{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:54:20Z","timestamp":1788216860249,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.ecoenv.2023.115532","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:19:13Z","timestamp":1696551553000},"page":"115532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Tim-3 facilitates immune escape in benzene-induced acute myeloid leukemia mouse model by promoting macrophage M2 polarization"],"prefix":"10.1016","volume":"266","author":[{"given":"Qiong","family":"Ning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzi","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longke","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ecoenv.2023.115532_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/molpharm.121.000303","article-title":"The benzene hematotoxic and reactive metabolite 1,4-benzoquinone impairs the activity of the histone methyltransferase SET domain containing 2 (SETD2) and causes aberrant histone H3 Lysine 36 Trimethylation (H3K36me3)","volume":"100","author":"Berthelet","year":"2021","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115532_bib2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ijrobp.2022.06.054","article-title":"Tumor-derived C-C Motif Ligand 2 induces the recruitment and polarization of tumor-associated macrophages and increases the metastatic potential of bladder cancer cells in the postirradiated microenvironment","volume":"114","author":"Chiang","year":"2022","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"7865","key":"10.1016\/j.ecoenv.2023.115532_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41586-021-03626-9","article-title":"TIM-3 restrains anti-tumour immunity by regulating inflammasome activation","volume":"595","author":"Dixon","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115532_bib4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13046-020-01786-6","article-title":"Progranulin induces immune escapein breast cancer via up-regulating PD-L1 expression on tumor-associatedmacrophages (TAMs) and promoting CD8+ T cell exclusion [published correction appears in J Exp Clin Cancer Res. 2022 Mar 12;41(1):93]","volume":"40","author":"Fang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.ecoenv.2023.115532_bib5","doi-asserted-by":"crossref","first-page":"46002","DOI":"10.1289\/EHP4381","article-title":"Association between outdoor air pollution and childhood leukemia: a systematic review and dose-response meta-analysis","volume":"127","author":"Filippini","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115532_bib6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ebiom.2017.07.018","article-title":"The tim-3-galectin-9 secretory pathway is involved in the immune escape of human acute myeloid leukemia cells","volume":"22","author":"Gon\u00e7alves Silva","year":"2017","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115532_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/nyas.12362","article-title":"The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment","volume":"1310","author":"Greim","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115532_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/10408444.2017.1401581","article-title":"Shanghai Health Study (2001-2009): What was learned about benzene health effects?","volume":"48","author":"Gross","year":"2018","journal-title":"Crit. Rev. Toxicol."},{"issue":"7","key":"10.1016\/j.ecoenv.2023.115532_bib9","first-page":"760","article-title":"[Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K\/AKT\/mTOR pathway]","volume":"39","author":"Hao","year":"2019","journal-title":"Nan Fang. Yi Ke Da Xue Xue Bao"},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115532_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109955","article-title":"Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors","volume":"37","author":"He","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.ecoenv.2023.115532_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.toxlet.2022.08.002","article-title":"DNA damage, DNA repair gene expression,and topoisomerase II\u03b1 activity in CD-1 mice following in utero benzeneexposure","volume":"368","author":"Holmes","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ecoenv.2023.115532_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119928","article-title":"High expression of HIF-1\u03b1 alleviates benzene-induced hematopoietic toxicity and immunosuppression in mice","volume":"311","author":"Huang","year":"2022","journal-title":"Environ. Pollut."},{"issue":"158","key":"10.1016\/j.ecoenv.2023.115532_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.envres.2017.06.015","article-title":"Benzene and childhood acute leukemia in Oklahoma [published correction appears in Environ Res. 2018 Mar 7]","author":"Janitz","year":"2017","journal-title":"Environ. Res."},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115532_bib14","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1211219","article-title":"Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis","volume":"5","author":"Jiang","year":"2016","journal-title":"Oncoimmunology"},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115532_bib15","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1111\/cas.15042","article-title":"TIM-3 in normal and malignant hematopoiesis: structure, function, and signaling pathways","volume":"112","author":"Kikushige","year":"2021","journal-title":"Cancer Sci."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115532_bib16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.stem.2015.07.011","article-title":"A TIM-3\/Gal-9 autocrine stimulatory loop drives self-renewal of human myeloid leukemia stem cells and leukemic progression","volume":"17","author":"Kikushige","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115532_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1744-313X.2009.00832.x","article-title":"Decreased T-cell receptor excision DNA circles in peripheral blood mononuclear cells among benzene-exposed workers","volume":"36","author":"Li","year":"2009","journal-title":"Int. J. Immunogenet."},{"issue":"10","key":"10.1016\/j.ecoenv.2023.115532_bib18","first-page":"6880","article-title":"Tim-3 is highly expressed in T cells in acute myeloid leukemia and associated with clinicopathological prognostic stratification","volume":"7","author":"Li","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115532_bib19","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41419-022-04899-2","article-title":"Tim-3+ decidual M\u03c6s induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenancevia CD132","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.ecoenv.2023.115532_bib20","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/S1470-2045(17)30832-X","article-title":"Carcinogenicity of benzene","volume":"18","author":"Loomis","year":"2017","journal-title":"Lancet Oncol."},{"issue":"6","key":"10.1016\/j.ecoenv.2023.115532_bib21","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.gendis.2022.05.020","article-title":"A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)","volume":"10","author":"Lv","year":"2023","journal-title":"GENES Dis."},{"key":"10.1016\/j.ecoenv.2023.115532_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.envres.2014.11.003","article-title":"Early hematological and immunological alterations in gasoline station attendants exposed to benzene","volume":"137","author":"Moro","year":"2015","journal-title":"Environ. Res"},{"issue":"11","key":"10.1016\/j.ecoenv.2023.115532_bib23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"27","key":"10.1016\/j.ecoenv.2023.115532_bib24","doi-asserted-by":"crossref","first-page":"eabl5165","DOI":"10.1126\/sciadv.abl5165","article-title":"Interrogating glioma-M2 macrophage interactions identifies Gal-9\/Tim-3 as a viable target against PTEN-null glioblastoma","volume":"8","author":"Ni","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ecoenv.2023.115532_bib25","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. alternatively activated macrophages [published correction appears in front immunol. 2020 Feb 25;11:234]","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.ecoenv.2023.115532_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biocel.2014.11.017","article-title":"The immune receptor Tim-3 mediates activation of PI3 kinase\/mTOR and HIF-1 pathways in human myeloid leukaemia cells","volume":"59","author":"Prokhorov","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115532_bib27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41590-022-01145-x","article-title":"PERK is a critical metabolic hub for immunosuppressive function in macrophages","volume":"23","author":"Raines","year":"2022","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115532_bib28","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/0008-5472.CAN-19-2374","article-title":"The immunosuppressive microenvironment in BRCA1-IRIS-overexpressing TNBC tumors is induced by bidirectional interaction with tumor-associated macrophages","volume":"80","author":"Sami","year":"2020","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.ecoenv.2023.115532_bib29","doi-asserted-by":"crossref","first-page":"9298","DOI":"10.3390\/ijerph120809298","article-title":"Altered expression of genes in signaling pathways regulating proliferation of hematopoietic stem and progenitor cells in mice with subchronic benzene exposure","volume":"12","author":"Sun","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115532_bib30","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1158\/0008-5472.CAN-19-2332","article-title":"Tim-3 hampers tumor surveillance of liver-resident and conventional NK cells by disrupting PI3K signaling","volume":"80","author":"Tan","year":"2020","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115532_bib31","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13046-020-01676-x","article-title":"Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway","volume":"39","author":"Tao","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"16","key":"10.1016\/j.ecoenv.2023.115532_bib32","doi-asserted-by":"crossref","first-page":"13885","DOI":"10.1007\/s11356-016-6366-1","article-title":"Association ofexposure to benzene and smoking with oxidative damage to nucleic acids by means of biological monitoring of general population volunteers","volume":"24","author":"Tranfo","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"12","key":"10.1016\/j.ecoenv.2023.115532_bib33","first-page":"917","article-title":"Impact of enterprise ownership and size on registered hematotoxicity in benzene-exposed workers","volume":"31","author":"Wang","year":"2018","journal-title":"Biomed. Environ. Sci."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115532_bib34","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/10428194.2021.1966785","article-title":"Prognostic significance of TIM-3 expression pattern at diagnosis in patients with t(8;21) acute myeloid leukemia","volume":"63","author":"Wang","year":"2022","journal-title":"Leuk. Lymphoma"},{"issue":"14","key":"10.1016\/j.ecoenv.2023.115532_bib35","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.3390\/molecules27144416","article-title":"The regulating effect of CII-3 and its active components from periplaneta americana on M1\/M2 macrophage polarization","volume":"27","author":"Xu","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115532_bib36","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/s41467-021-21099-2","article-title":"Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy","volume":"12","author":"Yang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ecoenv.2023.115532_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.toxlet.2023.01.005","article-title":"Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes","volume":"376","author":"Yang","year":"2023","journal-title":"Toxicol. Lett."},{"issue":"19","key":"10.1016\/j.ecoenv.2023.115532_bib38","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1182\/blood.2021011557","article-title":"The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13","volume":"138","author":"Zanetti","year":"2021","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115532_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7150\/thno.36930","article-title":"Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K\/AKT\/GSK3\u03b2\/\u03b2-catenin pathway","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ecoenv.2023.115532_bib40","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.2147\/DDDT.S75976","article-title":"Induction of apoptosis and autophagy via sirtuin1- and PI3K\/Akt\/mTOR-mediated pathways by plumbagin in human prostate cancer cells [retracted in: Drug Des Devel Ther. 2022 Jul 29;16:2437-2438]","volume":"9","author":"Zhou","year":"2015","journal-title":"Drug Des. Dev. Ther."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323010369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323010369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:17:18Z","timestamp":1758953838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323010369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":40,"alternative-id":["S0147651323010369"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115532","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tim-3 facilitates immune escape in benzene-induced acute myeloid leukemia mouse model by promoting macrophage M2 polarization","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115532","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115532"}}