{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:50:56Z","timestamp":1793062256955,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ecoenv.2022.113805","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T17:29:09Z","timestamp":1656350949000},"page":"113805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Ferulic acid alleviates AFB1-induced duodenal barrier damage in rats via up-regulating tight junction proteins, down-regulating ROCK, competing CYP450 enzyme and activating GST"],"prefix":"10.1016","volume":"241","author":[{"given":"Xinghe","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfang","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ishfaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changde","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ecoenv.2022.113805_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115424","article-title":"Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX","volume":"28","author":"Aneja","year":"2020","journal-title":"Bioorg. Med. Chem."},{"issue":"10","key":"10.1016\/j.ecoenv.2022.113805_bib2","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/mnfr.200800498","article-title":"The Ussing type chamber model to study the intestinal transport and modulation of specific tight-junction genes using a colonic cell line","volume":"53","author":"Bergmann","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113805_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0378-4274(90)90257-M","article-title":"Effect of aflatoxin B1 treatment in vivo on the in vitro activity of hepatic and extrahepatic glutathione S-transferase","volume":"50","author":"Carrillo","year":"1990","journal-title":"Toxicol. Lett."},{"issue":"12","key":"10.1016\/j.ecoenv.2022.113805_bib4","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1016\/j.psj.2020.09.055","article-title":"Curcumin ameliorates duodenal toxicity of AFB1 in chicken through inducing P-glycoprotein and downregulating cytochrome P450 enzymes","volume":"99","author":"Cheng","year":"2020","journal-title":"Poult. Sci."},{"issue":"11\u201312","key":"10.1016\/j.ecoenv.2022.113805_bib5","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1080\/10715762.2017.1388916","article-title":"Alteration of murine duodenal morphology and redox signalling events by reactive oxygen species generated after whole body \u03b3-irradiation and its prevention by ferulic acid","volume":"51","author":"Das","year":"2017","journal-title":"Free. Radic. Res."},{"key":"10.1016\/j.ecoenv.2022.113805_bib6","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s00204-014-1312-9","article-title":"Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences","volume":"88","author":"Dohnal","year":"2014","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113805_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12860-020-00259-0","article-title":"ILK supports RhoA\/ROCK-mediated contractility of human intestinal epithelial crypt cells by inducing the fibrillogenesis of endogenous soluble fibronectin during the spreading process","volume":"21","author":"Gagn\u00e9","year":"2020","journal-title":"BMC Mol. Cell Biol."},{"issue":"23","key":"10.1016\/j.ecoenv.2022.113805_bib8","doi-asserted-by":"crossref","first-page":"12791","DOI":"10.3390\/ijms222312791","article-title":"Determination of CYP450 expression levels in the human small intestine by mass spectrometry-based targeted proteomics","volume":"22","author":"Grangeon","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113805_bib9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3390\/toxins5020396","article-title":"Modulation of intestinal functions following mycotoxin ingestion: Meta-analysis of published experiments in animals","volume":"5","author":"Grenier","year":"2013","journal-title":"Toxins"},{"issue":"2","key":"10.1016\/j.ecoenv.2022.113805_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145236","article-title":"Protective effects of ferulic acid against heat stress-induced intestinal epithelial barrier dysfunction in vitro and in vivo","volume":"11","author":"He","year":"2016","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113805_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/toxins11010012","article-title":"Effect of compound probiotics and mycotoxin degradation enzymes on alleviating cytotoxicity of swine jejunal epithelial cells induced by aflatoxin B1 and zearalenone","volume":"11","author":"Huang","year":"2019","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.ecoenv.2022.113805_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119254","article-title":"Piezo1 regulates intestinal epithelial function by affecting the tight junction protein claudin-1 via the ROCK pathway","volume":"275","author":"Jiang","year":"2021","journal-title":"Life. Sci."},{"issue":"49","key":"10.1016\/j.ecoenv.2022.113805_bib13","doi-asserted-by":"crossref","first-page":"10730","DOI":"10.1021\/acs.jafc.7b03933","article-title":"Rutinosylated ferulic acid attenuates food allergic response and colitis by upregulating regulatory T cells in mouse models","volume":"65","author":"Katayama","year":"2017","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113805_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0041-008X(89)90057-4","article-title":"Intestinal absorption and excretion of aflatoxin in rats","volume":"97","author":"Kumagai","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.113805_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1046\/j.1365-2362.2003.01154.x","article-title":"Variable expression of CYP and Pgp genes in the human small intestine. Eur","volume":"33","author":"Lindell","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ecoenv.2022.113805_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108753","article-title":"Ferulic acid ameliorates nonalcoholic fatty liver disease and modulates the gut microbiota composition in high-fat diet fed ApoE -\/- Mice","volume":"113","author":"Ma","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.113805_bib17","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1007\/s11356-019-07532-6","article-title":"Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2\/HO-1 signaling in methotrexate-induced rats","volume":"27","author":"Mahmoud","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2022.113805_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1389450118666170125144557","article-title":"Cytochrome P450 structure, function and clinical significance: a review","volume":"19","author":"Manikandan","year":"2018","journal-title":"Curr. Drug. Targets"},{"key":"10.1016\/j.ecoenv.2022.113805_bib19","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3390\/foods9050644","article-title":"Characteristics, Occurrence, Detection and Detoxification of Aflatoxins in Foods and Feeds","volume":"9","author":"Nazhand","year":"2020","journal-title":"Foods"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.113805_bib20","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1177\/0192623313477256","article-title":"Integrative toxicopathological evaluation of aflatoxin B1 exposure in F344 rats","volume":"41","author":"Qian","year":"2013","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113805_bib21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/toxins11010055","article-title":"Differential transcriptome responses to aflatoxin B1 in the cecal tonsil of susceptible and resistant turkeys","volume":"11","author":"Reed","year":"2019","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.ecoenv.2022.113805_bib22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fphar.2019.00467","article-title":"Time-course effects of acute aflatoxin B1 exposure on hepatic mitochondrial lipids and oxidative stress in rats","volume":"10","author":"Rotimi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.113805_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.fct.2018.11.047","article-title":"Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods","volume":"124","author":"Rushing","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.113805_bib24","first-page":"3165","article-title":"Dietary lycopene supplementation could alleviate aflatoxin B (1) induced intestinal damage through improving immune function and anti-oxidant capacity in broilers","volume":"11","author":"Sarker","year":"2021","journal-title":"Anim. (Basel)"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113805_bib25","doi-asserted-by":"crossref","first-page":"13931","DOI":"10.1038\/s41598-018-32352-y","article-title":"Rotavirus-induced early activation of the RhoA\/ROCK\/MLC signaling pathway mediates the disruption of tight junctions in polarized MDCK cells","volume":"8","author":"Soliman","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2022.113805_bib26","series-title":"Effects of aflatoxin B1 on the digestive tract structure and function, blood biochemical parameters and production performance of meat duck","author":"Song","year":"2012"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.113805_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/asj.13357","article-title":"Regulation of the intestinal barrier by nutrients: The role of tight junctions","volume":"91","author":"Suzuki","year":"2020","journal-title":"Anim. Sci. J."},{"key":"10.1016\/j.ecoenv.2022.113805_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.foodchem.2016.07.079","article-title":"Phenolic compound in beans as protection against mycotoxins","volume":"214","author":"Telles","year":"2017","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113805_bib29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.toxicon.2007.04.005","article-title":"The effect of feeding piglets with the diet containing green tea extracts or coumarin on in vitro metabolism of aflatoxin B1 by their tissues","volume":"50","author":"Tulayakul","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.ecoenv.2022.113805_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112624","article-title":"Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2\/GST pathway and regulating mitochondrial pathway","volume":"224","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.113805_bib31","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3382\/ps\/pey358","article-title":"Water-soluble substances of wheat: a potential preventer of aflatoxin B1-induced liver damage in broilers","volume":"98","author":"Wang","year":"2019","journal-title":"Poult. Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.113805_bib32","first-page":"179","article-title":"Aflatoxin-albumin adducts: a basis for comparative carcinogenesis between animals and humans","volume":"5","author":"Wild","year":"1996","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.ecoenv.2022.113805_bib33","series-title":"Ferulic Acid Reduces The Liver Fibrosis Rat Portal Vein Pressure Through The Rhoa Signaling Pathway\u2014a Preliminary Research","author":"Xu","year":"2012"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322006455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322006455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:08:23Z","timestamp":1758953303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322006455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":33,"alternative-id":["S0147651322006455"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113805","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferulic acid alleviates AFB1-induced duodenal barrier damage in rats via up-regulating tight junction proteins, down-regulating ROCK, competing CYP450 enzyme and activating GST","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113805"}}