{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:56:00Z","timestamp":1793246160110,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:00:00Z","timestamp":1692403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of The Peoples Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070103"],"award-info":[{"award-number":["82070103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF0710800"],"award-info":[{"award-number":["2022YFF0710800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0703400"],"award-info":[{"award-number":["2021YFF0703400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ecoenv.2023.115393","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T23:27:29Z","timestamp":1692660449000},"page":"115393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["PM2.5 exposure promotes asthma in aged Brown-Norway rats: Implication of multiomics analysis"],"prefix":"10.1016","volume":"263","author":[{"given":"Lianlian","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baicun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisheng","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-2590","authenticated-orcid":false,"given":"Jianguo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ecoenv.2023.115393_bib1","doi-asserted-by":"crossref","first-page":"L337","DOI":"10.1152\/ajplung.00202.2003","article-title":"Airway responsiveness after acute exposure to urban particulate matter 1648 in a DO11.10 murine model","volume":"286","author":"Archer","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115393_bib2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1183\/09031936.00027409","article-title":"Differential gene expression and cytokine production from neutrophils in asthma phenotypes","volume":"35","author":"Baines","year":"2010","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115393_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2017.06.010","article-title":"Distinct asthma phenotypes among older adults with asthma","volume":"6","author":"Baptist","year":"2018","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115393_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.anai.2019.12.015","article-title":"A behavioral intervention can decrease asthma exacerbations in older adults","volume":"124","author":"Baptist","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115393_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2020.01.007","article-title":"The role of lung and gut microbiota in the pathology of asthma","volume":"52","author":"Barcik","year":"2020","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.ecoenv.2023.115393_bib6","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1289\/ehp.9621","article-title":"Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies","volume":"115","author":"Bell","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115393_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40733-015-0015-1","article-title":"Asthma in the elderly patient","volume":"2","author":"Boulet","year":"2016","journal-title":"Asthma Res. Pract."},{"issue":"4","key":"10.1016\/j.ecoenv.2023.115393_bib8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cger.2017.06.005","article-title":"Asthma in the elderly","volume":"33","author":"Braman","year":"2017","journal-title":"Clin. Geriatr. Med."},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115393_bib9","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1021\/acs.est.9b00392","article-title":"Metabolomics of children and adolescents exposed to industrial carcinogenic pollutants","volume":"53","author":"Chen","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.ecoenv.2023.115393_bib10","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1080\/02770903.2021.1989696","article-title":"Autoantibody of interleukin-17A induced by recombinant Mycobacterium smegmatis attenuates airway inflammation in mice with neutrophilic asthma","volume":"59","author":"Chen","year":"2022","journal-title":"J. Asthma: Off. J. Assoc. Care Asthma"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115393_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11882-022-01056-9","article-title":"Understanding the functional role of the microbiome and metabolome in asthma","volume":"23","author":"Cobos-Uribe","year":"2023","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115393_bib12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/JLB.3MR0720-472RR","article-title":"The role of the microbiome and the NLRP3 inflammasome in the gut and lung","volume":"108","author":"Donovan","year":"2020","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115393_bib13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/all.13258","article-title":"Asthma in the elderly and late-onset adult asthma","volume":"73","author":"Dunn","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.ecoenv.2023.115393_bib14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2147\/JAA.S153097","article-title":"Non-eosinophilic asthma: current perspectives","volume":"11","author":"Esteban-Gorgojo","year":"2018","journal-title":"J. Asthma Allergy"},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115393_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/15287394.2010.514235","article-title":"Determining when enhanced pause (Penh) is sensitive to changes in specific airway resistance","volume":"74","author":"Frazer","year":"2011","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115393_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12010066","article-title":"Multi-omics profiling approach to asthma: an evolving paradigm","volume":"12","author":"Gautam","year":"2022","journal-title":"J. Pers. Med."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115393_bib17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/ACI.0000000000000525","article-title":"Outcome measures to be considered on asthma in elderly","volume":"19","author":"Gonzalez-Diaz","year":"2019","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.ecoenv.2023.115393_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.673341","article-title":"Effect of cigarette smoke on gut microbiota: state of knowledge","volume":"12","author":"Gui","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ecoenv.2023.115393_bib19","article-title":"Oxidative stress and inflammatory effects in human lung epithelial A549 cells induced by phenanthrene, fluorene, and their binary mixture","author":"Guo","year":"2020","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115393_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114580","article-title":"The temporal characteristics of the disruption of gut microbiota, serum metabolome, and cytokines by silica exposure in wistar rats","volume":"252","author":"Guo","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115393_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2016.04.037","article-title":"IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation","volume":"139","author":"Hall","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ecoenv.2023.115393_bib22","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.2147\/JAA.S335590","article-title":"PM2.5 aggravated OVA-induced epithelial tight junction disruption through fas associated via death domain-dependent apoptosis in asthmatic mice","volume":"14","author":"He","year":"2021","journal-title":"J. Asthma Allergy"},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115393_bib23","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.4049\/jimmunol.161.9.5054","article-title":"Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels","volume":"161","author":"Hofstra","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ecoenv.2023.115393_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ecoenv.2016.02.003","article-title":"Polycyclic aromatic hydrocarbons (PAHs) and alkylated PAHs in the coastal seawater, surface sediment and oyster from Dalian, Northeast China","volume":"128","author":"Hong","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"34","key":"10.1016\/j.ecoenv.2023.115393_bib25","doi-asserted-by":"crossref","first-page":"43117","DOI":"10.1007\/s11356-020-10243-y","article-title":"Differential time-lag effects of ambient PM(2.5) and PM(2.5)-bound PAHs on asthma emergency department visits","volume":"27","author":"Hsu","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115393_bib26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.chest.2016.10.008","article-title":"Asthma metabolomics and the potential for integrative omics in research and the clinic","volume":"151","author":"Kelly","year":"2017","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115393_bib27","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/gbe\/evx076","article-title":"Comparative genomics of host-symbiont and free-living oceanobacillus species","volume":"9","author":"Kumar Mondal","year":"2017","journal-title":"Genome Biol. Evol."},{"issue":"7","key":"10.1016\/j.ecoenv.2023.115393_bib28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1164\/rccm.200710-1542OC","article-title":"Alterations of the arginine metabolome in asthma","volume":"178","author":"Lara","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.ecoenv.2023.115393_bib29","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/eji.1830230404","article-title":"T and B cell immune response to a 55-kDa endothelial cell-derived antigen in severe asthma","volume":"23","author":"Lassalle","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ecoenv.2023.115393_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2147\/JAA.S288052","article-title":"Impact of annual exposure to polycyclic aromatic hydrocarbons on acute exacerbation frequency in asthmatic patients","volume":"14","author":"Lee","year":"2021","journal-title":"J. Asthma Allergy"},{"issue":"12","key":"10.1016\/j.ecoenv.2023.115393_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224517","article-title":"Macmoondongtang modulates Th1-\/Th2-related cytokines and alleviates asthma in a murine model","volume":"14","author":"Lee","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ecoenv.2023.115393_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149471","article-title":"Impacts of benzo(a)pyrene exposure on scallop (Chlamys farreri) gut health and gut microbiota composition","volume":"799","author":"Li","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.115393_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137432","article-title":"PM2.5 exposure perturbs lung microbiome and its metabolic profile in mice","volume":"721","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115393_bib34","first-page":"7506","article-title":"Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases","volume":"15","author":"Li","year":"2018","journal-title":"Oncol. Lett."},{"issue":"Pt D","key":"10.1016\/j.ecoenv.2023.115393_bib35","article-title":"Arachidonic acid metabolism and inflammatory biomarkers associated with exposure to polycyclic aromatic hydrocarbons","volume":"212","author":"Lin","year":"2022","journal-title":"Environ. Res."},{"issue":"49","key":"10.1016\/j.ecoenv.2023.115393_bib36","doi-asserted-by":"crossref","first-page":"74500","DOI":"10.1007\/s11356-022-20506-5","article-title":"Metabolic profiling disturbance of PM(2.5) revealed by Raman spectroscopy and mass spectrometry-based nontargeted metabolomics","volume":"29","author":"Liu","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ecoenv.2023.115393_bib37","article-title":"PM2.5 exposure and asthma development: the key role of oxidative stress","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ecoenv.2023.115393_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2756147","article-title":"The correlation of PM2.5 exposure with acute attack and steroid sensitivity in asthma","volume":"2022","author":"Luo","year":"2022","journal-title":"Biomed. Res. Int."},{"issue":"2\u20133","key":"10.1016\/j.ecoenv.2023.115393_bib39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ejphar.2008.02.096","article-title":"Arginine homeostasis in allergic asthma","volume":"585","author":"Maarsingh","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115393_bib40","first-page":"527","article-title":"IL-13 and the IL-13 receptor as therapeutic targets for asthma and allergic disease","volume":"11","author":"Mitchell","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"issue":"12","key":"10.1016\/j.ecoenv.2023.115393_bib41","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nri954","article-title":"The lineage decisions of helper T cells","volume":"2","author":"Murphy","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.ecoenv.2023.115393_bib42","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000097357","article-title":"Role of cytokines in allergic airway inflammation","volume":"142","author":"Nakajima","year":"2007","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"4","key":"10.1016\/j.ecoenv.2023.115393_bib43","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3349\/ymj.2009.50.4.569","article-title":"The soluble tumor necrosis factor-alpha receptor suppresses airway inflammation in a murine model of acute asthma","volume":"50","author":"Nam","year":"2009","journal-title":"Yonsei Med. J."},{"issue":"19","key":"10.1016\/j.ecoenv.2023.115393_bib44","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1113\/JP280279","article-title":"Bugs, breathing and blood pressure: microbiota-gut-brain axis signalling in cardiorespiratory control in health and disease","volume":"598","author":"O'Connor","year":"2020","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115393_bib45","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/pupt.2002.0372","article-title":"Anti-immunoglobulin E therapy for asthma","volume":"15","author":"Owen","year":"2002","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"10","key":"10.1016\/j.ecoenv.2023.115393_bib46","first-page":"3700","article-title":"Apigenin attenuates PM2.5-induced airway hyperresponsiveness and inflammation by down-regulating NF-\u03baB in murine model of asthma","volume":"12","author":"Pang","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ecoenv.2023.115393_bib47","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3389\/fimmu.2020.00906","article-title":"The genus alistipes: gut bacteria with emerging implications to inflammation, cancer, and mental health","volume":"11","author":"Parker","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ecoenv.2023.115393_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2147\/JAA.S375325","article-title":"Characteristics of severe non-eosinophilic asthma: analysis of data from 1075 patients included in the FASE-CPHG study","volume":"16","author":"Portel","year":"2023","journal-title":"J. Asthma Allergy"},{"issue":"6","key":"10.1016\/j.ecoenv.2023.115393_bib49","doi-asserted-by":"crossref","first-page":"570","DOI":"10.5588\/ijtld.19.0394","article-title":"The impact of PM2.5 on lung function in adults with asthma","volume":"24","author":"Qibin","year":"2020","journal-title":"Int J. Tube Lung Dis."},{"key":"10.1016\/j.ecoenv.2023.115393_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115987","article-title":"Subchronic exposure to concentrated ambient PM2.5 perturbs gut and lung microbiota as well as metabolic profiles in mice","volume":"272","author":"Ran","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ecoenv.2023.115393_bib51","doi-asserted-by":"crossref","first-page":"31027","DOI":"10.1038\/srep31027","article-title":"Oral exposure to environmental pollutant benzo[a]pyrene impacts the intestinal epithelium and induces gut microbial shifts in murine model","volume":"6","author":"Ribiere","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115393_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/toxics10090497","article-title":"Polycyclic aromatic hydrocarbons (PAHs) exposure triggers inflammation and endothelial dysfunction in BALB\/c mice: a pilot study","volume":"10","author":"Rojas","year":"2022","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2023.115393_bib53","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"Rothenberg","year":"2006","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115393_bib54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12931-021-01619-w","article-title":"Asthma in elderly is characterized by increased sputum neutrophils, lower airway caliber variability and air trapping","volume":"22","author":"Schleich","year":"2021","journal-title":"Respir. Res."},{"issue":"C","key":"10.1016\/j.ecoenv.2023.115393_bib55","article-title":"Multi-omics analysis to reveal disorders of cell metabolism and integrin signaling pathways induced by PM(2.5)","volume":"424","author":"Song","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115393_bib56","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3920\/BM2015.0159","article-title":"Mostarica Stojkovic, M.; Miljkovic, D., Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis","volume":"7","author":"Stanisavljevic","year":"2016","journal-title":"Benef. Microbes"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115393_bib57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaci.2019.05.015","article-title":"Leveraging -omics for asthma endotyping","volume":"144","author":"Tyler","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115393_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11090567","article-title":"Research progress of metabolomics in asthma","volume":"11","author":"Wang","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.ecoenv.2023.115393_bib59","article-title":"Bifidobacterium infantis relieves allergic asthma in mice by regulating Th1\/Th2","volume":"26","author":"Wang","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ecoenv.2023.115393_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2018.02.028","article-title":"Diesel exhaust particles up-regulate interleukin-17A expression via ROS\/NF-\u03baB in airway epithelium","volume":"151","author":"Weng","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"15","key":"10.1016\/j.ecoenv.2023.115393_bib61","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1039\/D1FO00194A","article-title":"Tetrahydrocurcumin alleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota","volume":"12","author":"Wu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.ecoenv.2023.115393_bib62","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fcell.2020.00091","article-title":"The impact of PM(2.5) on the host defense of respiratory system","volume":"8","author":"Yang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115393_bib63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/toxres\/tfac001","article-title":"PM(2.5) induces inflammatory responses via oxidative stress-mediated mitophagy in human bronchial epithelial cells","volume":"11","author":"Zhai","year":"2022","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.ecoenv.2023.115393_bib64","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8841002","article-title":"Diagnosis of asthma based on routine blood biomarkers using machine learning","volume":"2020","author":"Zhan","year":"2020","journal-title":"Comput. Intell. Neurosci."},{"key":"10.1016\/j.ecoenv.2023.115393_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.110995","article-title":"Polycyclic aromatic hydrocarbons (PAHs) in marine organisms from two fishing grounds, South Yellow Sea, China: bioaccumulation and human health risk assessment","volume":"153","author":"Zhang","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.ecoenv.2023.115393_bib66","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fmicb.2020.00301","article-title":"The cross-talk between gut microbiota and lungs in common lung diseases","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115393_bib67","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0394632015627160","article-title":"Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice","volume":"29","author":"Zhang","year":"2016","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115393_bib68","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3164\/jcbn.14-140","article-title":"L-Arginine administration attenuates airway inflammation by altering L-arginine metabolism in an NC\/Nga mouse model of asthma","volume":"56","author":"Zhang","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"8","key":"10.1016\/j.ecoenv.2023.115393_bib69","first-page":"785","article-title":"Ambient PM2.5 exposure exacerbates severity of allergic asthma in previously sensitized mice","volume":"52","author":"Zhang","year":"2015","journal-title":"J. Asthma: Off. J. Assoc. Care Asthma"},{"key":"10.1016\/j.ecoenv.2023.115393_bib70","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chemosphere.2018.05.098","article-title":"Metabolic impact induced by total, water soluble and insoluble components of PM(2.5) acute exposure in mice","volume":"207","author":"Zhang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.ecoenv.2023.115393_bib71","article-title":"Plasma metabolites and gut microbiota are associated with T cell imbalance in BALB\/c model of eosinophilic asthma","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"17","key":"10.1016\/j.ecoenv.2023.115393_bib72","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1007\/s00253-020-10749-y","article-title":"Lactobacillus salivarius LI01 encapsulated in alginate-pectin microgels ameliorates D-galactosamine-induced acute liver injury in rats","volume":"104","author":"Zhuge","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"18","key":"10.1016\/j.ecoenv.2023.115393_bib73","doi-asserted-by":"crossref","first-page":"25010","DOI":"10.18632\/oncotarget.7075","article-title":"Characterization and redox mechanism of asthma in the elderly","volume":"7","author":"Zuo","year":"2016","journal-title":"Oncotarget"}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323008977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323008977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:04:06Z","timestamp":1777489446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323008977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":73,"alternative-id":["S0147651323008977"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115393","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PM2.5 exposure promotes asthma in aged Brown-Norway rats: Implication of multiomics analysis","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115393","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115393"}}