{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:05:22Z","timestamp":1790305522725,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T00:00:00Z","timestamp":1682726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.ecoenv.2023.114973","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T06:55:52Z","timestamp":1683528952000},"page":"114973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Oleanolic acid inhibits mercury chloride induced-liver ferroptosis by regulating ROS\/iron overload"],"prefix":"10.1016","volume":"258","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-2828","authenticated-orcid":false,"given":"Chuan","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ecoenv.2023.114973_bib1","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1007\/s11356-018-04062-5","article-title":"Mercury chloride toxicity in human erythrocytes: enhanced generation of ROS and RNS, hemoglobin oxidation, impaired antioxidant power, and inhibition of plasma membrane redox system","volume":"26","author":"Ahmad","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2023.114973_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccr.2020.213343","article-title":"Sulfhydryl groups as targets of mercury toxicity","volume":"417","author":"Ajsuvakova","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ecoenv.2023.114973_bib3","article-title":"Flaxseed oil ameliorates mercuric chloride-induced liver damage in rats","volume":"25","author":"AlRamadneh","year":"2022","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib4","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib5","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2174\/1874467213999201230211544","article-title":"Hypotensive effects of the triterpene oleanolic acid for cardiovascular prevention","volume":"14","author":"Antonio","year":"2021","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jtemb.2019.07.011","article-title":"Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis","volume":"56","author":"Cuneyt","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib7","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1289\/ehp.9918","article-title":"Relationship of blood mercury levels to health parameters in the loggerhead sea turtle (Caretta caretta)","volume":"115","author":"Day","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.114973_bib8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s10661-019-7743-2","article-title":"Sources, toxicity, and remediation of mercury: an essence review","volume":"191","author":"Deep","year":"2019","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.ecoenv.2023.114973_bib9","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.18632\/aging.103378","article-title":"Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1","volume":"12","author":"Dong","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.ecoenv.2023.114973_bib10","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1016\/j.psj.2020.08.031","article-title":"Selenium relieves oxidative stress, inflammation, and apoptosis within spleen of chicken exposed to mercuric chloride","volume":"99","author":"Fan","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ecoenv.2023.114973_bib11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s11418-021-01491-4","article-title":"Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1\/Nrf2-ARE signaling pathway to reduce ferroptosis","volume":"75","author":"Gao","year":"2021","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.ecoenv.2023.114973_bib12","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2023.114973_bib13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2020.04.001","article-title":"Lytic cell death in metabolic liver disease","volume":"73","author":"Gautheron","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2478\/intox-2014-0009","article-title":"Toxicity, mechanism and health effects of some heavymetals","volume":"7","author":"Jaishankar","year":"2014","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbrc.2021.01.028","article-title":"Oleanolic acid inhibits cervical cancer Hela cell proliferation through modulation of the ACSL4 ferroptosis signaling pathway","volume":"545","author":"Jiang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ecoenv.2023.114973_bib16","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1089\/ars.2017.7176","article-title":"The roles of NRF2 in modulating cellular iron homeostasis","volume":"29","author":"Kerins","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"55","key":"10.1016\/j.ecoenv.2023.114973_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/hep.24706","article-title":"Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease","volume":"2012","author":"Kowdley","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.ecoenv.2023.114973_bib18","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/cbf.3046","article-title":"Preventive effects of ZPDC glycoprotein (24 kDa) on hepatotoxicity induced by mercury chloride in vitro and in vivo","volume":"32","author":"Lee","year":"2014","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.ecoenv.2023.114973_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2023.114973_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111426","article-title":"Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2\/HO-1 pathway","volume":"208","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.114973_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.chemosphere.2019.06.096","article-title":"Exploring the kidney hazard of exposure to mercuric chloride in mice:disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis","volume":"234","author":"Li","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.114973_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jep.2005.05.024","article-title":"Oleanolic acid and ursolic acid: research perspectives","volume":"100","author":"Liu","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib23","doi-asserted-by":"crossref","first-page":"5361241","DOI":"10.1155\/2022\/5361241","article-title":"Vitamin C sensitizes pancreatic cancer cells to erastin-induced ferroptosis by activating the AMPK\/Nrf2\/HMOX1 pathway","volume":"19","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2023.114973_bib24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.toxlet.2014.09.027","article-title":"Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2","volume":"232","author":"Lu","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2023.114973_bib25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000514843","article-title":"Trimetazidine protects from mercuryinduced kidney injury","volume":"106","author":"Mar\u00eda","year":"2021","journal-title":"Pharmacology"},{"key":"10.1016\/j.ecoenv.2023.114973_bib26","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Matthew","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib28","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/15287394.2018.1474153","article-title":"Copper attenuates early and late biochemical alterations induced by inorganic mercury in young rats","volume":"81","author":"Moraes-Silva","year":"2018","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.ecoenv.2023.114973_bib29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/14756360701633187","article-title":"Oleanolic acid and related derivativesas medicinally important compounds","volume":"23","author":"Nighat","year":"2008","journal-title":"J. Enzym. Inhib. Med Chem."},{"key":"10.1016\/j.ecoenv.2023.114973_bib30","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1186\/s13054-014-0460-x","article-title":"Vitamin C revisited","volume":"18","author":"Oudemans-van Straaten","year":"2014","journal-title":"Crit. Care"},{"key":"10.1016\/j.ecoenv.2023.114973_bib31","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/CAD.0b013e328330fd90","article-title":"Triterpenoids as newpromisinganticancerdrugs","volume":"20","author":"Petronelli","year":"2009","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.ecoenv.2023.114973_bib32","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bcp.2008.12.028","article-title":"Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes","volume":"77","author":"Reisman","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/jbt.10074","article-title":"Relationship between expression of HSP70 and metallothionein and oxidative stress during mercury chloride induced acute liver injury in rats","volume":"17","author":"Reus","year":"2003","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0378-8741(02)00332-X","article-title":"Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves","volume":"84","author":"Somova","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib35","first-page":"5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"13","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2023.114973_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biopha.2018.06.060","article-title":"Magnesium isoglycyrrhizinate amelorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signal pathway","volume":"106","author":"Sui","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ecoenv.2023.114973_bib37","first-page":"317","article-title":"Rugulation of ferroptotic cancer cell death by Gpx4","author":"Wan","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ecoenv.2023.114973_bib38","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mce.2013.06.014","article-title":"Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects","volume":"376","author":"Wang","year":"2013","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.ecoenv.2023.114973_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2015.11.004","article-title":"The mechanisms associated with the development of hypertension after exposure to lead, mercury species or their mixtures differs with metal and the mixture ratio","volume":"339","author":"Wildemann","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.114973_bib40","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41420-021-00660-4","article-title":"Ferroptosis in liver disease: new insights into disease mechanisms","volume":"7","author":"Wu","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ecoenv.2023.114973_bib41","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11373-007-9216-9","article-title":"A novel synthetic oleanolic acid derivative (CPU-II2) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells","volume":"15","author":"Wu","year":"2008","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ecoenv.2023.114973_bib42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3390\/ijms18030553","article-title":"A new oleanolic acid derivative against CCl4-induced hepatic fibrosis in rats","volume":"18","author":"Xiang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2023.114973_bib43","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41419-020-2334-2","article-title":"Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure","volume":"11","author":"Yamada","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ecoenv.2023.114973_bib44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mrfmmm.2006.03.008","article-title":"Protective effects of ursolic acid and oleanolic acid in leukemic cells","volume":"600","author":"Zdenka","year":"2006","journal-title":"Mutat. Res"},{"key":"10.1016\/j.ecoenv.2023.114973_bib45","doi-asserted-by":"crossref","first-page":"40982","DOI":"10.18632\/oncotarget.17334","article-title":"Dietary luteolin attenuates chronic liver injury induced by mercuric chloride via the Nrf2\/NF-\u03baB\/P53 signaling pathway in rats","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ecoenv.2023.114973_bib46","first-page":"3641","article-title":"Oleanolic acid protects against oxidative stressinduced human umbilical vein endothelial cell injury by activating AKT\/eNOS signaling","volume":"18","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ecoenv.2023.114973_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/mtomcs\/mfab072","article-title":"Gut microbiota-mediated ferroptosis contributes to mercury exposure-induced brain injury in common carp","volume":"14","author":"Zhang","year":"2022","journal-title":"Metallomics"},{"key":"10.1016\/j.ecoenv.2023.114973_bib48","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1080\/15548627.2019.1687985","article-title":"RNA binding protein ZFP36\/TTP, protect against ferroptosis by regulating autophagy signaling pathway","volume":"16","author":"Zhang","year":"2019","journal-title":"Autophagy"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323004773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323004773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:13:45Z","timestamp":1758953625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323004773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":48,"alternative-id":["S0147651323004773"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114973","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oleanolic acid inhibits mercury chloride induced-liver ferroptosis by regulating ROS\/iron overload","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.114973","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114973"}}