{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:39:16Z","timestamp":1776789556646,"version":"3.51.2"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.ecoenv.2022.114130","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T06:05:23Z","timestamp":1664345123000},"page":"114130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Association between prenatal exposure to perfluoroalkyl substances and anogenital distance in female neonates"],"prefix":"10.1016","volume":"245","author":[{"given":"Jincan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengsheng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maohua","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wencheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ecoenv.2022.114130_bib1","doi-asserted-by":"crossref","first-page":"E1216","DOI":"10.1210\/jc.2015-2370","article-title":"Human chorionic gonadotropin partially mediates phthalate association with male and female anogenital distance","volume":"100","author":"Adibi","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2022.114130_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.envint.2018.08.034","article-title":"Prenatal exposure to phthalates and phenols and infant endocrine-sensitive outcomes: The MIREC study","volume":"120","author":"Arbuckle","year":"2018","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2022.114130_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.reprotox.2020.03.011","article-title":"Prenatal perfluoroalkyl substances and newborn anogenital distance in a Canadian cohort","volume":"94","author":"Arbuckle","year":"2020","journal-title":"Reprod. Toxicol."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114130_bib4","doi-asserted-by":"crossref","DOI":"10.1289\/EHP875","article-title":"First-trimester urinary bisphenol A concentration in relation to anogenital distance, an androgen-sensitive measure of reproductive development, in infant girls","volume":"125","author":"Barrett","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.114130_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2018.03.029","article-title":"Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro","volume":"291","author":"Behr","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/toxsci\/kfq379","article-title":"Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro","volume":"120","author":"Benninghoff","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"2 Pt A","key":"10.1016\/j.ecoenv.2022.114130_bib7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijheh.2016.12.005","article-title":"Maternal serum concentrations of perfluoroalkyl acids in five international birth cohorts","volume":"220","author":"Bjerregaard-Olesen","year":"2017","journal-title":"Int J. Hyg. Environ. Health"},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114130_bib8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/biostatistics\/kxu058","article-title":"Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures","volume":"16","author":"Bobb","year":"2015","journal-title":"Biostatistics"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12940-018-0413-y","article-title":"Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression","volume":"17","author":"Bobb","year":"2018","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2022.114130_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-069X-5-4","article-title":"Embryonic exposure to the fungicide vinclozolin causes virilization of females and alteration of progesterone receptor expression in vivo: an experimental study in mice","volume":"5","author":"Buckley","year":"2006","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2022.114130_bib11","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ecoenv.2019.01.027","article-title":"Protonation state effects of estrogen receptor \u03b1 on the recognition mechanisms by perfluorooctanoic acid and perfluorooctane sulfonate: a computational study","volume":"171","author":"Cao","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13253-014-0180-3","article-title":"Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting","volume":"20","author":"Carrico","year":"2015","journal-title":"J. Agric. Biol. Environ. Stat."},{"key":"10.1016\/j.ecoenv.2022.114130_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106729","article-title":"Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing","volume":"156","author":"Carwile","year":"2021","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114130_bib14","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/toxsci\/51.2.236","article-title":"Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro","volume":"51","author":"Casanova","year":"1999","journal-title":"Toxicol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.ecoenv.2022.114130_bib15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tox.2005.12.004","article-title":"Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB","volume":"220","author":"Ceccatelli","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2022.114130_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.reprotox.2021.06.016","article-title":"Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: A Faroese cohort study","volume":"104","author":"Christensen","year":"2021","journal-title":"Reprod. Toxicol."},{"issue":"Suppl 2","key":"10.1016\/j.ecoenv.2022.114130_bib17","first-page":"159","article-title":"Assessment of weighted quantile sum regression for modeling chemical mixtures and cancer risk","volume":"14","author":"Czarnota","year":"2015","journal-title":"Cancer Inf."},{"key":"10.1016\/j.ecoenv.2022.114130_bib18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.envint.2016.08.026","article-title":"Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1-4years among 359 children in the Odense Child Cohort","volume":"96","author":"Dalsager","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2022.114130_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ecoenv.2018.10.025","article-title":"Neonatal and juvenile exposure to perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS): advance puberty onset and kisspeptin system disturbance in female rats","volume":"167","author":"Du","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114130_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s10815-014-0410-1","article-title":"Anogenital distance as a measure of human male fertility","volume":"32","author":"Eisenberg","year":"2015","journal-title":"J. Assist Reprod. Genet"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib21","doi-asserted-by":"crossref","first-page":"17004","DOI":"10.1289\/EHP3567","article-title":"Exposure to perfluoroalkyl substances during fetal life and pubertal development in boys and girls from the danish national birth cohort","volume":"127","author":"Ernst","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114130_bib22","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/jat.3794","article-title":"Effect of perfluorooctanesulfonate exposure on steroid hormone levels and steroidogenic enzyme activities in juvenile Silurana tropicalis","volume":"39","author":"Fort","year":"2019","journal-title":"J. Appl. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114130_bib23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijheh.2008.04.007","article-title":"Perfluorinated compounds--exposure assessment for the general population in Western countries","volume":"212","author":"Fromme","year":"2009","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2022.114130_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2020.113563","article-title":"Association between pre\/perinatal exposure to POPs and children's anogenital distance at age 4 years: a study from the INMA-Asturias cohort","volume":"229","author":"Garc\u00eda-Villarino","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2022.114130_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113607","article-title":"Serum concentrations of persistent organic pollutants mixture during pregnancy and anogenital distance in 8-year-old children from the INMA-Asturias cohort","volume":"213","author":"Garc\u00eda-Villarino","year":"2022","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114130_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.taap.2014.03.012","article-title":"Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells","volume":"277","author":"Gorrochategui","year":"2014","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.ecoenv.2022.114130_bib27","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.envint.2018.03.025","article-title":"Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition","volume":"115","author":"Harris","year":"2018","journal-title":"Environ. Int"},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114130_bib28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.envint.2011.01.011","article-title":"Characterisation of human exposure pathways to perfluorinated compounds \u2014 Comparing exposure estimates with biomarkers of exposure","volume":"37","author":"Haug","year":"2011","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114130_bib29","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.rbmo.2018.08.020","article-title":"Assessment of anogenital distance as a diagnostic tool in polycystic ovary syndrome","volume":"37","author":"Hern\u00e1ndez-Pe\u00f1alver","year":"2018","journal-title":"Reprod. Biomed. Online"},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114130_bib30","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/humrep\/des087","article-title":"Caucasian male infants and boys with hypospadias exhibit reduced anogenital distance","volume":"27","author":"Hsieh","year":"2012","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114130_bib31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1023\/A:1022581902880","article-title":"Gender-specific steroid metabolism in neural differentiation","volume":"17","author":"Hutchison","year":"1997","journal-title":"Cell Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114130_bib32","doi-asserted-by":"crossref","DOI":"10.1289\/EHP5482","article-title":"Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort","volume":"127","author":"Inoue","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.114130_bib33","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.envres.2018.11.033","article-title":"Perfluoroalkyl substances follow inverted U-shaped distributions across various stages of glomerular function: implications for future research","volume":"169","author":"Jain","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.114130_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145119","article-title":"Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty: a study from the Odense Child Cohort","volume":"769","author":"Jensen","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.114130_bib35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.chemosphere.2014.01.080","article-title":"Endocrine disruption effects of long-term exposure to perfluorodecanoic acid (PFDA) and perfluorotridecanoic acid (PFTrDA) in zebrafish (Danio rerio) and related mechanisms","volume":"108","author":"Jo","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114130_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105355","article-title":"Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: a large-scale, prospective birth cohort study","volume":"136","author":"Kashino","year":"2020","journal-title":"Environ. Int."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114130_bib37","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/tox.21996","article-title":"Repeated dose and reproductive\/developmental toxicity of perfluorododecanoic acid in rats","volume":"30","author":"Kato","year":"2015","journal-title":"Environ. Toxicol."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114130_bib38","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1007\/s11356-013-1753-3","article-title":"Perfluorinated compounds affect the function of sex hormone receptors","volume":"20","author":"Kjeldsen","year":"2013","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"12","key":"10.1016\/j.ecoenv.2022.114130_bib39","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1093\/humrep\/det382","article-title":"Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction","volume":"28","author":"Kristensen","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ecoenv.2022.114130_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110178","article-title":"Intrauterine exposure to per- and polyfluoroalkyl substances may harm children's lung function development","volume":"192","author":"Kung","year":"2021","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114130_bib41","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","article-title":"Perfluoroalkyl acids: a review of monitoring and toxicological findings","volume":"99","author":"Lau","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12940-017-0338-x","article-title":"Prenatal exposure to persistent organic pollutants and child overweight\/obesity at 5-year follow-up: a prospective cohort study","volume":"17","author":"Lauritzen","year":"2018","journal-title":"Environ. Health"},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114130_bib43","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.chemosphere.2012.08.035","article-title":"Concentrations of perfluoroalkyl compounds in maternal and umbilical cord sera and birth outcomes in Korea","volume":"90","author":"Lee","year":"2013","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114130_bib44","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/tox.23119","article-title":"Perfluorotridecanoic acid inhibits fetal Leydig cell differentiation after in utero exposure in rats via increasing oxidative stress and autophagy","volume":"36","author":"Li","year":"2021","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/oemed-2017-104651","article-title":"Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water","volume":"75","author":"Li","year":"2018","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ecoenv.2022.114130_bib46","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.reprotox.2016.08.019","article-title":"Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort","volume":"68","author":"Lind","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114130_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105636","article-title":"Associations of per-\/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns","volume":"140","author":"Liu","year":"2020","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114130_bib48","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.rbmo.2018.09.008","article-title":"Prenatal exposure to persistent organic compounds and their association with anogenital distance in infants","volume":"37","author":"Loreto-G\u00f3mez","year":"2018","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.ecoenv.2022.114130_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2021.113706","article-title":"Association between prenatal exposure to polybrominated diphenyl ethers and anogenital distance in girls at ages 0-4 years","volume":"233","author":"Luan","year":"2021","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2022.114130_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106496","article-title":"Environmental exposure to per- and polyfluoroalkyl substances mixture and male reproductive hormones","volume":"152","author":"Luo","year":"2021","journal-title":"Environ. Int."},{"issue":"12","key":"10.1016\/j.ecoenv.2022.114130_bib51","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1289\/ehp.1408847","article-title":"Prenatal exposure to perfluoroalkyl acids and serum testosterone concentrations at 15 years of age in female ALSPAC study participants","volume":"123","author":"Maisonet","year":"2015","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.114130_bib52","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.reprotox.2013.09.001","article-title":"Effects of perinatal ethinyl estradiol exposure in male and female Wistar rats","volume":"42","author":"Mandrup","year":"2013","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib53","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00204-016-1678-y","article-title":"Comparing effect levels of regulatory studies with endpoints derived in targeted anti-androgenic studies: example prochloraz","volume":"91","author":"Melching-Kollmuss","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114130_bib54","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1289\/ehp.1103421","article-title":"Shorter anogenital distance predicts poorer semen quality in young men in Rochester, New York","volume":"119","author":"Mendiola","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF01541367","article-title":"Prenatal exposure to virilizing progestins: an adult follow-up study of twelve women","volume":"11","author":"Money","year":"1982","journal-title":"Arch. Sex. Behav."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114130_bib56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1289\/EHP246","article-title":"Prenatal exposure to perfluoroalkyl substances and adiposity in early and mid-childhood","volume":"125","author":"Mora","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.114130_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137568","article-title":"Effects of prenatal bisphenol A exposure on the hepatic transcriptome and proteome in rat offspring","volume":"720","author":"Nguyen","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12940-019-0493-3","article-title":"Prenatal plasma concentrations of Perfluoroalkyl and polyfluoroalkyl substances and neuropsychological development in children at four years of age","volume":"18","author":"Niu","year":"2019","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2022.114130_bib59","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.envint.2016.07.015","article-title":"Per- and polyfluoroalkyl substances (PFASs) - New endocrine disruptors in polar bears (Ursus maritimus)?","volume":"96","author":"Pedersen","year":"2016","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114130_bib60","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/pr.2017.287","article-title":"Anogenital distance as a phenotypic signature through infancy","volume":"83","author":"Priskorn","year":"2018","journal-title":"Pedia Res."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114130_bib61","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.rbmo.2017.01.002","article-title":"Investigation of anogenital distance as a diagnostic tool in endometriosis","volume":"34","author":"S\u00e1nchez-Ferrer","year":"2017","journal-title":"Reprod. Biomed. Online"},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114130_bib62","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00204-018-2350-5","article-title":"Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders","volume":"93","author":"Schwartz","year":"2019","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114130_bib63","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jhep.2021.09.039","article-title":"Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease","volume":"76","author":"Sen","year":"2022","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114130_bib64","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.toxlet.2009.04.014","article-title":"Chronic exposure to perfluorododecanoic acid disrupts testicular steroidogenesis and the expression of related genes in male rats","volume":"188","author":"Shi","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2022.114130_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111692","article-title":"Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and associations with attention-deficit\/hyperactivity disorder and autism spectrum disorder in children","volume":"202","author":"Skogheim","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.114130_bib66","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.envint.2018.01.010","article-title":"Biomonitoring PFAAs in blood and semen samples: investigation of a potential link between PFAAs exposure and semen mobility in China","volume":"113","author":"Song","year":"2018","journal-title":"Environ. Int"},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114130_bib67","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/hep.31483","article-title":"Prenatal exposure to perfluoroalkyl substances associated with increased susceptibility to liver injury in children","volume":"72","author":"Stratakis","year":"2020","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114130_bib68","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phthalate exposure","volume":"113","author":"Swan","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114130_bib69","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/andr.12156","article-title":"Anogenital distance as a marker of androgen exposure in humans","volume":"4","author":"Thankamony","year":"2016","journal-title":"Andrology"},{"key":"10.1016\/j.ecoenv.2022.114130_bib70","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.envint.2018.06.015","article-title":"Determinants of plasma concentrations of perfluoroalkyl and polyfluoroalkyl substances in pregnant women from a birth cohort in Shanghai, China","volume":"119","author":"Tian","year":"2018","journal-title":"Environ. Int."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114130_bib71","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/humrep\/dez058","article-title":"Maternal plasma concentrations of perfluoroalkyl and polyfluoroalkyl substances during pregnancy and anogenital distance in male infants","volume":"34","author":"Tian","year":"2019","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1289\/ehp.1409288","article-title":"Perfluorooctane sulfonate concentrations in amniotic fluid, biomarkers of fetal leydig cell function, and cryptorchidism and hypospadias in Danish boys (1980-1996)","volume":"124","author":"Toft","year":"2016","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114130_bib73","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/humrep\/deu350","article-title":"Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study","volume":"30","author":"V\u00e9lez","year":"2015","journal-title":"Hum. Reprod."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114130_bib74","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1897\/07-008R1.1","article-title":"Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus)","volume":"26","author":"Wei","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114130_bib75","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI34241","article-title":"Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism","volume":"118","author":"Welsh","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ecoenv.2022.114130_bib76","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1001\/jama.1960.03020100036007","article-title":"Masculinization of female fetus due to use of orally given progestins","volume":"172","author":"Wilkins","year":"1960","journal-title":"J. Am. Med. Assoc."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib77","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13048-021-00903-z","article-title":"Chronic exposure to perfluorohexane sulfonate leads to a reproduction deficit by suppressing hypothalamic kisspeptin expression in mice","volume":"14","author":"Yin","year":"2021","journal-title":"J. Ovarian Res."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114130_bib78","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/jc.2017-02783","article-title":"Association of perfluoroalkyl and polyfluoroalkyl substances with premature ovarian insufficiency in Chinese women","volume":"103","author":"Zhang","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114130_bib79","article-title":"Exposure to perfluorooctane sulfonate in utero reduces testosterone production in rat fetal Leydig cells","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS One"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322009708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322009708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:59:55Z","timestamp":1758952795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322009708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":79,"alternative-id":["S0147651322009708"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114130","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between prenatal exposure to perfluoroalkyl substances and anogenital distance in female neonates","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114130"}}