{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:55:40Z","timestamp":1782942940057,"version":"3.54.5"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T00:00:00Z","timestamp":1680912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901463"],"award-info":[{"award-number":["81901463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.ecoenv.2023.114892","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T14:46:26Z","timestamp":1681310786000},"page":"114892","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Di-n-butyl phthalate induces oversecretion of vascular endothelium-derived NAP-2 and promotes epithelial-mesenchymal transition of urothelial cells in newborn hypospadias rats"],"prefix":"10.1016","volume":"256","author":[{"given":"Shan","family":"Hua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqiao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2023.114892_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131013","article-title":"Disruption of the blood-brain barrier and its close environment following adult exposure to low doses of di(2-ethylhexyl)phthalate alone or in an environmental phthalate mixture in male mice","volume":"282","author":"Ahmadpour","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.114892_bib2","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1001\/jamapediatrics.2018.3115","article-title":"Association of prenatal phthalate exposure with language development in early childhood","volume":"172","author":"Bornehag","year":"2018","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.ecoenv.2023.114892_bib3","first-page":"330","article-title":"Do endocrine disruptors cause hypospadias?","volume":"3","author":"Botta","year":"2014","journal-title":"Transl. Androl. Urol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib4","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1002\/jcp.25797","article-title":"Epithelial-mesenchymal transition (EMT): a biological process in the development, stem cell differentiation, and tumorigenesis","volume":"232","author":"Chen","year":"2017","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib5","doi-asserted-by":"crossref","first-page":"8265","DOI":"10.1038\/s41598-017-08047-1","article-title":"An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2023.114892_bib6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/1746-6148-8-216","article-title":"Overexpression of chemokine ligand 7 is associated with the progression of canine transmissible venereal tumor","volume":"8","author":"Chiang","year":"2012","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.ecoenv.2023.114892_bib7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.trecan.2016.11.008","article-title":"Targeting TGF-beta signaling in cancer","volume":"3","author":"Colak","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.ecoenv.2023.114892_bib8","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1038\/sj.onc.1204801","article-title":"Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcription of nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells","volume":"20","author":"Delarue","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ecoenv.2023.114892_bib9","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1111\/1750-3841.14171","article-title":"Plasticizers and BPA residues in tunisian and italian culinary herbs and spices","volume":"83","author":"Di Bella","year":"2018","journal-title":"J. Food Sci."},{"key":"10.1016\/j.ecoenv.2023.114892_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12964-022-00879-3","article-title":"The ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells","volume":"20","author":"Ding","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ecoenv.2023.114892_bib11","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3892\/ol.2015.2881","article-title":"Cross-talk between endothelial and tumor cells via basic fibroblast growth factor and vascular endothelial growth factor signaling promotes lung cancer growth and angiogenesis","volume":"9","author":"Du","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ecoenv.2023.114892_bib12","unstructured":"EDSP Chronology. Available online: \u3008http:\/\/www.epa.gov\/endo\/pubs\/edspoverview\/chronology.htm\u3009."},{"key":"10.1016\/j.ecoenv.2023.114892_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/cbf.3447","article-title":"Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-beta signals","volume":"38","author":"Fan","year":"2020","journal-title":"Cell Biochem Funct."},{"key":"10.1016\/j.ecoenv.2023.114892_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.neuropharm.2013.08.004","article-title":"Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS\/RhoA\/PI3K\/PKB signaling pathway","volume":"75","author":"Gu","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ecoenv.2023.114892_bib15","article-title":"Fetal and childhood exposure to phthalate diesters and cognitive function in children up to 12 years of age: Taiwanese maternal and infant cohort study","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2023.114892_bib16","doi-asserted-by":"crossref","first-page":"18251","DOI":"10.1038\/s41598-020-75184-5","article-title":"Evaluation of surgical procedures of mouse urethra by visualization and the formation of fistula","volume":"10","author":"Hyuga","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2023.114892_bib17","doi-asserted-by":"crossref","first-page":"H1044","DOI":"10.1152\/ajpheart.00364.2017","article-title":"Plastics and cardiovascular health: phthalates may disrupt heart rate variability and cardiovascular reactivity","volume":"313","author":"Jaimes","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib18","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tox.2007.01.018","article-title":"Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP)","volume":"232","author":"Jiang","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.114892_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tox.2015.10.006","article-title":"Reduced Fgf10\/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): a study on the local and systemic toxicology of DBP","volume":"338","author":"Jiang","year":"2015","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.114892_bib20","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1002\/jcp.27350","article-title":"The genetic factors contributing to hypospadias and their clinical utility in its diagnosis","volume":"234","author":"Joodi","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ng1295-415","article-title":"Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction","volume":"11","author":"Kaartinen","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ecoenv.2023.114892_bib22","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1289\/ehp.1409535","article-title":"Endocrine-disrupting chemicals and oil and natural gas operations: potential environmental contamination and recommendations to assess complex environmental mixtures","volume":"124","author":"Kassotis","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.114892_bib23","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.3390\/ijms23073938","article-title":"Di-(2-ethylhexyl) phthalate triggers proliferation, migration, stemness, and epithelial-mesenchymal transition in human endometrial and endometriotic epithelial cells via the transforming growth factor-beta\/smad signaling pathway","volume":"23","author":"Kim","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2023.114892_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2131\/jts.44.237","article-title":"Di(2-ethylhexyl) phthalate promotes lung cancer cell line A549 progression via Wnt\/beta-catenin signaling","volume":"44","author":"Kim","year":"2019","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2023.114892_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11626-013-9712-3","article-title":"Upregulation of GM-CSF by TGF-beta1 in epithelial mesenchymal transition of human HERS\/ERM cells","volume":"50","author":"Lee","year":"2014","journal-title":"Vitr. Cell Dev. Biol. Anim."},{"key":"10.1016\/j.ecoenv.2023.114892_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147990","article-title":"Low-dose mono(2-ethylhexyl) phthalate promotes ovarian cancer development through PPARalpha-dependent PI3K\/Akt\/NF-kappaB pathway","volume":"790","author":"Leng","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.114892_bib27","article-title":"The chemokine CXCL7 is related to angiogenesis and associated with poor prognosis in colorectal cancer patients","volume":"11","author":"Li","year":"2021","journal-title":"Front Oncol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12870-017-1091-6","article-title":"Comparative transcriptome analysis reveals differentially expressed genes associated with sex expression in garden asparagus (Asparagus officinalis)","volume":"17","author":"Li","year":"2017","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3892\/etm.2013.1125","article-title":"The Rho\/Rho-associated protein kinase inhibitor fasudil in the protection of endothelial cells against advanced glycation end products through the nuclear factor kappaB pathway","volume":"6","author":"Lu","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ecoenv.2023.114892_bib30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12964-019-0434-3","article-title":"CXCL1-LCN2 paracrine axis promotes progression of prostate cancer via the Src activation and epithelial-mesenchymal transition","volume":"17","author":"Lu","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ecoenv.2023.114892_bib31","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/eurheartj\/ehac112","article-title":"Vascular dysfunction and increased cardiovascular risk in hypospadias","volume":"43","author":"Lucas-Herald","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ecoenv.2023.114892_bib32","doi-asserted-by":"crossref","first-page":"9635","DOI":"10.1021\/acs.jafc.8b03558","article-title":"Cell motility facilitated by mono(2-ethylhexyl) phthalate via activation of the AKT-beta-catenin-IL-8 axis in colorectal cancer","volume":"66","author":"Luo","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ecoenv.2023.114892_bib33","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1182\/blood-2015-09-672014","article-title":"N-linked glycan stabilization of the VWF A2 domain","volume":"127","author":"Lynch","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.ecoenv.2023.114892_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1210\/edrv.22.3.0432","article-title":"Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals","volume":"22","author":"McLachlan","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ecoenv.2023.114892_bib35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-beta: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib36","doi-asserted-by":"crossref","first-page":"a021873","DOI":"10.1101\/cshperspect.a021873","article-title":"TGF-beta and the TGF-beta family: context-dependent roles in cell and tissue physiology","volume":"8","author":"Morikawa","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib37","article-title":"ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis","volume":"4","author":"Nalkurthi","year":"2022","journal-title":"JHEP Rep."},{"key":"10.1016\/j.ecoenv.2023.114892_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","article-title":"Emt: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2023.114892_bib39","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jamapediatrics.2018.1492","article-title":"Association of in utero exposure to polybrominated diphenyl ethers with the risk of hypospadias","volume":"172","author":"Poon","year":"2018","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.ecoenv.2023.114892_bib40","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1289\/ehp.1205056","article-title":"Phthalate exposure changes the metabolic profile of cardiac muscle cells","volume":"120","author":"Posnack","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.114892_bib41","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.24152","article-title":"Prevalence and clustering of congenital heart defects among boys with hypospadias","volume":"5","author":"Richard","year":"2022","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.ecoenv.2023.114892_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122869","article-title":"TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells","volume":"398","author":"Shan","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2023.114892_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127725","article-title":"TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells","volume":"424","author":"Shan","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.ecoenv.2023.114892_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.toxlet.2021.12.006","article-title":"Integration of data from the in vitro long-term exposure study on human endothelial cells and the in silico analysis: a case of dibutyl phthalate-induced vascular dysfunction","volume":"356","author":"Stanic","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2023.114892_bib45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cmet.2012.01.009","article-title":"Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells","volume":"15","author":"Wang","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.ecoenv.2023.114892_bib46","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1055\/s-0042-110859","article-title":"Rutin prevents high glucose-induced renal glomerular endothelial hyperpermeability by inhibiting the ROS\/Rhoa\/ROCK signaling pathway","volume":"82","author":"Wang","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.ecoenv.2023.114892_bib47","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s41419-021-04231-4","article-title":"Monocytes secrete CXCL7 to promote breast cancer progression","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2023.114892_bib48","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.3390\/cancers12123526","article-title":"Visfatin enhances breast cancer progression through CXCL1 induction in tumor-associated macrophages","volume":"12","author":"Wang","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ecoenv.2023.114892_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2017.04.004","article-title":"Promotion of Wilms' tumor cells migration and invasion by mono-2-ethyhexyl phthalate (MEHP) via activation of NF-kappaB signals","volume":"270","author":"Wang","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ecoenv.2023.114892_bib50","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.jacc.2019.06.069","article-title":"Early-life environmental exposures and blood pressure in children","volume":"74","author":"Warembourg","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157443","article-title":"Adverse cardiovascular effects and potential molecular mechanisms of DEHP and its metabolites-a review","volume":"847","author":"Wen","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.114892_bib52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/toxsci\/kfy094","article-title":"Plasticizer Di-(2-ethylhexyl)phthalate induces epithelial-to-mesenchymal transition and renal fibrosis in vitro and in vivo","volume":"164","author":"Wu","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ecoenv.2023.114892_bib53","article-title":"Multifaceted roles of chemokine C-X-C motif ligand 7 in inflammatory diseases and cancer","volume":"13","author":"Wu","year":"2022","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153213","article-title":"Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-kappaB\/COX-2\/RANKL signaling in Sertoli cells","volume":"474","author":"Xie","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.114892_bib55","doi-asserted-by":"crossref","first-page":"7047","DOI":"10.1002\/jcp.26628","article-title":"Photochemical tissue bonding promotes the proliferation and migration of injured tenocytes through ROS\/RhoA\/NF-kappaB\/Dynamin 2 signaling pathway","volume":"233","author":"Yao","year":"2018","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ecoenv.2023.114892_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152573","article-title":"Activation of the RhoA\/ROCK pathway contributes to renal fibrosis in offspring rats induced by maternal exposure to di-n-butyl phthalate","volume":"443","author":"Ye","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.114892_bib57","doi-asserted-by":"crossref","first-page":"eabd1206","DOI":"10.1126\/scitranslmed.abd1206","article-title":"Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis","volume":"13","author":"Zhang","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ecoenv.2023.114892_bib58","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1089\/ars.2009.2908","article-title":"Mechanical strain-induced RhoA activation requires NADPH oxidase-mediated ROS generation in caveolae","volume":"13","author":"Zhang","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ecoenv.2023.114892_bib59","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tox.2018.07.013","article-title":"Maternal exposure to di-n-butyl phthalate (DBP) promotes epithelial-mesenchymal transition via regulation of autophagy in uroepithelial cell","volume":"406\u2013407","author":"Zhao","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.114892_bib60","first-page":"2408","article-title":"Vascularization of vessel pedicle in hypospadias and its relationship to near-period complications","volume":"16","author":"Zhao","year":"2018","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.ecoenv.2023.114892_bib61","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2023.114892_bib62","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tox.2009.03.017","article-title":"Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP)","volume":"260","author":"Zhu","year":"2009","journal-title":"Toxicology"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323003962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323003962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:16:59Z","timestamp":1758953819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323003962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":62,"alternative-id":["S0147651323003962"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114892","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Di-n-butyl phthalate induces oversecretion of vascular endothelium-derived NAP-2 and promotes epithelial-mesenchymal transition of urothelial cells in newborn hypospadias rats","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114892","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114892"}}