{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:04:17Z","timestamp":1793045057734,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ecoenv.2023.114805","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T18:22:14Z","timestamp":1679422934000},"page":"114805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Penthorum chinense Pursh compound flavonoids supplementation alleviates Aflatoxin B1-induced liver injury via modulation of intestinal barrier and gut microbiota in broiler"],"prefix":"10.1016","volume":"255","author":[{"given":"Weilai","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazul","family":"Nabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2023.114805_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxicon.2021.02.005","article-title":"Biodegradation of aflatoxin by bacterial species isolated from poultry farms","volume":"195","author":"Ali","year":"2021","journal-title":"Toxicon"},{"key":"10.1016\/j.ecoenv.2023.114805_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/ani9040166","article-title":"Activity and anti-aflatoxigenic effect of indigenously characterized Probiotic Lactobacilli against Aspergillus flavus\u2014a common poultry feed contaminant","volume":"9","author":"Azeem","year":"2019","journal-title":"Animals"},{"key":"10.1016\/j.ecoenv.2023.114805_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1080\/1547691X.2016.1264503","article-title":"Protective role of bentonite against aflatoxin B1- and ochratoxin A-induced immunotoxicity in broilers","volume":"14","author":"Bhatti","year":"2017","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature10814","article-title":"Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities","volume":"482","author":"Boyden","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2023.114805_bib5","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1021\/cr050001f","article-title":"Chemistry and biology of mycotoxins and related fungal metabolites","volume":"109","author":"Br\u00e4se","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ecoenv.2023.114805_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112754","article-title":"Aflatoxin B1 alters meat quality associated with oxidative stress, inflammation, and gut-microbiota in sheep","volume":"225","author":"Cao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114805_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110420","article-title":"Compound probiotics alleviating aflatoxin B(1) and zearalenone toxic effects on broiler production performance and gut microbiota","volume":"194","author":"Chang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114805_bib8","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.00654-21","article-title":"Supplementation with exogenous catalase from penicillium notatum in the diet ameliorates lipopolysaccharide-induced intestinal oxidative damage through affecting intestinal antioxidant capacity and microbiota in weaned pigs","volume":"9","author":"Chen","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.ecoenv.2023.114805_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112438","article-title":"Bacillus amyloliquefaciens B10 inhibits aflatoxin B1-induced cecal inflammation in mice by regulating their intestinal flora","volume":"156","author":"Chen","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib10","article-title":"Chlorogenic acid attenuates oxidative stress-induced intestinal mucosa disruption in weaned pigs","volume":"9","author":"Chen","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.ecoenv.2023.114805_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.701850","article-title":"Domestication and feed restriction programming organ index, dopamine, and hippocampal transcriptome profile in chickens","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.ecoenv.2023.114805_bib12","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1016\/j.psj.2020.09.055","article-title":"Curcumin ameliorates duodenal toxicity of AFB1 in chicken through inducing P-glycoprotein and downregulating cytochrome P450 enzymes","volume":"99","author":"Cheng","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ecoenv.2023.114805_bib13","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.gastro.2020.04.077","article-title":"Contribution of the intestinal microbiome and gut barrier to hepatic disorders","volume":"159","author":"Chopyk","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ecoenv.2023.114805_bib14","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1210\/me.2014-1108","article-title":"Minireview: Gut microbiota: the neglected endocrine organ","volume":"28","author":"Clarke","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib15","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2013.07.004","article-title":"The intestinal crypt, a prototype stem cell compartment","volume":"154","author":"Clevers","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2023.114805_bib16","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/molecules27030970","article-title":"The response surface optimization of supercritical CO(2) modified with ethanol extraction of p-anisic acid from acacia mearnsii flowers and mathematical modeling of the mass transfer","volume":"27","author":"da Silva","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2023.114805_bib17","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.3390\/ani12162042","article-title":"Modulatory effects of arctostaphylos uva-urs extract in ovo injected into broiler embryos contaminated by aflatoxin B1","volume":"12","author":"Elwan","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.ecoenv.2023.114805_bib18","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1080\/10408398.2019.1658570","article-title":"Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited \u2018FAO estimate\u2019 of 25 %","volume":"60","author":"Eskola","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ecoenv.2023.114805_bib19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jama.287.4.425","article-title":"Mycotoxins","volume":"287","author":"Etzel","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.ecoenv.2023.114805_bib20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.addr.2005.01.009","article-title":"Occludin: structure, function and regulation","volume":"57","author":"Feldman","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ecoenv.2023.114805_bib21","first-page":"260","article-title":"Studies on chemical constitutents from Penthorum chinense Pursh","volume":"26","author":"Feng","year":"2001","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.ecoenv.2023.114805_bib22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3390\/molecules22020292","article-title":"Wine flavonoids in health and disease prevention","volume":"22","author":"Fernandes","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2023.114805_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41575-018-0081-y","article-title":"Tales from the crypt: new insights into intestinal stem cells","volume":"16","author":"Gehart","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib24","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jcmgh.2021.02.007","article-title":"Regulation of intestinal barrier function by microbial metabolites","volume":"11","author":"Ghosh","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib25","doi-asserted-by":"crossref","first-page":"29340","DOI":"10.1038\/srep29340","article-title":"In-vivo absorption of pinocembrin-7-O-\u03b2-D-glucoside in rats and its in-vitro biotransformation","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2023.114805_bib26","unstructured":"Guowei, S., Zhu, C., Mingli, S., 2015. Pharmacopoeia of the People's Republic of China. China Medical Science and Technology Press, Beijing, China."},{"key":"10.1016\/j.ecoenv.2023.114805_bib27","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1101\/gr.085464.108","article-title":"Microbial community profiling for human microbiome projects: Tools, techniques, and challenges","volume":"19","author":"Hamady","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.ecoenv.2023.114805_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11130-018-0701-2","article-title":"Functional teas from the stems of penthorum chinense pursh.: phenolic constituents, antioxidant and hepatoprotective activity","volume":"74","author":"He","year":"2019","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.ecoenv.2023.114805_bib29","first-page":"1105","article-title":"Structural analysis and biological toxicity of aflatoxins B1 and B2 degradation products following detoxification by Ocimum basilicum and Cassia fistula aqueous extracts","volume":"7","author":"Iram","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041009","article-title":"Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins","volume":"7","author":"Johansson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2023.114805_bib31","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.7150\/thno.41225","article-title":"An intestinal model with a finger-like villus structure fabricated using a bioprinting process and collagen\/SIS-based cell-laden bioink","volume":"10","author":"Kim","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ecoenv.2023.114805_bib32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.foodchem.2013.07.104","article-title":"Relationship analysis between flavonoids structure and subcritical water extraction (SWE)","volume":"143","author":"Ko","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.ecoenv.2023.114805_bib33","first-page":"27","article-title":"Bioactive properties of extracts from Plectranthus barbatus (Coleus forskohlii) roots received using various extraction methods","author":"Kulbat-Warycha","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2023.114805_bib34","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3748\/wjg.v22.i11.3117","article-title":"Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer","volume":"22","author":"Landy","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib35","article-title":"The role of intestinal flora in the regulation of bone homeostasis","volume":"11","author":"Li","year":"2021","journal-title":"Front. Cell Infect. Microbiol"},{"key":"10.1016\/j.ecoenv.2023.114805_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2020.543698","article-title":"Risk factors for intestinal barrier impairment in patients with essential hypertension","volume":"7","author":"Li","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.ecoenv.2023.114805_bib37","doi-asserted-by":"crossref","first-page":"17109","DOI":"10.1038\/nplants.2017.109","article-title":"Demystifying traditional herbal medicine with modern approach","volume":"3","author":"Li","year":"2017","journal-title":"Nat. Plants"},{"key":"10.1016\/j.ecoenv.2023.114805_bib38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ecoenv.2019.03.089","article-title":"Detection of Aflatoxin adducts as potential markers and the role of curcumin in alleviating AFB1-induced liver damage in chickens","volume":"176","author":"Li","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114805_bib39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ecoenv.2019.03.089","article-title":"Detection of Aflatoxin adducts as potential markers and the role of curcumin in alleviating AFB1-induced liver damage in chickens","volume":"176","author":"Li","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114805_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111725","article-title":"Curcumin protects against Aflatoxin B1-induced liver injury in broilers via the modulation of long non-coding RNA expression","volume":"208","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114805_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12547","article-title":"QingBai decoction regulates intestinal permeability of dextran sulphate sodium-induced colitis through the modulation of notch and NF-\u03baB signalling","volume":"52","author":"Lin","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ecoenv.2023.114805_bib42","first-page":"11","article-title":"Resveratrol relieved acute liver damage in ducks (Anas platyrhynchos) induced by AFB1 via modulation of apoptosis and Nrf2 signaling pathways","author":"Liu","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.ecoenv.2023.114805_bib43","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3382\/ps\/pex342","article-title":"Effect of yeast cell wall on the growth performance and gut health of broilers challenged with aflatoxin B1 and necrotic enteritis","volume":"97","author":"Liu","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ecoenv.2023.114805_bib44","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/mi.2013.118","article-title":"Mouse and human Notch-1 regulate mucosal immune responses","volume":"7","author":"Mathern","year":"2014","journal-title":"Mucosal Immunol."},{"issue":"22","key":"10.1016\/j.ecoenv.2023.114805_bib45","article-title":"Chemical constituents of penthorum chinense pursh","volume":"48","author":"Ming","year":"2013","journal-title":"Chin. Pharm. J."},{"key":"10.1016\/j.ecoenv.2023.114805_bib46","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.bbrc.2013.12.061","article-title":"Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells","volume":"443","author":"Murano","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2023.114805_bib47","doi-asserted-by":"crossref","unstructured":"Nabi, F., Tao, W., Ye, R., Li, Z., Lu, Q., Shang, Y., Hu, Y., Fang, J., Bhutto, Z.A., Liu, J., 2022. Penthorum chinense Pursh Extract Alleviates Aflatoxin B1-Induced Liver Injury and Oxidative Stress Through Mitochondrial Pathways in Broilers. 9.","DOI":"10.3389\/fvets.2022.822259"},{"key":"10.1016\/j.ecoenv.2023.114805_bib48","doi-asserted-by":"crossref","first-page":"4254051","DOI":"10.1155\/2023\/4254051","article-title":"An updated review on efficiency of penthorum chinense pursh in traditional uses, toxicology, and clinical trials","volume":"2023","author":"Nabi","year":"2023","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.ecoenv.2023.114805_bib49","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.tcb.2020.08.004","article-title":"Tight junction structure and function revisited","volume":"30","author":"Otani","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib50","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1136\/gutjnl-2020-322260","article-title":"Mucus barrier, mucins and gut microbiota: the expected slimy partners?","volume":"69","author":"Paone","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.ecoenv.2023.114805_bib51","unstructured":"papillomaviruses, W.H.O.Jh, 2000. IARC monograph on the evaluation of carcinogenic risks to humans."},{"key":"10.1016\/j.ecoenv.2023.114805_bib52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12182","article-title":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ecoenv.2023.114805_bib53","doi-asserted-by":"crossref","first-page":"9254","DOI":"10.3390\/ijms21239254","article-title":"Secretory IgA in intestinal mucosal secretions as an adaptive barrier against microbial cells","volume":"21","author":"Pietrzak","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2023.114805_bib54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10856-010-4178-2","article-title":"Synthesis and characterization of gelatin nanoparticles using CDI\/NHS as a non-toxic cross-linking system","volume":"22","author":"Qazvini","year":"2011","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"937\u2013952","key":"10.1016\/j.ecoenv.2023.114805_bib55","article-title":"Mechanosensation of tight junctions depends on ZO-1 phase separation and flow","volume":"179","author":"Schwayer","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2023.114805_bib56","first-page":"20","article-title":"Oxidative stress: role and response of short guanine tracts at genomic locations","author":"Singh","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2023.114805_bib57","doi-asserted-by":"crossref","first-page":"972","DOI":"10.3390\/ijms21030972","article-title":"The integral role of tight junction proteins in the repair of injured intestinal epithelium","volume":"21","author":"Slifer","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2023.114805_bib58","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/toxins11020112","article-title":"The effect of probiotic supplementation on performance and the histopathological changes in liver and kidneys in broiler chickens fed diets with aflatoxin B\u2081","volume":"11","author":"\u015ali\u017cewska","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2023.114805_bib59","first-page":"11","article-title":"Evaluation of cellulosic polymers and curcumin to reduce aflatoxin B1 toxic effects on performance, biochemical, and immunological parameters of broiler chickens","author":"Solis-Cruz","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.ecoenv.2023.114805_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijfoodmicro.2019.108376","article-title":"Aflatoxin-producing fungi associated with pre-harvest maize contamination in Uganda","volume":"313","author":"Sserumaga","year":"2020","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib61","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-020-2039-9","article-title":"Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier","volume":"579","author":"Talbot","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2023.114805_bib62","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/ani12050569","article-title":"Hepatoprotective Effect of the Penthorum chinense Pursh Extract against the CCl4-Induced Acute Liver Injury via NF-\u03baB and p38-MAPK PATHWAYS in Dogs","volume":"12","author":"Tao","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.ecoenv.2023.114805_bib63","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41577-019-0198-4","article-title":"The intestinal microbiota fuelling metabolic inflammation","volume":"20","author":"Tilg","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib64","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib65","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib66","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1080\/10408398.2018.1433629","article-title":"Influence of functional food components on gut health","volume":"59","author":"Wan","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ecoenv.2023.114805_bib67","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1142\/S0192415X15500378","article-title":"Traditional chinese herbal medicine penthorum chinense pursh: a phytochemical and pharmacological review","volume":"43","author":"Wang","year":"2015","journal-title":"Am. J. Chin. Med"},{"key":"10.1016\/j.ecoenv.2023.114805_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112569","article-title":"A review of Penthorum chinense Pursh for hepatoprotection: traditional use, phytochemistry, pharmacology, toxicology and clinical trials","volume":"251","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib69","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jep.2012.07.033","article-title":"Compatibility art of traditional Chinese medicine: from the perspective of herb pairs","volume":"143","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112624","article-title":"Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2\/GST pathway and regulating mitochondrial pathway","volume":"224","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114805_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113805","article-title":"Ferulic acid alleviates AFB1-induced duodenal barrier damage in rats via up-regulating tight junction proteins, down-regulating ROCK, competing CYP450 enzyme and activating GST","volume":"241","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114805_bib72","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3382\/ps\/pey358","article-title":"Water-soluble substances of wheat: a potential preventer of aflatoxin B1-induced liver damage in broilers","volume":"98","author":"Wang","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ecoenv.2023.114805_bib73","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1017\/S0007114510005660","article-title":"Intestinal barrier function and absorption in pigs after weaning: a review","volume":"105","author":"Wijtten","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ecoenv.2023.114805_bib74","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-4274(85)90038-4","article-title":"Uptake and vascular transport of ingested aflatoxin","volume":"29","author":"Wilson","year":"1985","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2023.114805_bib75","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12011-018-1623-4","article-title":"The protective role of selenium against AFB(1)-induced liver apoptosis by death receptor pathway in broilers","volume":"191","author":"Wu","year":"2019","journal-title":"Biol. Trace Elem. Res"},{"key":"10.1016\/j.ecoenv.2023.114805_bib76","first-page":"27","article-title":"Optimization of ultrasonic-assisted extraction of total flavonoids from abrus cantoniensis (abriherba) by response surface methodology and evaluation of its anti-inflammatory effect","author":"Wu","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ecoenv.2023.114805_bib77","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/516S7a","article-title":"Perspective: time to face the fungal threat","volume":"516","author":"Wu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ecoenv.2023.114805_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119241","article-title":"Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity \u2013 a review","volume":"304","author":"Wu","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2023.114805_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112213","article-title":"AFB(1)-induced mice liver injury involves mitochondrial dysfunction mediated by mitochondrial biogenesis inhibition","volume":"216","author":"Xu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114805_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.685540","article-title":"Effects of dietary yucca schidigera extract and oral candida utilis on growth performance and intestinal health of weaned piglets","volume":"8","author":"Yang","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ecoenv.2023.114805_bib81","article-title":"Ameliorative effects of Lactobacillus against Aflatoxin B1","volume":"84","author":"Yasmeen","year":"2021","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111938","article-title":"Dietary Se deficiency dysregulates metabolic and cell death signaling in aggravating the AFB1 hepatotoxicity of chicks","volume":"149","author":"Zhao","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.114805_bib83","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1017\/S0007114516001100","article-title":"Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing hormone\/corticotropin-releasing hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge","volume":"115","author":"Zhu","year":"2016","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ecoenv.2023.114805_bib84","first-page":"267","article-title":"Inverse miniemulsion method for synthesis of gelatin nanoparticles in presence of CDI\/NHS as a non-toxic cross-linking system","volume":"4","author":"Zinatloo-Ajabshir","year":"2014","journal-title":"J. Nanostruct."},{"key":"10.1016\/j.ecoenv.2023.114805_bib85","doi-asserted-by":"crossref","first-page":"24695","DOI":"10.1016\/j.ceramint.2022.05.116","article-title":"Facile fabrication of efficient Pr2Ce2O7 ceramic nanostructure for enhanced photocatalytic performances under solar light","volume":"48","author":"Zinatloo-Ajabshir","year":"2022","journal-title":"Ceram. Int."},{"key":"10.1016\/j.ecoenv.2023.114805_bib86","first-page":"784","article-title":"Preparation and characterization of curcumin niosomal nanoparticles via a simple and eco-friendly route","volume":"9","author":"Zinatloo-Ajabshir","year":"2019","journal-title":"J. Nanostruct."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323003093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323003093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:15:58Z","timestamp":1758953758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323003093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":86,"alternative-id":["S0147651323003093"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114805","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Penthorum chinense Pursh compound flavonoids supplementation alleviates Aflatoxin B1-induced liver injury via modulation of intestinal barrier and gut microbiota in broiler","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114805"}}