{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:42:09Z","timestamp":1787240529555,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFD0502200"],"award-info":[{"award-number":["2017YFD0502200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFD0501205"],"award-info":[{"award-number":["2016YFD0501205"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072930"],"award-info":[{"award-number":["32072930"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572585"],"award-info":[{"award-number":["31572585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.ecoenv.2021.112040","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T17:30:23Z","timestamp":1613669423000},"page":"112040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Metabolomics analysis reveals the effect of copper on autophagy in myocardia of pigs"],"prefix":"10.1016","volume":"213","author":[{"given":"Quanwei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhao","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaiqin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianmei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ecoenv.2021.112040_bib1","doi-asserted-by":"crossref","first-page":"10451","DOI":"10.1038\/s41598-017-10856-3","article-title":"Investigation of mitochondrial metabolic response to doxorubicin in prostate cancer cells: an NADH, FAD and tryptophan FLIM Assay","volume":"7","author":"Alam","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.ecoenv.2021.112040_bib2","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1039\/C7MT00066A","article-title":"Cellular copper homeostasis: current concepts on its interplay with glutathione homeostasis and its implication in physiology and human diseases","volume":"9","author":"Bhattacharjee","year":"2017","journal-title":"Metallomics"},{"issue":"11","key":"10.1016\/j.ecoenv.2021.112040_bib3","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.7150\/ijbs.16245","article-title":"The evolving functions of autophagy in ocular health: a double-edged sword","volume":"12","author":"Chai","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ecoenv.2021.112040_bib4","doi-asserted-by":"crossref","first-page":"k3310","DOI":"10.1136\/bmj.k3310","article-title":"Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis","volume":"362","author":"Chowdhury","year":"2018","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.ecoenv.2021.112040_bib5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tcb.2003.12.002","article-title":"Autophagy: in sickness and in health","volume":"14","author":"Cuervo","year":"2004","journal-title":"Trends Cell Biol."},{"issue":"6","key":"10.1016\/j.ecoenv.2021.112040_bib6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"Doenst","year":"2013","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.ecoenv.2021.112040_bib7","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1177\/0748233714566875","article-title":"Influence of chronic cadmium exposure on the tissue distribution of copper and zinc and oxidative stress parameters in rats","volume":"32","author":"Erdem","year":"2016","journal-title":"Toxicol. Ind. Health"},{"issue":"1","key":"10.1016\/j.ecoenv.2021.112040_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res"},{"issue":"2","key":"10.1016\/j.ecoenv.2021.112040_bib9","doi-asserted-by":"crossref","first-page":"C186","DOI":"10.1152\/ajpcell.00132.2018","article-title":"Copper transporters and copper chaperones: roles in cardiovascular physiology and disease","volume":"315","author":"Fukai","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"13","key":"10.1016\/j.ecoenv.2021.112040_bib10","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1016\/j.celrep.2018.03.017","article-title":"Serine availability influences mitochondrial dynamics and function through lipid metabolism","volume":"22","author":"Gao","year":"2018","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.ecoenv.2021.112040_bib11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pharmthera.2010.11.004","article-title":"Copper and homocysteine in cardiovascular diseases","volume":"129","author":"Kang","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ecoenv.2021.112040_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128192","article-title":"Heavy metal contamination status in Greek surface waters: a review with application and evaluation of pollution indices","volume":"263","author":"Karaouzas","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2021.112040_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ecoenv.2017.10.018","article-title":"Regulation of autophagy factors by oxidative stress and cardiac enzymes imbalance during arsenic or\/and copper induced cardiotoxicity in Gallus gallus","volume":"148","author":"Li","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2021.112040_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125516","article-title":"Status of copper accumulation in agricultural soils across China (1985-2016)","volume":"244","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2021.112040_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109710","article-title":"Effects of copper on oxidative stress and autophagy in hypothalamus of broilers","volume":"185","author":"Liao","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2021.112040_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.phymed.2018.04.027","article-title":"Evaluations of the effect of HuangQi against heart failure based on comprehensive echocardiography index and metabonomics","volume":"50","author":"Liu","year":"2018","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.ecoenv.2021.112040_bib17","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1161\/CIRCRESAHA.117.311002","article-title":"Cardiovascular metabolomics","volume":"122","author":"McGarrah","year":"2018","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.ecoenv.2021.112040_bib18","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.15252\/embj.201489363","article-title":"Unsaturated fatty acids induce non-canonical autophagy","volume":"34","author":"Niso-Santano","year":"2015","journal-title":"EMBO J."},{"issue":"16","key":"10.1016\/j.ecoenv.2021.112040_bib19","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.31335","article-title":"Targeting autophagy in cancer","volume":"124","author":"Onorati","year":"2018","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.ecoenv.2021.112040_bib20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal"},{"issue":"3","key":"10.1016\/j.ecoenv.2021.112040_bib21","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/cdd.2014.219","article-title":"Phosphatidylethanolamine positively regulates autophagy and longevity","volume":"22","author":"Rockenfeller","year":"2015","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.ecoenv.2021.112040_bib22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41556-019-0281-x","article-title":"Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification","volume":"21","author":"\u015eent\u00fcrk","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ecoenv.2021.112040_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109421","article-title":"An integrated fecal microbiome and metabolome in the aged mice reveal anti-aging effects from the intestines and biochemical mechanism of FuFang zhenshu TiaoZhi (FTZ)","volume":"121","author":"Shenghua","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.ecoenv.2021.112040_bib24","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.2134\/jeq2010.0316","article-title":"Potential risks of copper, zinc, and cadmium pollution due to pig manure application in a soil-rice system under intensive farming: a case study of Nanhu, China","volume":"40","author":"Shi","year":"2011","journal-title":"J. Environ. Qual."},{"key":"10.1016\/j.ecoenv.2021.112040_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111543","article-title":"Acrylamide inhibits autophagy, induces apoptosis and alters cellular metabolic profiles","volume":"208","author":"Song","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"9","key":"10.1016\/j.ecoenv.2021.112040_bib26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.tem.2012.06.005","article-title":"The dynamic regulation of NAD metabolism in mitochondria","volume":"23","author":"Stein","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"issue":"13","key":"10.1016\/j.ecoenv.2021.112040_bib27","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2174\/092986712800167365","article-title":"Mitochondrial disturbances, tryptophan metabolites and neurodegeneration: medicinal chemistry aspects","volume":"19","author":"Szalardy","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"12","key":"10.1016\/j.ecoenv.2021.112040_bib28","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.biocel.2004.05.009","article-title":"LC3 conjugation system in mammalian autophagy","volume":"36","author":"Tanida","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"35","key":"10.1016\/j.ecoenv.2021.112040_bib29","doi-asserted-by":"crossref","first-page":"7795","DOI":"10.1021\/acs.jafc.5b02644","article-title":"Recombinant buckwheat trypsin inhibitor induces mitophagy by directly targeting mitochondria and causes mitochondrial dysfunction in HepG2 cells","volume":"63","author":"Wang","year":"2015","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2021.112040_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0005-2728(93)90004-Y","article-title":"Effect of fatty acids on energy coupling processes in mitochondria","volume":"1183","author":"Wojtczak","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"issue":"29","key":"10.1016\/j.ecoenv.2021.112040_bib31","doi-asserted-by":"crossref","first-page":"14368","DOI":"10.1039\/C8NR90147C","article-title":"Correction: Metabolomic profiles delineate the potential role of glycine in gold nanorod-induced disruption of mitochondria and blood-testis barrier factors in TM-4 cells","volume":"10","author":"Xu","year":"2018","journal-title":"Nanoscale"},{"issue":"4","key":"10.1016\/j.ecoenv.2021.112040_bib32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10126-012-9432-9","article-title":"Induction of autophagy by amino acid starvation in fish cells","volume":"14","author":"Yabu","year":"2012","journal-title":"Mar. Biotechnol."},{"issue":"18","key":"10.1016\/j.ecoenv.2021.112040_bib33","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1016\/j.bmc.2017.05.051","article-title":"Semisynthesis of autophagy protein LC3 conjugates","volume":"25","author":"Yang","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ecoenv.2021.112040_bib34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chemosphere.2018.03.192","article-title":"Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes","volume":"204","author":"Yang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2021.112040_bib35","first-page":"1","article-title":"An overview of the molecular mechanism of autophagy","volume":"335","author":"Yang","year":"2009","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.ecoenv.2021.112040_bib36","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jhazmat.2014.01.028","article-title":"Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species","volume":"270","author":"Yu","year":"2014","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2021.112040_bib37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jes.2020.08.013","article-title":"A meta-analysis of heavy metals pollution in farmland and urban soils in China over the past 20 years","volume":"101","author":"Yuan","year":"2021","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2021.112040_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2020.126561","article-title":"Effects of dose and duration of dietary copper administration on hepatic lipid peroxidation and ultrastructure alteration in piglets\u2019 model","volume":"61","author":"Zhang","year":"2020","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2021.112040_bib39","doi-asserted-by":"crossref","first-page":"16386","DOI":"10.1038\/s41598-019-52649-w","article-title":"Assessment of residents\u2019 total environmental exposure to heavy metals in China! Abstract","volume":"9","author":"Zhao","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2021.112040_bib40","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.scitotenv.2018.10.263","article-title":"Copper toxicity to blue mussel embryos (Mytilus galloprovincialis): the effect of natural dissolved organic matter on copper toxicity in estuarine waters","volume":"653","author":"Zitoun","year":"2019","journal-title":"Sci. Total Environ."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651321001512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651321001512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:58:10Z","timestamp":1777489090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651321001512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":40,"alternative-id":["S0147651321001512"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112040","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics analysis reveals the effect of copper on autophagy in myocardia of pigs","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112040"}}