{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T13:54:27Z","timestamp":1780754067675,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["Z2019010"],"award-info":[{"award-number":["Z2019010"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971405"],"award-info":[{"award-number":["81971405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273662"],"award-info":[{"award-number":["82273662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221307"],"award-info":[{"award-number":["BK20221307"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.ecoenv.2023.115072","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T11:59:42Z","timestamp":1685447982000},"page":"115072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice"],"prefix":"10.1016","volume":"260","author":[{"given":"Yijie","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuqin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ecoenv.2023.115072_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/1098-2795(200012)57:4<384::AID-MRD11>3.0.CO;2-U","article-title":"Fertilization promoting peptide and adenosine, acting as first messengers, regulate cAMP production and consequent protein tyrosine phosphorylation in a capacitation-dependent manner","volume":"57","author":"Adeoya-Osiguwa","year":"2000","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.ecoenv.2023.115072_bib2","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1021\/es0614870","article-title":"Modeling global-scale fate and transport of perfluorooctanoate emitted from direct sources","volume":"40","author":"Armitage","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00204-022-03409-9","article-title":"Applying the adverse outcome pathway concept for assessing non-monotonic dose responses: biphasic effect of bis(2-ethylhexyl) phthalate (DEHP) on testosterone levels","volume":"97","author":"Astuto","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/10408444.2014.952400","article-title":"Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: a systematic review","volume":"45","author":"Bach","year":"2015","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.129585","article-title":"Effects of maternal exposure to PFOA on testes of male offspring mice","volume":"272","author":"Bao","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.115072_bib6","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.2337\/dc18-2254","article-title":"Associations of perfluoroalkyl and polyfluoroalkyl substances with incident diabetes and microvascular disease","volume":"42","author":"Cardenas","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ecoenv.2023.115072_bib7","doi-asserted-by":"crossref","first-page":"20117","DOI":"10.1016\/S0021-9258(17)30477-5","article-title":"Sequence specificity of mRNA N6-adenosine methyltransferase","volume":"265","author":"Csepany","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2023.115072_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.envint.2016.08.026","article-title":"Association between prenatal exposure to perfluorinated compounds and symptoms of infections at age 1\u20134 years among 359 children in the Odense Child Cohort","volume":"96","author":"Dalsager","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2023.115072_bib9","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1210\/jc.2018-01855","article-title":"Endocrine disruption of androgenic activity by perfluoroalkyl substances: clinical and experimental evidence","volume":"104","author":"Di Nisio","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ecoenv.2023.115072_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1289\/EHP303","article-title":"Early-life exposure to perfluoroalkyl substances and childhood metabolic function","volume":"125","author":"Fleisch","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115072_bib11","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s40618-017-0790-z","article-title":"Impact of perfluorochemicals on human health and reproduction: a male's perspective","volume":"41","author":"Foresta","year":"2018","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.ecoenv.2023.115072_bib12","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1093\/nar\/18.19.5735","article-title":"Sequence specificity of the human mRNA N6-adenosine methylase in vitro","volume":"18","author":"Harper","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ecoenv.2023.115072_bib13","first-page":"218","article-title":"Research advances in exposure level of perfluoroalkyl and polyfluoroalkyl substances in human body","volume":"10","author":"Hou","year":"2020","journal-title":"J. Environ. Hyg."},{"key":"10.1016\/j.ecoenv.2023.115072_bib14","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cr.2017.99","article-title":"Ythdc2 is an N-6-methyladenosine binding protein that regulates mammalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.ecoenv.2023.115072_bib15","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/tox.23117","article-title":"Key proteins of proteome underlying sperm malformation of rats exposed to low fenvalerate doses are highly related to P53","volume":"36","author":"Huang","year":"2021","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib16","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.stemcr.2020.09.001","article-title":"WTAP function in sertoli cells is essential for sustaining the spermatogonial stem cell niche","volume":"15","author":"Jia","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ecoenv.2023.115072_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fphys.2020.00051","article-title":"Gestational perfluorooctanoic acid exposure inhibits placental development by dysregulation of labyrinth vessels and uNK cells and apoptosis in mice","volume":"11","author":"Jiang","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-022-00453-2","article-title":"Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR\/cAMP\/PKA\/StAR pathway","volume":"19","author":"Jin","year":"2022","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib19","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.3892\/ijmm.2015.2370","article-title":"Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK","volume":"36","author":"Kim","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ecoenv.2023.115072_bib20","first-page":"17","article-title":"Prenatal exposure to persistent organic pollutants and child overweight\/obesity at 5-year follow-up: a prospective cohort study","author":"Lauritzen","year":"2018","journal-title":"Environ. Health"},{"key":"10.1016\/j.ecoenv.2023.115072_bib21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1095\/biolreprod.108.070367","article-title":"Increased activity of the human sperm tyrosine kinase SRC by the cAMP-dependent pathway in the presence of calcium","volume":"79","author":"Lawson","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ecoenv.2023.115072_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4161\/oxim.1.1.6856","article-title":"Nitric oxide and cyclic nucleotides: their roles in junction dynamics and spermatogenesis","volume":"1","author":"Lee","year":"2008","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2023.115072_bib23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.12701\/yujm.2018.35.2.156","article-title":"Potential health effects of emerging environmental contaminants perfluoroalkyl compounds","volume":"35","author":"Lee","year":"2018","journal-title":"Yeungnam Univ. J. Med."},{"key":"10.1016\/j.ecoenv.2023.115072_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116219","article-title":"Perfluoroalkyl substances in the urine and hair of preschool children, airborne particles in kindergartens, and drinking water in Hong Kong","volume":"270","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2023.115072_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152633","article-title":"Perfluoroheptanoic acid induces Leydig cell hyperplasia but inhibits spermatogenesis in rats after pubertal exposure","volume":"448","author":"Li","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.ecoenv.2023.115072_bib26","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/cr.2017.117","article-title":"Mettl3-\/Mettl14-mediated mRNA N(6)-methyladenosine modulates murine spermatogenesis","volume":"27","author":"Lin","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.ecoenv.2023.115072_bib27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00244-019-00637-6","article-title":"Spatial distribution of perfluorinated compounds in atmosphere of the Pearl River Delta, China","volume":"77","author":"Liu","year":"2019","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.envres.2014.07.006","article-title":"Perfluorooctane sulfonate effects on the reproductive axis in adult male rats","volume":"134","author":"Lopez-Doval","year":"2014","journal-title":"Environ. Res."},{"key":"10.1016\/j.ecoenv.2023.115072_bib29","first-page":"309","article-title":"Reproductive toxicity of polyfluorinated chemicals: a mini review","volume":"38","author":"Ma","year":"2019","journal-title":"J. Int. Reprod. Health"},{"key":"10.1016\/j.ecoenv.2023.115072_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.133864","article-title":"Exposure assessment to parabens, bisphenol A and perfluoroalkyl compounds in children, women and men by hair analysis","volume":"695","author":"Martin","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.115072_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0167-4781(00)00154-8","article-title":"Testis- and developmental stage-specific expression of hnRNP A2\/B1 splicing isoforms, B0a\/b","volume":"1493","author":"Matsui","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ecoenv.2023.115072_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.706352","article-title":"Exposure to perfluoroalkyl chemicals and cardiovascular disease: experimental and epidemiological evidence","volume":"12","author":"Meneguzzi","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib33","doi-asserted-by":"crossref","first-page":"8291","DOI":"10.1021\/acs.est.0c02444","article-title":"Association between prenatal exposure to PFAS and fetal sex hormones: are the short-chain PFAS safer?","volume":"54","author":"Nian","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.reprotox.2017.11.004","article-title":"Male rat exposure to low dose of di(2-ethylhexyl) phthalate during pre-pubertal, pubertal and post-pubertal periods: impact on sperm count, gonad histology and testosterone secretion","volume":"75","author":"Oudir","year":"2018","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib35","doi-asserted-by":"crossref","first-page":"23020","DOI":"10.1074\/jbc.M116.748889","article-title":"N6-methyladenosine sequencing highlights the involvement of mRNA methylation in oocyte meiotic maturation and embryo development by regulating translation in xenopus laevis","volume":"291","author":"Qi","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ecoenv.2023.115072_bib36","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1523\/JNEUROSCI.0608-10.2010","article-title":"Grueneberg ganglion neurons are finely tuned cold sensors","volume":"30","author":"Schmid","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ecoenv.2023.115072_bib37","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijheh.2019.10.003","article-title":"Prenatal exposure to perfluoroalkyl substances and associations with symptoms of attention-deficit\/hyperactivity disorder and cognitive functions in preschool children","volume":"223","author":"Skogheim","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2023.115072_bib38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12958-017-0281-2","article-title":"The Catsper channel and its roles in male fertility: a systematic review","volume":"15","author":"Sun","year":"2017","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib39","doi-asserted-by":"crossref","first-page":"E325","DOI":"10.1073\/pnas.1717794115","article-title":"ALKBH5-dependent m6A demethylation controls splicing and stability of long 3\u2032-UTR mRNAs in male germ cells","volume":"115","author":"Tang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ecoenv.2023.115072_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202100126","article-title":"Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology","volume":"43","author":"Wikramanayake","year":"2021","journal-title":"Bioessays"},{"key":"10.1016\/j.ecoenv.2023.115072_bib41","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1534\/genetics.117.300574","article-title":"Mettl3 mutation disrupts gamete maturation and reduces fertility in zebrafish","volume":"208","author":"Xia","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.ecoenv.2023.115072_bib42","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s00128-016-1954-9","article-title":"The investigation of perfluorinated compounds in surface waters of the Xixi Wetland, Hangzhou, China","volume":"97","author":"Xu","year":"2016","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib43","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/cr.2017.100","article-title":"Mettl3-mediated m(6)A regulates spermatogonial differentiation and meiosis initiation","volume":"27","author":"Xu","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.ecoenv.2023.115072_bib44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.chemosphere.2015.08.079","article-title":"Non-monotonic dose-response effect of bisphenol A on rare minnow Gobiocypris rarus ovarian development","volume":"144","author":"Zhang","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.115072_bib45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrm.2016.132","article-title":"Post-transcriptional gene regulation by mRNA modifications","volume":"18","author":"Zhao","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ecoenv.2023.115072_bib46","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.molcel.2018.01.019","article-title":"N(6)-methyladenosine guides mRNA alternative translation during integrated stress response","volume":"69","author":"Zhou","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ecoenv.2023.115072_bib47","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.envint.2019.03.075","article-title":"Dietary intake, drinking water ingestion and plasma perfluoroalkyl substances concentration in reproductive aged Chinese women","volume":"127","author":"Zhou","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.ecoenv.2023.115072_bib48","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.theriogenology.2011.04.006","article-title":"Aquaporin inhibition changes protein phosphorylation pattern following sperm motility activation in fish","volume":"76","author":"Zilli","year":"2011","journal-title":"Theriogenology"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323005766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323005766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:14:43Z","timestamp":1758953683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323005766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":48,"alternative-id":["S0147651323005766"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115072","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115072"}}