{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:54:18Z","timestamp":1792425258203,"version":"4.5.0"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2022CXGC010607-06"],"award-info":[{"award-number":["2022CXGC010607-06"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015336","name":"National Modern Agriculture Industry Technology System","doi-asserted-by":"publisher","award":["SDAIT-02-10"],"award-info":[{"award-number":["SDAIT-02-10"]}],"id":[{"id":"10.13039\/501100015336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ecoenv.2022.114135","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T13:12:59Z","timestamp":1664802779000},"page":"114135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Direct toxicity of the herbicide florasulam against Chlorella vulgaris: An integrated physiological and metabolomic analysis"],"prefix":"10.1016","volume":"246","author":[{"given":"Qin","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2022.114135_bib1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.aquatox.2018.08.008","article-title":"Oxidative stress responses and cellular energy allocation changes in microalgae following exposure to widely used human antibiotics","volume":"203","author":"Aderemi","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cbpc.2015.04.001","article-title":"Teratogenicity, genotoxicity and oxidative stress in zebrafish embryos (Danio rerio) co-exposed to arsenic and atrazine","volume":"172\u2013173","author":"Adeyemi","year":"2015","journal-title":"Comp. Biochem. Physiol. Toxicol. Pharmacol. CBP"},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114135_bib3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12013-013-9750-1","article-title":"Citric acid cycle and role of its intermediates in metabolism","volume":"68","author":"Akram","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114135_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1360-1385(01)02010-6","article-title":"Molecular recognition in thylakoid structure and function","volume":"6","author":"Allen","year":"2001","journal-title":"Trends Plant Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.plipres.2012.09.002","article-title":"Membrane-perturbing effect of fatty acids and lysolipids","volume":"52","author":"Arouri","year":"2013","journal-title":"Prog. Lipid Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114135_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00726-005-0245-2","article-title":"The aspartic acid metabolic pathway, an exciting and essential pathway in plants","volume":"30","author":"Azevedo","year":"2006","journal-title":"Amino Acids"},{"issue":"12","key":"10.1016\/j.ecoenv.2022.114135_bib7","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.cropro.2007.03.007","article-title":"Weed control and wheat ( Triticum aestivum L.) yield under application of 2,4-D plus carfentrazone-ethyl and florasulam plus flumetsulam: evaluation of the efficacy","volume":"26","author":"Baghestani","year":"2007","journal-title":"Crop Prot."},{"issue":"10","key":"10.1016\/j.ecoenv.2022.114135_bib8","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1002\/etc.3086","article-title":"Evaluation and comparison of the relationship between NOEC and EC10 or EC20 values in chronic Daphnia toxicity testing","volume":"34","author":"Beasley","year":"2015","journal-title":"Environ. Toxicol. Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/nph.12631","article-title":"Metabolism and development - integration of micro computed tomography data and metabolite profiling reveals metabolic reprogramming from floral initiation to silique development","volume":"202","author":"Bellaire","year":"2014","journal-title":"N. Phytol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF01689451","article-title":"Growth, chlorophyll a content, nitrogen-fixing ability, and certain metabolic activities of Nostoc muscorum: effect of methylparathion and benthiocarb","volume":"47","author":"Bhunia","year":"1991","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11356-008-0077-1","article-title":"Time-dependent degradation and toxicity of diclofop-methyl in algal suspensions: emerging contaminants","volume":"16","author":"Cai","year":"2009","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"12","key":"10.1016\/j.ecoenv.2022.114135_bib12","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/chir.22226","article-title":"Enantioselective toxic effects and degradation of myclobutanil enantiomers in Scenedesmus obliquus","volume":"25","author":"Cheng","year":"2013","journal-title":"Chirality"},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib13","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1104\/pp.100.4.1909","article-title":"Resistance to acetolactate synthase-inhibiting herbicides in annual ryegrass (Lolium rigidum) involves at least two mechanisms","volume":"100","author":"Christopher","year":"1992","journal-title":"Plant Physiol."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114135_bib14","first-page":"908","article-title":"The role of contamination history and gender on the genotoxic responses of the crayfish Procambarus clarkii to a penoxsulam-based herbicide","volume":"27","author":"Costa","year":"2018","journal-title":"Ecotoxicol. (Lond., Engl. )"},{"key":"10.1016\/j.ecoenv.2022.114135_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128272","article-title":"Organochlorine pesticides and other pesticides in peanut oil: residue level, source, household processing factor and risk assessment","volume":"429","author":"Cui","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/eesa.1997.1556","article-title":"Sensitivity of macrophyte-dominated freshwater microcosms to chronic levels of the herbicide linuron. II. Community metabolism and invertebrates","volume":"38","author":"Cuppen","year":"1997","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.114135_bib17","first-page":"87","article-title":"Effects of pesticides on freshwater diatoms","volume":"203","author":"Debenest","year":"2010","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110392","article-title":"A study into the species sensitivity of green algae towards imidazolium-based ionic liquids using flow cytometry","volume":"194","author":"Deng","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.114135_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116135","article-title":"A simple and rapid algal assay kit to assess toxicity of heavy metal-contaminated water","volume":"269","author":"Eom","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.114135_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-4939-9790-9_7","article-title":"Enzymatic conversions of glutamate and \u03b3-aminobutyric acid as indicators of plant stress response","volume":"2057","author":"Eprintsev","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"15","key":"10.1016\/j.ecoenv.2022.114135_bib21","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1021\/es500434p","article-title":"Estimating half-lives for pesticide dissipation from plants","volume":"48","author":"Fantke","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-arplant-050312-120132","article-title":"ROS-mediated lipid peroxidation and RES-activated signaling","volume":"64","author":"Farmer","year":"2013","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0048-9697(05)80101-9","article-title":"Additive effects of herbicide combinations on aquatic non-target organisms","volume":"134","author":"Faust","year":"1993","journal-title":"Sci. Total Environ."},{"issue":"24","key":"10.1016\/j.ecoenv.2022.114135_bib24","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1021\/es071445r","article-title":"Comparative toxicity of nanoparticulate ZnO, bulk ZnO, and ZnCl2 to a freshwater microalga (Pseudokirchneriella subcapitata): the importance of particle solubility","volume":"41","author":"Franklin","year":"2007","journal-title":"Environ. Sci. Technol."},{"issue":"2\u20133","key":"10.1016\/j.ecoenv.2022.114135_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0048-9697(99)00537-9","article-title":"Routine determination of sulfonylurea, imidazolinone, and sulfonamide herbicides at nanogram-per-liter concentrations by solid-phase extraction and liquid chromatography\/mass spectrometry","volume":"248","author":"Furlong","year":"2000","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114135_bib26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/plb.13363","article-title":"Proline, a multifaceted signalling molecule in plant responses to abiotic stress: understanding the physiological mechanisms","volume":"24","author":"Ghosh","year":"2022","journal-title":"Plant Biol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib27","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.scitotenv.2017.04.122","article-title":"Pesticide mixtures in the Swedish streams: environmental risks, contributions of individual compounds and consequences of single-substance oriented risk mitigation","volume":"598","author":"Gustavsson","year":"2017","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114135_bib28","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/jpy.13026","article-title":"Characterization of Chlorella vulgaris (Trebouxiophyceae) associated microbial communities1","volume":"56","author":"Haberkorn","year":"2020","journal-title":"J. Phycol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib29","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ecoenv.2017.02.055","article-title":"Zinc-induced differential oxidative stress and antioxidant responses in Chlorella sorokiniana and Scenedesmus acuminatus","volume":"140","author":"Hamed","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114135_bib30","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.3390\/molecules26071887","article-title":"l-aspartate: an essential metabolite for plant growth and stress acclimation","volume":"26","author":"Han","year":"2021","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114135_bib31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ecoenv.2007.10.010","article-title":"Physiological and biochemical effects of allelochemical ethyl 2-methyl acetoacetate (EMA) on cyanobacterium Microcystis aeruginosa","volume":"71","author":"Hong","year":"2008","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114135_bib32","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1369-5266(02)00250-9","article-title":"Oxylipin metabolism in response to stress","volume":"5","author":"Howe","year":"2002","journal-title":"Curr. Opin. Plant Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/toxins7010066","article-title":"effects of natural flavonoids on photosynthetic activity and cell integrity in Microcystis aeruginosa","volume":"7","author":"Huang","year":"2015","journal-title":"Toxins"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114135_bib34","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/chir.22018","article-title":"Enantioselective toxic effects of hexaconazole enantiomers against Scenedesmus obliquus","volume":"24","author":"Huang","year":"2012","journal-title":"Chirality"},{"issue":"1(Supplementary)","key":"10.1016\/j.ecoenv.2022.114135_bib35","first-page":"263","article-title":"Antioxidant studies of citric acid and citrus fruits towards paraquat by cyclic voltammetry: an antidote of paraquat poisoning","volume":"33","author":"Iqbal","year":"2020","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.ecoenv.2022.114135_bib36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.envint.2017.10.020","article-title":"Potential impact of the herbicide 2,4-dichlorophenoxyacetic acid on human and ecosystems","volume":"111","author":"Islam","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2022.114135_bib37","first-page":"31","article-title":"Chemistry and fate of triazolopyrimidine sulfonamide herbicides","volume":"193","author":"Jabusch","year":"2008","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114135_bib38","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chemosphere.2011.12.071","article-title":"Bioaccumulation and catabolism of prometryne in green algae","volume":"87","author":"Jin","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114135_bib39","doi-asserted-by":"crossref","first-page":"14865","DOI":"10.1038\/ncomms14865","article-title":"Long-term trends in the intensity and relative toxicity of herbicide use","volume":"8","author":"Kniss","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114135_bib40","doi-asserted-by":"crossref","first-page":"fuaa061","DOI":"10.1093\/femsre\/fuaa061","article-title":"The PEP-pyruvate-oxaloacetate node: variation at the heart of metabolism","volume":"45","author":"Koendjbiharie","year":"2021","journal-title":"FEMS Microbiol. Rev."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib41","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1248\/bpb.35.606","article-title":"Phosphoenolpyruvic acid, an intermediary metabolite of glycolysis, as a potential cytoprotectant and anti-oxidant in HeLa cells","volume":"35","author":"Kondo","year":"2012","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114135_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057654","article-title":"Cyanobactericidal effect of streptomyces sp. HJC-D1 on microcystis auruginosa","volume":"8","author":"Kong","year":"2013","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114135_bib43","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1021\/jf991290+","article-title":"Photolytic degradation of florasulam on soil and in water","volume":"48","author":"Krieger","year":"2000","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib44","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1104\/pp.125.1.278","article-title":"Oligoguluronates elicit an oxidative burst in the brown algal kelp Laminaria digitata","volume":"125","author":"K\u00fcpper","year":"2001","journal-title":"Plant Physiol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114135_bib45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/1097-0320(20010701)44:3<226::AID-CYTO1115>3.0.CO;2-9","article-title":"Flow cytometric analysis of chronic and acute toxicity of copper(II) on the marine dinoflagellate Amphidinium carterae","volume":"44","author":"Lage","year":"2001","journal-title":"Cytometry"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib46","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1038\/s41598-019-39860-5","article-title":"New molecular insights on the response of the green alga Tetraselmis suecica to nitrogen starvation","volume":"9","author":"Lauritano","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114135_bib47","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0160-4120(00)00100-8","article-title":"Effects of atrazine and nicosulfuron on freshwater microalgae","volume":"26","author":"Leboulanger","year":"2001","journal-title":"Environ. Int."},{"issue":"2b","key":"10.1016\/j.ecoenv.2022.114135_bib48","first-page":"681","article-title":"Primus (florasulam 50 G\/L), a new triazolopyrimidine sulfonanilide herbicide to control broad-leaved weeds in maize when applied in early postemergence (1 to 6 leaf stage of maize). Preliminary results","volume":"66","author":"Lepiece","year":"2001","journal-title":"Meded. Rijksuniv. te Gent. Fak. Van. De. Landbouwkd. En. Toegep. Biol. Wet."},{"key":"10.1016\/j.ecoenv.2022.114135_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.136374","article-title":"The growth suppression effects of UV-C irradiation on Microcystis aeruginosa and Chlorella vulgaris under solo-culture and co-culture conditions in reclaimed water","volume":"713","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"Pt 2","key":"10.1016\/j.ecoenv.2022.114135_bib50","article-title":"Toxic effects of fludioxonil on the growth, photosynthetic activity, oxidative stress, cell morphology, apoptosis, and metabolism of Chlorella vulgaris","volume":"838","author":"Liu","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114135_bib51","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1007\/s11356-015-5439-x","article-title":"Photosynthesis performance, antioxidant enzymes, and ultrastructural analyses of rice seedlings under chromium stress","volume":"23","author":"Ma","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2022.114135_bib52","article-title":"Exogenous phosphatidylcholine treatment alleviates drought stress and maintains the integrity of root cell membranes in peach","volume":"259","author":"Maoxiang Sun","year":"2020","journal-title":"Sci. Hortic."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib53","doi-asserted-by":"crossref","first-page":"21636","DOI":"10.1038\/s41598-021-00921-3","article-title":"Toxicity thresholds of nine herbicides to coral symbionts (Symbiodiniaceae)","volume":"11","author":"Marzonie","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2022.114135_bib54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jhazmat.2019.02.084","article-title":"Applications of metabolomics in assessing ecological effects of emerging contaminants and pollutants on plants","volume":"373","author":"Matich","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.114135_bib55","doi-asserted-by":"crossref","first-page":"5.1.1","DOI":"10.1002\/cpim.40","article-title":"Flow cytometry: an overview","volume":"120","author":"McKinnon","year":"2018","journal-title":"Curr. Protoc. Immunol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib56","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/andr.12206","article-title":"Environmental signaling: from environmental estrogens to endocrine-disrupting chemicals and beyond","volume":"4","author":"McLachlan","year":"2016","journal-title":"Andrology"},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114135_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165890","article-title":"Degradation of herbicides in the tropical marine environment: influence of light and sediment","volume":"11","author":"Mercurio","year":"2016","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.plaphy.2006.01.007","article-title":"Phytochelatin synthesis and response of antioxidants during cadmium stress in Bacopa monnieri L","volume":"44","author":"Mishra","year":"2006","journal-title":"Plant Physiol. Biochem.: PPB"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10826068.2017.1381622","article-title":"Investigation of the effect of biologically active threo-Ds-isocitric acid on oxidative stress in Paramecium caudatum","volume":"48","author":"Morgunov","year":"2018","journal-title":"Prep. Biochem. Biotechnol."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114135_bib60","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1007\/s00253-019-09729-8","article-title":"Biosynthesis of isocitric acid in repeated-batch culture and testing of its stress-protective activity","volume":"103","author":"Morgunov","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib61","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aquatox.2005.02.007","article-title":"Toxicity of selenite in the unicellular green alga Chlamydomonas reinhardtii: comparison between effects at the population and sub-cellular level","volume":"73","author":"Morlon","year":"2005","journal-title":"Aquat. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib62","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/etc.1749","article-title":"Comparative effects of the herbicides chlortoluron and mesotrione on freshwater microalgae","volume":"31","author":"Moro","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114135_bib63","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1021\/es0627390","article-title":"Single cell level microalgal ecotoxicity assessment by confocal microscopy and digital image analysis","volume":"41","author":"Nancharaiah","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbi.2022.102197","article-title":"Jasmonate: a hormone of primary importance for plant metabolism","volume":"67","author":"Nguyen","year":"2022","journal-title":"Curr. Opin. Plant Biol."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114135_bib65","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbabio.2006.05.013","article-title":"A new paradigm for the action of reactive oxygen species in the photoinhibition of photosystem II","volume":"1757","author":"Nishiyama","year":"2006","journal-title":"Biochim. Et. Biophys. Acta"},{"issue":"20","key":"10.1016\/j.ecoenv.2022.114135_bib66","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1021\/acs.jafc.5b04710","article-title":"Spatial and temporal variability in pesticide exposure downstream of a heavily irrigated cropping area: application of different monitoring techniques","volume":"64","author":"O'Brien","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2022.114135_bib67","first-page":"1","article-title":"Freshwater alga and cyanobacteria","author":"OECD Test No. 201","year":"2011","journal-title":"Growth Inhib. Test. Oecd Guidel. Test. Chem."},{"issue":"32","key":"10.1016\/j.ecoenv.2022.114135_bib68","doi-asserted-by":"crossref","first-page":"18104","DOI":"10.1021\/acsami.5b05328","article-title":"Envelopment-Internalization Synergistic Effects and Metabolic Mechanisms of Graphene Oxide on Single-Cell Chlorella vulgaris Are Dependent on the Nanomaterial Particle Size","volume":"7","author":"Ouyang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"24","key":"10.1016\/j.ecoenv.2022.114135_bib69","doi-asserted-by":"crossref","first-page":"9009","DOI":"10.1073\/pnas.1402130111","article-title":"Metabolomics and proteomics reveal impacts of chemically mediated competition on marine plankton","volume":"111","author":"Poulson-Ellestad","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114135_bib70","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.envint.2008.06.012","article-title":"Comparison of the sensitivity of different toxicity test endpoints in a microalga exposed to the herbicide paraquat","volume":"35","author":"Prado","year":"2009","journal-title":"Environ. Int."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2022.114135_bib71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aquatox.2010.12.013","article-title":"Characterization of cell response in Chlamydomonas moewusii cultures exposed to the herbicide paraquat: Induction of chlorosis","volume":"102","author":"Prado","year":"2011","journal-title":"Aquat. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib72","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.aquatox.2008.05.009","article-title":"Effects of glufosinate on antioxidant enzymes, subcellular structure, and gene expression in the unicellular green alga Chlorella vulgaris","volume":"88","author":"Qian","year":"2008","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114135_bib73","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.chemosphere.2008.12.040","article-title":"Allelochemical stress causes oxidative damage and inhibition of photosynthesis in Chlorella vulgaris","volume":"75","author":"Qian","year":"2009","journal-title":"Chemosphere"},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2022.114135_bib74","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.envpol.2018.06.055","article-title":"Toxic effects of boscalid on the growth, photosynthesis, antioxidant system and metabolism of Chlorella vulgaris","volume":"242","author":"Qian","year":"2018","journal-title":"Environ. Pollut."},{"issue":"3\u20134","key":"10.1016\/j.ecoenv.2022.114135_bib75","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-445X(01)00254-5","article-title":"Algal esterase activity as a biomeasure of environmental degradation in a freshwater creek","volume":"59","author":"Regel","year":"2002","journal-title":"Aquat. Toxicol. (Amst., Neth. )"},{"issue":"27","key":"10.1016\/j.ecoenv.2022.114135_bib76","doi-asserted-by":"crossref","first-page":"21938","DOI":"10.1007\/s11356-017-9860-1","article-title":"Foliar application of aspartic acid lowers cadmium uptake and Cd-induced oxidative stress in rice under Cd stress","volume":"24","author":"Rizwan","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114135_bib77","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0968-0004(01)01953-3","article-title":"Herbicide-induced oxidative stress in photosystem II","volume":"26","author":"Rutherford","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ecoenv.2022.114135_bib78","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72593","article-title":"Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism","volume":"10","author":"Ryan","year":"2021","journal-title":"eLife"},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib79","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s001289900527","article-title":"Effects of technical grade and a commercial formulation of glyphosate on algal population growth","volume":"59","author":"S\u00e1enz","year":"1997","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib80","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ecoenv.2015.09.034","article-title":"Assessment of chronic effects of tebuconazole on survival, reproduction and growth of Daphnia magna after different exposure times","volume":"124","author":"Sancho","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.114135_bib81","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s10811-010-9569-8","article-title":"Protein, fatty acid, and pigment content of Chlorella vulgaris under different light regimes","volume":"23","author":"Seyfabadi","year":"2011","journal-title":"J. Appl. Phycol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114135_bib82","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.marpolbul.2009.08.026","article-title":"Monitoring pesticides in the Great Barrier Reef","volume":"60","author":"Shaw","year":"2010","journal-title":"Mar. Pollut. Bull."},{"issue":"9\u201310","key":"10.1016\/j.ecoenv.2022.114135_bib83","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0891-5849(99)00177-X","article-title":"Glutathione and its role in cellular functions","volume":"27","author":"Sies","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2022.114135_bib84","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biortech.2018.07.079","article-title":"Adaptive evolution of microalgae Schizochytrium sp. under high salinity stress to alleviate oxidative damage and improve lipid biosynthesis","volume":"267","author":"Sun","year":"2018","journal-title":"Bioresource technology"},{"issue":"9","key":"10.1016\/j.ecoenv.2022.114135_bib85","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0753-3322(02)00285-8","article-title":"II. Glutamine and glutamate","volume":"56","author":"Tapiero","year":"2002","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib86","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.chemosphere.2005.06.031","article-title":"Oxidative stress in Scenedesmus sp. during short- and long-term exposure to Cu2+ and Zn2+","volume":"62","author":"Tripathi","year":"2006","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114135_bib87","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1007\/s11356-013-2340-3","article-title":"Response of the cyanobacterium Microcystis flos-aquae to levofloxacin","volume":"21","author":"Wan","year":"2014","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2022.114135_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.jgg.2022.04.002","article-title":"Regulation and integration of plant jasmonate signaling: a comparative view of monocot and dicot","author":"Wan","year":"2022","journal-title":"J. Genet. Genom. Yi chuan xue bao"},{"key":"10.1016\/j.ecoenv.2022.114135_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2020.104748","article-title":"Florasulam resistance status of flixweed (Descurainia sophia L.) and alternative herbicides for its chemical control in the North China plain","volume":"172","author":"Wang","year":"2021","journal-title":"Pestic. Biochem. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2022.114135_bib90","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1191\/074823399678846592","article-title":"An introduction to ALS-inhibiting herbicides","volume":"15","author":"Whitcomb","year":"1999","journal-title":"Toxicol. Ind. Health"},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2022.114135_bib91","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0045-6535(99)00408-7","article-title":"Effects of 2,4-D, glyphosate and paraquat on growth, photosynthesis and chlorophyll-a synthesis of Scenedesmus quadricauda Berb 614","volume":"41","author":"Wong","year":"2000","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114135_bib92","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pestbp.2019.05.002","article-title":"Acute toxicity of triflumizole to freshwater green algae Chlorella vulgaris","volume":"158","author":"Xi","year":"2019","journal-title":"Pestic. Biochem. Physiol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib93","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00244-017-0454-1","article-title":"The effect of bisphenol A on growth, morphology, lipid peroxidation, antioxidant enzyme activity, and PS II in cylindrospermopsis raciborskii and scenedesmus quadricauda","volume":"74","author":"Xiang","year":"2018","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib94","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s11356-010-0398-8","article-title":"). Toxic effect of tetracycline exposure on growth, antioxidative and genetic indices of wheat (Triticum aestivum L.)","volume":"18","author":"Xie","year":"2011","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114135_bib95","doi-asserted-by":"crossref","first-page":"29","DOI":"10.14715\/cmb\/2019.65.4.5","article-title":"Humic acid reduces the CuO and ZnO nanoparticles cellular toxicity in rapeseed (Brassica napus)","volume":"65","author":"Yarmohammadi","year":"2019","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125668","article-title":"Effects of mesotrione on oxidative stress, subcellular structure, and membrane integrity in Chlorella vulgaris","volume":"247","author":"Zhang","year":"2020","journal-title":"Chemosphere"},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2022.114135_bib97","article-title":"Toxicity of the novel fungicide oxathiapiprolin to Chlorella vulgaris: assessments at different levels of biological organization","volume":"291","author":"Zhang","year":"2022","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114135_bib98","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.semcdb.2012.03.017","article-title":"Glutathione synthesis and its role in redox signaling","volume":"23","author":"Zhang","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2022.114135_bib99","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jhazmat.2016.03.017","article-title":"The effect of natural organic matter on bioaccumulation and toxicity of chlorobenzenes to green algae","volume":"311","author":"Zhang","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.114135_bib100","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.chemosphere.2016.05.073","article-title":"Enantioselective toxic effects of cyproconazole enantiomers against Chlorella pyrenoidosa","volume":"159","author":"Zhang","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114135_bib101","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ecoenv.2017.05.022","article-title":"Evaluation of the toxicity of herbicide topramezone to Chlorella vulgaris: Oxidative stress, cell morphology and photosynthetic activity","volume":"143","author":"Zhao","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322009757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322009757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T05:59:03Z","timestamp":1758952743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322009757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":101,"alternative-id":["S0147651322009757"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114135","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct toxicity of the herbicide florasulam against Chlorella vulgaris: An integrated physiological and metabolomic analysis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114135"}}