{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:12:05Z","timestamp":1790806325790,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.ecoenv.2021.112306","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T01:02:19Z","timestamp":1620694939000},"page":"112306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Cadmium disturbs epigenetic modification and induces DNA damage in mouse preimplantation embryos"],"prefix":"10.1016","volume":"219","author":[{"given":"Jiaqiao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhutao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangqin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2021.112306_bib1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.envint.2018.05.007","article-title":"Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation","volume":"118","author":"Abraham","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2021.112306_bib2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humupd\/dmz025","article-title":"In-utero stress and mode of conception: impact on regulation of imprinted genes, fetal development and future health","volume":"25","author":"Argyraki","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ecoenv.2021.112306_bib3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/tox.20248","article-title":"Mechanism of DNA damage by cadmium and interplay of antioxidant enzymes and agents","volume":"22","author":"Badisa","year":"2007","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.envint.2018.02.014","article-title":"Epigenetics as a mechanism linking developmental exposures to long-term toxicity","volume":"114","author":"Barouki","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2021.112306_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.envres.2014.09.042","article-title":"Exposure determinants of cadmium in European mothers and their children","volume":"141","author":"Berglund","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2021.112306_bib6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jhazmat.2015.09.056","article-title":"In vivo DNA mismatch repair measurement in zebrafish embryos and its use in screening of environmental carcinogens","volume":"302","author":"Chen","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2021.112306_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114684","article-title":"Reproductive toxicity of acute Cd exposure in mouse: resulting in oocyte defects and decreased female fertility","volume":"379","author":"Cheng","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pnpbp.2017.06.036","article-title":"The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression","volume":"80","author":"Czarny","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ecoenv.2021.112306_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.reprotox.2017.07.021","article-title":"The environment and male reproduction: the effect of cadmium exposure on reproductive function and its implication in fertility","volume":"73","author":"de Angelis","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib10","doi-asserted-by":"crossref","first-page":"9843","DOI":"10.1007\/s10661-013-3296-y","article-title":"Affects of mining activities on Cd pollution to the paddy soils and rice grain in Hunan province, Central South China","volume":"185","author":"Du","year":"2013","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.ecoenv.2021.112306_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.taap.2014.10.004","article-title":"Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage","volume":"281","author":"Ganesan","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41580-019-0159-6","article-title":"The diverse roles of DNA methylation in mammalian development and disease","volume":"20","author":"Greenberg","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4103\/0971-6580.111558","article-title":"Cadmium level in pregnancy, influence on neonatal birth weight and possible amelioration by some essential trace elements","volume":"20","author":"Ikeh-Tawari","year":"2013","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.ecoenv.2021.112306_bib14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41580-019-0151-1","article-title":"Roles and regulation of histone methylation in animal development","volume":"20","author":"Jambhekar","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib15","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2217\/epi.12.53","article-title":"Epigenetics and the developmental origins of disease: the key to unlocking the door of personalized medicine","volume":"4","author":"Joss-Moore","year":"2012","journal-title":"Epigenomics"},{"key":"10.1016\/j.ecoenv.2021.112306_bib16","doi-asserted-by":"crossref","first-page":"eaat2624","DOI":"10.1126\/sciadv.aat2624","article-title":"Establishment of environmentally sensitive DNA methylation states in the very early human embryo","volume":"4","author":"Kessler","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ecoenv.2021.112306_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/MED.0000000000000305","article-title":"Maternal epigenetics and fetal and neonatal growth","volume":"24","author":"Kitsiou-Tzeli","year":"2017","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.ecoenv.2021.112306_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1515\/reveh-2019-0016","article-title":"Cadmium toxicity: effects on human reproduction and fertility","volume":"34","author":"Kumar","year":"2019","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.ecoenv.2021.112306_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/gene.10168","article-title":"Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse","volume":"35","author":"Lane","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.ecoenv.2021.112306_bib20","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ecoenv.2014.12.025","article-title":"Contamination and health risks of soil heavy metals around a lead\/zinc smelter in southwestern China","volume":"113","author":"Li","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2021.112306_bib21","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/oem.2010.059758","article-title":"Does prenatal cadmium exposure affect fetal and child growth?","volume":"68","author":"Lin","year":"2011","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ecoenv.2021.112306_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ygeno.2007.10.005","article-title":"Diploid parthenogenetic embryos adopt a maternal-type methylation pattern on both sets of maternal chromosomes","volume":"91","author":"Liu","year":"2008","journal-title":"Genomics"},{"key":"10.1016\/j.ecoenv.2021.112306_bib23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ydbio.2008.04.011","article-title":"Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos","volume":"319","author":"Ma","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.scitotenv.2018.03.011","article-title":"Contamination source apportionment and health risk assessment of heavy metals in soil around municipal solid waste incinerator: a case study in North China","volume":"631\u2013632","author":"Ma","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2021.112306_bib25","first-page":"267","article-title":"Evaluation of selected parameters of a metabolic profile and levels of cadmium in reproductive organs of rabbits after an experimental administration","volume":"83","author":"Massanyi","year":"1995","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.ecoenv.2021.112306_bib26","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1101\/gad.234294.113","article-title":"DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos","volume":"28","author":"Messerschmidt","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.ecoenv.2021.112306_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00294-016-0640-0","article-title":"A common strategy for initiating the transition from proliferation to quiescence","volume":"63","author":"Miles","year":"2017","journal-title":"Curr. Genet."},{"key":"10.1016\/j.ecoenv.2021.112306_bib28","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.reprotox.2009.08.001","article-title":"Adverse effects of cadmium exposure on mouse sperm","volume":"28","author":"Oliveira","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137130","article-title":"Effects of combined stressors to cadmium and high temperature on antioxidant defense, apoptotic cell death, and DNA methylation in zebrafish (Danio rerio) embryos","volume":"716","author":"Park","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2021.112306_bib30","first-page":"135","article-title":"Cadmium toxicity and treatment: an update","volume":"8","author":"Rafati Rahimzadeh","year":"2017","journal-title":"Casp. J. Intern. Med."},{"key":"10.1016\/j.ecoenv.2021.112306_bib31","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrm.2017.53","article-title":"The multifaceted roles of PARP1 in DNA repair and chromatin remodelling","volume":"18","author":"Ray Chaudhuri","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib32","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1063443","article-title":"Epigenetic reprogramming in mammalian development","volume":"293","author":"Reik","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2021.112306_bib33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s42003-020-1012-3","article-title":"The methylation status of the embryonic limb skeletal progenitors determines their cell fate in chicken","volume":"3","author":"Sanchez-Fernandez","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/jcb.10761","article-title":"Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts","volume":"91","author":"Shih","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ecoenv.2021.112306_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib36","doi-asserted-by":"crossref","first-page":"776","DOI":"10.17772\/gp\/1639","article-title":"Effects of the cigarette smoking on the newborn clinical parametrs and the accumulation of cadmium and lead in the placenta of women from Upper Silesia","volume":"84","author":"Suprewicz","year":"2013","journal-title":"Ginekol. Pol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib37","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.reprotox.2008.02.001","article-title":"Cadmium: toxic effects on the reproductive system and the embryo","volume":"25","author":"Thompson","year":"2008","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12011-009-8391-0","article-title":"Effects of gestational cadmium exposure on pregnancy outcome and development in the offspring at age 4.5 years","volume":"132","author":"Tian","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2021.112306_bib39","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature05458","article-title":"Histone arginine methylation regulates pluripotency in the early mouse embryo","volume":"445","author":"Torres-Padilla","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2021.112306_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.envres.2006.08.003","article-title":"Gender differences in the disposition and toxicity of metals","volume":"104","author":"Vahter","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2021.112306_bib41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1258\/136218004774202364","article-title":"Toxic metals and the menopause","volume":"10","author":"Vahter","year":"2004","journal-title":"J. Br. Menopause Soc."},{"key":"10.1016\/j.ecoenv.2021.112306_bib42","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000477113","article-title":"Exposure to cadmium impairs sperm functions by reducing CatSper in mice","volume":"42","author":"Wang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ecoenv.2021.112306_bib43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12011-011-9177-8","article-title":"Correlations of trace element levels in the diet, blood, urine, and feces in the Chinese male","volume":"145","author":"Wang","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2021.112306_bib44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tcb.2017.10.008","article-title":"Epigenome in\u00a0early mammalian development: inheritance, reprogramming and establishment","volume":"28","author":"Xu","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121819","article-title":"Sex differences in shotgun proteome analyses for chronic oral intake of cadmium in mice","volume":"10","author":"Yamanobe","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2021.112306_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114768","article-title":"ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway","volume":"383","author":"Yan","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib47","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1128\/AEM.03417-12","article-title":"Protective effects of Lactobacillus plantarum CCFM8610 against acute cadmium toxicity in mice","volume":"79","author":"Zhai","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ecoenv.2021.112306_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186727","article-title":"Reproductive effects of cadmium on sperm function and early embryonic development in vitro","volume":"12","author":"Zhao","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2021.112306_bib49","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.3892\/etm.2015.2777","article-title":"Effects of paternal cadmium exposure on the sperm quality of male rats and the neurobehavioral system of their offspring","volume":"10","author":"Zhao","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ecoenv.2021.112306_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113194","article-title":"Glutathione alleviates the cadmium exposure-caused porcine oocyte meiotic defects via eliminating the excessive ROS","volume":"255","author":"Zhou","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2021.112306_bib51","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/toxsci\/kfy089","article-title":"Cadmium exposure of female mice impairs the meiotic maturation of oocytes and subsequent embryonic development","volume":"164","author":"Zhu","year":"2018","journal-title":"Toxicol. Sci."},{"issue":"960","key":"10.1016\/j.ecoenv.2021.112306_bib52","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/s41598-017-00922-1","article-title":"A lack of coordination between sister-chromatids segregation and cytokinesis in the oocytes of B6.YTIR (XY) sex-reversed female mice","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2021.112306_bib53","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651321004176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651321004176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:33:02Z","timestamp":1758951182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651321004176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":53,"alternative-id":["S0147651321004176"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112306","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium disturbs epigenetic modification and induces DNA damage in mouse preimplantation embryos","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112306"}}