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Acad. Sci."},{"key":"10.1016\/j.ecoenv.2022.114430_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-61143-7","article-title":"Long-term metal exposure changes gut microbiota of residents surrounding a mining and smelting area","volume":"10","author":"Shao","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2022.114430_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10661-018-6816-y","article-title":"The health hazards of potentially toxic metals in the daily diets of adults and children from a mining and smelting region (Hezhang County) in southwestern China","volume":"190","author":"Shao","year":"2018","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.ecoenv.2022.114430_bib80","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3390\/ijerph5050450","article-title":"Effects of heavy metal contamination upon soil microbes: lead-induced changes in general and dneitrifying microbial communities as evidenced by molecular markers","volume":"5","author":"Sobolev","year":"2008","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.ecoenv.2022.114430_bib81","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature24621","article-title":"A communal catalogue reveals Earth\u2019s multiscale microbial diversity","volume":"551","author":"Thompson","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2022.114430_bib82","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1289\/ehp.908955","article-title":"Lead exposure in young children from dust and soil in the United Kingdom","volume":"89","author":"Thornton","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.114430_bib83","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1099\/jmm.0.46488-0","article-title":"Effect of gamma irradiation on viability and DNA of Staphylococcus epidermidis and Escherichia coli","volume":"55","author":"Trampuz","year":"2006","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ecoenv.2022.114430_bib84","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ecoenv.2022.114430_bib85","unstructured":"U. S. National Library of Medicine. ChemIDplus: Lead acetate, RN 6080\u201356-4. \u3008https:\/\/chem.nlm.nih.gov\/chemidplus\/rn\/6080\u201356-4\u3009, retrieved 11\/25\/2022."},{"key":"10.1016\/j.ecoenv.2022.114430_bib86","unstructured":"U.S. Environmental Protection Agency (USEPA). 1994. United States Environmental Protection Agency (USEPA) Guidance Manual for the Integrated Exposure Uptake Biokinetic Model for Lead in Children. EPA\/540\/R-93\/081, 1\u2013248."},{"key":"10.1016\/j.ecoenv.2022.114430_bib87","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10482-009-9345-4","article-title":"New mobile genetic elements in Cupriavidus metallidurans CH34, their possible roles and occurrence in other bacteria","volume":"96","author":"Van Houdt","year":"2009","journal-title":"Antonie Van. 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