{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:01:22Z","timestamp":1789441282186,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013291","name":"Huazhong University of Science and Technology Tongji Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013291","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.ecoenv.2021.112077","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T07:32:39Z","timestamp":1614670359000},"page":"112077","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Roles of endoplasmic reticulum stress in 2,2\u2019,4,4\u2019-tetrabromodiphenylether-induced thyroid cell apoptosis and autophagy"],"prefix":"10.1016","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-7443","authenticated-orcid":false,"given":"Rulin","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0701-9789","authenticated-orcid":false,"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2021.112077_bib1","first-page":"172","article-title":"Polybrominated diphenyl ether (PBDE) flame retardants: environmental contamination, human body burden and potential adverse health effects","volume":"79","author":"Costa","year":"2008","journal-title":"Acta Biomed."},{"key":"10.1016\/j.ecoenv.2021.112077_bib2","doi-asserted-by":"crossref","first-page":"S386","DOI":"10.1016\/j.chemosphere.2006.05.133","article-title":"Plasma PBDE and thyroxine levels in rats exposed to Bromkal or BDE-47","volume":"67","author":"Darnerud","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2021.112077_bib3","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s00018-012-1173-4","article-title":"Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress","volume":"70","author":"Deegan","year":"2013","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ecoenv.2021.112077_bib4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2353\/ajpath.2007.070188","article-title":"Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability","volume":"171","author":"Ding","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ecoenv.2021.112077_bib5","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1007\/s00204-018-2292-y","article-title":"PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero\/postnatal exposure in the rat","volume":"92","author":"Dunnick","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2021.112077_bib6","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1289\/ehp.01109903","article-title":"Brominated flame retardants: a novel class of developmental neurotoxicants in our environment?","volume":"109","author":"Eriksson","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2021.112077_bib7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ygcen.2013.02.038","article-title":"Thyroid hormones in male reproductive development: evidence for direct crosstalk between the androgen and thyroid hormone axes","volume":"192","author":"Flood","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ecoenv.2021.112077_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.envres.2016.05.022","article-title":"Serum polybrominated diphenyl ether concentrations and thyroid function in young children","volume":"149","author":"Jacobson","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2021.112077_bib9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0962-8924(00)01852-3","article-title":"Aggresomes, inclusion bodies and protein aggregation","volume":"10","author":"Kopito","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ecoenv.2021.112077_bib10","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1289\/ehp.11570","article-title":"Dietary exposure to 2,2\u2032,4,4\u2032-tetrabromodiphenyl ether (PBDE-47) alters thyroid status and thyroid hormone-regulated gene transcription in the pituitary and brain","volume":"116","author":"Lema","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2021.112077_bib11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.scitotenv.2018.07.138","article-title":"Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity","volume":"645","author":"Li","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2021.112077_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00204-015-1457-1","article-title":"Human exposure to PBDE and critical evaluation of health hazards","volume":"89","author":"Linares","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2021.112077_bib13","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/jc.2014-2745","article-title":"Endoplasmic reticulum stress as a novel mechanism in amiodarone-induced destructive thyroiditis","volume":"100","author":"Lombardi","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2021.112077_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.clinbiochem.2016.08.014","article-title":"Proteomic analysis reveals aberrant expression of CALR and HSPA5 in thyroid tissues of Graves\u2019 disease","volume":"50","author":"Meng","year":"2017","journal-title":"Clin. Biochem"},{"key":"10.1016\/j.ecoenv.2021.112077_bib15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI65252","article-title":"Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions","volume":"123","author":"Mittag","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ecoenv.2021.112077_bib16","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2021.112077_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","article-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","volume":"11","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2021.112077_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tox.2016.05.022","article-title":"An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity","volume":"376","author":"Pereira","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2021.112077_bib19","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.4161\/auto.7.10.16818","article-title":"Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis","volume":"7","author":"Shi","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2021.112077_bib20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1289\/ehp.10536","article-title":"In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring","volume":"116","author":"Talsness","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2021.112077_bib21","doi-asserted-by":"crossref","first-page":"G498","DOI":"10.1152\/ajpgi.00482.2007","article-title":"CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury","volume":"294","author":"Tamaki","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ecoenv.2021.112077_bib22","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/cdd.2012.60","article-title":"CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma","volume":"19","author":"Tang","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ecoenv.2021.112077_bib23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.reprotox.2016.07.013","article-title":"Roles of endoplasmic reticulum stress, apoptosis and autophagy in 2,2\u2032,4,4\u2032-tetrabromodiphenyl ether-induced rat ovarian injury","volume":"65","author":"Wang","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2021.112077_bib24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ecoenv.2019.02.080","article-title":"A comparison of the thyroid disruption induced by decabrominated diphenyl ethers (BDE-209) and decabromodiphenyl ethane (DBDPE) in rats","volume":"174","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2021.112077_bib25","doi-asserted-by":"crossref","first-page":"23219","DOI":"10.1007\/s11356-019-05768-w","article-title":"The occurrence of polybrominated diphenyl ether (PBDE) contamination in soil, water\/sediment, and air","volume":"26","author":"Wu","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2021.112077_bib26","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ecoenv.2021.112077_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3892\/ol.2017.6101","article-title":"Expression of autophagy-associated proteins in papillary thyroid carcinoma","volume":"14","author":"Yang","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ecoenv.2021.112077_bib28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4161\/auto.3653","article-title":"Endoplasmic reticulum stress: a new pathway to induce autophagy","volume":"3","author":"Yorimitsu","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2021.112077_bib29","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.etap.2017.10.007","article-title":"Oxidative stress-elicited autophagosome accumulation contributes to human neuroblastoma SH-SY5Y cell death induced by PBDE-47","volume":"56","author":"Zhang","year":"2017","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.ecoenv.2021.112077_bib30","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.toxlet.2015.01.017","article-title":"Troxerutin inhibits 2,2\u2032,4,4\u2032-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function","volume":"233","author":"Zhang","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2021.112077_bib31","doi-asserted-by":"crossref","first-page":"F763","DOI":"10.1152\/ajprenal.00225.2016","article-title":"4-PBA improves lithium-induced nephrogenic diabetes insipidus by attenuating ER stress","volume":"311","author":"Zheng","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651321001883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651321001883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:28:23Z","timestamp":1758950903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651321001883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":31,"alternative-id":["S0147651321001883"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112077","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of endoplasmic reticulum stress in 2,2\u2019,4,4\u2019-tetrabromodiphenylether-induced thyroid cell apoptosis and autophagy","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112077"}}