{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:31:22Z","timestamp":1793388682921,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.ecoenv.2022.113702","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T08:36:03Z","timestamp":1653640563000},"page":"113702","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Antibiotic exposure and risk of overweight\/obesity in school children: A multicenter, case-control study from China"],"prefix":"10.1016","volume":"240","author":[{"given":"Juan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhemin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2022.113702_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.micpath.2016.11.002","article-title":"Weight gain by gut microbiota manipulation in productive animals","volume":"106","author":"Angelakis","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ecoenv.2022.113702_bib2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.envres.2018.11.040","article-title":"Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: a review","volume":"169","author":"Ben","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.113702_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.115699","article-title":"Efficient detection and assessment of human exposure to trace antibiotic residues in drinking water","volume":"175","author":"Ben","year":"2020","journal-title":"Water Res."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.113702_bib4","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.3382\/ps.2007-00249","article-title":"History of the use of antibiotic as growth promoters in European poultry feeds","volume":"86","author":"Castanon","year":"2007","journal-title":"Poult. Sci."},{"issue":"9","key":"10.1016\/j.ecoenv.2022.113702_bib5","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-018-1031-3","article-title":"Gender and sex differences in adipose tissue","volume":"18","author":"Chang","year":"2018","journal-title":"Curr. Diabetes Rep."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113702_bib6","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.17577","article-title":"Association of repeated antibiotic exposure up to age 4 years with body mass at age 4.5 years","volume":"3","author":"Chelimo","year":"2020","journal-title":"Jama Netw. Open"},{"issue":"27","key":"10.1016\/j.ecoenv.2022.113702_bib7","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1021\/acs.jafc.9b01334","article-title":"Antibiotic residues in food: extraction, analysis, and human health concerns","volume":"67","author":"Chen","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.113702_bib8","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/s41366-020-0572-0","article-title":"Implication of gut microbiota in the association between infant antibiotic exposure and childhood obesity and adiposity accumulation","volume":"44","author":"Chen","year":"2020","journal-title":"Int. J. Obes."},{"issue":"7413","key":"10.1016\/j.ecoenv.2022.113702_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature11400","article-title":"Antibiotics in early life alter the murine colonic microbiome and adiposity","volume":"488","author":"Cho","year":"2012","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113702_bib10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrendo.2014.210","article-title":"OPINION antibiotics in early life and obesity","volume":"11","author":"Cox","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113702_bib11","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-019-1449-8","article-title":"The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action","volume":"17","author":"Di Cesare","year":"2019","journal-title":"Bmc Med."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.113702_bib12","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1136\/gutjnl-2016-312297","article-title":"Antibiotics as deep modulators of gut microbiota: between good and evil","volume":"65","author":"Ianiro","year":"2016","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.113702_bib13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/chi.2018.0040","article-title":"Childhood obesity and firmicutes\/bacteroidetes ratio in the gut microbiota: a systematic review","volume":"14","author":"Indiani","year":"2018","journal-title":"Child. Obes."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.113702_bib14","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.envres.2010.06.008","article-title":"Influence of water and food consumption on inadvertent antibiotics intake among general population","volume":"110","author":"Ji","year":"2010","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.113702_bib15","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s12519-018-00223-1","article-title":"Antibiotic use in early childhood and risk of obesity: longitudinal analysis of a national cohort","volume":"15","author":"Kelly","year":"2019","journal-title":"World J. Pediatr."},{"key":"10.1016\/j.ecoenv.2022.113702_bib16","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3389\/fimmu.2017.01107","article-title":"Detection of increased plasma interleukin-6 levels and prevalence of Prevotella copri and Bacteroides vulgatus in the feces of type 2 diabetes patients","volume":"8","author":"Leite","year":"2017","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113702_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrgastro.2016.4","article-title":"Gut microbiota in 2015: Prevotella in the gut: choose carefully","volume":"13","author":"Ley","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ecoenv.2022.113702_bib18","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.envint.2017.08.014","article-title":"Veterinary antibiotics in food, drinking water, and the urine of preschool children in Hong Kong","volume":"108","author":"Li","year":"2017","journal-title":"Environ. Int."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.113702_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181690","article-title":"Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2022.113702_bib20","first-page":"2","article-title":"Effect of antibiotic growth promoters on intestinal microbiota in food animals: a novel model for studying the relationship between gut microbiota and human obesity?","author":"Lin","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ecoenv.2022.113702_bib21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.envint.2013.06.012","article-title":"Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China","volume":"59","author":"Liu","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2022.113702_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.scitotenv.2017.04.216","article-title":"Antibiotics in a general population: relations with gender, body mass index (BMI) and age and their human health risks","volume":"599","author":"Liu","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113702_bib23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s12020-021-02630-3","article-title":"Prevalence of precocious puberty among Chinese children: a school population-based study","volume":"72","author":"Liu","year":"2021","journal-title":"Endocrine"},{"key":"10.1016\/j.ecoenv.2022.113702_bib24","unstructured":"Ministry of Agriculture of the People's Republic of China (MOA), 2019. Approval of 10 veterinary drugs including live genetic engineered vaccine of Vibrio turbot (MVAV6203 strains) declared by 27 institutions including East China University of Science and Technology as new veterinary drugs (in Chinese). \u3008http:\/\/www.moa.gov.cn\/govpublic\/SYJ\/201904\/t20190412_6178955.htm\u3009, (Accessed 11 October 2021)."},{"key":"10.1016\/j.ecoenv.2022.113702_bib25","unstructured":"Ministry of Agriculture of the People's Republic of China (MOA), 2017. Publish announcement of catalogues and usage norms of drug feed additives (version of public consultation) (in Chinese). \u3008http:\/\/www.moa.gov.cn\/govpublic\/SYJ\/201711\/t20171102_5858821.htm\u3009, (Accessed 11 October 2021)."},{"key":"10.1016\/j.ecoenv.2022.113702_bib26","unstructured":"Ministry of Agriculture of the People's Republic of China (MOA), 2013. First batch catalogue of veterinary prescription drugs (in Chinese). \u3008http:\/\/www.moa.gov.cn\/nybgb\/2013\/dshiq\/201712\/t20171227_6126416.htm\u3009, (Accessed 11 October 2021)."},{"key":"10.1016\/j.ecoenv.2022.113702_bib27","unstructured":"National health commission of People\u2019s Republic of China, 2018. Screening criterion for overweight and obesity of school-age children and adolescents (in Chinese). \u3008http:\/\/www.chinacdc.cn\/jkzt\/yyhspws\/xzdc\/201804\/t20180418_162494.html\u3009, (Accessed 11 October 2021)."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113702_bib28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/wer.1237","article-title":"Physicochemical properties of antibiotics: a review with an emphasis on detection in the aquatic environment","volume":"92","author":"Ozumchelouei","year":"2020","journal-title":"Water Environ. Res."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.113702_bib29","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/s41396-018-0068-2","article-title":"Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota","volume":"12","author":"Serena","year":"2018","journal-title":"Isme J."},{"key":"10.1016\/j.ecoenv.2022.113702_bib30","unstructured":"Shanghai Municipal Health Commission, 2021. Catalogue of clinical antibiotics for hierarchial management in Shanghai municipality (2021 version) (in Chinese). \u3008http:\/\/wsjkw.sh.gov.cn\/yzgl4\/20210316\/7bf75a6fe963446d9ff97d99fef5572f.html\u3009, (Accessed 11 October 2021)."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113702_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00535-018-1488-5","article-title":"Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects","volume":"54","author":"Takagi","year":"2019","journal-title":"J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.113702_bib32","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3945\/jn.116.240481","article-title":"Microbiota-gut-brain axis: modulator of host metabolism and appetite","volume":"147","author":"van de Wouw","year":"2017","journal-title":"J. Nutr."},{"key":"10.1016\/j.ecoenv.2022.113702_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.foodcont.2017.04.034","article-title":"Antibiotic residues in meat, milk and aquatic products in Shanghai and human exposure assessment","volume":"80","author":"Wang","year":"2017","journal-title":"Food Control"},{"issue":"30","key":"10.1016\/j.ecoenv.2022.113702_bib34","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1007\/s00216-014-8197-6","article-title":"Rapid and sensitive screening and selective quantification of antibiotics in human urine by two-dimensional ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry","volume":"406","author":"Wang","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ecoenv.2022.113702_bib35","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.envint.2016.02.005","article-title":"Antibiotics detected in urines and adipogenesis in school children","volume":"89\u201390","author":"Wang","year":"2016","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.113702_bib36","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1021\/acs.est.5b05749","article-title":"Antibiotics in drinking water in Shanghai and their contribution to antibiotic exposure of school children","volume":"50","author":"Wang","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.113702_bib37","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1021\/es5059428","article-title":"Antibiotic body burden of Chinese school children: a multisite biomonitoring-based study","volume":"49","author":"Wang","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.113702_bib38","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1017\/S1368980018000290","article-title":"What factors may contribute to sex differences in childhood obesity prevalence in China?","volume":"21","author":"Wang","year":"2018","journal-title":"Public Health Nutr."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.113702_bib39","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/j.clnu.2020.11.014","article-title":"The associations of the gut microbiome composition and short-chain fatty acid concentrations with body fat distribution in children","volume":"40","author":"Wei","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ecoenv.2022.113702_bib40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.envint.2018.04.011","article-title":"Antibiotics and antibiotic resistance genes in global lakes: a review and meta-analysis","volume":"116","author":"Yang","year":"2018","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113702_bib41","doi-asserted-by":"crossref","first-page":"314","DOI":"10.5056\/jnm20208","article-title":"Roles of sex hormones and gender in the gut microbiota","volume":"27","author":"Yoon","year":"2021","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.ecoenv.2022.113702_bib42","first-page":"191","article-title":"Antibiotic exposure across three generations from Chinese families and cumulative health risk","author":"Zhang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113702_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.110945","article-title":"Detection of antibiotics in the urine of children and pregnant women in Jiangsu, China","volume":"196","author":"Zhou","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.113702_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113311","article-title":"Antibiotic body burden of elderly Chinese population and health risk assessment: a human biomonitoring-based study","volume":"256","author":"Zhu","year":"2020","journal-title":"Environ. Pollut."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322005425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322005425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:55:11Z","timestamp":1758952511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322005425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":44,"alternative-id":["S0147651322005425"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113702","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotic exposure and risk of overweight\/obesity in school children: A multicenter, case-control study from China","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113702","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113702"}}