{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:09:21Z","timestamp":1793678961327,"version":"4.5.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ecoenv.2022.114375","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T04:41:40Z","timestamp":1670560900000},"page":"114375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Polystyrene nanoplastics promote the apoptosis in Caco-2 cells induced by okadaic acid more than microplastics"],"prefix":"10.1016","volume":"249","author":[{"given":"Linhong","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peichun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanggao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0018-165X","authenticated-orcid":false,"given":"Chengyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2022.114375_bib1","first-page":"9","article-title":"Physisorption and chemisorption mechanisms influencing micro (nano) plastics-organic chemical contaminants interactions: a review","author":"Agboola","year":"2021","journal-title":"Front. Environ. Sci."},{"key":"10.1016\/j.ecoenv.2022.114375_bib2","series-title":"Transport into the Cell from the Plasma Membrane: Endocytosis","article-title":"Molecular biology of the cell","author":"Alberts","year":"2002"},{"key":"10.1016\/j.ecoenv.2022.114375_bib3","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1093\/nar\/gkt563","article-title":"The eIF2\u03b1\/ATF4 pathway is essential for stress-induced autophagy gene expression","volume":"41","author":"B\u2019chir","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2022.114375_bib4","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/2211-5463.13120","article-title":"From plastics to microplastics and organisms","volume":"11","author":"Bajt","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.ecoenv.2022.114375_bib5","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1098\/rstb.2008.0205","article-title":"Accumulation and fragmentation of plastic debris in global environments","volume":"364","author":"Barnes","year":"2009","journal-title":"Philos. Trans. R. Soc., B"},{"issue":"21","key":"10.1016\/j.ecoenv.2022.114375_bib6","article-title":"Apoptotic bodies: particular extracellular vesicles involved in intercellular communication","volume":"9","author":"Battistelli","year":"2020","journal-title":"Biology"},{"key":"10.1016\/j.ecoenv.2022.114375_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.carbon.2006.08.009","article-title":"Probing the interaction of single walled carbon nanotubes within cell culture medium as a precursor to toxicity testing","volume":"45","author":"Casey","year":"2007","journal-title":"Carbon"},{"key":"10.1016\/j.ecoenv.2022.114375_bib8","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1073\/pnas.0608582104","article-title":"Understanding the nanoparticle\u2013protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles","volume":"104","author":"Cedervall","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ecoenv.2022.114375_bib9","article-title":"Food-borne disease outbreak of diarrhetic shellfish poisoning due to toxic mussel consumption: the first recorded outbreak in China","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2022.114375_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127871","article-title":"The nephrotoxic potential of polystyrene microplastics at realistic environmental concentrations","volume":"427","author":"Chen","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.114375_bib11","first-page":"272","article-title":"Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells","volume":"7","author":"Cort\u00e9s","year":"2020","journal-title":"Environ. Sci.: Nano"},{"key":"10.1016\/j.ecoenv.2022.114375_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111322","article-title":"Sorption of okadaic acid lipophilic toxin onto plastics in seawater","volume":"157","author":"Costa","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.114375_bib13","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1021\/acs.est.9b01517","article-title":"Human consumption of microplastics","volume":"53","author":"Cox","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2022.114375_bib14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.gloenvcha.2018.05.002","article-title":"Why is the global governance of plastic failing the oceans","volume":"51","author":"Dauvergne","year":"2018","journal-title":"Glob. Environ. Change"},{"key":"10.1016\/j.ecoenv.2022.114375_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.112552","article-title":"Embryotoxicity of polystyrene microplastics in zebrafish Danio rerio","volume":"208","author":"De Marco","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2022.114375_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.108937","article-title":"Comparison of long-term versus short-term effects of okadaic acid on the apoptotic status of human HepaRG cells","volume":"317","author":"Dietrich","year":"2020","journal-title":"Chem. -Biol. Inter."},{"key":"10.1016\/j.ecoenv.2022.114375_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124232","article-title":"Effects of microplastic on arsenic accumulation in Chlamydomonas reinhardtii in a freshwater environment","volume":"405","author":"Dong","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.114375_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.marpolbul.2018.11.022","article-title":"Microplastics: finding a consensus on the definition","volume":"138","author":"Frias","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2022.114375_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700782","article-title":"Production, use, and fate of all plastics ever made","volume":"3","author":"Geyer","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ecoenv.2022.114375_bib20","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.envpol.2018.01.024","article-title":"Current opinion: what is a nanoplastic","volume":"235","author":"Gigault","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.114375_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.hal.2021.101992","article-title":"Global harmful algal bloom status reporting","volume":"102","author":"Hallegraeff","year":"2021","journal-title":"Harmful Algae"},{"key":"10.1016\/j.ecoenv.2022.114375_bib22","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/07388551.2017.1355293","article-title":"An overview on biodegradation of polystyrene and modified polystyrene: the microbial approach","volume":"38","author":"Ho","year":"2018","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.ecoenv.2022.114375_bib23","doi-asserted-by":"crossref","first-page":"20020","DOI":"10.2807\/ese.16.46.20020-en","article-title":"Food poisoning outbreaks linked to mussels contaminated with okadaic acid and ester dinophysistoxin-3 in France, June 2009","volume":"16","author":"Hossen","year":"2011","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.ecoenv.2022.114375_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101620","article-title":"Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways","volume":"37","author":"Hu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2022.114375_bib25","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1038\/s41598-020-64464-9","article-title":"Potential toxicity of polystyrene microplastic particles","volume":"10","author":"Hwang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2022.114375_bib26","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3390\/md19060322","article-title":"Okadaic acid exposure induced neural tube defects in chicken (Gallus gallus) embryos","volume":"19","author":"Jiao","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ecoenv.2022.114375_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.114375_bib28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neuro.2013.05.002","article-title":"Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer\u2019s disease pathology","volume":"37","author":"Kamat","year":"2013","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.ecoenv.2022.114375_bib29","article-title":"Analysis of cell viability by the lactate dehydrogenase assay","volume":"2018","author":"Kumar","year":"2018","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.ecoenv.2022.114375_bib30","series-title":"Comprehensive Toxicology (Second Edition)","first-page":"81","article-title":"7.04 - Mechanisms of toxicant-induced acute kidney injury","author":"Lash","year":"2010"},{"key":"10.1016\/j.ecoenv.2022.114375_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2022.114375_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126025","article-title":"Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload","volume":"417","author":"Li","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.114375_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136767","article-title":"Influence of polystyrene microplastics on the growth, photosynthetic efficiency and aggregation of freshwater microalgae Chlamydomonas reinhardtii","volume":"714","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2022.114375_bib34","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/tox.23548","article-title":"Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction","volume":"37","author":"Li","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2022.114375_bib35","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.1021\/acsnano.1c02407","article-title":"Nanoplastic-induced genotoxicity and intestinal damage in freshwater benthic clams (Corbicula fluminea): comparison with microplastics","volume":"15","author":"Li","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.ecoenv.2022.114375_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112885","article-title":"Nanoplastics aggravate the toxicity of arsenic to AGS cells by disrupting ABC transporter and cytoskeleton","volume":"227","author":"Lin","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.114375_bib37","first-page":"3186","article-title":"Do polystyrene nanoplastics aggravate the toxicity of single contaminants (okadaic acid)?","volume":"8","author":"Lin","year":"2021","journal-title":"Using AGS Cells a Biol. Model. Environ. Sci.: Nano"},{"key":"10.1016\/j.ecoenv.2022.114375_bib38","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhazmat.2018.10.056","article-title":"Quantification of the combined toxic effect of polychlorinated biphenyls and nano-sized polystyrene on Daphnia magna","volume":"364","author":"Lin","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ecoenv.2022.114375_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127629","article-title":"Polystyrene microplastics induced female reproductive toxicity in mice","volume":"424","author":"Liu","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"8","key":"10.1016\/j.ecoenv.2022.114375_bib40","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.3201\/eid1908.121824","article-title":"Diarrhetic shellfish poisoning, Washington, USA, 2011","volume":"19","author":"Lloyd","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ecoenv.2022.114375_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cis.2007.04.021","article-title":"The nanoparticle\u2013protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century","volume":"134\u2013135","author":"Lynch","year":"2007","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.ecoenv.2022.114375_bib42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10495-016-1317-3","article-title":"Reduced risk of apoptosis: mechanisms of stress responses","volume":"22","author":"Milisav","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.ecoenv.2022.114375_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132944","article-title":"Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice","volume":"291","author":"Mu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114375_bib44","unstructured":"Plastics - the Facts 2021 \u2022 Plastics Europe, 2021. Available from: https:\/\/plasticseurope.org\/knowledge-hub\/plastics-the-facts-2021\/."},{"key":"10.1016\/j.ecoenv.2022.114375_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10495-010-0554-0","article-title":"Modulation of ROS\/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism","volume":"16","author":"Ravindran","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.ecoenv.2022.114375_bib46","unstructured":"Reddy, S., Lau, W., 2020. Breaking the Plastic Wave: Top Findings for Preventing Plastic Pollution | The Pew Charitable Trusts. Available from:https:\/\/www.pewtrusts.org\/en\/research-and-analysis\/articles\/2020\/07\/23\/breaking-the-plastic-wave-top-findings."},{"key":"10.1016\/j.ecoenv.2022.114375_bib47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ecoenv.2022.114375_bib48","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/cbin.11148","article-title":"Ultrastructural traits of apoptosis","volume":"43","author":"Snigirevskaya","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ecoenv.2022.114375_bib49","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41590-018-0287-8","article-title":"The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum","volume":"20","author":"Srikanth","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ecoenv.2022.114375_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126705","article-title":"Mechanism of low concentrations of polystyrene microplastics influence the cytotoxicity of Ag ions to Escherichia coli","volume":"253","author":"Sun","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114375_bib51","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1166\/jbn.2016.2289","article-title":"Renal epithelial cell injury induced by calcium oxalate monohydrate depends on their structural features: size, surface, and crystalline structure","volume":"12","author":"Sun","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ecoenv.2022.114375_bib52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ecoenv.2022.114375_bib53","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3390\/md11051669","article-title":"Outbreak of diarrhetic shellfish poisoning associated with mussels, British Columbia, Canada","volume":"11","author":"Taylor","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ecoenv.2022.114375_bib54","doi-asserted-by":"crossref","first-page":"33997","DOI":"10.1038\/srep33997","article-title":"Plastic microfibre ingestion by deep-sea organisms","volume":"6","author":"Taylor","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2022.114375_bib55","unstructured":"Turn the tide on plastic\u2019 urges UN, as microplastics in the seas now outnumber stars in our galaxy, 2017. UN News. https:\/\/news.un.org\/en\/story\/2017\/02\/552052-turn-tide-plastic-urges-un-microplastics-seas-now-outnumber-stars-our-galaxy."},{"key":"10.1016\/j.ecoenv.2022.114375_bib56","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ecoenv.2013.03.009","article-title":"The marine toxin okadaic acid induces alterations in the expression level of cancer-related genes in human neuronal cells","volume":"92","author":"Valdiglesias","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2022.114375_bib57","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.3390\/md11114328","article-title":"Okadaic acid: more than a diarrheic toxin","volume":"11","author":"Valdiglesias","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ecoenv.2022.114375_bib58","first-page":"7","article-title":"Marine biotoxins: occurrence, toxicity, regulatory limits and reference methods","author":"Visciano","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ecoenv.2022.114375_bib59","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.jprot.2012.01.010","article-title":"Quantitative proteomic analysis of okadaic acid treated mouse small intestines reveals differentially expressed proteins involved in diarrhetic shellfish poisoning","volume":"75","author":"Wang","year":"2012","journal-title":"J. Proteom."},{"key":"10.1016\/j.ecoenv.2022.114375_bib60","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s10495-019-01555-7","article-title":"Aspirin induces oncosis in tumor cells","volume":"24","author":"Wang","year":"2019","journal-title":"Apoptosis"},{"key":"10.1016\/j.ecoenv.2022.114375_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126788","article-title":"Effects of bisphenol A and nanoscale and microscale polystyrene plastic exposure on particle uptake and toxicity in human Caco-2 cells","volume":"254","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2022.114375_bib62","unstructured":"World Economic Forum, Ellen MacArthur Foundation, McKinsey & Company, 2016. The New Plastics Economy \u2014 Rethinking the future of plastics. http:\/\/www.ellenmacarthurfoundation.org\/publications."},{"key":"10.1016\/j.ecoenv.2022.114375_bib63","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.ecoenv.2022.114375_bib64","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1471-4159.2008.05805.x","article-title":"Mechanism of okadaic acid-induced neuronal death and the effect of estrogens","volume":"108","author":"Yi","year":"2009","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ecoenv.2022.114375_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106842","article-title":"Unraveling individual and combined toxicity of nano\/microplastics and ciprofloxacin to Synechocystis sp. at the cellular and molecular levels","volume":"157","author":"You","year":"2021","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2022.114375_bib66","doi-asserted-by":"crossref","first-page":"1900513","DOI":"10.2807\/1560-7917.ES.2019.24.35.1900513","article-title":"Outbreak of diarrhetic shellfish poisoning associated with consumption of mussels, United Kingdom, May to June 2019","volume":"24","author":"Young","year":"2019","journal-title":"Eurosurveillance"},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114375_bib67","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.2174\/1871520621666211126090906","article-title":"Role of Mitochondrial Membrane Potential and Lactate Dehydrogenase A in Apoptosis","volume":"22","author":"Zaib","year":"2022","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"10.1016\/j.ecoenv.2022.114375_bib68","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1021\/acs.jafc.9b00011","article-title":"Portable multiplex immunochromatographic assay for quantitation of two typical algae toxins based on dual-color fluorescence microspheres","volume":"67","author":"Zhang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2022.114375_bib69","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1021\/acs.estlett.1c00559","article-title":"Occurrence of polyethylene terephthalate and polycarbonate microplastics in infant and adult feces","volume":"8","author":"Zhang","year":"2021","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.ecoenv.2022.114375_bib70","doi-asserted-by":"crossref","first-page":"13394","DOI":"10.1007\/s11356-020-10388-w","article-title":"Polystyrene nanoplastics affect growth and microcystin production of Microcystis aeruginosa","volume":"28","author":"Zheng","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.ecoenv.2022.114375_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.algal.2021.102277","article-title":"Microcystin biosynthesis and toxic effects","volume":"55","author":"Zhou","year":"2021","journal-title":"Algal Res"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322012155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322012155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:03:16Z","timestamp":1758952996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322012155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":71,"alternative-id":["S0147651322012155"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114375","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polystyrene nanoplastics promote the apoptosis in Caco-2 cells induced by okadaic acid more than microplastics","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114375"}}