{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:34:16Z","timestamp":1789220056568,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ecoenv.2022.113368","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T18:11:02Z","timestamp":1646244662000},"page":"113368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["PM2.5 increases mouse blood pressure by activating toll-like receptor 3"],"prefix":"10.1016","volume":"234","author":[{"given":"Jinna","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rucheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2022.113368_bib1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2022.113368_bib2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.freeradbiomed.2017.08.027","article-title":"Poly (I:C) impairs NO donor-induced relaxation by overexposure to NO via the NF-kappa B\/iNOS pathway in rat superior mesenteric arteries","volume":"112","author":"Ando","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2022.113368_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.ackd.2019.03.001","article-title":"Inflammation, immunity, and oxidative stress in hypertension-partners in crime?","volume":"26","author":"Barrows","year":"2019","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.ecoenv.2022.113368_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.12.001","article-title":"Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats","volume":"122","author":"Bomfim","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2022.113368_bib5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"Bui","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12989-020-00362-2","article-title":"PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis","volume":"17","author":"Chen","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2119\/molmed.2010.00178","article-title":"A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma","volume":"17","author":"Cuenca","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.ecoenv.2022.113368_bib8","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1001\/jama.2017.17923","article-title":"Association of short-term exposure to air pollution with mortality in older adults","volume":"318","author":"Di","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.ecoenv.2022.113368_bib9","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1161\/HYPERTENSIONAHA.119.13408","article-title":"Acute effects of high-level PM2.5 exposure on central blood pressure","volume":"74","author":"Fan","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.ecoenv.2022.113368_bib10","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1007\/s00424-015-1697-1","article-title":"Activation of Toll-like receptor 3 increases mouse aortic vascular smooth muscle cell contractility through ERK1\/2 pathway","volume":"467","author":"Hardigan","year":"2015","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.ecoenv.2022.113368_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112524","article-title":"Ambient fine particulate matter exposure disrupts circadian rhythm and oscillation of the HPA axis in a mouse model","volume":"222","author":"Hu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113368_bib12","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/CIRCRESAHA.110.237560","article-title":"Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways","volume":"108","author":"Kampfrath","year":"2011","journal-title":"Circ. Res"},{"key":"10.1016\/j.ecoenv.2022.113368_bib13","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1074\/jbc.M310175200","article-title":"mRNA is an endogenous ligand for Toll-like receptor 3","volume":"279","author":"Kariko","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2022.113368_bib14","first-page":"105","article-title":"Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-dietinduced obese mice","volume":"16","author":"Kawanishi","year":"2010","journal-title":"Exerc Immunol. Rev."},{"key":"10.1016\/j.ecoenv.2022.113368_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/5584_2016_90","article-title":"Endothelial dysfunction and hypertension","volume":"956","author":"Konukoglu","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114668","article-title":"Lipidomics insight into chronic exposure to ambient air pollution in mice","volume":"262","author":"Li","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.113368_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24214002","article-title":"Oleanolic acid acetate exerts anti-inflammatory activity via ikkalpha\/beta suppression in TLR3-mediated NF-kappaB activation","volume":"24","author":"Lim","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2022.113368_bib18","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.scitotenv.2017.01.133","article-title":"Associations between ambient fine particulate air pollution and hypertension: a nationwide cross-sectional study in China","volume":"584\u2013585","author":"Liu","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.113368_bib19","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.addr.2007.11.005","article-title":"TLR3: interferon induction by double-stranded RNA including poly(I:C)","volume":"60","author":"Matsumoto","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ecoenv.2022.113368_bib20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1089\/ars.2013.5302","article-title":"Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research","volume":"20","author":"Montezano","year":"2014","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.ecoenv.2022.113368_bib21","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1097\/HJH.0000000000000965","article-title":"Endothelial dysfunction in human essential hypertension","volume":"34","author":"Mordi","year":"2016","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ecoenv.2022.113368_bib22","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/HYPERTENSIONAHA.119.14636","article-title":"Increased blood pressure causes lymphatic endothelial dysfunction via oxidative stress in spontaneously hypertensive rats","volume":"76","author":"Mukohda","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.ecoenv.2022.113368_bib23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1254\/jphs.12088FP","article-title":"Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats","volume":"120","author":"Mukohda","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ecoenv.2022.113368_bib24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jacc.2017.05.035","article-title":"Impact of oxidative stress on the heart and vasculature: Part 2 of a 3-part series","volume":"70","author":"Munzel","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib25","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2018.07.099","article-title":"Air pollution and cardiovascular disease: JACC state-of-the-art review","volume":"72","author":"Rajagopalan","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108890","article-title":"Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation","volume":"180","author":"Riggs","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.113368_bib27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/jat.3143","article-title":"PM2.5-induced oxidative stress increases adhesion molecules expression in human endothelial cells through the ERK\/AKT\/NF-kappaB-dependent pathway","volume":"36","author":"Rui","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2018.09.001","article-title":"The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process","volume":"48","author":"Salminen","year":"2018","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.ecoenv.2022.113368_bib29","doi-asserted-by":"crossref","first-page":"II1","DOI":"10.1161\/01.HYP.19.2_Suppl.II1-a","article-title":"Reactivity of small blood vessels in hypertension: relation with structural changes. State of the art lecture","volume":"19","author":"Schiffrin","year":"1992","journal-title":"Hypertension"},{"key":"10.1016\/j.ecoenv.2022.113368_bib30","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3233\/JAD-190563","article-title":"Fine particulate matter exposure and cerebrospinal fluid markers of vascular injury","volume":"71","author":"Shaffer","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ecoenv.2022.113368_bib31","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1161\/CIRCRESAHA.115.306539","article-title":"Myeloid suppressor cells accumulate and regulate blood pressure in hypertension","volume":"117","author":"Shah","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ecoenv.2022.113368_bib32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/10937404.2020.1822971","article-title":"Effects of ambient particulate matter on vascular tissue: a review","volume":"23","author":"Shkirkova","year":"2020","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.ecoenv.2022.113368_bib33","doi-asserted-by":"crossref","first-page":"H1027","DOI":"10.1152\/ajpheart.00697.2018","article-title":"Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3- and TLR4-dependent pathways","volume":"316","author":"Singh","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib34","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.immuni.2013.02.009","article-title":"Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2","volume":"38","author":"Speer","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.ecoenv.2022.113368_bib35","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/1471-2458-12-378","article-title":"Blood pressure and particulate air pollution in schoolchildren of Lahore, Pakistan","volume":"12","author":"Sughis","year":"2012","journal-title":"BMC Public Health"},{"key":"10.1016\/j.ecoenv.2022.113368_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10111784","article-title":"mu-opioid receptor-mediated AT1R-TLR4 crosstalk promotes microglial activation to modulate blood pressure control in the central nervous system","volume":"10","author":"Sun","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ecoenv.2022.113368_bib37","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1161\/ATVBAHA.108.166967","article-title":"Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho\/ROCK","volume":"28","author":"Sun","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1681\/ASN.2015050562","article-title":"Immune mechanisms in arterial hypertension","volume":"27","author":"Wenzel","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/toxsci\/kfr211","article-title":"Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue","volume":"124","author":"Xu","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2022.113368_bib40","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/ATVBAHA.110.215350","article-title":"Effect of early particulate air pollution exposure on obesity in mice: role of p47phox","volume":"30","author":"Xu","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib41","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.4049\/jimmunol.1202574","article-title":"TLR3-triggered reactive oxygen species contribute to inflammatory responses by activating signal transducer and activator of transcription-1","volume":"190","author":"Yang","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12989-015-0092-6","article-title":"Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats","volume":"12","author":"Ying","year":"2015","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib43","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1289\/ehp.1307151","article-title":"Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation","volume":"122","author":"Ying","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.113368_bib44","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41569-019-0260-8","article-title":"NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets","volume":"17","author":"Zhang","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ecoenv.2022.113368_bib45","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1161\/CIRCRESAHA.111.243246","article-title":"Activation of endothelial toll-like receptor 3 impairs endothelial function","volume":"108","author":"Zimmer","year":"2011","journal-title":"Circ. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322002081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322002081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:48:07Z","timestamp":1758952087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322002081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":45,"alternative-id":["S0147651322002081"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113368","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PM2.5 increases mouse blood pressure by activating toll-like receptor 3","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113368","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113368"}}