{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:25:14Z","timestamp":1785295514475,"version":"3.55.0"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31702394"],"award-info":[{"award-number":["31702394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ecoenv.2022.114313","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T18:54:53Z","timestamp":1668797693000},"page":"114313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Parental whole life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) disrupts embryonic development and thyroid system in zebrafish offspring"],"prefix":"10.1016","volume":"248","author":[{"given":"Hongkai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangke","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangshu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weini","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ecoenv.2022.114313_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3390\/toxics8040109","article-title":"Tris(2-chloroethyl) phosphate (TCEP) elicits hepatotoxicity by activating human cancer pathway genes in HepG2 cells","volume":"8","author":"Al-Salem","year":"2020","journal-title":"Toxics"},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114313_bib2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1080\/10934529.2016.1191819","article-title":"The cytotoxicity of organophosphate flame retardants on HepG2, A549 and Caco-2 cells","volume":"51","author":"An","year":"2016","journal-title":"J. Environ. Sci. Health A: Toxic Hazard. Subst. Environ. Eng."},{"key":"10.1016\/j.ecoenv.2022.114313_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/15287394.2016.1171978","article-title":"Lipid peroxidation and oxidative stress responses in juvenile salmon exposed to waterborne levels of the organophosphate compounds tris (2-butoxyethyl)-and tris (2-chloroethyl) phosphates","volume":"79","author":"Arukwe","year":"2016","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"10.1016\/j.ecoenv.2022.114313_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.aquatox.2018.01.014","article-title":"Novel aspects of uptake patterns, metabolite formation and toxicological responses in salmon exposed to the organophosphate esters-tris (2-butoxyethyl) and tris (2-chloroethyl) phosphate","volume":"196","author":"Arukwe","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0166-445X(86)90010-X","article-title":"Vertebral deformities and physiological effects in fourhorn sculpin (Myoxocephalus quadricornis) after long term exposure to a simulated heavy metal-containing effluent","volume":"9","author":"Bengtsson","year":"1986","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114313_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1021\/es801845a","article-title":"Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water","volume":"43","author":"Benotti","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408440601123529","article-title":"The hypothalamic-pituitary-thyroid (HPT) axis in fish and its role in fish development and reproduction","volume":"37","author":"Blanton","year":"2007","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2015.12.012","article-title":"Zebrafish embryos as a screen for DNA methylation modifications after compound exposure","volume":"291","author":"Bouwmeester","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.scitotenv.2014.08.072","article-title":"Tracing organophosphorus and brominated flame retardants and plasticizers in an estuarine food web","volume":"505","author":"Brandsma","year":"2015","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2022.114313_bib10","first-page":"259","article-title":"Effects of phosalone on mineral contents and spinal deformities in common carp (Cyprinus carpio, L.1758)","volume":"12","author":"\u00c7elik","year":"2012","journal-title":"Turk. J. Fish. Aquat. Sc."},{"key":"10.1016\/j.ecoenv.2022.114313_bib11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2108\/zsj.29.181","article-title":"Changes in thyroid hormone levels during zebrafish development","volume":"29","author":"Chang","year":"2012","journal-title":"Zool. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114313_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chroma.2011.11.046","article-title":"Determination of non-halogenated, chlorinated and brominated organophosphate flame retardants in herring gull eggs based on liquid chromatography\u2212tandem quadrupole mass spectrometry","volume":"1220","author":"Chen","year":"2012","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.ecoenv.2022.114313_bib13","first-page":"13122","article-title":"Life cycle exposure to environmentally relevant concentrations of Diphenyl Phosphate (DPhP) inhibits growth and energy metabolism of zebrafish in a sex-specific manner","volume":"55","author":"Chen","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib14","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.envpol.2017.07.061","article-title":"Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity","volume":"230","author":"Cheng","year":"2017","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114313_bib15","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1039\/C8EN00174J","article-title":"Adverse reproductive performance in zebrafish with increased bioconcentration of microcystin-LR in the presence of titanium dioxide nanoparticles","volume":"5","author":"Cheng","year":"2018","journal-title":"Environ. Sci. Nano"},{"key":"10.1016\/j.ecoenv.2022.114313_bib16","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1002\/etc.5620191223","article-title":"Cellular and molecular basis of cadmium-induced deformities in zebrafish embryos","volume":"19","author":"Cheng","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2022.114313_bib17","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1002\/etc.5620191223","article-title":"Cellular and molecular basis of cadmium-induced deformities in zebrafish embryos","volume":"19","author":"Cheng","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.ecoenv.2022.114313_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.emcon.2019.05.003","article-title":"Occurrence, distribution and ecological risk assessment of organophosphorus flame retardants and plasticizers in sediment samples along the Vaal River catchment, South Africa","volume":"5","author":"Chokwe","year":"2019","journal-title":"Emerg. Contam."},{"key":"10.1016\/j.ecoenv.2022.114313_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.aca.2015.05.024","volume":"885","author":"Chu","year":"2015","journal-title":"Anal. Chim."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114313_bib20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2022.114313_bib21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.envpol.2013.04.001","article-title":"Occurrence and risk assessment of organophosphorus and brominated flame retardants in the River Aire (UK)","volume":"179","author":"Cristale","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.114313_bib22","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.7717\/peerj.4156","article-title":"Tris (1,3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos","volume":"5","author":"Dasgupta","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.ecoenv.2022.114313_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ygcen.2005.10.014","article-title":"Role of corticotropin-releasing hormone as a thyrotropin-releasing factor in non-mammalian vertebrates","volume":"146","author":"De Groef","year":"2006","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-60761-411-1_4","article-title":"Identification of ROS using oxidized DCFDA and flow-cytometry","volume":"594","author":"Eruslanov","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"15","key":"10.1016\/j.ecoenv.2022.114313_bib25","doi-asserted-by":"crossref","first-page":"10192","DOI":"10.1021\/acs.est.0c08822","article-title":"Long-range transport, trophic transfer, and ecological risks of organophosphate esters in remote areas","volume":"55","author":"Fu","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib26","first-page":"21","article-title":"DNA damage and oxidative stress induced by acetylsalicylic acid in Daphnia magna","volume":"164","author":"G\u00f3mez-Oliv\u00e1n","year":"2014","journal-title":"Comp. Biochem. Physiol. Part C."},{"key":"10.1016\/j.ecoenv.2022.114313_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135777","article-title":"Chlorinated phosphorus flame retardants exert oxidative damage to SMMC-7721 human hepatocarcinoma cells","volume":"705","author":"Guo","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2022.114313_bib28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bbrc.2010.02.071","article-title":"Antioxidants: molecules, medicines, and myths","volume":"393","author":"Gutteridge","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2022.114313_bib29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aquatox.2017.06.020","article-title":"Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring","volume":"190","author":"Han","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105477","article-title":"Effects of tris (2-chloroethyl) phosphate (TCEP) on growth, reproduction and gene transcription in the protozoan Tetrahymena thermophila","volume":"222","author":"Hao","year":"2020","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114313_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00244-017-0432-7","article-title":"Occurrence and distribution of organophosphate esters in surface soil and street dust from Chongqing, China: implications for human exposure","volume":"73","author":"He","year":"2017","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/toxsci\/kfi201","article-title":"Accumulation, tissue distribution, and maternal transfer of dietary 2,3,7,8-TCDD: impacts on reproductive success of zebrafish","volume":"87","author":"Heiden","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2022.114313_bib33","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1210\/en.2013-1660","article-title":"Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish","volume":"155","author":"Heijlen","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.ecoenv.2022.114313_bib34","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aquatox.2014.04.010","article-title":"Mechanisms of hexabromocyclododecanes induced developmental toxicity in marine medaka (Oryzias melastigma) embryos","volume":"152","author":"Hong","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/toxsci\/55.1.78","article-title":"Differential effects of microsomal enzyme inducers on in vitro thyroxine (T-4) and triiodothyronine (T-3) glucuronidation","volume":"55","author":"Hood","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2022.114313_bib36","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.chemosphere.2016.03.003","article-title":"Review of OPFRs in animals and humans: absorption, bioaccumulation, metabolism, and internal exposure research","volume":"153","author":"Hou","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114313_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2021.103600","article-title":"Effects of environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) on early life stages of zebrafish (Danio rerio)","volume":"83","author":"Hu","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2019.104762","article-title":"Parental exposure to deepwater horizon oil in different environmental scenarios alters development of sheepshead minnow (Cyprinodon variegatus) offspring","volume":"150","author":"Jasperse","year":"2019","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.114313_bib39","article-title":"DMSO Concentrations up to 1\u00a0% are Safe to be Used in the Zebrafish Embryo Developmental Toxicity Assay","volume":"3","author":"Jente","year":"2021","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.aquatox.2013.05.022","article-title":"DMSO modifies the permeability of the zebrafish (Danio rerio) chorion-implications for the fish embryo test (FET)","volume":"140\u2013141","author":"Kais","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.ecoenv.2022.114313_bib42","first-page":"53","article-title":"Distribution of organophosphoric acid triesters between water and sediment at a sea-based solid waste disposal site","volume":"1","author":"Kawagoshi","year":"1999","journal-title":"J. Mater. Cycles Waste"},{"key":"10.1016\/j.ecoenv.2022.114313_bib43","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cbpb.2006.05.003","article-title":"Transactivation activity of thyroid hormone receptors in fish (Conger myriaster) in response to thyroid hormones","volume":"144","author":"Kawakami","year":"2006","journal-title":"Comp. Biochem. Physiol. Part B"},{"key":"10.1016\/j.ecoenv.2022.114313_bib44","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.aquatox.2015.01.016","article-title":"Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos\/larvae, and in GH3 and FRTL-5 cell lines","volume":"160","author":"Kim","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib45","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.watres.2016.07.034","article-title":"Occurrence and exposure assessment of organophosphate flame retardants (OPFRs) through the consumption of drinking water in Korea","volume":"103","author":"Lee","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.ecoenv.2022.114313_bib46","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1872-2040(15)60840-4","article-title":"Determination of organo- phosphate esters in human serum using gel permeation chromatograph and solid phase extraction coupled with gas chromatography-mass spectrometry","volume":"43","author":"Li","year":"2015","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.ecoenv.2022.114313_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124936","article-title":"Parental exposure to triphenyltin inhibits growth and disrupts thyroid function in zebrafish larvae","volume":"240","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114313_bib48","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.chemosphere.2018.12.198","article-title":"The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos\/larvae","volume":"220","author":"Li","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114313_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110769","article-title":"Toxicity of tris(2-chloroethyl) phosphate in Daphnia magna after lifetime exposure: Changes in growth, reproduction, survival and gene transcription","volume":"200","author":"Li","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.114313_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1046\/j.1432-0436.2002.700104.x","article-title":"Thyroid hormones are important for embryonic to larval transitory phase in zebrafish","volume":"70","author":"Liu","year":"2002","journal-title":"Differentiation"},{"key":"10.1016\/j.ecoenv.2022.114313_bib51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1677\/jme.0.0260051","article-title":"Molecular cloning and characterization of thyroid hormone receptors in teleost fish","volume":"26","author":"Marchand","year":"2001","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib52","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0045-6535(03)00666-0","article-title":"Screening of organophosphorus compounds and their distribution in various indoor environments","volume":"53","author":"Marklund","year":"2003","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114313_bib53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.scitotenv.2022.153160","article-title":"Organophosphate flame retardants induce oxidative stress and Chop\/Caspase 3-related apoptosis via Sod1\/p53\/Map3k6\/Fkbp5 in NCI-1975 cells","volume":"819","author":"Meng","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.ecoenv.2022.114313_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116237","article-title":"Effects of waterborne exposure to environmentally relevant concentrations of selenite on reproductive function of female zebrafish: a life cycle assessment","volume":"270","author":"Mo","year":"2021","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.ecoenv.2022.114313_bib55","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1021\/acs.est.6b00223","article-title":"Parental whole life cycle exposure to dietary methylmercury in zebrafish (Danio rerio) affects the behavior of offspring","volume":"50","author":"Mora-Zamorano","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib56","first-page":"25","article-title":"Vertebral column damage and decrease of calcium concentration in fish exposed experimentally to cadmium","volume":"24","author":"Muramoto","year":"1985","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.114313_bib57","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.tiv.2013.02.012","article-title":"Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals","volume":"27","author":"Murk","year":"2013","journal-title":". Toxicol. . Vitr."},{"key":"10.1016\/j.ecoenv.2022.114313_bib58","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1248\/jhs.50.220","article-title":"Life cycle stages and length of zebrafish (Danio rerio) exposed to DDT","volume":"50","author":"Njiwa","year":"2004","journal-title":"J. Health Sci."},{"key":"10.1016\/j.ecoenv.2022.114313_bib59","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.chemosphere.2015.06.014","article-title":"Wastewater analysis of Census day samples to investigate per capita input of organophosphorus flame retardants and plasticizers into wastewater","volume":"138","author":"O'Brien","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114313_bib60","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1089\/thy.2005.15.799","article-title":"Thyroid hormone deiodination in fish","volume":"15","author":"Orozco","year":"2005","journal-title":"Thyroid"},{"key":"10.1016\/j.ecoenv.2022.114313_bib61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/kfq268","article-title":"Cell death mechanisms and their implications in toxicology","volume":"119","author":"Orrenius","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"1\u20131662","key":"10.1016\/j.ecoenv.2022.114313_bib62","first-page":"247","article-title":"Organophosphate flame retardants (OPFRs): a review on analytical methods and occurrence in wastewater and aquatic environment","volume":"649","author":"Pantelaki","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2022.114313_bib63","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2009.05.011","article-title":"Thyroid gland development and function in the zebrafish model","volume":"312","author":"Porazzi","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib64","first-page":"447","article-title":"Thyroid hormones in growth and de- velopment of fish","volume":"130","author":"Power","year":"2001","journal-title":"Comp. Biochem. Physiol. Part C."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114313_bib65","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.reprotox.2011.09.001","article-title":"Zebrafish eleutheroembryos as an alternative system for screening chemicals disrupting the mammalian thyroid gland morphogenesis and function","volume":"33","author":"Rald\u00faa","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib66","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.trac.2008.07.002","article-title":"Organophosphorus flame retardants and plasticizers in water and air I. Occurrence and fate","volume":"27","author":"Reemtsma","year":"2008","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.ecoenv.2022.114313_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109449","article-title":"Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) disrupts zebrafish tail fin development","volume":"182","author":"Rhyu","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114313_bib68","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.aquatox.2004.05.007","article-title":"Effects of the brominated flame retardants hexabromocyclododecane (HBCDD), and tetrabromobisphenol A (TBBPA), on hepatic enzymes and other biomarkers in juvenile rainbow trout and feral eelpout","volume":"69","author":"Ronisz","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib69","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1096\/fj.10-168203","article-title":"Immunological regulation of metabolism-a novel quintessential role for the immune system in health and disease","volume":"25","author":"Schaefer","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.ecoenv.2022.114313_bib70","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.scitotenv.2019.02.198","article-title":"Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish","volume":"665","author":"Shi","year":"2019","journal-title":"Sci. Total. Environ."},{"issue":"13","key":"10.1016\/j.ecoenv.2022.114313_bib71","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-020-08001-1","article-title":"Occurrence, composition and biological risk of organophosphate esters (OPEs) in water of the Pearl River Estuary, South China","volume":"27","author":"Shi","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2022.114313_bib72","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ntt.2016.03.003","article-title":"Developmental exposure of zebrafish larvae to organophosphate flame retardants causes neurotoxicity","author":"Sun","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"issue":"27","key":"10.1016\/j.ecoenv.2022.114313_bib73","doi-asserted-by":"crossref","first-page":"34369","DOI":"10.1007\/s11356-020-09527-0","article-title":"Biochemical responses of a freshwater fish Cirrhinus mrigala exposed to tris (2-chloroethyl) phosphate (TCEP)","volume":"27","author":"Sutha","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2022.114313_bib74","article-title":"Long term exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in reproductive hormones, vitellogenin, antioxidant enzymes, and histology of gonads in zebrafish (Danio rerio): In vivo and computational analysis","author":"Sutha","year":"2022","journal-title":"Comp. Biochem. Physiol. Part C."},{"key":"10.1016\/j.ecoenv.2022.114313_bib75","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.toxlet.2014.03.023","article-title":"Toxicity of TDCPP and TCEP on PC12 cell: changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels","volume":"227","author":"Ta","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2022.114313_bib76","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1095-8649.2007.01665.x","article-title":"Caspases and apoptosis in fish","volume":"71","author":"Takle","year":"2007","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127169","article-title":"Parental exposure to perfluorobutane sulfonate disturbs the transfer of maternal transcripts and offspring embryonic development in zebrafish","volume":"256","author":"Tang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114313_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2019.105384","article-title":"Life cycle exposure to propiconazole reduces fecundity by disrupting thesteroidogenic pathway and altering DNA methylation in zebrafsh (Danio rerio)","volume":"135","author":"Teng","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2022.114313_bib79","first-page":"147","article-title":"Survival in air of Mytilus trossulus following long-term exposure to spilled Exxon Valdez crude oil in Prince William sound","volume":"122","author":"Thomas","year":"1999","journal-title":"Comp. Biochem. Physiol. Part C."},{"key":"10.1016\/j.ecoenv.2022.114313_bib80","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.carbon.2007.04.021","article-title":"In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish","volume":"45","author":"Usenko","year":"2007","journal-title":"Carbon"},{"key":"10.1016\/j.ecoenv.2022.114313_bib81","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.chemosphere.2012.03.067","article-title":"Phosphorus flame retardants: properties, pro-duction, environmental occurrence, toxicity and analysis","volume":"88","author":"Van der Veen","year":"2012","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114313_bib82","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1021\/acs.est.5b00558","article-title":"Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae","volume":"49","author":"Wang","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib83","doi-asserted-by":"crossref","first-page":"6705","DOI":"10.1016\/j.chroma.2011.07.067","article-title":"Development of an ultra-high-performance liquid chromatography-tandem mass spectrometry method for high throughput determination of organophosphorus flame retardants in environmental water","volume":"1218","author":"Wang","year":"2011","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.ecoenv.2022.114313_bib84","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.envpol.2018.09.042","article-title":"Transgenerational thyroid endocrine disruption induced by bisphenol S affects the early development of zebrafish offspring","volume":"243","author":"Wei","year":"2018","journal-title":"Environ. Pollut."},{"issue":"15","key":"10.1016\/j.ecoenv.2022.114313_bib85","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1242\/dev.129.15.3751","article-title":"Pax2.1 is required for the development of thyroid follicles in zebrafish","volume":"129","author":"Wendl","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ecoenv.2022.114313_bib86","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.etap.2018.05.022","article-title":"Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis","volume":"61","author":"Wu","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib87","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.envpol.2017.06.036","article-title":"Effects of organophosphorus flame retardant TDCPP on normal human corneal epithelial cells: implications for human health","volume":"230","author":"Xiang","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.114313_bib88","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.aquatox.2015.04.014","article-title":"Microcystin-RR exposure results in growth impairment by disrupting thyroid endocrine in zebrafish larvae","volume":"164","author":"Xie","year":"2015","journal-title":"Aquat. Toxicol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114313_bib89","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cbpc.2003.08.013","article-title":"Apoptosis in zebrafish development","volume":"136","author":"Yamashita","year":"2003","journal-title":"Comp. Biochem. Physiol., Part B"},{"key":"10.1016\/j.ecoenv.2022.114313_bib90","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/bdra.23594","article-title":"Association of essential trace metals in maternal hair with the risk of neural tube defects in offspring","volume":"109","author":"Yan","year":"2017","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.ecoenv.2022.114313_bib91","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S1872-2040(11)60586-0","article-title":"Determination of organophosphorus flame retardants in surface water by solid phase extraction coupled with gas chromatography-mass spectrometry","volume":"40","author":"Yan","year":"2012","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.ecoenv.2022.114313_bib92","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ecoenv.2018.04.012","article-title":"Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm","volume":"158","author":"Yang","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.114313_bib93","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jhazmat.2018.07.110","article-title":"Polystyrene microplastics alter the behavior, energy reserve and nutritional composition of marine jacopever (Sebastes schlegelii)","volume":"360","author":"Yin","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.114313_bib94","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.aquatox.2009.10.022","article-title":"Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae","volume":"97","author":"Yu","year":"2010","journal-title":"Aquat. Toxicol."},{"issue":"24","key":"10.1016\/j.ecoenv.2022.114313_bib95","doi-asserted-by":"crossref","first-page":"10652","DOI":"10.1021\/es2026592","article-title":"Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish","volume":"45","author":"Yu","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib96","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.envpol.2016.09.039","article-title":"Parental transfer of tris (1, 3-dichloro-2-propyl) phosphate and transgenerational inhibition of growth of zebrafish exposed to environmentally relevant concentrations","volume":"220","author":"Yu","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.114313_bib97","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.chemosphere.2019.01.074","article-title":"OPFRs and BFRs induced A549cell apoptosis by caspase-dependent mitochondrial pathway","volume":"221","author":"Yu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114313_bib98","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.aquaculture.2019.03.072","article-title":"Growth performance, physiological response and histology changes of juvenile blunt snout bream, Megalobrama amblycephala exposed to chronic ammonia","volume":"506","author":"Zhang","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.ecoenv.2022.114313_bib99","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.envpol.2018.09.114","article-title":"Chemical and biological transfer: which one is responsible for the maternal transfer toxicity of tris (1,3-dichloro-2-propyl) phosphate in zebrafish?","volume":"243","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.114313_bib100","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.etap.2016.10.004","article-title":"Life-cycle exposure to BDE-47 results in thyroid endocrine disruption to adults and offsprings of zebrafish (Danio rerio)","volume":"48","author":"Zhao","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2022.114313_bib101","first-page":"1382","article-title":"Effects of Tris (2-chloroethyl) phosphate (TCEP) on survival, growth, histological changes and gene expression in juvenile yellow catfish Pelteobagrus fulvidraco","author":"Zhao","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322011538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322011538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:03:20Z","timestamp":1758953000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322011538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":101,"alternative-id":["S0147651322011538"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114313","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parental whole life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) disrupts embryonic development and thyroid system in zebrafish offspring","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114313","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114313"}}