{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:20:22Z","timestamp":1789788022034,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.ecoenv.2023.115030","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T11:53:09Z","timestamp":1684583589000},"page":"115030","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Prenatal exposure to bisphenol AF induced male offspring reproductive dysfunction by triggering testicular innate and adaptive immune responses"],"prefix":"10.1016","volume":"259","author":[{"given":"Senlin","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenrui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-1305","authenticated-orcid":false,"given":"Wei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2023.115030_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/1573412052953328","article-title":"Enantioselective toxicity and carcinogenesis","volume":"1","author":"Ali","year":"2005","journal-title":"Curr. Pharm. Anal."},{"key":"10.1016\/j.ecoenv.2023.115030_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2174\/157488512800389164","article-title":"Thalidomide: a banned drug resurged into future anticancer drug","volume":"7","author":"Ali","year":"2012","journal-title":"Curr. Drug Ther."},{"key":"10.1016\/j.ecoenv.2023.115030_bib3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.molliq.2017.03.112","article-title":"Insights into the pharmacology of new heterocycles embedded with oxopyrrolidine rings: DNA binding, molecular docking, and anticancer studies","volume":"234","author":"Ali","year":"2017","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ecoenv.2023.115030_bib4","article-title":"Progress in polymeric nano-medicines for theranostic cancer treatment","volume":"12","author":"Ali","year":"2020","journal-title":"Polym. (Basel)"},{"key":"10.1016\/j.ecoenv.2023.115030_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.743991","article-title":"Effects of bisphenols on RACK1 expression and their immunological implications in THP-1 cells","volume":"12","author":"Buoso","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12958-018-0447-6","article-title":"\"Bisphenol a: an emerging threat to male fertility\"","volume":"17","author":"Cariati","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/andr.12656","article-title":"Immune mechanisms and possible immune therapy in testicular germ cell tumours","volume":"7","author":"Chovanec","year":"2019","journal-title":"Andrology"},{"key":"10.1016\/j.ecoenv.2023.115030_bib8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.toxlet.2012.03.802","article-title":"Bisphenol AF may cause testosterone reduction by directly affecting testis function in adult male rats","volume":"211","author":"Feng","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2023.115030_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130213","article-title":"Comparison of the materno-fetal transfer of fifteen structurally related bisphenol analogues using an ex vivo human placental perfusion model","volume":"276","author":"G\u00e9ly","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.115030_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.113747","article-title":"Sex-dependent and long-lasting effects of bisphenol AF exposure on emotional behaviors in mice","volume":"249","author":"Gong","year":"2022","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ecoenv.2023.115030_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-0378(02)00016-5","article-title":"Macrophages and the immune responsiveness of the testis","volume":"57","author":"Hedger","year":"2002","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib12","article-title":"Bisphenol AF induces apoptosis via estrogen receptor beta (ER\u03b2) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN","volume":"270","author":"Huang","year":"2021","journal-title":"Environ. Pollut. Barking Essex 1987"},{"key":"10.1016\/j.ecoenv.2023.115030_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/153537020623100101","article-title":"Physiologic interactions between macrophages and Leydig cells","volume":"231","author":"Hutson","year":"2006","journal-title":"Exp. Biol. Med. Maywood N. J."},{"key":"10.1016\/j.ecoenv.2023.115030_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157793","article-title":"New insights into the effect of bisphenol AF exposure on maternal mammary glands at various stages of gestation in mice","volume":"850","author":"Ji","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.115030_bib15","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00244-015-0199-7","article-title":"Maternal transfer of bisphenol A during nursing causes sperm impairment in male offspring","volume":"70","author":"Kalb","year":"2016","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.715723","article-title":"Type I interferon induction in cutaneous DNA damage syndromes","volume":"12","author":"Klein","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1741-4520.2010.00279.x","article-title":"Dietary exposure to low doses of bisphenol A: effects on reproduction and development in two generations of C57BL\/6J mice","volume":"50","author":"Kobayashi","year":"2010","journal-title":"Congenit. Anom."},{"key":"10.1016\/j.ecoenv.2023.115030_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ecoenv.2023.115030_bib20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.chemosphere.2016.08.059","article-title":"Gestational and lactational exposure to bisphenol AF in maternal rats increases testosterone levels in 23-day-old male offspring","volume":"163","author":"Li","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.115030_bib21","series-title":"Encyclopedia of Reproduction","first-page":"215","article-title":"Leydig Cell Androgen Synthesis","author":"Li","year":"2018"},{"key":"10.1016\/j.ecoenv.2023.115030_bib22","series-title":"The Immune Response","first-page":"247","article-title":"10 - MHC: The major histocompatibility complex","author":"Mak","year":"2006"},{"key":"10.1016\/j.ecoenv.2023.115030_bib23","first-page":"93","article-title":"Perinatal oral exposure to low doses of bisphenol A, S or F impairs immune functions at intestinal and systemic levels in female offspring mice","volume":"19","author":"Malais\u00e9","year":"2020","journal-title":"Environ. Health. a Glob. Access Sci. Source"},{"key":"10.1016\/j.ecoenv.2023.115030_bib24","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1289\/ehp.0901819","article-title":"Bisphenol AF is a full agonist for the estrogen receptor ERalpha but a highly specific antagonist for ERbeta","volume":"118","author":"Matsushima","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115030_bib25","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-065X.2011.01025.x","article-title":"Innate immunity in allergic disease","volume":"242","author":"Minnicozzi","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ecoenv.2023.115030_bib26","doi-asserted-by":"crossref","first-page":"10201","DOI":"10.1128\/JVI.00419-07","article-title":"Alpha interferon enhances TRIM5alpha-mediated antiviral activities in human and rhesus monkey cells","volume":"81","author":"Sakuma","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib27","first-page":"56","article-title":"Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis","volume":"265","author":"Salian","year":"2009"},{"key":"10.1016\/j.ecoenv.2023.115030_bib28","doi-asserted-by":"crossref","unstructured":"S. Song.\u00a0et al. Perinatal BPA exposure induces hyperglycemia, oxidative stress and decreased adiponectin production in later life of male rat offspring 11 2014 3728 3742.","DOI":"10.3390\/ijerph110403728"},{"key":"10.1016\/j.ecoenv.2023.115030_bib29","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ecoenv.2018.11.101","article-title":"Serum concentrations of bisphenol A and its alternatives in elderly population living around e-waste recycling facilities in China: Associations with fasting blood glucose","volume":"169","author":"Song","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.115030_bib30","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1021\/acs.jproteome.9b00548","article-title":"Bisphenol A activates an innate viral immune response pathway","volume":"19","author":"Sowers","year":"2020","journal-title":"J. Proteome Res"},{"key":"10.1016\/j.ecoenv.2023.115030_bib31","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2023.115030_bib32","unstructured":"Swan, S.H., Kristensen, D.M., Anogenital Distance: A Marker of Steroidal Endocrine Disruption. 2014."},{"key":"10.1016\/j.ecoenv.2023.115030_bib33","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/35073080","article-title":"A weak signal for strong responses: interferon-alpha\/beta revisited","volume":"2","author":"Taniguchi","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116069","article-title":"In utero bisphenol AF exposure causes fetal Leydig cell dysfunction and induces multinucleated gonocytes by generating oxidative stress and reducing the SIRT1\/PGC1\u03b1 signals","volume":"447","author":"Tian","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcdb.2016.03.003","article-title":"Development, function and fate of fetal Leydig cells","volume":"59","author":"Wen","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124410","article-title":"Bisphenol AF compromises blood-testis barrier integrity and sperm quality in mice","volume":"237","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.115030_bib37","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1007\/s11356-018-3933-7","article-title":"Several environmental endocrine disruptors in beverages from South China: occurrence and human exposure","volume":"26","author":"Wu","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2023.115030_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105659","article-title":"Prenatal NO2 exposure and neurodevelopmental disorders in offspring mice: Transcriptomics reveals sex-dependent changes in cerebral gene expression","volume":"138","author":"Yan","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2023.115030_bib39","first-page":"145","article-title":"Deciphering the pathways to antiviral innate immunity and inflammation","author":"Yang","year":"2020","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.ecoenv.2023.115030_bib40","article-title":"Bisphenol AF blocks Leydig cell regeneration from stem cells in male rats","volume":"298","author":"Yu","year":"2022","journal-title":"Environ. Pollut. Barking Essex 1987"},{"key":"10.1016\/j.ecoenv.2023.115030_bib41","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/cmi.2014.38","article-title":"Testicular defense systems: immune privilege and innate immunity","volume":"11","author":"Zhao","year":"2014","journal-title":"Cell. Mol. Immunol."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323005341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323005341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:18:08Z","timestamp":1758953888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323005341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":41,"alternative-id":["S0147651323005341"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115030","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal exposure to bisphenol AF induced male offspring reproductive dysfunction by triggering testicular innate and adaptive immune responses","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115030"}}