{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T21:59:08Z","timestamp":1776808748853,"version":"3.51.2"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ecoenv.2022.113570","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T12:14:02Z","timestamp":1651493642000},"page":"113570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Toxicological effects of traffic-related air pollution on the lungs: Evidence, biomarkers and intervention"],"prefix":"10.1016","volume":"238","author":[{"given":"Jiani","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2022.113570_bib1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1164\/rccm.201006-0937OC","article-title":"Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study","volume":"183","author":"Andersen","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ecoenv.2022.113570_bib2","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1007\/s11033-020-05607-z","article-title":"Melatonin and vitamin e alleviate homocysteine-induced oxidative injury and apoptosis in endothelial cells","volume":"47","author":"Aykutoglu","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ecoenv.2022.113570_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/1060028016673072","article-title":"Use of vitamin e and c supplements for the prevention of cognitive decline","volume":"51","author":"Basambombo","year":"2017","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.ecoenv.2022.113570_bib4","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.envint.2018.09.050","article-title":"Assessment of impact of traffic-related air pollution on morbidity and mortality in copenhagen municipality and the health gain of reduced exposure","volume":"121","author":"Br\u00f8nnum-Hansen","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2022.113570_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00128-009-9757-x","article-title":"Oxidative damage of the extracts of condensate, particulate and semivolatile organic compounds from gasoline engine exhausts on testicles of rats","volume":"83","author":"Che","year":"2009","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib6","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(17)30505-6","article-title":"Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015","volume":"389","author":"Cohen","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2022.113570_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107523","article-title":"Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders","volume":"210","author":"Costa","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ecoenv.2022.113570_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.etap.2019.04.006","article-title":"Different biological effects of pm(2.5) from coal combustion, gasoline exhaust and urban ambient air relate to the pah\/metal compositions","volume":"69","author":"Cui","year":"2019","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.envres.2018.11.014","article-title":"Particle deposition in the human lung: Health implications of particulate matter from different sources","volume":"169","author":"Deng","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.113570_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.envres.2016.05.050","article-title":"Exposure to outdoor air pollution during trimesters of pregnancy and childhood asthma, allergic rhinitis, and eczema","volume":"150","author":"Deng","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.113570_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.rmed.2016.10.016","article-title":"Early life exposure to traffic-related air pollution and allergic rhinitis in preschool children","volume":"121","author":"Deng","year":"2016","journal-title":"Respir. Med."},{"key":"10.1016\/j.ecoenv.2022.113570_bib12","first-page":"54","article-title":"Air pollution, lung function and copd: Results from the population-based uk biobank study","author":"Doiron","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ecoenv.2022.113570_bib13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.etap.2014.08.003","article-title":"Effects of ultrafine petrol exhaust particles on cytotoxicity, oxidative stress generation, DNA damage and inflammation in human a549 lung cells and murine raw 264.7 macrophages","volume":"38","author":"Durga","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ecoenv.2018.10.090","article-title":"Exposure to nanoscale diesel exhaust particles: oxidative stress, neuroinflammation, anxiety and depression on adult male mice","volume":"168","author":"Ehsanifar","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113570_bib15","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1007\/s11356-019-06754-y","article-title":"Protective effects of melatonin and vitamin e in acetamiprid-induced nephrotoxicity","volume":"27","author":"Erdemli","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2022.113570_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147854","article-title":"Are standardized diesel exhaust particles (dep) representative of ambient particles in air pollution toxicological studies?","volume":"788","author":"Farahani","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.113570_bib17","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0140-6736(16)31679-8","article-title":"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Forouzanfar","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2022.113570_bib18","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3389\/fphar.2019.01361","article-title":"Ma xing shi gan decoction attenuates pm2.5 induced lung injury via inhibiting hmgb1\/tlr4\/nf\u03bab signal pathway in rat","volume":"10","author":"Fei","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2016.09.017","article-title":"Vitamin e: Emerging aspects and new directions","volume":"102","author":"Galli","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2022.113570_bib20","first-page":"1923","volume":"392","author":"GBD","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ecoenv.2022.113570_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17051481","article-title":"Ambient pm2.5 and annual lung cancer incidence: a nationwide study in 295 chinese counties","volume":"17","author":"Guo","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2022.113570_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.clnu.2015.01.020","article-title":"Serum tocopherol levels and vitamin e intake are associated with lung function in the normative aging study","volume":"35","author":"Hanson","year":"2016","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ecoenv.2022.113570_bib23","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.dld.2019.06.005","article-title":"Dietary vitamin e and c intake is inversely associated with the severity of nonalcoholic fatty liver disease","volume":"51","author":"Ivancovsky-Wajcman","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.ecoenv.2022.113570_bib24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.atmosenv.2017.11.043","article-title":"Outdoor particulate air pollution and indoor renovation associated with childhood pneumonia in china","volume":"174","author":"Jiang","year":"2018","journal-title":"Atmos. Environ."},{"key":"10.1016\/j.ecoenv.2022.113570_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2019.151433","article-title":"Edaravone attenuates lung injury in a hind limb ischemia-reperfusion rat model: A histological, immunohistochemical and biochemical study","volume":"228","author":"Kassab","year":"2020","journal-title":"Ann. Anat."},{"key":"10.1016\/j.ecoenv.2022.113570_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118426","article-title":"Tiron protects against nicotine-induced lung and liver injury through antioxidant and anti-inflammatory actions in rats in vivo","volume":"260","author":"Khaled","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ecoenv.2022.113570_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138577","article-title":"The spatial relationship between traffic-related air pollution and noise in two Danish cities: implications for health-related studies","volume":"726","author":"Khan","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.113570_bib28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/08958370490490572","article-title":"Effects of concentrated ambient particles on airway responsiveness and pulmonary inflammation in pulmonary hypertensive rats","volume":"16","author":"Lei","year":"2004","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12931-020-01529-3","article-title":"Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat copd model","volume":"21","author":"Li","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.ecoenv.2022.113570_bib30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1056\/NEJMoa1817364","article-title":"Ambient particulate air pollution and daily mortality in 652 cities","volume":"381","author":"Liu","year":"2019","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.ecoenv.2022.113570_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jdermsci.2016.11.004","article-title":"Preconceptional and perinatal exposure to traffic-related air pollution and eczema in preschool children","volume":"85","author":"Lu","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ecoenv.2022.113570_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123455","article-title":"In vivo respiratory toxicology of cooking oil fumes: Evidence, mechanisms and prevention","volume":"402","author":"Ma","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.113570_bib33","first-page":"15","article-title":"Comparison of airway responses induced in a mouse model by the gas and particulate fractions of gasoline direct injection engine exhaust","author":"Maikawa","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2022.113570_bib34","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.scitotenv.2018.10.188","article-title":"Diesel exhausts particles: their role in increasing the incidence of asthma. Reviewing the evidence of a causal link","volume":"652","author":"Mu\u00f1oz","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"S4","key":"10.1016\/j.ecoenv.2022.113570_bib35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/2047-783X-14-S4-170","article-title":"Assessment of airway hyperreactivity: comparison of forced spirometry and body plethysmography for methacholine challenge tests","volume":"14","author":"Nensa","year":"2009","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.ecoenv.2022.113570_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111753","article-title":"Associations of long-term exposure to traffic-related air pollution with risk of valvular heart disease based on a cross-sectional study","volume":"209","author":"Pang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113570_bib37","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/aje\/kwx166","article-title":"Long-term pm2.5 exposure and respiratory, cancer, and cardiovascular mortality in older us adults","volume":"186","author":"Pun","year":"2017","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib38","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.3109\/08958370902806159","article-title":"Irritant and adjuvant effects of gaseous formaldehyde on the ovalbumin-induced hyperresponsiveness and inflammation in a rat model","volume":"21","author":"Qiao","year":"2009","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib39","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1164\/rccm.201410-1875OC","article-title":"Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the framingham heart study","volume":"191","author":"Rice","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ecoenv.2022.113570_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/08958378.2020.1757791","article-title":"Development of chronic lung injury and pulmonary fibrosis in mice following acute exposure to nitrogen mustard","volume":"32","author":"Solopov","year":"2020","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib41","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00204-016-1736-5","article-title":"Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms","volume":"90","author":"Steiner","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib42","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.envres.2016.04.025","article-title":"A national study of the association between traffic-related air pollution and adverse pregnancy outcomes in canada, 1999-2008","volume":"148","author":"Stieb","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.113570_bib43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/08958370590904616","article-title":"Proinflammatory and anti-inflammatory cytokine balance in gasoline exhaust induced pulmonary injury in mice","volume":"17","author":"Sureshkumar","year":"2005","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.113570_bib44","unstructured":"United Nations. Transforming our world: The 2030 Agenda for Sustainable Development. 2016. Available at: \u3008https:\/\/sdgs.un.org\/2030agenda\u3009 (accessed April 12, 2022)."},{"key":"10.1016\/j.ecoenv.2022.113570_bib45","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.scitotenv.2019.06.309","article-title":"Air pollution at human scales in an urban environment: impact of local environment and vehicles on particle number concentrations","volume":"688","author":"von Schneidemesser","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.113570_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109686","article-title":"Gestational b-vitamin supplementation alleviates pm(2.5)-induced autism-like behavior and hippocampal neurodevelopmental impairment in mice offspring","volume":"185","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113570_bib47","series-title":"Global Air Quality Guidelines: Particulate Matter (PM2.5 and PM10), Ozone, Nitrogen Dioxide, Sulfur Dioxide and Carbon Monoxide","author":"WHO","year":"2021"},{"key":"10.1016\/j.ecoenv.2022.113570_bib48","first-page":"23","article-title":"Health risk impacts of exposure to airborne metals and benzo(a)pyrene during episodes of high pm10 concentrations in poland","volume":"31","author":"Widziewicz","year":"2018","journal-title":"Biomed. Environ. Sci.: BES"},{"key":"10.1016\/j.ecoenv.2022.113570_bib49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pharmthera.2009.03.015","article-title":"Dietary factors lead to innate immune activation in asthma","volume":"123","author":"Wood","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ecoenv.2022.113570_bib50","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00011-019-01280-6","article-title":"Tipe2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury","volume":"68","author":"Wu","year":"2019","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ecoenv.2022.113570_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138631","article-title":"Pm(2.5)-bound polycyclic aromatic hydrocarbons (pahs) and nitrated-pahs (npahs) emitted by gasoline vehicles: characterization and health risk assessment","volume":"727","author":"Zhao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.113570_bib52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.taap.2019.01.010","article-title":"Time-course effects of antioxidants and phase ii enzymes on diesel exhaust particles-induced oxidative damage in the mouse lung","volume":"366","author":"Zheng","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322004109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322004109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:52:04Z","timestamp":1758952324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322004109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":52,"alternative-id":["S0147651322004109"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113570","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxicological effects of traffic-related air pollution on the lungs: Evidence, biomarkers and intervention","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113570"}}