture","volume":"3","author":"Seiler","year":"2012","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.ecoenv.2020.111822_bib29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/jac\/dkt479","article-title":"Co-transfer of resistance to high concentrations of copper and first-line antibiotics among Enterococcus from different origins (humans, animals, the environment and foods) and clonal lineages","volume":"69","author":"Silveira","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"issue":"5","key":"10.1016\/j.ecoenv.2020.111822_bib30","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1021\/acs.est.6b05342","article-title":"Comparison of metals and tetracycline as selective agents for development of tetracycline resistant bacterial communities in agricultural soil","volume":"51","author":"Song","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.ecoenv.2020.111822_bib31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1128\/jb.154.3.1263-1268.1983","article-title":"Plasmid-controlled resistance to copper in Escherichia coli","volume":"154","author":"Tetaz","year":"1983","journal-title":"J. Bacteriol."},{"issue":"4","key":"10.1016\/j.ecoenv.2020.111822_bib32","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3390\/antibiotics4040567","article-title":"Co-selection of resistance to antibiotics, biocides and heavy metals, and its relevance to foodborne pathogens","volume":"4","author":"Wales","year":"2015","journal-title":"Antibiot. (Basel)"},{"key":"10.1016\/j.ecoenv.2020.111822_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biortech.2017.03.134","article-title":"Effects of chlortetracycline and copper on tetracyclines and copper resistance genes and microbial community during swine manure anaerobic digestion","volume":"238","author":"Wang","year":"2017","journal-title":"Bioresour. Technol."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2020.111822_bib34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.marpolbul.2013.08.025","article-title":"Heavy metal pollution in coastal areas of South China: a review","volume":"76","author":"Wang","year":"2013","journal-title":"Mar. Pollut. Bull."},{"issue":"2","key":"10.1016\/j.ecoenv.2020.111822_bib35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00248-015-0583-x","article-title":"Antibiotics, antibiotic resistance genes, and bacterial community composition in fresh water aquaculture environment in China","volume":"70","author":"Xiong","year":"2015","journal-title":"Microb. Ecol."},{"issue":"11","key":"10.1016\/j.ecoenv.2020.111822_bib36","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.resconrec.2010.02.005","article-title":"Copper content in animal manures and potential risk of soil copper pollution with animal manure use in agriculture. Copper content in animal manures and potential risk of soil copper pollution with animal manure use in agriculture","volume":"54","author":"Xiong","year":"2010","journal-title":"Resour. Conserv. Recycl."},{"key":"10.1016\/j.ecoenv.2020.111822_bib37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biortech.2016.02.140","article-title":"Fate of antibiotic resistance genes and its drivers during anaerobic co-digestion of food waste and sewage sludge based on microwave pretreatment","volume":"217","author":"Zhang","year":"2016","journal-title":"Bioresour. Technol."},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2020.111822_bib38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biortech.2017.07.035","article-title":"Behavior of antibiotic resistance genes during co-composting of swine manure with Chinese medicinal herbal residues","volume":"244","author":"Zhang","year":"2017","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ecoenv.2020.111822_bib39","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.envpol.2018.01.032","article-title":"Sub-inhibitory concentrations of heavy metals facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes in water environment","volume":"237","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"issue":"8","key":"10.1016\/j.ecoenv.2020.111822_bib40","doi-asserted-by":"crossref","first-page":"8182","DOI":"10.1007\/s11356-018-04065-2","article-title":"Dissemination of resistance genes in duck\/fish polyculture ponds in Guangdong Province: correlations between Cu and Zn and antibiotic resistance genes","volume":"26","author":"Zhou","year":"2019","journal-title":"Environ. Sci. Pollut. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320316584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651320316584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:25:36Z","timestamp":1758950736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651320316584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":40,"alternative-id":["S0147651320316584"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111822","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The response of copper resistance genes, antibiotic resistance genes, and intl1\/2 to copper addition during anaerobic digestion in laboratory","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111822"}}