{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:52:18Z","timestamp":1790790738112,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R01AG049321\u201301A1"],"award-info":[{"award-number":["1R01AG049321\u201301A1"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/P004695\/1"],"award-info":[{"award-number":["BB\/P004695\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874259"],"award-info":[{"award-number":["81874259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173494"],"award-info":[{"award-number":["82173494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["XJ201941"],"award-info":[{"award-number":["XJ201941"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2008085QH385"],"award-info":[{"award-number":["2008085QH385"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.ecoenv.2022.114019","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T23:20:23Z","timestamp":1661469623000},"page":"114019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Wnt 5a mediated inflammatory injury of renal tubular epithelial cells dependent on calcium signaling pathway in Trichloroethylene sensitized mice"],"prefix":"10.1016","volume":"243","author":[{"given":"Xulei","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinru","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ecoenv.2022.114019_bib1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/15459620701301763","article-title":"Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review","volume":"4","author":"Bakke","year":"2007","journal-title":"J. Occup. Environ. Hyg."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114019_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004018","article-title":"Role of calmodulin-calmodulin kinase II, cAMP\/protein kinase A and ERK 1\/2 on Aeromonas hydrophila-induced apoptosis of head kidney macrophages","volume":"10","author":"Banerjee","year":"2014","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114019_bib3","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.bbrc.2012.12.036","article-title":"Autocrine stimulation of osteoblast activity by Wnt5a in response to TNF-alpha in human mesenchymal stem cells","volume":"430","author":"Briolay","year":"2013","journal-title":"Biochem Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114019_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/toxsci\/kfn078","article-title":"Trichloroethylene disrupts cardiac gene expression and calcium homeostasis in rat myocytes","volume":"104","author":"Caldwell","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2022.114019_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jsbmb.2015.04.002","article-title":"A review of 1alpha,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling","volume":"152","author":"Doroudi","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114019_bib6","first-page":"62","article-title":"Historical occupational trichloroethylene air concentrations based on inspection measurements from Shanghai, China","volume":"59","author":"Friesen","year":"2015","journal-title":"Ann. Occup. Hyg."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114019_bib7","doi-asserted-by":"crossref","first-page":"13095","DOI":"10.1002\/jcb.28582","article-title":"Tao-Hong-Si-Wu decoction reduces ischemia reperfusion rat myoblast cells calcium overloading and inflammation through the Wnt\/IP3R\/CAMKII pathway","volume":"120","author":"Fuping","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114019_bib8","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/HYPERTENSIONAHA.114.05096","article-title":"MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells","volume":"65","author":"Han","year":"2015","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114019_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.taap.2013.08.014","article-title":"Identification of serum biomarkers for occupational medicamentosa-like dermatitis induced by trichloroethylene using mass spectrometry","volume":"273","author":"Hong","year":"2013","journal-title":"Toxicol. Appl. Pharm."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114019_bib10","first-page":"4152","article-title":"Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency","volume":"130","author":"Kawarazaki","year":"2020","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114019_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41419-020-03377-x","article-title":"Wnt5a promotes renal tubular inflammation in diabetic nephropathy by binding to CD146 through noncanonical Wnt signaling","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114019_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/1547691X.2017.1420712","article-title":"NF-kappaB signaling pathway-enhanced complement activation mediates renal injury in trichloroethylene-sensitized mice","volume":"15","author":"Liu","year":"2018","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.ecoenv.2022.114019_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148451","article-title":"Enhanced trichloroethylene biodegradation: Roles of biochar-microbial collaboration beyond adsorption","volume":"792","author":"Liu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.114019_bib14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tox.2017.01.004","article-title":"Trichloroethylene-induced formic aciduria in the male C57 Bl\/6 mouse","volume":"378","author":"Lock","year":"2017","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114019_bib15","article-title":"Wnt-5A\/B signaling in hematopoiesis throughout life","volume":"9","author":"Mastelaro","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114019_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.celrep.2017.09.023","article-title":"A Wnt\/Calcium signaling cascade regulates neuronal excitability and trafficking of NMDARs","volume":"21","author":"McQuate","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114019_bib17","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1038\/s41598-021-82067-w","article-title":"Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis","volume":"11","author":"Nalesso","year":"2021","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114019_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080826","article-title":"WNT signaling in disease","volume":"8","author":"Ng","year":"2019","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114019_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41419-019-1483-7","article-title":"ATG5-mediated autophagy suppresses NF-\u03baB signaling to limit epithelial inflammatory response to kidney injury","volume":"10","author":"Peng","year":"2019","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114019_bib20","first-page":"863","article-title":"Oxidative CaMKII as a potential target for inflammatory disease (Review)","volume":"20","author":"Qu","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"195","key":"10.1016\/j.ecoenv.2022.114019_bib21","doi-asserted-by":"crossref","first-page":"195r","DOI":"10.1126\/scitranslmed.3006135","article-title":"CaMKII is essential for the proasthmatic effects of oxidation","volume":"5","author":"Sanders","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114019_bib22","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1073\/pnas.050574297","article-title":"Expression and function of wingless and frizzled homologs in rheumatoid arthritis","volume":"97","author":"Sen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114019_bib23","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1093\/carcin\/bgs191","article-title":"Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene","volume":"33","author":"Vermeulen","year":"2012","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114019_bib24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/1091581815591222","article-title":"An animal model of Trichloroethylene-induced skin sensitization in BALB\/c Mice","volume":"34","author":"Wang","year":"2015","journal-title":"Int. J. Toxicol."},{"issue":"Suppl 2","key":"10.1016\/j.ecoenv.2022.114019_bib25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1289\/ehp.00108s2359","article-title":"Exposure assessment of Trichloroethylene","volume":"108 Suppl 2","author":"Wu","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.114019_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111439","article-title":"C5b-9 membrane attack complex activated NLRP3 inflammasome mediates renal tubular immune injury in trichloroethylene sensitized mice","volume":"208","author":"Xie","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.114019_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.652446","article-title":"Remdesivir alleviates acute kidney injury by inhibiting the activation of NLRP3 inflammasome","volume":"12","author":"Yin","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114019_bib28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/cbf.1446","article-title":"Role of Ca2+\/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension","volume":"26","author":"Yousif","year":"2008","journal-title":"CELL Biochem. Funct."},{"key":"10.1016\/j.ecoenv.2022.114019_bib29","article-title":"TNF-\u03b1\/TNFR1 regulates the polarization of Kupffer cells to mediate trichloroethylene-induced liver injury","volume":"230","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114019_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/1348-9585.12142","article-title":"Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in guinea pigs","volume":"62","author":"Zhao","year":"2020","journal-title":"J. Occup. Health"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322008594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322008594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:02:40Z","timestamp":1758952960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322008594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":30,"alternative-id":["S0147651322008594"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114019","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt 5a mediated inflammatory injury of renal tubular epithelial cells dependent on calcium signaling pathway in Trichloroethylene sensitized mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114019"}}