{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:28:48Z","timestamp":1778124528890,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ecoenv.2022.113568","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T14:23:45Z","timestamp":1651155825000},"page":"113568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Chlorine disinfection byproduct of diazepam affects nervous system function and possesses gender-related difference in zebrafish"],"prefix":"10.1016","volume":"238","author":[{"given":"Xiaole","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muke","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2022.113568_bib1","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1038\/s41467-019-10462-z","article-title":"XX sex chromosome complement promotes atherosclerosis in mice","volume":"10","author":"AlSiraj","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2022.113568_bib2","first-page":"64","article-title":"Branched-chain amino acid metabolism in cancer","volume":"21","author":"Ananieva","year":"2018","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.ecoenv.2022.113568_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrn3856","article-title":"The neuroprotective actions of oestradiol and oestrogen receptors","volume":"16","author":"Arevalo","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ecoenv.2022.113568_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.100787","article-title":"Molecular mechanisms and cellular events involved in the neuroprotective actions of estradiol. Analysis of sex differences","volume":"55","author":"Azcoitia","year":"2019","journal-title":"Front Neuroendocr."},{"key":"10.1016\/j.ecoenv.2022.113568_bib5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","article-title":"A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer\u2019s disease","volume":"30","author":"Baik","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.ecoenv.2022.113568_bib6","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.neuron.2016.09.006","article-title":"Basal forebrain cholinergic circuits and signaling in cognition and cognitive decline","volume":"91","author":"Ballinger","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.ecoenv.2022.113568_bib7","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1126\/science.1226850","article-title":"Dilute concentrations of a psychiatric drug alter behavior of fish from natural populations","volume":"339","author":"Brodin","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ecoenv.2022.113568_bib8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.chemosphere.2013.01.050","article-title":"Clotrimazole, but not dexamethasone, is a potent in vitro inhibitor of cytochrome P450 isoforms CYP1A and CYP3A in rainbow trout","volume":"92","author":"Burkina","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.113568_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2017.10.013","article-title":"Cancer chemoprevention revisited: cytochrome P450 family 1B1 as a target in the tumor and the microenvironment","volume":"63","author":"D\u2019Uva","year":"2018","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ecoenv.2022.113568_bib10","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1289\/ehp.7370","article-title":"PCB exposure and in vivo CYP1A2 activity among Native Americans","volume":"113","author":"Fitzgerald","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.113568_bib11","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1093\/molbev\/msm200","article-title":"Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family","volume":"24","author":"Goldstone","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.abb.2008.12.002","article-title":"Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD","volume":"482","author":"Goldstone","year":"2009","journal-title":"Arch. Biochem Biophys."},{"key":"10.1016\/j.ecoenv.2022.113568_bib13","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1001\/jamainternmed.2016.5766","article-title":"Endocrine-disrupting chemicals","volume":"176","author":"Gore","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.ecoenv.2022.113568_bib14","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1021\/acs.analchem.5b00680","article-title":"Ambient mass spectrometry imaging metabolomics method provides novel insights into the action mechanism of drug candidates","volume":"87","author":"He","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ecoenv.2022.113568_bib15","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1021\/acs.est.7b05825","article-title":"Characterized in vitro metabolism kinetics of alkyl organophosphate esters in fish liver and intestinal microsomes","volume":"52","author":"Hou","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-physiol-021909-135917","article-title":"Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics","volume":"72","author":"Huang","year":"2010","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ecoenv.2019.01.050","article-title":"Ca(2+) protect zebrafish embryos from water acidification","volume":"172","author":"Huang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113568_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112416","article-title":"Chlorinated disinfection byproducts of diazepam perturb cell metabolism and induce behavioral toxicity in zebrafish larvae","volume":"220","author":"Huang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113568_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1501723","article-title":"A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence","volume":"2","author":"Kakizawa","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ecoenv.2022.113568_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1742-7843.2008.00252.x","article-title":"In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions","volume":"103","author":"Karjalainen","year":"2008","journal-title":"Basic Clin. Pharm. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142648","article-title":"Occurrence, fate and mass loading of benzodiazepines and their transformation products in eleven wastewater treatment plants in Guangdong province, China","volume":"755","author":"Lei","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.113568_bib22","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1016\/j.watres.2013.04.059","article-title":"Treating wastewater from a pharmaceutical formulation facility by biological process and ozone","volume":"47","author":"Lester","year":"2013","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2022.113568_bib23","doi-asserted-by":"crossref","first-page":"14398","DOI":"10.1021\/acs.est.9b05327","article-title":"Experimental study of OH-initiated heterogeneous oxidation of organophosphate flame retardants: kinetics, mechanism, and toxicity","volume":"53","author":"Liu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.114969","article-title":"Sonolytic degradation of bisphenol S: effect of dissolved oxygen and peroxydisulfate, oxidation products and acute toxicity","volume":"165","author":"Lu","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2022.113568_bib25","doi-asserted-by":"crossref","first-page":"16999","DOI":"10.1038\/s41598-017-15462-x","article-title":"Bioaccumulation of pharmaceuticals and personal care product chemicals in fish exposed to wastewater effluent in an urban wetland","volume":"7","author":"Muir","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2022.113568_bib26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1124\/pr.117.014407","article-title":"Interindividual differences in caffeine metabolism and factors driving caffeine consumption","volume":"70","author":"Nehlig","year":"2018","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.ecoenv.2022.113568_bib27","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1073\/pnas.0501703102","article-title":"The contribution of GABA to glutamate\/glutamine cycling and energy metabolism in the rat cortex in vivo","volume":"102","author":"Patel","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2022.113568_bib28","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1021\/acs.chemrev.8b00299","article-title":"Pharmaceuticals of emerging concern in aquatic systems: chemistry, occurrence, effects, and removal methods","volume":"119","author":"Patel","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ecoenv.2022.113568_bib29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/clpt.1992.203","article-title":"Racial and gender differences in N\u2010acetyltransferase, xanthine oxidase, and CYP1A2* activities","volume":"52","author":"Relling","year":"1992","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ecoenv.2022.113568_bib30","doi-asserted-by":"crossref","first-page":"E6673","DOI":"10.1073\/pnas.1516729112","article-title":"Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain","volume":"112","author":"Sareddy","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2022.113568_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8386362","article-title":"Chlorinated phospholipids and fatty acids: (patho)physiological relevance, potential toxicity, and analysis of lipid chlorohydrins","volume":"2016","author":"Schroter","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ecoenv.2022.113568_bib32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1677\/JOE-10-0075","article-title":"Cytochrome P450-mediated 17beta-estradiol metabolism in zebrafish (Danio rerio)","volume":"206","author":"Scornaienchi","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ebiom.2016.02.030","article-title":"Child stunting is associated with low circulating essential amino acids","volume":"6","author":"Semba","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ecoenv.2022.113568_bib34","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1038\/s41467-018-05362-7","article-title":"Glucose promotes cell growth by suppressing branched-chain amino acid degradation","volume":"9","author":"Shao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2022.113568_bib35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.talanta.2017.04.050","article-title":"An integrated strategy for the quantitative analysis of endogenous proteins: A case of gender-dependent expression of P450 enzymes in rat liver microsome","volume":"170","author":"Shao","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.ecoenv.2022.113568_bib36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ccell.2019.12.011","article-title":"Emerging roles for branched-chain amino acid metabolism in cancer","volume":"37","author":"Sivanand","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ecoenv.2022.113568_bib37","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/mp.2017.135","article-title":"Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors","volume":"23","author":"van der Kooij","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ecoenv.2022.113568_bib38","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","article-title":"Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy","volume":"15","author":"Vezzani","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib39","doi-asserted-by":"crossref","first-page":"15379","DOI":"10.1007\/s11356-017-8922-8","article-title":"Occurrence of diazepam and its metabolites in wastewater and surface waters in Beijing","volume":"24","author":"Wang","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2022.113568_bib40","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/mp.2017.72","article-title":"Brain-derived neurotrophic factor Val(66)Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study","volume":"23","author":"Wei","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ecoenv.2022.113568_bib41","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1021\/es203529z","article-title":"Aqueous phototransformation of diazepam and related human metabolites under simulated sunlight","volume":"46","author":"West","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib42","doi-asserted-by":"crossref","first-page":"9734","DOI":"10.1021\/jf4012054","article-title":"Metabolic pathways of T-2 toxin in vivo and in vitro systems of Wistar rats","volume":"61","author":"Yang","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2022.113568_bib43","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2020.01.001","article-title":"Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury","volume":"31","author":"Yurdagul","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.ecoenv.2022.113568_bib44","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2013.12.019","article-title":"Brain-derived estrogen exerts anti-inflammatory and neuroprotective actions in the rat hippocampus","volume":"389","author":"Zhang","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.ecoenv.2022.113568_bib45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.chemosphere.2018.11.076","article-title":"Determination of emerging chlorinated byproducts of diazepam in drinking water","volume":"218","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.113568_bib46","first-page":"237","article-title":"Distribution visualization of the chlorinated disinfection byproduct of diazepam in zebrafish with desorption electrospray ionization mass spectrometry imaging","author":"Zhao","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.ecoenv.2022.113568_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.watres.2016.10.048","article-title":"Chlorination of bisphenol F and the estrogenic and peroxisome proliferator-activated receptor gamma effects of its disinfection byproducts","volume":"107","author":"Zheng","year":"2016","journal-title":"Water Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322004080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322004080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:51:25Z","timestamp":1758952285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322004080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":47,"alternative-id":["S0147651322004080"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113568","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chlorine disinfection byproduct of diazepam affects nervous system function and possesses gender-related difference in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113568"}}