{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:17:15Z","timestamp":1782623835466,"version":"3.54.5"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ecotoxicology and Environmental Safety"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ecoenv.2023.115727","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T10:22:51Z","timestamp":1701512571000},"page":"115727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The role of estrogen receptors (ERs)-Notch pathway in thyroid toxicity induced by Di-2-ethylhexyl phthalate (DEHP) exposure: Population data and in vitro studies"],"prefix":"10.1016","volume":"269","author":[{"given":"Xueting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ecoenv.2023.115727_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21062138","article-title":"Hericium erinaceus prevents DEHP-induced mitochondrial dysfunction and apoptosis in PC12 cells","volume":"21","author":"Amara","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115727_bib2","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.fct.2011.05.013","article-title":"A twenty-volunteer study using deuterium labelling to determine the kinetics and fractional excretion of primary and secondary urinary metabolites of di-2-ethylhexylphthalate and di-iso-nonylphthalate","volume":"49","author":"Anderson","year":"2011","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115727_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0668.2010.00684.x","article-title":"Organophosphate and phthalate esters in air and settled dust - a multi-location indoor study","volume":"21","author":"Bergh","year":"2011","journal-title":"Indoor Air"},{"key":"10.1016\/j.ecoenv.2023.115727_bib4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.envint.2013.07.012","article-title":"Urinary concentrations of environmental contaminants and phytoestrogens in adults in Israel","volume":"59","author":"Berman","year":"2013","journal-title":"Environ. Int"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115727_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mrrev.2012.03.001","article-title":"DEHP: genotoxicity and potential carcinogenic mechanisms-a review","volume":"751","author":"Caldwell","year":"2012","journal-title":"Mutat. Res."},{"issue":"24","key":"10.1016\/j.ecoenv.2023.115727_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232416012","article-title":"Exposure to endocrine disruptors (Di(2-Ethylhexyl)phthalate (DEHP) and bisphenol A (BPA)) in women from different residing areas in Italy: data from the LIFE PERSUADED project","volume":"23","author":"Carli","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ecoenv.2023.115727_bib7","article-title":"Estimated daily intake and cumulative risk assessment of phthalates in the general taiwanese after the 2011 DEHP food scandal","volume":"7","author":"Chang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ecoenv.2023.115727_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147371","article-title":"The effects of phthalate ester exposure on human health: a review","volume":"786","author":"Chang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.ecoenv.2023.115727_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.reprotox.2021.10.011","article-title":"Weighted gene coexpression network analysis reveals ESR1, FLNA and Furin as hub genes for DEHP-induced prepubertal testicular injury","volume":"106","author":"Chen","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ecoenv.2023.115727_bib10","article-title":"Role of estrogen receptors in health and disease","volume":"13","author":"Chen","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ecoenv.2023.115727_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144173","article-title":"Levels and determinants of urinary phthalate metabolites in Chinese community-dwelling older adults","volume":"762","author":"Cheng","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115727_bib12","doi-asserted-by":"crossref","first-page":"8116","DOI":"10.1080\/21655979.2021.1985341","article-title":"Angiopoietin-2 silence alleviates lipopolysaccharide-induced inflammation, barrier dysfunction and endoplasmic reticulum stress of intestinal epithelial cells by blocking Notch signaling pathway","volume":"12","author":"Dai","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.ecoenv.2023.115727_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106795","article-title":"Association of phthalate exposure with thyroid function during pregnancy","volume":"157","author":"Derakhshan","year":"2021","journal-title":"Environ. Int"},{"issue":"10","key":"10.1016\/j.ecoenv.2023.115727_bib14","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1111\/j.1349-7006.2011.02017.x","article-title":"Overexpression of estrogen receptor-\u03b1 in human papillary thyroid carcinomas studied by laser- capture microdissection and molecular biology","volume":"102","author":"Di Vito","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ecoenv.2023.115727_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109541","article-title":"Urinary levels of phthalate metabolites and their association with lifestyle behaviors in Chinese adolescents and young adults","volume":"183","author":"Ding","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115727_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19052702","article-title":"Distribution dynamics of phthalate esters in surface water and sediment of the middle-lower Hanjiang River, China","volume":"19","author":"Dong","year":"2022","journal-title":"Int. J. Environ. Res Public Health"},{"issue":"44","key":"10.1016\/j.ecoenv.2023.115727_bib17","doi-asserted-by":"crossref","first-page":"18178","DOI":"10.1074\/jbc.M117.790121","article-title":"Estrogen receptor \u03b2-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor \u03b1 (TNF\u03b1)-induced apoptosis","volume":"292","author":"Fortini","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115727_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijheh.2019.10.002","article-title":"Changes in urinary excretion of phthalates, phthalate substitutes, bisphenols and other polychlorinated and phenolic substances in young Danish men; 2009-2017","volume":"223","author":"Frederiksen","year":"2020","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.ecoenv.2023.115727_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106218","article-title":"Incidence of uterine leiomyoma in relation to urinary concentrations of phthalate and phthalate alternative biomarkers: a prospective ultrasound study","volume":"147","author":"Fruh","year":"2021","journal-title":"Environ. Int"},{"issue":"Pt A","key":"10.1016\/j.ecoenv.2023.115727_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.scitotenv.2015.11.005","article-title":"Phthalate metabolites in urine of Chinese young adults: concentration, profile, exposure and cumulative risk assessment","volume":"543","author":"Gao","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.ecoenv.2023.115727_bib21","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1089\/thy.2010.0444","article-title":"Delta-like 4\/Notch pathway is differentially regulated in benign and malignant thyroid tissues","volume":"21","author":"Geers","year":"2011","journal-title":"Thyroid"},{"key":"10.1016\/j.ecoenv.2023.115727_bib22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.envint.2017.12.016","article-title":"Multi-pathway human exposure assessment of phthalate esters and DINCH","volume":"112","author":"Giovanoulis","year":"2018","journal-title":"Environ. Int"},{"key":"10.1016\/j.ecoenv.2023.115727_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152734","article-title":"Role of estrogen receptor alpha in MEHP-induced proliferation and invasion of SH-SY5Y cells","volume":"453","author":"Guo","year":"2021","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115727_bib24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/onc.2009.323","article-title":"Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells","volume":"29","author":"Hao","year":"2010","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.ecoenv.2023.115727_bib25","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1111\/jcmm.13882","article-title":"STAT1 facilitates oestrogen receptor \u03b1 transcription and stimulates breast cancer cell proliferation","volume":"22","author":"Hou","year":"2018","journal-title":"J. Cell Mol. Med"},{"issue":"8","key":"10.1016\/j.ecoenv.2023.115727_bib26","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2166\/wh.2022.140","article-title":"Endocrine-disruptor endpoints in the ovary and thyroid of adult female rats exposed to realistic doses of di-(2-ethylhexyl) phthalate","volume":"20","author":"Jebara","year":"2022","journal-title":"J. Water Health"},{"key":"10.1016\/j.ecoenv.2023.115727_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.envint.2015.08.005","article-title":"Exposure assessment issues in epidemiology studies of phthalates","volume":"85","author":"Johns","year":"2015","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115727_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19020626","article-title":"Profile of Environmental Chemicals in the Korean Population-Results of the Korean National Environmental Health Survey (KoNEHS) Cycle 3, 2015-2017","volume":"19","author":"Jung","year":"2022","journal-title":"Int J. Environ. Res Public Health"},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115727_bib29","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/01.MP.0000066800.44492.1B","article-title":"Estrogen receptors (alpha and beta) and 17beta-hydroxysteroid dehydrogenase type 1 and 2 in thyroid disorders: possible in situ estrogen synthesis and actions","volume":"16","author":"Kawabata","year":"2003","journal-title":"Mod. Pathol."},{"issue":"7","key":"10.1016\/j.ecoenv.2023.115727_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00204-004-0642-4","article-title":"New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP","volume":"79","author":"Koch","year":"2005","journal-title":"Arch. Toxicol."},{"issue":"12","key":"10.1016\/j.ecoenv.2023.115727_bib31","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s00204-012-0908-1","article-title":"Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses","volume":"86","author":"Koch","year":"2012","journal-title":"Arch. Toxicol."},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115727_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00204-003-0522-3","article-title":"Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP","volume":"78","author":"Koch","year":"2004","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115727_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2605.2009.01047.x","article-title":"Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessment","volume":"33","author":"Kortenkamp","year":"2010","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.ecoenv.2023.115727_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134053","article-title":"Prenatal and childhood phthalate exposure and attention deficit hyperactivity disorder traits in child temperament: a 12-year follow-up birth cohort study","volume":"699","author":"Ku","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.ecoenv.2023.115727_bib35","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/s41388-018-0562-z","article-title":"Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer","volume":"38","author":"Kumar","year":"2019","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.ecoenv.2023.115727_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/toxics9080193","article-title":"Review on toxic effects of Di(2-ethylhexyl) phthalate on zebrafish embryos","volume":"9","author":"Kwan","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.ecoenv.2023.115727_bib37","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.scitotenv.2018.08.294","article-title":"Nine phthalate metabolites in human urine for the comparison of health risk between population groups with different water consumptions","volume":"649","author":"Li","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115727_bib38","article-title":"Modeling human thyroid development by fetal tissue-derived organoid culture","volume":"9","author":"Liang","year":"2022","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"16","key":"10.1016\/j.ecoenv.2023.115727_bib39","doi-asserted-by":"crossref","first-page":"12711","DOI":"10.1007\/s11356-015-4567-7","article-title":"DEHP reduces thyroid hormones via interacting with hormone synthesis-related proteins, deiodinases, transthyretin, receptors, and hepatic enzymes in rats","volume":"22","author":"Liu","year":"2015","journal-title":"Environ. Sci. Pollut. Res Int"},{"key":"10.1016\/j.ecoenv.2023.115727_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/1195149","article-title":"Notch signaling pathway promotes Th17 cell differentiation and participates in thyroid autoimmune injury in experimental autoimmune thyroiditis mice","volume":"2023","author":"Liu","year":"2023","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115727_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000505496","article-title":"Thyroid carcinoma: do we need to treat men and women differently?","volume":"36","author":"Lorenz","year":"2020","journal-title":"Visc. Med"},{"issue":"4","key":"10.1016\/j.ecoenv.2023.115727_bib42","first-page":"239","article-title":"Estrogen and thyroid diseases: an update","volume":"107","author":"Lu","year":"2016","journal-title":"Minerva Med"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115727_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40618-017-0715-x","article-title":"Role of Jagged1-Notch pathway in thyroid development","volume":"41","author":"Marelli","year":"2018","journal-title":"J. Endocrinol. Invest"},{"issue":"6","key":"10.1016\/j.ecoenv.2023.115727_bib44","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1289\/ehp.8663","article-title":"Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance","volume":"114","author":"Marsee","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ecoenv.2023.115727_bib45","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jare.2020.08.010","article-title":"Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor \u03b1-mediated autophagy","volume":"28","author":"Meng","year":"2021","journal-title":"J. Adv. Res"},{"issue":"3","key":"10.1016\/j.ecoenv.2023.115727_bib46","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10549-017-4442-y","article-title":"BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-\u03b1 occupancy in the IKKB promoter and inhibits NF-\u03baB activity in antiestrogen-resistant human breast cancer cells","volume":"166","author":"Nathan","year":"2017","journal-title":"Breast Cancer Res Treat."},{"issue":"6","key":"10.1016\/j.ecoenv.2023.115727_bib47","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/bpa.12343","article-title":"Targeting Notch signaling and autophagy increases cytotoxicity in glioblastoma neurospheres","volume":"26","author":"Natsumeda","year":"2016","journal-title":"Brain Pathol."},{"issue":"16","key":"10.1016\/j.ecoenv.2023.115727_bib48","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s40265-020-01394-w","article-title":"Targeting the PI3K\/AKT\/mTOR pathway in hormone-positive breast cancer","volume":"80","author":"Nunnery","year":"2020","journal-title":"Drugs"},{"issue":"Suppl 4","key":"10.1016\/j.ecoenv.2023.115727_bib49","article-title":"Hesperetin activates the Notch1 signaling cascade, causes apoptosis, and induces cellular differentiation in anaplastic thyroid cancer","volume":"21","author":"Patel","year":"2014","journal-title":"Ann. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.ecoenv.2023.115727_bib50","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3109\/10799893.2014.959592","article-title":"Estrogen-related receptor alpha and mitochondria: tale of the titans","volume":"35","author":"Ranhotra","year":"2015","journal-title":"J. Recept Signal Transduct. Res"},{"key":"10.1016\/j.ecoenv.2023.115727_bib51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.envpol.2013.06.041","article-title":"Concentrations and geographic distribution of selected organic pollutants in Scottish surface soils","volume":"182","author":"Rhind","year":"2013","journal-title":"Environ. Pollut."},{"issue":"13","key":"10.1016\/j.ecoenv.2023.115727_bib52","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.1158\/0008-5472.CAN-07-5744","article-title":"Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches","volume":"68","author":"Rizzo","year":"2008","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115727_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-019-0367-x","article-title":"Estrogen receptor \u03b1-NOTCH1 axis enhances basal stem-like cells and epithelial-mesenchymal transition phenotypes in prostate cancer","volume":"17","author":"Shen","year":"2019","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.ecoenv.2023.115727_bib54","article-title":"Intrauterine exposure to di(2-ethylhexyl) phthalate (DEHP) disrupts the function of the hypothalamus-pituitary-thyroid axis of the F1 rats during adult life","volume":"13","author":"Sousa-Vidal","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"Pt 1","key":"10.1016\/j.ecoenv.2023.115727_bib55","article-title":"Estimated daily intake of phthalates, parabens, and bisphenol A in hospitalised very low birth weight infants","volume":"309","author":"Str\u00f8mmen","year":"2022","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.ecoenv.2023.115727_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098356","article-title":"Serelaxin Alleviates Fibrosis in Thyroid-Associated Ophthalmopathy via the Notch Pathway","volume":"24","author":"Sun","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115727_bib57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1507\/endocrj.EJ17-0272r","article-title":"Effect of Di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-thyroid axis in adolescent rat","volume":"69","author":"Sun","year":"2022","journal-title":"Endocr. J."},{"key":"10.1016\/j.ecoenv.2023.115727_bib58","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.chemosphere.2018.12.155","article-title":"Positive association of low-level environmental phthalate exposure with sperm motility was mediated by DNA methylation: a pilot study","volume":"220","author":"Tian","year":"2019","journal-title":"Chemosphere"},{"issue":"18","key":"10.1016\/j.ecoenv.2023.115727_bib59","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1080\/14767058.2019.1569613","article-title":"Phthalate exposure in pregnant women and the influence of exposure to environmental tobacco smoke","volume":"33","author":"Wang","year":"2020","journal-title":"J. Matern Fetal Neonatal Med"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115727_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/toxics7020021","article-title":"A review of biomonitoring of phthalate exposures","volume":"7","author":"Wang","year":"2019","journal-title":"Toxics"},{"issue":"2","key":"10.1016\/j.ecoenv.2023.115727_bib61","first-page":"504","article-title":"Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated PI3K\/AKT signaling in the regulation of endometrial cancer cell proliferation","volume":"27","author":"Wei","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ecoenv.2023.115727_bib62","doi-asserted-by":"crossref","DOI":"10.1136\/jmg-2022-108866","article-title":"Pathogenic variations in MAML2 and MAMLD1 contribute to congenital hypothyroidism due to dyshormonogenesis by regulating the Notch signalling pathway","author":"Wu","year":"2023","journal-title":"J. Med Genet"},{"issue":"4","key":"10.1016\/j.ecoenv.2023.115727_bib63","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.11930","article-title":"Novel insights into di\u2011(2\u2013ethylhexyl)phthalate activation: implications for the hypothalamus\u2011pituitary\u2011thyroid axis","volume":"23","author":"Wu","year":"2021","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.ecoenv.2023.115727_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114496","article-title":"Bisphenol A and Di(2-Ethylhexyl) phthalate promote pulmonary carcinoma in female rats via estrogen receptor beta: in vivo and in silico analysis","volume":"250","author":"Xiao","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ecoenv.2023.115727_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.104007","article-title":"Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: an in vitro mechanistic investigation","volume":"96","author":"Xu","year":"2022","journal-title":"Environ. Toxicol. Pharm."},{"issue":"1","key":"10.1016\/j.ecoenv.2023.115727_bib66","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/JOE-13-0029","article-title":"Oestrogen action on thyroid progenitor cells: relevant for the pathogenesis of thyroid nodules?","volume":"218","author":"Xu","year":"2013","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ecoenv.2023.115727_bib67","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.biopha.2016.11.043","article-title":"Estrogen and thyroid cancer is a stem affair: a preliminary study","volume":"85","author":"Zane","year":"2017","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.ecoenv.2023.115727_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118106","article-title":"Phthalate metabolites: characterization, toxicities, global distribution, and exposure assessment","volume":"291","author":"Zhang","year":"2021","journal-title":"Environ. Pollut."},{"issue":"13","key":"10.1016\/j.ecoenv.2023.115727_bib69","doi-asserted-by":"crossref","first-page":"19081","DOI":"10.1007\/s11356-021-16909-5","article-title":"The associations of urinary DEHP metabolite levels, serum thyroid hormones, and thyroid-related genes among the adolescent students from China: a cross-sectional study","volume":"29","author":"Zhao","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."}],"container-title":["Ecotoxicology and Environmental Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323012319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147651323012319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:21:56Z","timestamp":1758954116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147651323012319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":69,"alternative-id":["S0147651323012319"],"URL":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115727","relation":{},"ISSN":["0147-6513"],"issn-type":[{"value":"0147-6513","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of estrogen receptors (ERs)-Notch pathway in thyroid toxicity induced by Di-2-ethylhexyl phthalate (DEHP) exposure: Population data and in vitro studies","name":"articletitle","label":"Article Title"},{"value":"Ecotoxicology and Environmental Safety","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ecoenv.2023.115727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115727"}}