{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:34:16Z","timestamp":1789076056569,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ecoenv.2022.114456","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T13:06:00Z","timestamp":1671541560000},"page":"114456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Hawthorn total flavonoids ameliorate ambient fine particulate matter-induced insulin resistance and metabolic abnormalities of lipids in mice"],"prefix":"10.1016","volume":"249","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-0981","authenticated-orcid":false,"given":"Weijia","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-5487","authenticated-orcid":false,"given":"Ruiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rucheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghou","family":"Shui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0393-7806","authenticated-orcid":false,"given":"Cuiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ecoenv.2022.114456_bib1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/hep.26672","article-title":"Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes","volume":"59","author":"Birkenfeld","year":"2014","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114456_bib2","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1042\/bst0251232","article-title":"Isoforms of acetyl-CoA carboxylase: structures, regulatory properties and metabolic functions","volume":"25","author":"Brownsey","year":"1997","journal-title":"Biochem Soc. Trans."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114456_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.mce.2012.06.014","article-title":"The role of AMP-activated protein kinase in regulating white adipose tissue metabolism","volume":"366","author":"Ceddia","year":"2013","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.ecoenv.2022.114456_bib4","doi-asserted-by":"crossref","unstructured":"Choe, S.-A., et al. Air Pollution and Gestational Diabetes in New York City. in ISEE Conference Abstracts. 2018.","DOI":"10.1289\/isesisee.2018.P02.1760"},{"key":"10.1016\/j.ecoenv.2022.114456_bib5","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.3389\/fmicb.2016.01186","article-title":"The mechanisms underlying the hypolipidaemic effects of grifola frondosa in the liver of rats","volume":"7","author":"Ding","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ecoenv.2022.114456_bib6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1742-2094-7-97","article-title":"Immunomodulatory effect of hawthorn extract in an experimental stroke model","volume":"7","author":"Elango","year":"2010","journal-title":"J. Neuroinflamm."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114456_bib7","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaci.2005.02.023","article-title":"Adipose tissue, adipokines, and inflammation","volume":"115","author":"Fantuzzi","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ecoenv.2022.114456_bib8","article-title":"Joint effects of heat stress and PM2.5 exposure on glucose metabolism and hepatic insulin signaling","author":"Gu","year":"2022","journal-title":"Clin. Complement. Med. Pharmacol."},{"issue":"12","key":"10.1016\/j.ecoenv.2022.114456_bib9","doi-asserted-by":"crossref","first-page":"29911","DOI":"10.3390\/ijms161226206","article-title":"Downregulation of de novo fatty acid synthesis in subcutaneous adipose tissue of moderately obese women","volume":"16","author":"Guiu-Jurado","year":"2015","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2022.114456_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112524","article-title":"Ambient fine particulate matter exposure disrupts circadian rhythm and oscillation of the HPA axis in a mouse model","volume":"222","author":"Hu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114456_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/J157v03n02_03","article-title":"Hawthorn evokes a potent anti-hyperglycemic capacity in streptozotocin-induced diabetic rats","volume":"3","author":"Jouad","year":"2003","journal-title":"J. Herb. Pharm."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114456_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114456_bib13","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00125-009-1282-2","article-title":"Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations","volume":"52","author":"Kotronen","year":"2009","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114456_bib14","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.2337\/db14-0631","article-title":"Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity","volume":"64","author":"Kwon","year":"2015","journal-title":"Diabetes"},{"issue":"35","key":"10.1016\/j.ecoenv.2022.114456_bib15","doi-asserted-by":"crossref","first-page":"55970","DOI":"10.18632\/oncotarget.11190","article-title":"Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging","volume":"7","author":"Lam","year":"2016","journal-title":"Oncotarget"},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114456_bib16","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/s42255-021-00425-4","article-title":"A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19","volume":"3","author":"Lam","year":"2021","journal-title":"Nat. Metab."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114456_bib17","volume":"182","author":"Li","year":"2020","journal-title":"Snapshot.: FABP Funct. Cell"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114456_bib18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12931-019-1045-7","article-title":"Amelioration of PM(2.5)-induced lung toxicity in rats by nutritional supplementation with fish oil and vitamin E","volume":"20","author":"Li","year":"2019","journal-title":"Respir. Res"},{"key":"10.1016\/j.ecoenv.2022.114456_bib19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.freeradbiomed.2021.06.027","article-title":"Gut inflammation exacerbates high-fat diet induced steatosis by suppressing VLDL-TG secretion through HNF4\u03b1 pathway","volume":"172","author":"Li","year":"2021","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.ecoenv.2022.114456_bib20","article-title":"Ambient Fine Particulate Matter Disrupts Hepatic Circadian Oscillation and Lipid Metabolism in a Mouse Model","volume":"262","author":"Li","year":"2020"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114456_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12989-020-00343-5","article-title":"Sex-dependent effects of ambient PM(2.5) pollution on insulin sensitivity and hepatic lipid metabolism in mice","volume":"17","author":"Li","year":"2020","journal-title":"Part Fibre Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114456_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12986-022-00664-6","article-title":"L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKK\u03b2-AMPK signaling pathway","volume":"19","author":"Liang","year":"2022","journal-title":"Nutr. Metab."},{"issue":"16","key":"10.1016\/j.ecoenv.2022.114456_bib23","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.jacc.2018.12.093","article-title":"Cardiovascular benefits of fish-oil supplementation against fine particulate air pollution in China","volume":"73","author":"Lin","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ecoenv.2022.114456_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12989-014-0053-5","article-title":"Central IKK\u03b2 inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes","volume":"11","author":"Liu","year":"2014","journal-title":"Part Fibre Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114456_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.1306841","article-title":"Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice","volume":"122","author":"Liu","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2022.114456_bib26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.envint.2016.03.028","article-title":"Associations between long-term exposure to ambient particulate air pollution and type 2 diabetes prevalence, blood glucose and glycosylated hemoglobin levels in China","volume":"92\u201393","author":"Liu","year":"2016","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114456_bib27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12989-017-0187-3","article-title":"Particulate air pollution mediated effects on insulin resistance in mice are independent of CCR2","volume":"14","author":"Liu","year":"2017","journal-title":"Part Fibre Toxicol."},{"issue":"11","key":"10.1016\/j.ecoenv.2022.114456_bib28","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.2337\/dc19-0100","article-title":"High-coverage targeted lipidomics reveals novel serum lipid predictors and lipid pathway dysregulation antecedent to type 2 diabetes onset in normoglycemic chinese adults","volume":"42","author":"Lu","year":"2019","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114456_bib29","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1103\/PhysRevC.32.796","article-title":"Shell model calculation for the 71Ga( nu,e-)71Ge solar neutrino detector","volume":"32","author":"Mathews","year":"1985","journal-title":"Phys. Rev. C. Nucl. Phys."},{"issue":"7","key":"10.1016\/j.ecoenv.2022.114456_bib30","first-page":"351","article-title":"Flavonoids of crataegus orientalis","volume":"138","author":"Melikoglu","year":"1999","journal-title":"J. Boll. Chim. -Farm."},{"issue":"12","key":"10.1016\/j.ecoenv.2022.114456_bib31","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1164\/rccm.201508-1599OC","article-title":"Ozone exposure increases circulating stress hormones and lipid metabolites in humans","volume":"193","author":"Miller","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med"},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114456_bib32","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2337\/db10-0589","article-title":"Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance","volume":"60","author":"Mulvihill","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.ecoenv.2022.114456_bib33","unstructured":"P.R.C., N.H.C.o, Notice of the Ministry of Health on Further Standardizing the Management of Health Food Raw Materials. 2002."},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2022.114456_bib34","article-title":"miRNAs Deregulation in Serum of Mice is Associated with Lung Cancer Related Pathway Deregulation Induced by PM2.5","volume":"254","author":"Ning","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2022.114456_bib35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ecoenv.2019.04.038","article-title":"AMPK activation attenuates inflammatory response to reduce ambient PM(2.5)-induced metabolic disorders in healthy and diabetic mice","volume":"179","author":"Pan","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.ecoenv.2022.114456_bib36","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/EDE.0000000000000908","article-title":"Diabetes status and susceptibility to the effects of PM2.5 exposure on cardiovascular mortality in a national canadian cohort","volume":"29","author":"Pinault","year":"2018","journal-title":"Epidemiology"},{"issue":"3","key":"10.1016\/j.ecoenv.2022.114456_bib37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10549-007-9678-5","article-title":"Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75","volume":"109","author":"Puig","year":"2008","journal-title":"Breast Cancer Res Treat."},{"issue":"5","key":"10.1016\/j.ecoenv.2022.114456_bib38","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/pca.853","article-title":"Isolation and identification of flavonoids, including flavone rotamers, from the herbal drug 'crataegi folium cum flore' (Hawthorn)","volume":"16","author":"Rayyan","year":"2005","journal-title":"Phytochem Anal."},{"key":"10.1016\/j.ecoenv.2022.114456_bib39","first-page":"417","article-title":"Hawthorn: Pharmacology and Therapeutic Uses","volume":"59","author":"Rigelsky","year":"2002"},{"issue":"2","key":"10.1016\/j.ecoenv.2022.114456_bib40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cmet.2020.06.016","article-title":"Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis","volume":"32","author":"Song","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.ecoenv.2022.114456_bib41","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3389\/fimmu.2018.00495","article-title":"De novo fatty acid synthesis during mycobacterial infection is a prerequisite for the function of highly proliferative T cells, but not for dendritic cells or macrophages","volume":"9","author":"St\u00fcve","year":"2018","journal-title":"Front Immunol."},{"issue":"4","key":"10.1016\/j.ecoenv.2022.114456_bib42","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/CIRCULATIONAHA.108.799015","article-title":"Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity","volume":"119","author":"Sun","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114456_bib43","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00125-010-1895-5","article-title":"Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice","volume":"54","author":"Turpin","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.ecoenv.2022.114456_bib44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ecoenv.2018.11.001","article-title":"Atmospheric PM2.5 aspiration causes tauopathy by disturbing the insulin signaling pathway","volume":"169","author":"Wei","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.ecoenv.2022.114456_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/modpathol.2016.170","article-title":"Fatty acid-binding protein 1 is preferentially lost in microsatellite instable colorectal carcinomas and is immune modulated via the interferon \u03b3 pathway","volume":"30","author":"Wood","year":"2017","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.ecoenv.2022.114456_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2020.103700","article-title":"Rapid analysis and identification of flavonoid and organic acid metabolites in hawthorn using an on-line flow injection assisted electrochemical microreactor combined with quadrupole time-of-flight tandem mass spectrometry","volume":"96","author":"Yang","year":"2021","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.ecoenv.2022.114456_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116193","article-title":"Lipid metabolic adaption to long-term ambient PM(2.5) exposure in mice","volume":"269","author":"Yang","year":"2021","journal-title":"Environ. Pollut."},{"issue":"44","key":"10.1016\/j.ecoenv.2022.114456_bib48","doi-asserted-by":"crossref","first-page":"62991","DOI":"10.1007\/s11356-021-15160-2","article-title":"Impact of meteorological conditions at multiple scales on ozone concentration in the Yangtze river delta","volume":"28","author":"Zhao","year":"2021","journal-title":"Environ. Sci. Pollut. Res Int"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322012969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651322012969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:14:55Z","timestamp":1758953695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651322012969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":48,"alternative-id":["S0147651322012969"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114456","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hawthorn total flavonoids ameliorate ambient fine particulate matter-induced insulin resistance and metabolic abnormalities of lipids in mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2022.114456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114456"}}