{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:05:39Z","timestamp":1789441539586,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21S11901000"],"award-info":[{"award-number":["21S11901000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1804503"],"award-info":[{"award-number":["2019YFC1804503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873834"],"award-info":[{"award-number":["81873834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003414"],"award-info":[{"award-number":["82003414"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ecoenv.2022.113512","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T18:02:35Z","timestamp":1649872955000},"page":"113512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Maternal exposure to ambient PM2.5 causes fetal growth restriction via the inhibition of spiral artery remodeling in mice"],"prefix":"10.1016","volume":"237","author":[{"given":"Shimin","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzhen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12016-016-8596-x","article-title":"Tumor necrosis factor-alpha and pregnancy: focus on biologics. an updated and comprehensive review","volume":"53","author":"Alijotas-Reig","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib2","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14710","article-title":"Physical activity differentially regulates VEGF, PlGF, and their receptors in the human placenta","volume":"9","author":"Bhattacharjee","year":"2021","journal-title":"Physiol. Rep."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/toxsci\/kfs008","article-title":"Cadmium associated with inhaled cadmium oxide nanoparticles impacts fetal and neonatal development and growth","volume":"126","author":"Blum","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.113512_bib4","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1029","article-title":"Exposure to ambient particulate matter during specific gestational periods produces adverse obstetric consequences in mice","volume":"125","author":"Blum","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113512_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \u201cgreat obstetrical syndromes\u201d are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.113512_bib6","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12989-017-0201-9","article-title":"Programming of mouse obesity by maternal exposure to concentrated ambient fine particles","volume":"14","author":"Chen","year":"2017","journal-title":"Part Fibre Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1164\/rccm.201609-1862OC","article-title":"Fine particulate air pollution and daily mortality. A nationwide analysis in 272 Chinese cities","volume":"196","author":"Chen","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.113512_bib9","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.2353\/ajpath.2007.061035","volume":"170","author":"Cindrova-Davies","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1600-0897.1998.tb00398.x","article-title":"Circulating levels of immunoreactive cytokines in women with preeclampsia","volume":"40","author":"Conrad","year":"1998","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.113512_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218799","article-title":"Exposure of trophoblast cells to fine particulate matter air pollution leads to growth inhibition, inflammation and ER stress","volume":"14","author":"Familari","year":"2019","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.ecoenv.2022.113512_bib12","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1172\/JCI76864","article-title":"Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications","volume":"124","author":"Fan","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2022.113512_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2005.104141","article-title":"Programming placental nutrient transport capacity","volume":"572","author":"Fowden","year":"2006","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.113512_bib14","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1161\/HYPERTENSIONAHA.107.096594","article-title":"Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression","volume":"50","author":"Gilbert","year":"2007","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"4\u20135","key":"10.1016\/j.ecoenv.2022.113512_bib16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.diff.2013.02.002","article-title":"Regulation of murine placentogenesis by the retroviral genes Syncytin-A, Syncytin-B and Peg10","volume":"85","author":"Henke","year":"2013","journal-title":"Differentiation"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ydbio.2011.07.036","article-title":"Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta","volume":"358","author":"Hu","year":"2011","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.113512_bib18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1289\/EHP508","article-title":"Fetal thyroid function, birth weight, and in utero exposure to fine particle air pollution: a birth cohort study","volume":"125","author":"Janssen","year":"2017","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1095\/biolreprod.111.095380","article-title":"Hemodynamic, vascular, and reproductive impact of FMS-like tyrosine kinase 1 (FLT1) blockade on the uteroplacental circulation during normal mouse pregnancy","volume":"86","author":"Khankin","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2022.113512_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.freeradbiomed.2017.01.010","article-title":"Aspirin prevents TNF-alpha-induced endothelial cell dysfunction by regulating the NF-kappaB-dependent miR-155\/eNOS pathway: role of a miR-155\/eNOS axis in preeclampsia","volume":"104","author":"Kim","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.113512_bib21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.ecoenv.2022.113512_bib22","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113512_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/3129","article-title":"Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth","volume":"20","author":"Li","year":"1998","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.ecoenv.2022.113512_bib24","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1080\/14767058.2019.1636371","article-title":"Placental weight and size in relation to fetal growth restriction: a case-control study","volume":"34","author":"Liu","year":"2021","journal-title":"J. Matern. Fetal Neonatal. Med."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.113512_bib25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/sj.jes.7500503","article-title":"Association between maternal exposure to ambient air pollutants during pregnancy and fetal growth restriction","volume":"17","author":"Liu","year":"2007","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.113512_bib26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ecoenv.2022.113512_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2164-6-4","article-title":"Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus","volume":"6","author":"McLellan","year":"2005","journal-title":"BMC Genom."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib28","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1038\/s41598-018-27575-y","article-title":"Bisphenol A exposure during early pregnancy impairs uterine spiral artery remodeling and provokes intrauterine growth restriction in mice","volume":"8","author":"Muller","year":"2018","journal-title":"Sci. Rep."},{"issue":"10258","key":"10.1016\/j.ecoenv.2022.113512_bib29","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Murray","year":"2020","journal-title":"Lancet"},{"issue":"75","key":"10.1016\/j.ecoenv.2022.113512_bib30","article-title":"Urban PM2.5 induces cellular toxicity, hormone dysregulation, oxidative damage, inflammation, and mitochondrial interference in the HRT8 trophoblast cell line","volume":"11","author":"Naav","year":"2020","journal-title":"Front. Endocrinol."},{"issue":"5723","key":"10.1016\/j.ecoenv.2022.113512_bib31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1126\/science.1108752","article-title":"Atmosphere. Air pollution-related illness: effects of particles","volume":"308","author":"Nel","year":"2005","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.113512_bib32","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.placenta.2015.05.013","article-title":"Genetic ablation of placental sinusoidal trophoblast giant cells causes fetal growth restriction and embryonic lethality","volume":"36","author":"Outhwaite","year":"2015","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCRESAHA.116.308304","article-title":"CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia","volume":"119","author":"Przybyl","year":"2016","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113512_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ng0398-271","article-title":"The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis","volume":"18","author":"Riley","year":"1998","journal-title":"Nat. Genet."},{"issue":"6773","key":"10.1016\/j.ecoenv.2022.113512_bib35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/35003601","article-title":"Eomesodermin is required for mouse trophoblast development and mesoderm formation","volume":"404","author":"Russ","year":"2000","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.preghy.2013.01.004","article-title":"Determination of placental growth factor (PlGF) levels in healthy pregnant women without signs or symptoms of preeclampsia","volume":"3","author":"Saffer","year":"2013","journal-title":"Pregnancy Hypertens."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib37","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ydbio.2014.05.007","article-title":"Hectd1 is required for development of the junctional zone of the placenta","volume":"392","author":"Sarkar","year":"2014","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib38","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1128\/MCB.20.2.530-541.2000","article-title":"The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms","volume":"20","author":"Scott","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ecoenv.2022.113512_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41612-020-0124-2","article-title":"Half the world\u2019s population are exposed to increasing air pollution","volume":"3","author":"Shaddick","year":"2020","journal-title":"Npj Clim. Atmos. Sci."},{"issue":"24","key":"10.1016\/j.ecoenv.2022.113512_bib40","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.3109\/14767058.2016.1154525","article-title":"Intrauterine growth restriction \u2013 Part 2","volume":"29","author":"Sharma","year":"2016","journal-title":"J. Matern. Fetal Neonatal. Med."},{"key":"10.1016\/j.ecoenv.2022.113512_bib41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4137\/CMPed.S40070","article-title":"Intrauterine growth restriction: antenatal and postnatal aspects","volume":"10","author":"Sharma","year":"2016","journal-title":"Clin. Med. Insights Pediatr."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jb\/mvs136","article-title":"Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases","volume":"153","author":"Shibuya","year":"2013","journal-title":"J. Biochem."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1095\/biolreprod.108.067629","article-title":"MUC1 expression is increased during human placental development and suppresses trophoblast-like cell invasion in vitro","volume":"79","author":"Shyu","year":"2008","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113512_bib44","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ydbio.2007.01.009","article-title":"Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta","volume":"304","author":"Simmons","year":"2007","journal-title":"Dev. Biol."},{"issue":"12","key":"10.1016\/j.ecoenv.2022.113512_bib45","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1242\/dev.020099","article-title":"Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth","volume":"135","author":"Simmons","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2022.113512_bib46","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/1471-2164-9-352","article-title":"Spatial and temporal expression of the 23 murine prolactin\/placental lactogen-related genes is not associated with their position in the locus","volume":"9","author":"Simmons","year":"2008","journal-title":"BMC Genom."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.113512_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183314","article-title":"Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system","volume":"12","author":"Soto","year":"2017","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.ecoenv.2022.113512_bib48","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1242\/dev.01801","article-title":"Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst","volume":"132","author":"Strumpf","year":"2005","journal-title":"Development"},{"issue":"22","key":"10.1016\/j.ecoenv.2022.113512_bib49","doi-asserted-by":"crossref","first-page":"15224","DOI":"10.1074\/jbc.M808892200","article-title":"The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies","volume":"284","author":"Tewari","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113512_bib50","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1095\/biolreprod.108.069591","article-title":"Particulate urban air pollution affects the functional morphology of mouse placenta","volume":"79","author":"Veras","year":"2008","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113512_bib51","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cyto.2011.12.005","article-title":"Targeting TNF superfamily members for therapeutic intervention in rheumatoid arthritis","volume":"57","author":"Vinay","year":"2012","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.ecoenv.2022.113512_bib52","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/biolre\/ioaa158","article-title":"Acetylcholine ameliorated TNF-alpha-induced primary trophoblast malfunction via muscarinic receptorsdagger","volume":"103","author":"Wang","year":"2020","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib53","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2005.09.009","article-title":"Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice","volume":"163","author":"Xu","year":"2006","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12989-019-0312-6","article-title":"Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model","volume":"16","author":"Xu","year":"2019","journal-title":"Part Fibre Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib55","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1289\/ehp.1307151","article-title":"Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation","volume":"122","author":"Ying","year":"2014","journal-title":"Environ. Health Perspect."},{"issue":"30","key":"10.1016\/j.ecoenv.2022.113512_bib56","doi-asserted-by":"crossref","first-page":"37527","DOI":"10.1007\/s11356-020-10112-8","article-title":"The impact of particulate matter 2.5 on the risk of preeclampsia: an updated systematic review and meta-analysis","volume":"27","author":"Yu","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2022.113512_bib57","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.scitotenv.2019.02.101","article-title":"Gestational exposure to PM2.5 impairs vascularization of the placenta","volume":"665","author":"Yue","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.113512_bib58","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1159\/000430157","article-title":"Acetylcholine attenuated TNF-alpha-induced apoptosis in H9c2 cells: role of calpain and the p38-MAPK pathway","volume":"36","author":"Zhao","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113512_bib59","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ydbio.2007.09.025","article-title":"Characterization of connexin31.1-deficient mice reveals impaired placental development","volume":"312","author":"Zheng-Fischhofer","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ecoenv.2022.113512_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111281","article-title":"Maternal PM2.5 exposure and abnormal placental nutrient transport","volume":"207","author":"Zhu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322003529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322003529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:50:49Z","timestamp":1758952249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322003529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":60,"alternative-id":["S0147651322003529"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113512","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal exposure to ambient PM2.5 causes fetal growth restriction via the inhibition of spiral artery remodeling in mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113512","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113512"}}