{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:31:18Z","timestamp":1786987878052,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008787","name":"National Institute of Fisheries Science","doi-asserted-by":"publisher","award":["R2022019"],"award-info":[{"award-number":["R2022019"]}],"id":[{"id":"10.13039\/501100008787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ecoenv.2022.113337","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T15:52:33Z","timestamp":1645717953000},"page":"113337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Comparative toxicity study of waterborne two booster biocides (CuPT and ZnPT) on embryonic flounder (Paralichthys olivaceus)"],"prefix":"10.1016","volume":"233","author":[{"given":"Dongju","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youmi","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Yang","family":"Soon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moonkoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Hyun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2022.113337_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s10646-015-1597-3","article-title":"The effects of copper pyrithione, an antifouling agent, on developing zebrafish embryos","volume":"25","author":"Almond","year":"2016","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.ecoenv.2022.113337_bib2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.marpolbul.2011.02.041","article-title":"Acute toxicities of five commonly used antifouling booster biocides to selected subtropical and cosmopolitan marine species","volume":"62","author":"Bao","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.113337_bib3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.aquatox.2014.09.013","article-title":"Acute and chronic toxicities of zinc pyrithione alone and in combination with copper to the marine copepod Tigriopus japonicus","volume":"157","author":"Bao","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat. Rev. Drug Disco"},{"key":"10.1016\/j.ecoenv.2022.113337_bib5","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.marpolbul.2005.06.010","article-title":"Embryotoxicity of the antifouling biocide zinc pyrithione to sea urchin (Paracentrotus lividus) and mussel (Mytilus edulis)","volume":"50","author":"Bellas","year":"2005","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.113337_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.gene.2014.09.003","article-title":"Deep sequencing-based transcriptome profiling analysis of Chlamys farreri exposed to benzo[a]pyrene","volume":"551","author":"Cai","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.ecoenv.2022.113337_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.drudis.2015.10.001","article-title":"Expanding roles of superoxide dismutases in cell regulation and cancer","volume":"21","author":"Che","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ecoenv.2022.113337_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105615","article-title":"Is hull cleaning wastewater a potential source of developmental toxicity on coastal non-target organisms?","volume":"227","author":"Choi","year":"2020","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105883","article-title":"Sediment quality assessment combining chemical and biological (non)target analysis","volume":"238","author":"Choi","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1749-6632.2002.tb02112.x","article-title":"Involvement of mitochondria and other free radical sources in normal and abnormal fetal development","volume":"959","author":"Fantel","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2022.113337_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/enrs.1998.3944","article-title":"Embryotoxicity of zinc pyrithione, an antidandruff chemical, in fish","volume":"81","author":"Goka","year":"1999","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.113337_bib12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2353\/ajpath.2009.080758","article-title":"Wnt signaling, Lgr5, and stem cells in the intestine and skin","volume":"174","author":"Haegebarth","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib13","first-page":"156","article-title":"Exposure to sublethal concentrations of zinc pyrithione inhibits growth and survival of marine polychaete through induction of oxidative stress and DNA damage","author":"Haque","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.113337_bib14","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1017\/S0025315406014147","article-title":"Concentrations of booster biocides in sediment and clams from Vietnam","volume":"86","author":"Harino","year":"2006","journal-title":"J. Mar. Biol. Assoc. Uk."},{"key":"10.1016\/j.ecoenv.2022.113337_bib15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00244-006-0087-2","article-title":"Concentrations of antifouling biocides in sediment and mussel samples collected from Otsuchi Bay, Japan","volume":"52","author":"Harino","year":"2007","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib16","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1210\/mend.12.12.0211","article-title":"Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region","volume":"12","author":"Hsu","year":"1998","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ecoenv.2022.113337_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0304-3940(95)12092-I","article-title":"Expression of a Mads box gene, Mef2d, in neurons of the mouse central-nervous-system - implication of its binary function in myogenic and neurogenic cell lineages","volume":"200","author":"Ikeshima","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ecoenv.2022.113337_bib19","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.chemosphere.2013.01.019","article-title":"Geologically distinct crude oils cause a common cardiotoxicity syndrome in developing zebrafish","volume":"91","author":"Jung","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.113337_bib20","doi-asserted-by":"crossref","first-page":"13639","DOI":"10.1021\/acs.est.5b03729","article-title":"Differential Toxicokinetics Determines the Sensitivity of Two Marine Embryonic Fish Exposed to Iranian Heavy Crude Oil","volume":"49","author":"Jung","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpc.2017.02.010","article-title":"RNA seq- and DEG-based comparison of developmental toxicity in fish embryos of two species exposed to Iranian heavy crude oil","volume":"196","author":"Jung","year":"2017","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.marpolbul.2004.02.034","article-title":"New biocide-free anti-fouling paints are toxic","volume":"49","author":"Karlsson","year":"2004","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.113337_bib23","unstructured":"Kj\u00f8lholt, J., Nielsen, P.J., Sams\u00f8e-Petersen, L., Inventory of Biocides used in Denmark. Environmental Project. 2001."},{"key":"10.1016\/j.ecoenv.2022.113337_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mce.2011.09.027","article-title":"Reproductive and developmental toxicity of dioxin in fish","volume":"354","author":"King-Heiden","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.113337_bib25","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0025-326X(02)00052-8","article-title":"Effects of new antifouling compounds on the development of sea urchin","volume":"44","author":"Kobayashi","year":"2002","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.113337_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ecoenv.2017.08.039","article-title":"The influence of seawater properties on toxicity of copper pyrithione and its degradation product to brine shrimp Artemia salina","volume":"147","author":"Lavtizar","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113337_bib27","first-page":"4","article-title":"The Wnt Co-receptor Lrp6 is required for normal mouse mammary gland development","author":"Lindvall","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2022.113337_bib28","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/gim.2018.34","article-title":"Congenital heart disease and aortic arch variants associated with mutation in PHOX2B","volume":"20","author":"Lombardo","year":"2018","journal-title":"Genet. Med."},{"key":"10.1016\/j.ecoenv.2022.113337_bib29","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.marpolbul.2003.11.013","article-title":"Indirect estimation of degradation time for zinc pyrithione and copper pyrithione in seawater","volume":"48","author":"Maraldo","year":"2004","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.113337_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biopha.2005.03.005","article-title":"SOD, oxidative stress and human pathologies: a brief history and a future vision","volume":"59","author":"McCord","year":"2005","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ecoenv.2022.113337_bib31","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/dbio.1999.9546","article-title":"Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane","volume":"217","author":"Miner","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib32","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1897\/05-688R.1","article-title":"Acute toxicity of pyrithione antifouling biocides and joint toxicity with copper to red sea bream (Pagrus major) and toy shrimp (Heptacarpus futilirostris)","volume":"25","author":"Mochida","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2022.113337_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1897\/07-176R1.1","article-title":"Early life-stage toxicity test for copper pyrithione and induction of skeletal anomaly in a teleost, the mummichog (Fundulus heteroclitus)","volume":"27","author":"Mochida","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2022.113337_bib34","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.marpolbul.2017.11.046","article-title":"Acute toxicity test of copper pyrithione on Javanese medaka and the behavioural stress symptoms","volume":"127","author":"Mohamat-Yusuff","year":"2018","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.113337_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ecoenv.2019.04.070","article-title":"Overlapping and unique toxic effects of three alternative antifouling biocides (Diuron, Irgarol 1051 (R), Sea-Nine 211 (R)) on non-target marine fish","volume":"180","author":"Moon","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113337_bib36","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/dvdy.24592","article-title":"Refuting the hypothesis that semaphorin-3f\/neuropilin-2 exclude blood vessels from the cap mesenchyme in the developing kidney","volume":"246","author":"Munro","year":"2017","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ecoenv.2022.113337_bib37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00244-017-0367-z","article-title":"Comparison of toxicities of metal pyrithiones including their degradation compounds and organotin antifouling biocides to the japanese killifish oryzias latipes","volume":"73","author":"Ohji","year":"2017","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib38","unstructured":"Onduka, T., Mochida, K., Acute toxicity of pyrithione photodegradation products to some marine organisms. 2007. International Symposium on Shiping Technology proceeding 99\u2013106."},{"key":"10.1016\/j.ecoenv.2022.113337_bib39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/mcne.1999.0826","article-title":"Specification of the central noradrenergic phenotype by the homeobox gene Phox2b","volume":"15","author":"Pattyn","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ecoenv.2022.113337_bib40","doi-asserted-by":"crossref","first-page":"9515","DOI":"10.1073\/pnas.1406191111","article-title":"Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy","volume":"111","author":"Petchey","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113337_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-0981(91)90116-E","article-title":"Short-term accumulation of cadmium by embryos, larvae, and adults of an Hawaiian bivalve, isognomon californicum","volume":"149","author":"Ringwood","year":"1991","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib42","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1242\/dev.030007","article-title":"Prox1 maintains muscle structure and growth in the developing heart","volume":"136","author":"Risebro","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2022.113337_bib43","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1089\/ars.2013.5297","article-title":"Manganese superoxide dismutase in cancer prevention","volume":"20","author":"Robbins","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2022.113337_bib44","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.aquatox.2005.06.003","article-title":"Unexpected effects of zinc pyrithione and imidacloprid on Japanese medaka fish (Oryzias latipes)","volume":"74","author":"Sanchez-Bayo","year":"2005","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ng.3732","article-title":"The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry","volume":"49","author":"Shao","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2022.113337_bib46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10571-015-0294-3","article-title":"Disease mechanisms in ALS: misfolded SOD1 transferred through exosome-dependent and exosome-independent pathways","volume":"36","author":"Silverman","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ecoenv.2022.113337_bib47","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ecoenv.2022.113337_bib48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/08927010009386308","article-title":"Pyrithiones as antifoulants: environmental chemistry and preliminary risk assessment","volume":"15","author":"Turley","year":"2000","journal-title":"Biofouling"},{"key":"10.1016\/j.ecoenv.2022.113337_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/08927010500044351","article-title":"Pyrithiones as antifoulants: environmental fate and loss of toxicity","volume":"21","author":"Turley","year":"2005","journal-title":"Biofouling"},{"key":"10.1016\/j.ecoenv.2022.113337_bib50","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1073\/pnas.1116158109","article-title":"Superoxide dismutase is dispensable for normal animal lifespan","volume":"109","author":"Van Raamsdonk","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ecoenv.2022.113337_bib51","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s12011-012-9439-0","article-title":"Effects of oxidative stress on immunosuppression induced by selenium deficiency in chickens","volume":"149","author":"Zhang","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.ecoenv.2022.113337_bib52","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.chemosphere.2018.04.010","article-title":"Acute toxic responses of embryo-larval zebrafish to zinc pyrithione (ZPT) reveal embryological and developmental toxicity","volume":"205","author":"Zhao","year":"2018","journal-title":"Chemosphere"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322001774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322001774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:52:04Z","timestamp":1758952324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322001774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":52,"alternative-id":["S0147651322001774"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113337","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative toxicity study of waterborne two booster biocides (CuPT and ZnPT) on embryonic flounder (Paralichthys olivaceus)","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113337"}}