{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:50:52Z","timestamp":1793321452546,"version":"4.5.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41821005"],"award-info":[{"award-number":["41821005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["121311KYSB20190071"],"award-info":[{"award-number":["121311KYSB20190071"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ecoenv.2023.114719","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T12:17:00Z","timestamp":1678796220000},"page":"114719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Melatonin ameliorates glyphosate- and hard water-induced renal tubular epithelial cell senescence via PINK1-Parkin-dependent mitophagy"],"prefix":"10.1016","volume":"255","author":[{"given":"Lin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruojing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2023.114719_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2020.104586","article-title":"Effects of quercetin loaded nanostructured lipid carriers on the paraquat-induced toxicity in human lymphocytes","volume":"167","author":"Ahmadian","year":"2020","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.ecoenv.2023.114719_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106019","article-title":"Kidney developmental effects of metal-herbicide mixtures: implications for chronic kidney disease of unknown etiology","volume":"144","author":"Babich","year":"2020","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.ecoenv.2023.114719_bib3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/sj.embor.embor806","article-title":"Cell senescence and hypermitogenic arrest","volume":"4","author":"Blagosklonny","year":"2003","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1172\/JCI64125","article-title":"The role of mitochondria in aging","volume":"123","author":"Bratic","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ecoenv.2023.114719_bib5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/bs.acc.2014.11.001","article-title":"Manganese superoxide dismutase and oxidative stress modulation","volume":"68","author":"Bresciani","year":"2015","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.ecoenv.2023.114719_bib6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","article-title":"Aging, cellular senescence, and cancer","volume":"75","author":"Campisi","year":"2013","journal-title":"Annu. Rev. Physiol."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12718","article-title":"Melatonin rescues the reproductive toxicity of low-dose glyphosate-based herbicide during mouse oocyte maturation via the GPER signaling pathway","volume":"70","author":"Cao","year":"2021","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ecoenv.2023.114719_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106186","article-title":"Elabela ameliorates doxorubicin-induced cardiotoxicity by promoting autophagic flux through TFEB pathway","volume":"178","author":"Chen","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41419-017-0127-z","article-title":"Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy","volume":"9","author":"Chen","year":"2018","journal-title":"Cell death Dis."},{"key":"10.1016\/j.ecoenv.2023.114719_bib10","doi-asserted-by":"crossref","unstructured":"Chen Q., Ames B.N. (1994) Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proceedings of the National Academy of Sciences of the United States of America 91(10):4130\u20134 doi:10.1073\/pnas.91.10.4130.","DOI":"10.1073\/pnas.91.10.4130"},{"key":"10.1016\/j.ecoenv.2023.114719_bib11","article-title":"Anti-apoptosis and autophagy effects of melatonin protect rat chondrocytes against oxidative stress via regulation of AMPK\/Foxo3 pathways","author":"Chen","year":"2021","journal-title":"Cartil. 13(2_suppl):1041s-1053s"},{"key":"10.1016\/j.ecoenv.2023.114719_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101394","article-title":"The potential role of melatonin in retarding intervertebral disc ageing and degeneration: a systematic review","volume":"70","author":"Cheng","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"7","key":"10.1016\/j.ecoenv.2023.114719_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069720","article-title":"Mitochondrial autophagy involving renal injury and aging is modulated by caloric intake in aged rat kidneys","volume":"8","author":"Cui","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.ecoenv.2023.114719_bib14","doi-asserted-by":"crossref","unstructured":"Dimri G.P., Lee X., Basile G., et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proceedings of the National Academy of Sciences of the United States of America 92(20):9363\u20137 doi:10.1073\/pnas.92.20.9363.","DOI":"10.1073\/pnas.92.20.9363"},{"key":"10.1016\/j.ecoenv.2023.114719_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113803","article-title":"Melatonin ameliorates renal dysfunction in glyphosate- and hard water-treated mice","volume":"241","author":"Ding","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"11","key":"10.1016\/j.ecoenv.2023.114719_bib16","article-title":"Application of advanced nanomaterials for kidney failure treatment and regeneration","volume":"14","author":"Eftekhari","year":"2021","journal-title":"Mater. (Basel, Switz. )"},{"issue":"12","key":"10.1016\/j.ecoenv.2023.114719_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9121299","article-title":"Melatonin reduces NLRP3 inflammasome activation by increasing \u03b17 nAChR-mediated autophagic flux","volume":"9","author":"Farr\u00e9-Alins","year":"2020","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.ecoenv.2023.114719_bib18","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/jat.3795","article-title":"Activation of the N-methyl-d-aspartate receptor is involved in glyphosate-induced renal proximal tubule cell apoptosis","volume":"39","author":"Gao","year":"2019","journal-title":"J. Appl. Toxicol.: JAT"},{"issue":"7584","key":"10.1016\/j.ecoenv.2023.114719_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Garc\u00eda-Prat","year":"2016","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ecoenv.2023.114719_bib20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nrm1987","article-title":"Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all","volume":"7","author":"Gil","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.ecoenv.2023.114719_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125176","article-title":"Protective role of PGC-1\u03b1 in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling","volume":"10","author":"Guo","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.ecoenv.2023.114719_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101915","article-title":"Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis","volume":"41","author":"Guo","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2023.114719_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113500","article-title":"Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity","volume":"236","author":"Han","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.ecoenv.2023.114719_bib24","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41419-021-04184-8","article-title":"AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice","volume":"12","author":"Han","year":"2021","journal-title":"Cell death Dis."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.114719_bib25","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12535","article-title":"Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrP(C) -dependent enhancement of the mitochondrial function","volume":"66","author":"Han","year":"2019","journal-title":"J. Pineal Res."},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2023.114719_bib26","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.envpol.2019.05.128","article-title":"Roundup(\u00ae) confers cytotoxicity through DNA damage and mitochondria-associated apoptosis induction","volume":"252","author":"Hao","year":"2019","journal-title":"Environ. Pollut. (Barking, Essex: 1987)"},{"issue":"13","key":"10.1016\/j.ecoenv.2023.114719_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/cells11132111","article-title":"Activation of autophagic flux maintains mitochondrial homeostasis during cardiac ischemia\/reperfusion injury","volume":"11","author":"He","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib28","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cmet.2020.01.009","article-title":"An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance","volume":"31","author":"He","year":"2020","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.ecoenv.2023.114719_bib29","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1111\/jcmm.15256","article-title":"Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1\/PARKIN pathway","volume":"24","author":"Huang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ecoenv.2023.114719_bib30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1476-069X-14-6","article-title":"Drinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka","volume":"14","author":"Jayasumana","year":"2015","journal-title":"Environ. Health.: a Glob. Access Sci. Source"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib31","first-page":"234","article-title":"Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants","volume":"32","author":"Jayasumana","year":"2017","journal-title":"Nephrol., Dial., Transplant.: Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc."},{"key":"10.1016\/j.ecoenv.2023.114719_bib32","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/1471-2369-14-180","article-title":"Chronic kidney disease of uncertain aetiology: prevalence and causative factors in a developing country","volume":"14","author":"Jayatilake","year":"2013","journal-title":"BMC Nephrol."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib33","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/15548627.2021.1946739","article-title":"RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging","volume":"18","author":"Jin","year":"2022","journal-title":"Autophagy"},{"issue":"19","key":"10.1016\/j.ecoenv.2023.114719_bib34","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1056\/NEJMra1813869","article-title":"Chronic kidney disease of unknown cause in agricultural communities","volume":"380","author":"Johnson","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.ecoenv.2023.114719_bib35","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/jpi.12319","article-title":"Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis","volume":"60","author":"Kang","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.ecoenv.2023.114719_bib36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.dnarep.2016.04.008","article-title":"Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage","volume":"42","author":"Karimian","year":"2016","journal-title":"DNA Repair"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib37","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/jcp.29940","article-title":"Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells","volume":"236","author":"Kim","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cell.2006.10.003","article-title":"The regulation of INK4\/ARF in cancer and aging","volume":"127","author":"Kim","year":"2006","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ecoenv.2023.114719_bib39","doi-asserted-by":"crossref","DOI":"10.4161\/jkst.25763","article-title":"IL-6-STAT3 signaling and premature senescence","volume":"2","author":"Kojima","year":"2013","journal-title":"Jak. -Stat."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13111","article-title":"Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway","volume":"19","author":"Lee","year":"2020","journal-title":"Aging Cell"},{"issue":"6","key":"10.1016\/j.ecoenv.2023.114719_bib41","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","article-title":"Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques","volume":"25","author":"Lee","year":"2022","journal-title":"Nat. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.ecoenv.2023.114719_bib42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological Functions of Autophagy Genes: A Disease Perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2023.114719_bib43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2022.04.016","article-title":"Melatonin promotes peripheral nerve repair through Parkin-mediated mitophagy","volume":"185","author":"Li","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2023.114719_bib44","doi-asserted-by":"crossref","first-page":"2640209","DOI":"10.1155\/2022\/2640209","article-title":"San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1\/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway","volume":"2022","author":"Li","year":"2022","journal-title":"J. Diabetes Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.114719_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12964-020-00572-3","article-title":"Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation","volume":"18","author":"Lim","year":"2020","journal-title":"Cell Commun. Signal.: CCS"},{"key":"10.1016\/j.ecoenv.2023.114719_bib46","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3389\/fncel.2019.00550","article-title":"Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss","volume":"13","author":"Lin","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ecoenv.2023.114719_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101254","article-title":"PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2023.114719_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101963","article-title":"LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss","volume":"43","author":"Liu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2023.114719_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118116","article-title":"Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1\/PINK1\/mitophagy axis","volume":"257","author":"Liu","year":"2020","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib50","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2215\/CJN.07500715","article-title":"CKD of Uncertain Etiology: A Systematic Review","volume":"11","author":"Lunyera","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol.: CJASN"},{"key":"10.1016\/j.ecoenv.2023.114719_bib51","doi-asserted-by":"crossref","first-page":"9286458","DOI":"10.1155\/2018\/9286458","article-title":"Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition","volume":"2018","author":"Ma","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2023.114719_bib52","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jes.2019.09.018","article-title":"Ca(2+) and SO(4)(2-) interactions with dissolved organic matter: Implications of groundwater quality for CKDu incidence in Sri Lanka","volume":"88","author":"Makehelwala","year":"2020","journal-title":"J. Environ. Sci. (China)"},{"issue":"12","key":"10.1016\/j.ecoenv.2023.114719_bib53","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1096\/fj.99-0865fje","article-title":"Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress","volume":"14","author":"Mart\u00edn","year":"2000","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.ecoenv.2023.114719_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105414","article-title":"Use of human neuroblastoma SH-SY5Y cells to evaluate glyphosate-induced effects on oxidative stress, neuronal development and cell death signaling pathways","volume":"135","author":"Mart\u00ednez","year":"2020","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib55","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.200910140","article-title":"PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy","volume":"189","author":"Matsuda","year":"2010","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib56","first-page":"408","article-title":"Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging","volume":"50","author":"McCully","year":"2020","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib57","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.ecoenv.2023.114719_bib58","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narendra","year":"2008","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.ecoenv.2023.114719_bib59","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(03)00401-X","article-title":"Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence","volume":"113","author":"Narita","year":"2003","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.ecoenv.2023.114719_bib60","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.tcb.2016.05.008","article-title":"Deciphering the molecular signals of PINK1\/Parkin mitophagy","volume":"26","author":"Nguyen","year":"2016","journal-title":"Trends Cell Biol."},{"issue":"556","key":"10.1016\/j.ecoenv.2023.114719_bib61","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aat5185","article-title":"Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence","volume":"11","author":"Nishimura","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ecoenv.2023.114719_bib62","doi-asserted-by":"crossref","unstructured":"Ravishankar A., Cumming J.R., Gallagher J.E.G. (2020) Mitochondrial metabolism is central for response and resistance of Saccharomyces cerevisiae to exposure to a glyphosate-based herbicide. Environmental pollution (Barking, Essex: 1987) 262. 114359 doi:10.1016\/j.envpol.2020.114359.","DOI":"10.1016\/j.envpol.2020.114359"},{"issue":"21","key":"10.1016\/j.ecoenv.2023.114719_bib63","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell. Mol. life Sci.: CMLS"},{"key":"10.1016\/j.ecoenv.2023.114719_bib64","doi-asserted-by":"crossref","unstructured":"Rizza S., Cardaci S., Montagna C., et al. (2018) S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy. Proceedings of the National Academy of Sciences of the United States of America 115(15):E3388-e3397 doi:10.1073\/pnas.1722452115.","DOI":"10.1073\/pnas.1722452115"},{"issue":"12","key":"10.1016\/j.ecoenv.2023.114719_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/0021-9681(72)90006-9","article-title":"The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx","volume":"25","author":"Rothman","year":"1972","journal-title":"J. Chronic Dis."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib66","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gad.235184.113","article-title":"Cellular senescence and its effector programs","volume":"28","author":"Salama","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.ecoenv.2023.114719_bib67","doi-asserted-by":"crossref","first-page":"7546265","DOI":"10.1155\/2016\/7546265","article-title":"Upregulation of Oxidative Stress Related Genes in a Chronic Kidney Disease Attributed to Specific Geographical Locations of Sri Lanka","volume":"2016","author":"Sayanthooran","year":"2016","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.ecoenv.2023.114719_bib68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-1-4939-2522-3_10","article-title":"Measuring autophagy in stressed cells","volume":"1292","author":"Sharifi","year":"2015","journal-title":"Methods Mol. Biol. (Clifton, NJ)"},{"issue":"10","key":"10.1016\/j.ecoenv.2023.114719_bib69","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1158\/0008-5472.CAN-16-0707","article-title":"Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels","volume":"77","author":"Sobecki","year":"2017","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.ecoenv.2023.114719_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111141","article-title":"Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin","volume":"9","author":"Stacchiotti","year":"2014","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib71","doi-asserted-by":"crossref","first-page":"494","DOI":"10.18632\/aging.101173","article-title":"CDKN2A\/p16INK4(a) expression is associated with vascular progeria in chronic kidney disease","volume":"9","author":"Stenvinkel","year":"2017","journal-title":"Aging"},{"issue":"4","key":"10.1016\/j.ecoenv.2023.114719_bib72","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/14756360500381210","article-title":"Investigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives: discussion on possible antioxidant mechanisms and comparison with melatonin","volume":"21","author":"Suzen","year":"2006","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.114719_bib73","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/15548627.2016.1247143","article-title":"Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence","volume":"13","author":"Tai","year":"2017","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.ecoenv.2023.114719_bib74","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1080\/15548627.2017.1405880","article-title":"PINK1-PRKN\/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury","volume":"14","author":"Tang","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.ecoenv.2023.114719_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.889729","article-title":"Melatonin alleviates renal injury by activating mitophagy in diabetic nephropathy","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"10","key":"10.1016\/j.ecoenv.2023.114719_bib76","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/ndt\/gfu395","article-title":"Cell cycle control in the kidney","volume":"30","author":"Thomasova","year":"2015","journal-title":". Nephrol., Dial., Transplant.: Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc."},{"issue":"04","key":"10.1016\/j.ecoenv.2023.114719_bib77","first-page":"158","article-title":"Analysis and Occurrences of Glyphosate and Its Degradation Product in Soil and Sediment Samples from Sri Lanka, Asian Journal of Ecotoxicology","volume":"15","author":"Tian","year":"2020"},{"issue":"5","key":"10.1016\/j.ecoenv.2023.114719_bib78","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12272-020-01239-w","article-title":"Role of autophagy in regulation of cancer cell death\/apoptosis during anti-cancer therapy: focus on autophagy flux blockade","volume":"43","author":"Tilija Pun","year":"2020","journal-title":"Arch. pharmacal Res."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib79","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-079X.2005.00248.x","article-title":"A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes","volume":"39","author":"Tom\u00e1s-Zapico","year":"2005","journal-title":"J. Pineal Res."},{"issue":"7","key":"10.1016\/j.ecoenv.2023.114719_bib80","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.18632\/aging.100976","article-title":"Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate","volume":"8","author":"Vazquez-Martin","year":"2016","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib81","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.kint.2019.11.009","article-title":"Chronic interstitial nephritis in agricultural communities is a toxin-induced proximal tubular nephropathy","volume":"97","author":"Vervaet","year":"2020","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib82","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.kint.2018.11.011","article-title":"Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET)","volume":"95","author":"Wang","year":"2019","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib83","doi-asserted-by":"crossref","first-page":"130","DOI":"10.21037\/atm-20-7739","article-title":"Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2","volume":"9","author":"Wang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.ecoenv.2023.114719_bib84","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev-pharmtox-020821-111552","article-title":"Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology","volume":"62","author":"Wang","year":"2022","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"11","key":"10.1016\/j.ecoenv.2023.114719_bib85","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/s41419-018-1152-2","article-title":"PINK1\/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury","volume":"9","author":"Wang","year":"2018","journal-title":"Cell death Dis."},{"key":"10.1016\/j.ecoenv.2023.114719_bib86","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1","volume":"11","author":"Xiao","year":"2017","journal-title":"Redox Biol."},{"issue":"16","key":"10.1016\/j.ecoenv.2023.114719_bib87","doi-asserted-by":"crossref","first-page":"E859","DOI":"10.1097\/BRS.0000000000003942","article-title":"Melatonin Alleviates Radiculopathy Against Apoptosis and NLRP3 Inflammasomes Via the Parkin-Mediated Mitophagy Pathway","volume":"46","author":"Xie","year":"2021","journal-title":"Spine"},{"issue":"3","key":"10.1016\/j.ecoenv.2023.114719_bib88","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41419-018-0358-7","article-title":"Ischemic preconditioning attenuates ischemia\/reperfusion-induced kidney injury by activating autophagy via the SGK1 signaling pathway","volume":"9","author":"Xie","year":"2018","journal-title":"Cell death Dis."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.114719_bib89","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1681\/ASN.2016070731","article-title":"High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney","volume":"28","author":"Yamamoto","year":"2017","journal-title":"J. Am. Soc. Nephrol.: JASN"},{"issue":"7","key":"10.1016\/j.ecoenv.2023.114719_bib90","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1080\/15548627.2020.1782034","article-title":"Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux","volume":"17","author":"Yamamoto","year":"2021","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.ecoenv.2023.114719_bib91","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1080\/15548627.2020.1782034","article-title":"Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux","volume":"17","author":"Yamamoto","year":"2021","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.ecoenv.2023.114719_bib92","doi-asserted-by":"crossref","first-page":"12324","DOI":"10.1096\/fj.202001252R","article-title":"Melatonin pretreatment alleviates renal ischemia-reperfusion injury by promoting autophagic flux via TLR4\/MyD88\/MEK\/ERK\/mTORC1 signaling","volume":"34","author":"Yang","year":"2020","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.114719_bib93","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41467-020-16312-7","article-title":"Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.114719_bib94","first-page":"25","article-title":"Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1\/RIP3-exosome axis","volume":"9","author":"Zeng","year":"2022","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.ecoenv.2023.114719_bib95","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijcard.2016.11.161","article-title":"Involvement of PINK1\/Parkin-mediated mitophagy in AGE-induced cardiomyocyte aging","volume":"227","author":"Zha","year":"2017","journal-title":"Int. J. Cardiol."},{"issue":"6","key":"10.1016\/j.ecoenv.2023.114719_bib96","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1681\/ASN.2014050457","article-title":"Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease","volume":"26","author":"Zhan","year":"2015","journal-title":"J. Am. Soc. Nephrol.: JASN"},{"key":"10.1016\/j.ecoenv.2023.114719_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124435","article-title":"The toxic effects and possible mechanisms of glyphosate on mouse oocytes","volume":"237","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.114719_bib98","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.freeradbiomed.2021.09.019","article-title":"Drp1-dependent mitochondrial fission mediates corneal injury induced by alkali burn","volume":"176","author":"Zhang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ecoenv.2023.114719_bib99","doi-asserted-by":"crossref","unstructured":"Zhang L., Ding F., Wang R., et al. (2021b) Involvement of mitochondrial fission in renal tubular pyroptosis in mice exposed to high and environmental levels of glyphosate combined with hard water. Environmental pollution (Barking, Essex: 1987) 283:117082 doi:10.1016\/j.envpol.2021.117082.","DOI":"10.1016\/j.envpol.2021.117082"},{"key":"10.1016\/j.ecoenv.2023.114719_bib100","doi-asserted-by":"crossref","unstructured":"Zhang L., Ji X., Ding F., Wu X., Tang N., Wu Q. (2022a) Apoptosis and blood-testis barrier disruption during male reproductive dysfunction induced by PAHs of different molecular weights. Environmental pollution (Barking, Essex: 1987) 300:118959 doi:10.1016\/j.envpol.2022.118959.","DOI":"10.1016\/j.envpol.2022.118959"},{"key":"10.1016\/j.ecoenv.2023.114719_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113078","article-title":"PINK1\/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity","volume":"164","author":"Zhang","year":"2022","journal-title":"Food Chem. Toxicol.: Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.114719_bib102","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.yexcr.2016.12.015","article-title":"Pink1\/Parkin-mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injury","volume":"350","author":"Zhao","year":"2017","journal-title":"Exp. Cell Res."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.114719_bib103","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1159\/000494445","article-title":"Ethyl pyruvate attenuates CaCl2-induced tubular epithelial cell injury by inhibiting autophagy and inflammatory responses","volume":"43","author":"Zhao","year":"2018","journal-title":"Kidney blood Press. Res."},{"issue":"7","key":"10.1016\/j.ecoenv.2023.114719_bib104","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s11064-022-03575-3","article-title":"Electroacupuncture ameliorates cognitive impairment through the inhibition of NLRP3 inflammasome activation by regulating melatonin-mediated mitophagy in stroke rats","volume":"47","author":"Zhong","year":"2022","journal-title":"Neurochem. Res."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323002233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323002233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:09:06Z","timestamp":1758953346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323002233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":104,"alternative-id":["S0147651323002233"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114719","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin ameliorates glyphosate- and hard water-induced renal tubular epithelial cell senescence via PINK1-Parkin-dependent mitophagy","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114719"}}