{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:57:05Z","timestamp":1789077425752,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFE0127300"],"award-info":[{"award-number":["2018YFE0127300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ecoenv.2022.114252","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T13:40:44Z","timestamp":1667310044000},"page":"114252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Effects of maternal T-2 toxin exposure on microorganisms and intestinal barrier function in young mice"],"prefix":"10.1016","volume":"247","author":[{"given":"Ruifen","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneela","family":"Perveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2\u20133","key":"10.1016\/j.ecoenv.2022.114252_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.tox.2012.08.007","article-title":"T-2 toxin induced skin inflammation and cutaneous injury in mice","volume":"302","author":"Agrawal","year":"2012","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114252_bib2","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1053\/j.gastro.2014.07.020","article-title":"Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota","volume":"147","author":"Albenberg","year":"2014","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114252_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrm3721","article-title":"Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration","volume":"15","author":"Barker","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114252_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065100","article-title":"The EhCPADH112 complex of entamoeba histolytica interacts with tight junction proteins occludin and claudin-1 to produce epithelial damage","volume":"8","author":"Betanzos","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114252_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/109374000281113","article-title":"Immunomodulation by fungal toxins","volume":"3","author":"Bondy","year":"2000","journal-title":"J. Toxicol. Environ. Health B"},{"key":"10.1016\/j.ecoenv.2022.114252_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.anifeedsci.2017.09.012","article-title":"Technology, Gastrointestinal functionality in animal nutrition and health: new opportunities for sustainable animal production","volume":"234","author":"Celi","year":"2017","journal-title":"Anim. Feed Sci. Tech."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2022.114252_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/tox.21895","article-title":"Differential effects of route of T\u20102 toxin exposure on hepatic oxidative damage in mice","volume":"30","author":"Chaudhary","year":"2015","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114252_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/ibd\/izy281","article-title":"Bacteroides thetaiotaomicron ameliorates colon inflammation in preclinical models of Crohn\u2019s disease","volume":"25","author":"Delday","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114252_bib9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/02652030902788953","article-title":"Contaminants, Fusarium mycotoxin content of UK organic and conventional oats","volume":"26","author":"Edwards","year":"2009","journal-title":"Food Addit. Contam."},{"issue":"12","key":"10.1016\/j.ecoenv.2022.114252_bib10","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.2903\/j.efsa.2011.2481","article-title":"Scientific Opinion on the risks for animal and public health related to the presence of T\u20102 and HT\u20102 toxin in food and feed","volume":"9","author":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","year":"2011","journal-title":"EFSA J."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114252_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-6148-8-245","article-title":"Porcine intestinal epithelial barrier disruption by the Fusarium mycotoxins deoxynivalenol and T-2 toxin promotes transepithelial passage of doxycycline and paromomycin","volume":"8","author":"Goossens","year":"2012","journal-title":"Bmc Vet. Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114252_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","article-title":"Intestinal barrier function: Molecular regulation and disease pathogenesis","volume":"124","author":"Groschwitz","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114252_bib13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/toxins11070375","article-title":"Global mycotoxin occurrence in feed: a ten-year survey","volume":"11","author":"Gruber-Dorninger","year":"2019","journal-title":"Toxins"},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114252_bib14","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00726-011-1191-9","article-title":"Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide","volume":"43","author":"Hou","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.ecoenv.2022.114252_bib15","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.freeradbiomed.2019.12.002","article-title":"Nitrate ameliorates dextran sodium sulfate-induced colitis by regulating the homeostasis of the intestinal microbiota","volume":"152","author":"Hu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114252_bib16","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.it.2014.07.010","article-title":"Modulation of immune development and function by intestinal microbiota","volume":"35","author":"Kabat","year":"2014","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114252_bib17","doi-asserted-by":"crossref","first-page":"e00470","DOI":"10.1128\/mBio.00470-17","article-title":"Gut microbiota mediates the protective effects of dietary capsaicin against chronic low-grade inflammation and associated obesity induced by high-fat diet","volume":"8","author":"Kang","year":"2017","journal-title":"mBio"},{"issue":"12","key":"10.1016\/j.ecoenv.2022.114252_bib18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.17221\/156\/2009-VETMED","article-title":"The role of mycotoxins in pig reproduction: a review","volume":"54","author":"Kanora","year":"2009","journal-title":"Vet. Med-Czech"},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2022.114252_bib19","first-page":"64","article-title":"Transplacental transfer of T2-toxin: Pathological effect","volume":"10","author":"Lafarge-Frayssinet","year":"1990","journal-title":"J. Environ. Pathol. Toxicol."},{"issue":"31","key":"10.1016\/j.ecoenv.2022.114252_bib20","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Knight, R. D. Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2022.114252_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110661","article-title":"DNA methylation is involved in pro-inflammatory cytokines expression in T-2 toxin-induced liver injury","volume":"132","author":"Liu","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114252_bib22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.chemosphere.2019.06.080","article-title":"Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice","volume":"234","author":"Liu","year":"2019","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114252_bib23","first-page":"158","article-title":"Mycotoxin review \u2013 2","volume":"16","author":"Moss","year":"2002","journal-title":"Fusarium. Mycol."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114252_bib24","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/ibd.20148","article-title":"Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance","volume":"13","author":"Mudter","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"issue":"9","key":"10.1016\/j.ecoenv.2022.114252_bib25","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cgh.2013.07.001","article-title":"Intestinal permeability defects: is it time to treat?","volume":"11","author":"Odenwald","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ecoenv.2022.114252_bib26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fimmu.2013.00280","article-title":"Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics","volume":"4","author":"Pastorelli","year":"2013","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114252_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"1\u20133","key":"10.1016\/j.ecoenv.2022.114252_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0301-6226(97)00057-2","article-title":"Factors influencing the structure and function of the small intestine in the weaned pig: a review","volume":"51","author":"Pluske","year":"1997","journal-title":"Livest. Prod. Sci."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114252_bib29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3168\/jds.S0022-0302(79)83301-9","article-title":"Transmission of T-2 toxin into bovine and porcine milk","volume":"62","author":"Robinson","year":"1979","journal-title":"J. Dairy Sci."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114252_bib30","doi-asserted-by":"crossref","first-page":"C1213","DOI":"10.1152\/ajpcell.00558.2003","article-title":"The tight junction: a multifunctional complex","volume":"286","author":"Schneeberger","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2022.114252_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.toxlet.2004.04.045","article-title":"Collection of occurrence data of fusarium toxin in food and assessment of dietary intake by the population of EU member states","volume":"153","author":"Schothorst","year":"2004","journal-title":"Toxicol. Lett."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114252_bib32","first-page":"65E","article-title":"Report on toxicity data on trichothecene mycotoxins HT\u20102 and T\u20102 toxins","volume":"7","author":"Schuhmacher\u2010Wolz","year":"2010","journal-title":"EFSA Support. Publ."},{"issue":"9","key":"10.1016\/j.ecoenv.2022.114252_bib33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114252_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0378-4274(03)00116-4","article-title":"Trichothecenes in the environment: relevance to human health","volume":"143","author":"Sudakin","year":"2003","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114252_bib35","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s00253-019-09617-1","article-title":"Novel strains of Bacteroides fragilis and Bacteroides ovatus alleviate the LPS-induced inflammation in mice","volume":"103","author":"Tan","year":"2019","journal-title":"Appl. Microbiol Biot."},{"key":"10.1016\/j.ecoenv.2022.114252_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114129","article-title":"Glyphosate exposure induces inflammatory responses in the small intestine and alters gut microbial composition in rats","volume":"261","author":"Tang","year":"2020","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114252_bib37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/35067088","article-title":"Multifunctional strands in tight junctions","volume":"2","author":"Tsukita","year":"2001","journal-title":"Nat. Rev. Mol. Cell Bio"},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2022.114252_bib38","first-page":"29","article-title":"Changes induced in newborn piglets by the trichothecene toxin T-2","volume":"39","author":"V\u00e1nyi","year":"1991","journal-title":"Acta Vet. Hung."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114252_bib39","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s00394-016-1189-x","article-title":"Aspartate attenuates intestinal injury and inhibits TLR4 and NODs\/NF-\u03baB and p38 signaling in weaned pigs after LPS challenge","volume":"56","author":"Wang","year":"2017","journal-title":"Eur. J. Nutr."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114252_bib40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/19393210.2013.764506","article-title":"T-2 toxin, zearalenone and fumonisin B1 in feedstuffs from China","volume":"6","author":"Wang","year":"2013","journal-title":"Food Addit. Contam."},{"key":"10.1016\/j.ecoenv.2022.114252_bib41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fcimb.2018.00060","article-title":"Mycotoxin: its impact on gut health and microbiota","volume":"8","author":"Winnie-Pui-Pui","year":"2018","journal-title":"Front. Cell Infect. Ml"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114252_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0015-6264(81)90300-X","article-title":"Metabolic fate of T-2 toxin in a lactating cow","volume":"19","author":"Yoshizawa","year":"1981","journal-title":"Food Cosmet. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114252_bib43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.lfs.2018.11.048","article-title":"Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs","volume":"216","author":"Zhuang","year":"2019","journal-title":"Life Sci."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322010922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322010922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:05:59Z","timestamp":1758953159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322010922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":43,"alternative-id":["S0147651322010922"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114252","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of maternal T-2 toxin exposure on microorganisms and intestinal barrier function in young mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114252"}}